Journal of Environmental Health Sciences (한국환경보건학회지)
- Volume 26 Issue 4
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- Pages.88-96
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- 2000
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- 1738-4087(pISSN)
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- 2233-8616(eISSN)
Changes on the Methylmercury-induced Cytotoxicity by Control of Cell Membrane Transport System
세포막 물질수송계의 조절에 의한 유기수은의 세포독성 변화에 대한 연구
Abstract
The aim of the current study was to evaluate the transport system in EMT-6 cell for the uptake of the methylmercury(MeHg). Several inhibitors ere used to test used to test which potential transport system might be involoved in MeHg uptake. Probenecid was used to test the organic transport system, valinomycin for testing the effect of the membrane potential, cytochalasin B for testing the facilitated diffusive D-glucose transport system and colchicine for testing the microtubule system. Ouabain for evaluating active transport system, 4',4-diisothiocyano-2',2-stilbenedisulfonic acid(DIDS) the Cl- ion transport system and verapamil for the