• Journal of the Korean Chemical Society
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• v.62 no.5
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• pp.352-357
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• 2018

Celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) is a cyclooxygenase-2 inhibitor used in the treatment of arthritis, acute pain, and dysmenorrhoea. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Several polymorphs of celecoxib have been identified as Form I, Form II, and Form III with melting points of about $162.8^{\circ}C$, $161.5^{\circ}C$, and $160.8^{\circ}C$, respectively. Form IV was generated from the precipitated suspension in the presence of HPMC (Hydroxypropyl methylcellulose) and Polysorbate 80. A rapid rate of dissolution is useful because the rate of dissolution of a drug typically increases its bioavailability. The aim of this study was to investigate the possibility of production of new crystal form of celecoxib that has higher solubility than Form III. New crystal form of celecoxib (Form A) has been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). Form A was dissolved faster than Form III. At 30 minutes, the dissolution of Form A was 97.3%, whereas the dissolution of Form III was 82.2% (p < 0.1). After storage of three months at $20^{\circ}C$, in 24% RH (Relative Humidity), the crystal form was not transformed.

• Magazine of the Korea Concrete Institute
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• v.7 no.4
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• pp.157-168
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• 1995

The structural performance of Slip-Form system was examined to make use of many advantages of fast construction and high quality c0ncret.e. However, the separate cor~struction of wall and slabs may cause some weaknesses around the wall-slab connection region. Thus, the purpose of the study is to examine the structural performance of wall-type structure constructed by Slip-Form method and to develop an efficient connection system between wall and slabs. In order to investigate the system, 7 wall specimens and 8 wall-slab joint specimens were tested and the experimental results were compared with the design equations and theoretical analysis. A satisfactory performance was obtained from the wall specimen tests. However, wall-slab joint specimens with rebar connection materials I Ilalfen] were shown that. the strength of' wall should be checked during design porocess.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.9
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• pp.609-616
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• 2022

The performance of antenna reflectors crucially depends on the faceting error of the surface. The force density method (FDM) has been widely used for the form-finding analysis of the cable nets of reflectors. However, after performing form-finding of some cable nets, the effective reflective area will decrease. In addition, nonlinear deformations of the cable can not be achieved by using the FDM. Thus, an effective form-find methodology is proposed in this research. The whole parts of the cable networks are described by the absolute nodal coordinate formulation. The form-finding analysis of the reflector with standard configuration is performed to validate the proposed methodology. The influence of boundary condition changes on the configuration accuracy of the cable net is investigated.

• 제어로봇시스템학회:학술대회논문집
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• 1988.10b
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• pp.837-842
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• 1988

We propose a new algorithm to obtain the output feedback controller for power system generators. The performance criterion of this controller is the integral of quadratic form of output differences between reference model and controlled system. With this criterion, we can easily compute the output feedback gains using Astrom's algorithm for the integral calculation of quadratic form. Simulations on a one machine infinite bus system shows the effectiveness of this approach.

• Journal of the Society of Naval Architects of Korea
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• v.49 no.5
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• pp.367-375
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• 2012

In this study, hull form of main vessel of Korean large purse seiner fishing industry is developed for the improvement of resistance performance as well as for the satisfaction to the Standard of Fishing Convention, ILO. Through the modification of reference hull form parameters and local characteristics, the hull form development is carried out. The optimum hull form parameters are searched by Sequential Quadratic Programing(SQP) method with the power estimation method of Holtrop & Mannen. To minimize the wave resistance, bulbous bow parameters are determined by the bulbous bow design method of Alvarino. The plasmatic curve is redesigned from that of the reference hull by using Lackenby method. The resistance performances of the reference and designed hull forms are estimated by using numerical simulation method. Also, the judgment of seakeeping ability and the estimation of intact stability for the designed hull form is carried out. As a result, the optimum hull form is proposed. To verify the improvement of resistance performance, model tests are carried out in towing tank. The results show that the resistance of the designed hull form is about 14% smaller than that of the reference hull from at design speed. A new hull form proposed in this study can contribute to the development of the main vessel hull form of Korean large purse seiner fishing system.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10b
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• pp.95-99
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• 1993

In this paper, we discuss H$_{\infty}$ robust performance problem for uncertain system described in a descriptor form. We show that the method based on Riccati equation can be extended to solve this problem. First, such a sufficient condition is given that the system described in a descriptor form is quadratic stable and H$_{\infty}$ norm of a specified transfer function is less than a given level. Using this result, a state feedback law which ensures H$_{\infty}$ robust performance of closed loop system is derived based on a positive definite solution of a Riccati equation. This result shows that a solution of the problem can be also obtained by solving H$_{\infty}$ standard problem for an extended plant. Finally, a design example and simulation results will be given.ven.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.7
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• pp.65-71
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• 2001

The development process of the polishing system for the aspherical lens mold for opto-electronics industry is described. The system uses the method that polishing tool is scanned on the surface under PC-NC control for the aspherical lens mold. The two axes interpolation of the minimum translation mechanism is applied to give uniform working condition by motion analysis. An aspherical surface is divided into multiple sections and each dwell time is calculated from the polishing rate model based on the Preston equation. As result of form error compensation experiment, initial form error is decreased about 25% while an average value of surface roughness is also reduced successfully from 180nm to 19nm.

• Proceedings of the KIPE Conference
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• 2000.07a
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• pp.748-751
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• 2000

in this paper the design procedure of three phase voltage source inverter output filter is described. The 'd' axis transfer function of the filter output voltage to the load current is described with the capacitor value and the system time constant including the controller. This means that the relation between the filter capacitor value and the system time constant is given as the closed form. By using the above closed form the capacitor value can be calculated with the system time constant is given as the closed,. form the capacitor value can be calculated with the system time constant which can be implemented practically not using the try and error method. And as the effect of the load is connected.

• Journal of the Korean Institute of Intelligent Systems
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• v.8 no.3
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• pp.41-49
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• 1998

Agent, as a independent module, exchanges knowledge & information which are classified to their characteristics according to shared protocol. i.e. Agent Communication Language(AC1,). Fuzzy inference system represents the experiential knowledge as li~~guisticco ntrol rule and enables us to execute the knowledge using fuzzy inference. This study tries connecting fuzzy inference system with agent-based system and inspects applicability to hull form design through inferring principle dimension and hull form coefficients.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2004.11a
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• pp.65-71
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• 2004

The Development of GPS practical using and systematic fixing for GPS Quality Control System on On-Line. Developed the program that can prove GPS quality about GPS permanent observation stations or user GPS data in server client system environment of Web-Based objectively Developed Save-module of graph display of analysis result data and reporter form. Developed the program for making an estimate of GPS satellite information in server client system environment of Web-Based. Designed that the Display can be possible and store estimate result can expresses the form such as Sky Plot, DOPs, Satellite Elevation, satellite number cf predict-time and then the result can be preserved for report form.