• 한국환경보건학회지
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• 제30권2호
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• pp.161-166
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• 2004

The impact of dissolved wastewater constituents on the treatment of synthetic bisphenol A (BPA) solutions was investigated under a variety of reaction conditions. The laccase enzyme from Trametes vesicolor was used for the BPA treatment. The constituents studied included various inorganic salts, organic compounds and heavy metal ions. BPA degradation was inhibited by sulfate, thiosulfate, sulfide, nitrite, and cyanide ions at 25 mg/$\ell$, 100mg/$\ell$, 25 mg/$\ell$ 150 mg/$\ell$, and 2.5 mg/$\ell$, respectively. However, the inhibitive effects of sulfide and sulfite on BPA degradation were diminished by additional aeration to oxidize them. Formaldehyde significantly reduced the rate of BPA degradation at 1.0% among organic compounds studied. Among heavy metal ions tested, Fe(II) substantially suppressed BPA removal at 1 mM. MgCl$_2$ and CaCl$_2$ exhibited great inhibition of BPA degradation at 25mM.

• 산업경영시스템학회지
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• 제38권2호
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• pp.56-62
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• 2015

The Hausdorff distance is commonly used as a similarity measure between two-dimensional binary images. Since the document images may be contaminated by a variety of noise sources during transmission, scanning or conversion to digital form, the measure should be robust to the noise. Original Hausdorff distance has been known to be sensitive to outliers. Transforming the given image to grayscale image is one of methods to deal with the noises. In this paper, we propose a Hausdorff distance applied to grayscale images. The proposed method is tested with synthetic images with various levels of noises and compared with other methods to show its robustness.

• 기술사
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• 제45권6호
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• pp.28-32
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• 2012

Namhae chemical is one of the largest fertilizer manufacturing company in Korea which company has operating 4 unit agitator gear boxes and producing variety kinds of fertilizer production. The gearbox operating temperature of agitator is approximated in $55^{\circ}C{\sim}90^{\circ}C$ and required to keep operating continuous without stopping. The system required high performance oil and longer oil drain interval as limited workforce in maintenance team. It was lubricated by mineral gear oil of ISO VG 320 and also need to change to new oil frequently. Namhae Chemical would expect to keep stable operating condition without shut down and consider, lower cost of operation and equipment protection.

• Korean Journal of Geomatics
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• 제4권1호
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• pp.17-22
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• 2004

It is very important to manage efficient data for safety and maintenance of those constructs. Estimation for structural safety can be evaluated by using data that surveys various structural durability and safety elements. so, it should be based on synthetic and efficient data that includes a variety of related safety elements obtained from a structure. It will subsequently be managed properly and economically. Accordingly, we will approach efficient maintenance management using a Geographic Information System (GIS) with data from structural-safety diagnosis and a Global Positioning System (GPS). In this study, we noted that by using the data that measures the factors (crack, incline, settlement etc.) of various structures as evaluate safety degree. And the horizontal coordinate variation/time of structure was monitored using the GPS easily.

• 통합자연과학논문집
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• 제9권1호
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• pp.28-34
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• 2016

A number of chiral selectors have been developed and applied for enantiomer separation of a variety of chiral compounds. Among these chiral selectors are chiral crown ethers, a class of synthetic host polyether molecules that bind protonated chiral primary amines with high selectivity and affinity. In this paper, two important chiral crown ethers as chiral selectors of bis-(1,1'-binaphthyl)-22-crown-6 and (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) are focused. They have been widely used to resolve the enantiomers of chiral compounds containing a primary amino moiety using chiral stationary phases (CSPs) or chiral selectors by high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and so on in chirotechnology. Also, it was described that the commercially available covalent type HPLC CSPs derived from (+)- and (-)-18-C-6-TA have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.

• Animal Bioscience
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• 제34권3_spc호
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• pp.345-353
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• 2021

Phytobiotics, also known as phytochemicals or phytogenics, have a wide variety of biological activities and have recently emerged as alternatives to synthetic antibiotic growth promoters. Numerous studies have reported the growth-promoting effects of phytobiotics in chickens, but their precise mechanism of action is yet to be elucidated. Phytobiotics are traditionally known for their antioxidant activity. However, extensive investigations have shown that these compounds also have anti-inflammatory, antimicrobial, and transcription-modulating effects. Phytobiotics are non-nutritive constituents, and their bioavailability is low. Nonetheless, their beneficial effects have been observed in several tissues or organs. The health benefits of the ingestion of phytobiotics are attributed to their antioxidant activity. However, several studies have revealed that not all these benefits could be explained by the antioxidant effects alone. In this review, I focused on the bioavailability of phytobiotics and the possible mechanisms underlying their overall effects on intestinal barrier functions, inflammatory status, gut microbiota, systemic inflammation, and metabolism, rather than the specific effects of each compound. I also discuss the possible mechanisms by which phytobiotics contribute to growth promotion in chickens.

• ETRI Journal
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• 제44권5호
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• pp.769-779
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• 2022

Spectral clustering has become a typical and efficient clustering method used in a variety of applications. The critical step of spectral clustering is the similarity measurement, which largely determines the performance of the spectral clustering method. In this paper, we propose a novel spectral clustering algorithm based on the local similarity measure of shared neighbors. This similarity measurement exploits the local density information between data points based on the weight of the shared neighbors in a directed k-nearest neighbor graph with only one parameter k, that is, the number of nearest neighbors. Numerical experiments on synthetic and real-world datasets demonstrate that our proposed algorithm outperforms other existing spectral clustering algorithms in terms of the clustering performance measured via the normalized mutual information, clustering accuracy, and F-measure. As an example, the proposed method can provide an improvement of 15.82% in the clustering performance for the Soybean dataset.

• 한국초지조사료학회지
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• 제35권1호
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• pp.26-30
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• 2015

본 시험은 엔도파이트 프리 톨 페스큐 신품종을 개발하기 위하여 2008년부터 2014년까지 농촌진흥청 국립축산과 학원 초지사료과에서 수행되었다. 톨 페스큐 신품종 '그린마스터2호'는 6배체 품종으로서 잎은 녹색이며, 출수기가 5월 16일경으로서 대비품종인 'Fawn' 보다 5일 늦은 중생품종이고, 출수기에 초장은 82.5 cm 정도이다. 지역적응시험 4개 지역평균 건물수량은 '그린마스터2호'가 15.1톤/ha로서 대비품종인 'Fawn' 보다 29% 많았으며, 지역별로는 4개 지역 모두에서 'Fawn' 보다 생산성이 우수하였다. '그린마 스터2호'의 사료가치는 조단백질(CP) 함량이 13.9%, 건물소화율(IVDMD)이 69.9%, 가소화양분총량(TDN)이 63.8%, 중성세제불용섬유(NDF)가 59.4%, 산성세제불용섬유(ADF) 는 33.5%로서 Fawn과 대등하였다. '그린마스터2호'는 엔도파이트에 감염되지 않는 품종이면서 'Fawn' 보다 국내 기후환경 적응성과 영속성이 우수하여 초지조성에 알맞은 품종으로서 우리나라 전국에서 재배 가능하다.

• 한국초지조사료학회지
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• 제23권3호
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• pp.203-206
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• 2003

본 연구는 우량(내습, 내하고 및 다수성 등) 오차드그라스 신품종을 육성하여 안정적 양질조사료 생산과 국내육성 목초품종의 국제경쟁력을 향상시키고자 수행하였다. 울릉도에서 수집된 생태형 오차드그라스 계통들로부터 생육특성 및 내재해성이 우수한 5계통을 집단교배하여 생산된 합성종자를 1995년부터 1998년까지 수원에서 생산력 검정시험이 수행되었고, 1999년부터 2002년까지 3년동안 지역적응성 시험으로 수원, 남원, 대관령 및 제주지역에서 생육특성 및 수량성이 조사되었다. 2002년 직무육성 신품종 선정심의회에서 생육특성과 수량성이 우수한 합성계통을 신품종 “장벌 101호”로 명명되었다. 장벌 101호의 주요 특성을 요약하면 다음과 같다. 장벌 101호의 월동전 및 봄의 초형은 중간형이며, 엽의 색은 농녹이고, 출수기에 지엽의 길이는 중간인 편이며, 상부절간장의 길이는 짧고 풍엽성이 양호하였다. 출수기는 5월 14일로 표준품종 Ambassador 5월 12일보다 2일 정도가 늦었으며, 출수기 초장은 83cm로 Ambassador의 초장 88cm보다 5cm가 짧았다. 내한성은 장벌 101호가 Ambassador에 비하여 약간 강하였으며, 도복은 장벌 101호와 Ambassador가 비슷하였고, 재생력은 장벌 101호가 Ambassador에 비하여 우수한 편이었다. 내습성은 수원에서만 검정이 이루어졌으나 장벌 101호가 우수하였고, 엽부병 및 녹병은 장벌 101호가 Ambassador에 비하여 약간 강한 편이었다. 장벌 101호의 4개지역 3년간 평균 수량성은 ha당 건물수량은 12,374kg으로 Ambassador 보다 9% 많았고, 특히 수원과 제주지역에서 증수되었다. 사료 품질특성은 Ambassador와 비슷한 것으로 나타났다. 이상의 결과를 요약하면 장벌 101호는 내습성이 강한 중만생 계통으로 내한성, 재생력 및 도복에 강하고, 내병성이 강한 청예, 건물 다수성 품종으로 초지 조사료 생산을 위한 방목용으로 적합한 품종이다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 추계학술대회
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• pp.47-50
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• 1997

Drug development began with the finding of biologically active compounds which are obtained by chemical synthesis or from natural sources. The advent of Combinatorial Chemistry is recognized as a strategy which has a potential to change the methodology of research and development(R&D) of new drugs. Drug development has been carried out with diverse strategies. In the past several decades a variety of new methodology have been introduced in R&D. Random screening of accumulated synthetic samples which had been synthesized for development of other drugs led to the discovery of new drugs. The typical examples are anti-asthma drug trimethoquinol and calcium antagonist diltiazem. (herbesser). In particular the latter drug has been used as a calcium antagonist worldwide, however it was first synthesized to find new tranquilizer and this is the reason why diltiazem has benzodiazepam skeleton. The random screening contributed in the finding of new drugs were carried out with whole animal test and it is a standard methodology in R&D of new drugs. Aspirin is the first synthetic non-steroidal antiinflammatory drug(NSAID) and has been used for more than one hundred years. It is the first example of drug developed from natural product. Salicin is the main constituent of willow bark which had been used in Europe for a long time to treat arthritis and aspirin was developed from salicin. Most of NSAID used clinically were developed from the structure of aspirin, however it took 70 years to clarify why aspirin exhibits its antiinflammatory, analgesic and antipyretic activities. The target of aspirin is cyclooxygenase(COX)which is the first enzyme involved in arachidonate cascade leading to the production of prostaglandins(PG) and thromboxan(TX). Side effect of aspirin causing ulcer in stomach is rather serious problem, since aspirin is so popular drug easily obtained in drug store(OTP). This problem is now going to be solved by a new finding on COX, which have two different types, one is constitutionally expressed COX 1 in almost all organs and the other is inducible COX 2. COX 2 is the responsible enzyme in inflammation etc and now the search of COX 2 specific inhibitors is the target of R&D of next generation NSAID.