• JSTS:Journal of Semiconductor Technology and Science
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• 제17권1호
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• pp.147-155
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• 2017

A new endurance test-pattern generation on NAND-flash memory is proposed to improve test cost. We mainly focus on the correlation between the data-pattern and the device error-rate during endurance testing. The novelty is the development of testing method using quasi-random pattern based on device architectures in order to increase the test efficiency during time-consuming endurance testing. It has been proven by the experiments using the commercial 32 nm NAND flash-memory. Using the proposed method, the error-rate increases up to 18.6% compared to that of the conventional method which uses pseudo-random pattern. Endurance testing time using the proposed quasi-random pattern is faster than that of using the conventional pseudo-random pattern since it is possible to reach the target error rate quickly using the proposed one. Accordingly, the proposed method provides more low-cost testing solutions compared to the previous pseudo-random testing patterns.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 추계학술대회 초록집
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• pp.88.1-88.1
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• 2010

In recent days, the study for the renewable energy is required to supplement traditional energy source. One of the renewable energy of Fuel Cell is classified according to the electrolytes. It is the MCFC (Molten Carbonate Fuel Cell) for this study. One of the equipments of the heat exchangers is important component for efficiency and cost. In MCFC system, several heat exchangers are used according to the application. It is named for the humidifier because it is to preheat the fuel and water so that a reactor will convert some of the incoming fuel to hydrogen. Then, hot side fluid service is used the exhausted gas from the fuel cell and cold side fluid service is the fuel and water. The operation temperature range is about 25~500 Celsius Degree. This heat exchanger has the problems of heat transfer considering to multiphase fluid and phase changing. So it is necessary to analyze the heat transfer characteristics and to propose the reasonable design methodology for the humidifier. In this study, the thermal characteristic for the humidifier is estimated by using commercial tool of heat exchanger design and rating. And this study provides the testing methodology and presents the results for test facility of fabrication and for testing.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2000년도 전력전자학술대회 논문집
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• pp.10-13
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• 2000

This paper proposes the virtual implementation of solar cell(VISC) for photovoltaic system. It is required to make operation condition of solar cell arrays where is the limit of time and space, The main advantage of the simulator is its ability to simulate different types and sizes of arrays considering V-I characteristics of data sheet. The VISC with buch-boost converter can be used to study the short-term and long-term performances of PV cells. The simulator is a far more cost effective and reliable replacement for field and filight testing.

• Journal of Genetic Medicine
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• 제16권2호
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• pp.76-80
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• 2019

About 15% to 20% of all clinically recognized pregnancies result in spontaneous abortion or miscarriage, and chromosomal anomalies can be identified in up to 50% of first trimester miscarriages. Chromosomal microarray analysis (CMA) is currently considered first-tier testing for detecting fetal chromosomal abnormalities and is supported by the absence of cell culture failure or erroneous results due to cell contamination in pregnancy loss. Triploidy is a lethal chromosome number abnormality characterized by an extra haploid set of chromosomes. Triploidy is one of the most common chromosomal aberrations in first trimester spontaneous abortions. Here, we report two cases of triploidy abortion that were not detected using array comparative genomic hybridization-based CMA. The aim of this report was to remind clinicians of the limitations of chromosomal testing and the misdiagnosis that can result from biased test selection.

• 대한전자공학회논문지
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• 제26권8호
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• pp.1270-1281
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• 1989

This paper presents two new storage schemes of 3-D objects to accelerate the finding of the first intersecting object and the shadow computation steps in ray tracing. The 3-D objects which are potentially intersected with the first reflection (refraction)ray are enrolled within a so called reflection (refraction) frustum' for a polygon object. Only those objects registered in the corres ponding frustum are immediately checked for intersection with the secondary rays emanating from the same polygon. The other is called a shadow pyramid' which contains the candidate objects possibly blocking the path from the relevant light source to any point on the relevant polgon. The shadow testing of a point is performed only against the objects contained in the associated shadow pyramid. Despite the cost needed for registration of objects within frusta or shadow pyramids, the total rendering time of ray tracing using the proposed approaches was reduced by approximately 50% (10% in color rendering time and 70% in shadoe testing time) from the conventional cell 50% (10% in color rendering time and 70% in shadow testing time) from the conventional cell traversal scheme under the 3-D uniform subdivision environment due to the fast finding of candidate objects for intersection and the reduced number of intersection calculations.

• 한국환경보건학회지
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• 제26권4호
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• pp.88-96
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• 2000

The aim of the current study was to evaluate the transport system in EMT-6 cell for the uptake of the methylmercury(MeHg). Several inhibitors ere used to test used to test which potential transport system might be involoved in MeHg uptake. Probenecid was used to test the organic transport system, valinomycin for testing the effect of the membrane potential, cytochalasin B for testing the facilitated diffusive D-glucose transport system and colchicine for testing the microtubule system. Ouabain for evaluating active transport system, 4',4-diisothiocyano-2',2-stilbenedisulfonic acid(DIDS) the Cl- ion transport system and verapamil for the $Ca^{2+}$ transprot system. Significantly, MeHg decreased the synthesis of nitric oxcide(NO) and intracellular ATP in ENT-6 cells. In the condition of ouabain containing with MeHg decreased the production of NO and intracelluar ATP. In the treatment of inhibitors, ouabain showed protective effect against cytotoxicity of MeHg but ather inhibitors not showed protective effects. The protective effects of ouabain against the cytotoxicity of MeHg deoended on the concentration of added ouabain to the culture medium for MET-6 cells. These result showed that the uptake of MeHg might be involved in the active transport system. Active transports system seems to share similarities with the transport systems for the uptake of MeHg when using MeHg and MeHg-glutathione complex.x.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1996년도 봄 학술발표회 논문집
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• pp.348-353
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• 1996

This study addresses the evaluation of the durability of reinforced concrete marine structures subjected to fatigue loading. The laboratory investigation was carried out on full and half size reinforced concrete specimens with three different water cement ratios (0.3, 0.4, and 0.56), static and fatigue loading conditions, and epoxy-coated and regular black steel reinforcements. The marine tidal zone was simulated by alternate filling and draining of the tank (wet and dry cycled), and a galvanostatic corrosion technique to accelerate corrosion of reinforcement was used. Half-cell potentials and changes of crack width were measured periodically during the exposure and followed by ultimate strength testing. The significant findings include adverse effect of fatigue loading, existence of an explicit size effect, poor performance of epoxy coated steel, and negative effect of increasing water/cement ratio.

• Interdisciplinary Bio Central
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• 제1권3호
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• pp.10.1-10.5
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• 2009

Toxicity is usually investigated using a set of standardized animal-based studies which, unfortunately, fail to detect all compounds that induce human adverse events and do not provide detailed mechanistic information of observed toxicity. As an alternative to conventional toxicology, toxicogenomics takes advantage of currently advanced technologies in genomics, proteomics, metabolomics, and bioinformatics to gain a molecular level understanding of toxicity and to enhance the predictive power of toxicity testing in drug development and risk/safety assessment. In addition, there has been a renewed interest, particularly in various government agencies, to prioritize and/or supplement animal testing with a battery of mechanistically informative in vitro assays. This article provides a brief summary of the issues, challenges and lessons learned in these fields and discuss the ways forward to further advance toxicology using these technologies.

• Journal of Genetic Medicine
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• 제11권2호
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• pp.43-48
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• 2014

Chorionic villus sampling has gained importance as a tool for early cytogenetic diagnosis with a shift toward first trimester screening. First trimester screening using nuchal translucency and biomarkers is effective for screening. Chorionic villus sampling generally is performed at 10-12 weeks by either the transcervical or transabdominal approach. There are two methods of analysis; the direct method and the culture method. While the direct method may prevent maternal cell contamination, the culture method may be more representative of the true fetal karyotype. There is a concern for mosaicism which occurs in approximately 1% of cases, and mosaic results require genetic counseling and follow-up amniocentesis or fetal blood sampling. In terms of complications, procedure-related pregnancy loss rates may be the same as those for amniocentesis when undertaken in experienced centers. When the procedure is performed after 9 weeks gestation, the risk of limb reduction is not greater than the risk in the general population. At present, chorionic villus sampling is the gold standard method for early fetal karyotyping; however, we anticipate that improvements in noninvasive prenatal testing methods, such as cell free fetal DNA testing, will reduce the need for invasive procedures in the near future.

• Toxicological Research
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• 제33권2호
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• pp.107-118
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• 2017

Although alternative test methods based on the 3Rs (Replacement, Reduction, Refinement) are being developed to replace animal testing in reproductive and developmental toxicology, they are still in an early stage. Consequently, we aimed to develop alternative test methods in male animals using mouse spermatogonial stem cells (mSSCs). Here, we modified the OECD TG 489 and optimized the in vitro comet assay in our previous study. This study aimed to verify the validity of in vitro tests involving mSSCs by comparing their results with those of in vivo tests using C57BL/6 mice by gavage. We selected hydroxyurea (HU), which is known to chemically induce male reproductive toxicity. The 50% inhibitory concentration ($IC_{50}$) value of HU was 0.9 mM, as determined by the MTT assay. In the in vitro comet assay, % tail DNA and Olive tail moment (OTM) after HU administration increased significantly, compared to the control. Annexin V, PI staining and TUNEL assays showed that HU caused apoptosis in mSSCs. In order to compare in vitro tests with in vivo tests, the same substances were administered to male C57BL/6 mice. Reproductive toxicity was observed at 25, 50, 100, and 200 mg/kg/day as measured by clinical measures of reduction in sperm motility and testicular weight. The comet assay, DCFH-DA assay, H&E staining, and TUNEL assay were also performed. The results of the test with C57BL/6 mice were similar to those with mSSCs for HU treatment. Finally, linear regression analysis showed a strong positive correlation between results of in vitro tests and those of in vivo. In conclusion, the present study is the first to demonstrate the effect of HU-induced DNA damage, ROS formation, and apoptosis in mSSCs. Further, the results of the current study suggest that mSSCs could be a useful model to predict male reproductive toxicity.