• Title/Summary/Keyword: synergistic effect

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Cell Biological Studies on Growth and Development Effect of$Ca^{2+}$ and polyamine of $\beta-glucan$synthetase activity in carrot root protoplast (생체생장에 관한 세포생물학적 연구 당근 뿌리의 원형질체에서 polyamine과 $Ca^{2+}$$\beta-glucan$ synthetase 활성도에 미치는 영향)

  • 이순희
    • Journal of Plant Biology
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    • v.30 no.3
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    • pp.173-179
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    • 1987
  • The effect of polyamine, Ca2+ and calmodulin on GS ($\beta$-glucan synthetase) activity was studied in Daucus carota root. The Ca2+ is shown to have no effect on the GS activity whereas the GS II activity is increased in response to increase in concentration of the Ca2+. When the protoplasts are cultured, for 4 days, the GS II activity increases as a tunction of time and reachs a maximum after 3 days at a time when the network of cellulose microfibrils is known to be synthesized. The effect of the Ca2+ and 1mM spermine on the GS II activity turns out to be synergistic, especially more synergistic at lower concentration of the Ca2+. The GS II activity seems to be enhanced by the Ca2+. The GS II activity in the protoplast treated by the calcium channel blocker, verapamil, turns out to be lower than that of the control. Cumulative results suggest that the Ca2+ stimulates the cell wall regeneration via enhancement of the GS II activity responsible for synthesizing the cell wall component throught synergistic effect with spermine.

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Exploring Synergistic Effect in Metro Station Areas: A Case Study of Shanghai, China

  • Zhuang, Yu;Zhang, Lingzhu
    • International Journal of High-Rise Buildings
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    • v.5 no.2
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    • pp.105-115
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    • 2016
  • In the process of exploring sustainable development, major cities in China are expanding metro systems as a strategy to reduce the negative environmental and social consequences of fast-paced motorization. A metro station is not only a transportation node, but also a place where diverse activities can be performed. Therefore, the realization of the spatial potential for human interaction is the essence of the strategy for integrated development in metro station areas. For this paper, 10 well-developed metro stations in Central Shanghai were selected to investigate the correlation between accessibility and spatial performance in station areas. The spatial performance in station areas is significantly affected by metro configuration. However, both vehicle and pedestrian accessibility show weak influence on spatial performance. A synergistic model was then developed to provide quantitative support for transit-oriented development in metro station areas.

Effect of Perfluidone - Bifenox Mixture I. Interaction of Perfluidone and Bifenox Mixture (Perfluidone과 Bifenox의 혼합효과(混合效果) 제1보(第1報 제초제(除草劑) Perfluidone과 Bifenox의 상호작용(相互作用))

  • Ryang, H.S.;Jang, I.S.;Ma, S.Y.
    • Korean Journal of Weed Science
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    • v.5 no.2
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    • pp.187-193
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    • 1985
  • The experiment was carried out to evaluated the interaction between perfluidone(2-methyl-4-phenylsulphonyltrifluoromethylsulphoanilide) and bifenox(2,4-dichlorophenyl-3-methoxycarbonyl-4-nitrophenylether). A synergistic effect was found between perfluidone and bifenox. The highest synergistic effect on Echinochloa crus-galli (L.). Beauv. was obtained when 10 g a.i./10a of perfluidone was combined with 24.9 g a.i./10a of bifenox. However, bifenox should be increased to 33.3, g a.i./10a to obtain the highest synergistic effect when applied to Cyperus serotinus Rottb. at 1.0-1.5 leaf stage. Sagittaria pygmaea Miq. at 0.5-1.0sleaf stage was completely controlled by the lowest combination rate employed.

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Synergistic Effect of Notopterygium incisum with Clematis manshurica in the Anti-inflammatory Activity (강활(羌活)과 위령선(威靈仙)의 항염증 상승작용에 관한 연구)

  • Kim, Seung-Ju;Chun, Jin-Mi;Yang, Won-Kyung;Cheon, Myeong-Sook;Sung, Yoon-Young;Park, Jun-Yeon;Kim, Ho-Kyoung
    • The Korea Journal of Herbology
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    • v.25 no.4
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    • pp.11-16
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    • 2010
  • Objective : Oriental medicines have been combined oriental medical theory which based on the seven modes of emotions. Notopterygium incisum (N. incisum) and Clematis manshurica (C. manshurica) have been used as an anti-rheumatic and analgesic medicine for the treatment of rheumatism, headache, cold, etc. In this study, we evaluate the synergistic anti-inflammatory effect of N. incisum and C. manshurica. Method : To evaluate the synergistic anti-inflammatory effect of a herbal mixture N. incisum and C. manshurica, we examined the changed ear thickness in 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema model after topical application of herbal mixture. In addition, the levels of markers for inflammation, such as tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$, prostaglandin $G_2$ ($PGE_2$), and nitric oxide (NO) were measured by ELISA assay and Griess reagent in lipopolysaccharide-stimulated Raw 264.7 cells. Results : Our results showed that aqueous extracts of N. incisum and C. manshurica combination significantly inhibited the mouse ear edema induced by TPA. Moreover, the aqueous extracts of N. incisum and C. manshurica combination exhibited synergistic effects in down-regulating TNF-${\alpha}$, IL-$1{\beta}$, $PGE_2$ level, but not NO. Conclusions : This study suggested that combined treatment of N. incisum and C. manshurica, based on seven methods in prescription compatibility, has a synergistic effect in down-regulating inflammatory response both in vitro and in vivo models.

Combination Effects of Potassium Sorbate and Sodium Benzoate with Sodium Chloride on the Growth of Bacillus subtilis (Bacillus subtilis의 생육에 미치는 식염과 Potassium Sorbate, Sodium Benzoate의 병용효과)

  • Yang, Yeo-Young;Youn, Jung-Hae;Cho, Nam-Sook;Choi, Eon-Ho
    • Korean Journal of Food Science and Technology
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    • v.20 no.1
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    • pp.23-27
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    • 1988
  • In order to investigate the combined effect of potassium sorbate and sodium benzoate and the synergistic effect of sodium chloride on bacterial cell growth inhibition, Bacillus subtilis was cultured with or without shaking in tryptone-glucose-yeast extract broth containing 0.1% potassium sorbate and/or 0.03% sodium benzoat, which are equivalent to half of the maximum permissible levels, respectively. The combined treatment of the two preservatives did not show any synergistic effect of tne growth inhibition of B. subtilis. Addition of 2% sodium chloride, however, showed remarkable synergistic effect on the growth inhibition of the bacterium by potassium sorbate.

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Antilisterial Synergistic Effect of Falcarindiol Isolated from Dystaemia takesimana Kitagawa with Monoglycride (섬바디로부터 분리된 Falcarindiol과 유화제와의 혼합에 따른 Listeria monocytogenes에 대한 항균 상승효과)

  • Oh, Jin-Ah;Shin, Dong-Hwa;Ahn, Young-Sun
    • Korean Journal of Food Science and Technology
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    • v.31 no.3
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    • pp.864-869
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    • 1999
  • Synergistic effects of the falcarindiol mixed with monoglyceride in broth exhibited strong growth inhibition on all test strains. It was confirmed that the falcarindiol mixed with monoglyceride exhibited bactericidal effect in broth against L. monocytogenes ATCC 19111 and ATCC 19114 at the same level.

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The high thermal stability induced by a synergistic effect of ZrC nanoparticles and Re solution in W matrix in hot rolled tungsten alloy

  • Zhang, T.;Du, W.Y.;Zhan, C.Y.;Wang, M.M.;Deng, H.W.;Xie, Z.M.;Li, H.
    • Nuclear Engineering and Technology
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    • v.54 no.8
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    • pp.2801-2808
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    • 2022
  • The synergistic effect of ZrC nanoparticle pining and Re solution in W matrix on the thermal stability of tungsten was studied by investigating the evolution of the microstructure, hardness and tensile properties after annealing in a temperature range of 1000-1700 ℃. The results of metallography, electron backscatter diffraction pattern and Vickers micro-hardness indicate that the rolled W-1wt%Re-0.5 wt% ZrC alloy has a higher recrystallization temperature (1600 ℃-1700 ℃) than that of the rolled pure W (1200 ℃), W-0.5 wt%ZrC (1300 ℃), W-0.5 wt%HfC (1400-1500 ℃) and W-K-3wt%Re alloy fabricated by the same technology. The molecular dynamics simulation results indicated that solution Re atoms in W matrix can slow down the self-diffusion of W atoms and form dragging effect to delay the growth of W grain, moreover, the diffusion coefficient decrease with increasing Re content. In addition, the ZrC nanoparticles can pin the grain boundaries and dislocations effectively, preventing the recrystallization. Therefore, synergistic effect of solid solution Re element and dispersed ZrC nanoparticles significantly increase recrystallization temperature.

Effect of Leptin on the Expression of Lipopolysaccharide-Induced Chemokine KC mRNA in the Mouse Peritoneal Macrophages

  • Lee, Dong-Eun;Kim, Hyo-Young;Song, In-Hwan;Kim, Sung-Kwang;Seul, Jung-Hyun;Kim, Hee-Sun
    • Journal of Microbiology and Biotechnology
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    • v.14 no.4
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    • pp.722-729
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    • 2004
  • Leptin is an adipocyte-secreted hormone and its plasma levels correlate with total body fat mass, however, it also plays a regulatory role in immunity, inflammation, and hematopoiesis. Chemokine is known as a chemoattractant cytokine in inflammatory reaction, but its role in leptin reaction has not been well studied. In this study, the direct effect of leptin on the expression of chemokine mRNAs and lipopolysaccharide (LPS)-induced chemokine KC mRNA in mouse peritoneal macrophages was investigated. Leptin did not induce the expression of lymphotactin, RANTES, eotaxin, MIP-1$\beta$, MIP-1$\alpha$, MIP-2, MCP-1, IP-10, TCA-3, and KC mRNA in mouse peritoneal macrophages, and had no direct effect on the expression of these LPS-induced chemokine mRNAs except KC mRNA. The synergistic effect of leptin on the expression of LPS-induced KC mRNA occurred late in the time course of response to LPS. The increased expressions of Ob-Rb mRNA and leptin receptor protein were detected during the LPS treatment. Leptin produced a substantial increase in the stability of the LPS-induced KC mRNA, and the synergistic effect of leptin on LPS-induced KC mRNA expression was further augmented by cycloheximide (CHX). Pyrrolidine dithiocarbamate (PDTC) did not block the synergistic effect of leptin on LPS-induced KC mRNA expression in mouse peritoneal macrophages. These data suggest that although leptin has no direct effect on the expression of lymphotactin, RANTES, eotaxin, MIP-1$\beta$, MIP-1$\alpha$, MIP-2, MCP-1, IP-10, TCA-3, and KC mRNA in mouse peritoneal macrophages, the synergistic effect of leptin on the expression of LPS-induced KC mRNA has the possibility that LPS might induce the expression of the Ob-Rb receptor or an unknown gene(s) that sensitizes macrophages to the synergistic function of leptin. Therefore, further studies are necessary to examine leptin as a regulatory factor of chemokine production.

Machiavellianism in a Synergistic Tax Climate

  • CAHYONOWATI, Nur;RATMONO, Dwi;DEWAYANTO, Totok
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.12
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    • pp.1175-1184
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    • 2020
  • This research examines the personal (i.e., Machiavellianism) and situational factors (i.e., tax climate) that are believed to be psychologically salient aspects in tax compliance. To the best of our knowledge, no research has been carried out to investigate the interaction effect of the two factors. This study uses a paper-and-pencil laboratory experiment 2x2 between-subject factorial design that involved 158 participants. The results indicate that a taxpayer who has a low Machiavellianism score or who is in a high synergistic tax climate reports a higher level of income. In the high synergistic tax climate, where tax norms apply, personal ethics do not play a significant role in tax compliance decisions. Where the synergistic relationship between taxpayer and authorities is low, personal ethics play an important role, i.e., low Machiavellians report a higher reported income than high Machiavellians do. This research contributes to the literature that deviates from the traditional model of tax compliance. Taxpayers are not always rational, but they might pay tax for reasons other than financial motives (Alm, 1991, 2018), that is, personal ethics in this study. This research implies the need for policymakers to consider other approaches rather than only relying on audits and fines.