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http://dx.doi.org/10.13160/ricns.2016.9.1.28

Investigation of Enantiomer Separation Using Chiral Crown Ethers as Chiral Selectors  

Lee, Wonjae (College of Pharmacy, Chosun University)
Publication Information
Journal of Integrative Natural Science / v.9, no.1, 2016 , pp. 28-34 More about this Journal
Abstract
A number of chiral selectors have been developed and applied for enantiomer separation of a variety of chiral compounds. Among these chiral selectors are chiral crown ethers, a class of synthetic host polyether molecules that bind protonated chiral primary amines with high selectivity and affinity. In this paper, two important chiral crown ethers as chiral selectors of bis-(1,1'-binaphthyl)-22-crown-6 and (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) are focused. They have been widely used to resolve the enantiomers of chiral compounds containing a primary amino moiety using chiral stationary phases (CSPs) or chiral selectors by high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and so on in chirotechnology. Also, it was described that the commercially available covalent type HPLC CSPs derived from (+)- and (-)-18-C-6-TA have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.
Keywords
Chiral Crown Ether; Chiral Selector; Chiral Stationary Phase; 18-Crown-6-2,3,11,12-tetracarboxylic Acid; Capillary Electrophoresis; High-performance Liquid Chromatography;
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Times Cited By KSCI : 8  (Citation Analysis)
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