• 생약학회지
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• 제13권3호
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• pp.116-121
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• 1982

In order to investigate the side-effects of crude drugs, twenty drugs have been tested for the teratogenic effect in rats. Among seven drugs contained alkaloid as their ingredients, no one showed teratogenic effect, but Veratri rhizoma showed embryo-toxic as revealed by severe retardation in growth of the fetuses. The other thirteen drugs which have been used freguently in oriental medicines exhibited no teratogenic effect. Cyclophosphamide used as a reference compound showed severe malformation and retardation in the growth of rat fetuses. These findings suggest that the drug extracts adopted for the study might have no teratogenic effect in the rats.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6831-6839
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• 2015

Multidrug resistance is a principal mechanism by which tumors become resistant to structurally and functionally unrelated anticancer drugs. Resistance to chemotherapy has been correlated with overexpression of p-glycoprotein (p-gp), a member of the ATP-binding cassette (ABC) superfamily of membrane transporters. P-gp mediates resistance to a broad-spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively expelling the drugs from cells. Use of specific inhibitors/blocker of p-gp in combination with clinically important anticancer drugs has emerged as a new paradigm for overcoming multidrug resistance. The aim of this paper is to review p-gp regulation by dietary nutraceuticals and to correlate this dietary nutraceutical induced-modulation of p-gp with activity of anticancer drugs.

• 생약학회지
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• 제11권1호
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• pp.7-10
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• 1980

Antitumor activity test was achieved with 20 crude drugs which are folkmedicine and recorded in Dong-eu-bo-gam. Three crude drugs showed above 60% effect on life span of mouse and 5 crude drugs showed under 50% effect. After death, body weight was decreased with 3 crude drugs and increased with most other crude drugs, which were tested in this study. The solid cancer tissue weight was decreased slightly with 4 crude drugs.

• 생약학회지
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• 제3권4호
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• pp.199-204
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• 1972

A new physico-chemical method for identifying botanical drugs was investigated. Fifty drugs were chosen from the presently exported botanical drugs and were classified into 12 groups chemotaxonomically. Various extract(either, 50% ethanol and water) of each group were developed with same solvent system by using chromatographic method(TLC) and observed a characteristic pattern of each drugs. This method, therefore, can be applicable to identify each botanical drug out of the combined phyto-preparations.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.113-125
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• 1994

Many types of drugs affect functions of tile gastrointestinal tract. Investigators may be interested in discovery or pharmacological characterization of drugs as therapeutic agents intended for treatment of gastrointestinal disorders or in identification of gastrointestinal side effects of drugs intended for non-gastrointestinal indications. Examples of drug categories often associated with significant gastrointestinal side effects include cardiovascular drugs, antibiotics (erythromycin in particular), anti-inflammatory drugs, antiemetics, analgesics (especially opiates), antihistamines, antidepressants, and antipsychotics. Whether tile objective is development of gastrointestinal therapeutic agents or evaluation of gastrointestinal side effects, appropriate laboratory models for experimentation are essential.

• Biomolecules & Therapeutics
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• 제5권1호
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• pp.8-11
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• 1997

The odor theory (기미론) has been defined as the Nature (기) and the Taste(미) of traditional herbal medicine to find the logic in treatment of various diseases by them. There is a strong possibility these Na1ures of the drug can be categorized according to yin (음) and yang (음). There is a neutral Nature which does not fit into one of these four categories. To understand the Natures of traditional herbal drugs in modern scientific approaches, changes in rectal temperature of rats have been measured at 0,30, 60, 90 min after a 10 g/Kg oral administration each of 34 different drugs. Following the classification of the four Natures of drugs, only the temperatures of warm group at 30, 60, and 90 min were elevated significantly from the control and the rest groups. Following a modified classification of 3 groups such as cold and cool, warm and hot, and neutral Nature, changes in temperatures after administration of Hot and Warm drugs were also increased significantly from the control (P<0.01). Thus, the measurement of rectal temperature can be a tool to define the Nature (기) of traditional herbal drugs, but the modified classification is another way to do.

• Fisheries and Aquatic Sciences
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• 제22권12호
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• pp.29.1-29.7
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• 2019

Veterinary drugs are widely used to protect production-related diseases and promote the growth of farmed fish. The use of large amounts of veterinary drugs may have potential risk and cause adverse effects on both humans and the environment. In this study, we developed risk-based ranking based on a scoring system to be applied in the national residue program. In this approach, the following three factors of veterinary drugs that may occur as residues in fishery products were considered: potency (acceptable daily intake), usage (number of dose and withdrawal period), and residue occurrence. The overall ranking score was calculated using the following equation: potency × usage (sum of the number of sales and withdrawal period) × residue occurrence. The veterinary drugs that were assigned high score by applying this approach were enrofloxacin, amoxicillin, oxolinic acid, erythromycin, and trimethoprim. The risk-based approach for monitoring veterinary drugs can provide a reliable inspection priority in fishery products. The developed ranking system can be applied in web-based systems and residuemonitoring programs and to ensure safe management of fishery products in Korea.

• 의료커뮤니케이션
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• 제13권2호
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• pp.185-193
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• 2018

Background: Nursing college students are exposed to information about diseases or drugs, and are likely to have a distorted perception of drug knowledge or behavior. The study aimed to identify knowledge and attitude about drugs and current status of self-medication among nursing students. Methods: The subjects were 172 nursing students from a university in Busan. Data were collected with structured questionnaires and analyzed using descriptive analysis, t-test, and one-way ANOVA using SPSS 23.0. Results: Nursing students had a high level of knowledge about drugs, but attitudes toward drugs were relatively low. 83.7% of patients had experience of self-medication. The methods to acquire information for self-administration were 29.9% by smart phone and 27.1% by internet. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) among self-medication drugs was the highest. The most common reason for self-medication was 'I thought it to be a mild disease', and the pharmacists were the most affected by choice of self-medication. The knowledge about drugs was statistically significant according to grade, school life satisfaction and subjective health status. The attitudes about medication were statistically significant according to grade and self-medication experience. Conclusion: Nursing college students need drug safety education to improve awareness and practice of correct drug use.

• 대한수의학회지
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• 제38권1호
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• pp.129-132
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• 1998

Avian coccidiosis is a very important disease of poultry industry. In recent years, many researchers studied for the immunology of avian coccidiosis. Coccidial vaccines have been used at some poultry farms in many countries. In order to evaluate the anticoccidial effects of coccidial vaccine to chicken treated with anticoccidial drugs, 4 week-old chicken were administered anticoccidial drugs and challenged with avian coccidia at 2 weeks after vaccination of coccidia. The body weight gains, lesion scores, oocyst indices and anticoccidial indices of chicken were investigated at the time of vaccination, challenge and necropsy. The body weight gains and feed conversion rates of groups immunized with coccidial vaccine and treated with anticoccidial drugs were moderately higher and lower than those of groups treated with anticoccidial drugs, respectively. The lesion score and oocyst indices of all groups immunized with coccidial vaccine and/or treated with anticoccidial drugs were milder than those of infected control groups. The anticoccidial indices of groups immunized with coccidial vaccine and treated with anticoccidial drugs were moderately higher and lower than those of groups. treated with anticoccidial drugs. But all of the investigated items were not statistically significant.

• 한국가정과교육학회지
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• 제10권2호
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• pp.145-161
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• 1998

The purpose of this study was to survey the actual condition of the Middle School Students on a Drug. In this study, 500 middle school students in Seoul response to a questionnaire which is composed to analyse two categories, i.e. general facts, the actual condition of drug use (the frequency of drug use, the degree of perception on drugs, the people using a drug surrounding the degree of purchase on drugs). And the students are classified by satisfactory degree on their home backgrounds, satisfactory degree on their school life, and school record. The data is analysed by means of frequency, percentage, chi-square test and Pearson's correlation using the $SPSS-PC^+$ package program. The results of this study were as follow : The frequency of drug use except a alcohol and the degree of perception on a drug among female students are higher than among male. The female students are more permissive on the drug use and they are also tend to think more easily the purchase of a drug. The frequency of drug use and the degree of perception on drugs are higher in the group of the lower satisfactory degree on their home background. Especially, there are many people using drugs surrounding the students in the lower group. The frequency of drug use and the degree of perception on drugs are higher in the group that has the lower satisfactory degree on school life. The students in the group having low school record have more dangerous thought about the use of drugs than the students of high record. The degree of perception on a drug is higher in a higher group, and the students in a higher group also think more easily the purchase of drugs. The percentage of students using drugs are not high, but the high percentage of students are interested in the drugs and they have permissive attitudes on drugs. Thus, the preventive education for drug abuse must be done rapidly.