• IMMUNE NETWORK
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• v.11 no.4
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• pp.196-202
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• 2011

Background: B cell-activating factor belonging to the TNF family (BAFF) is primarily expressed by macrophages and dendritic cells, and stimulates B cell proliferation, differentiation, survival, and Ig production. In the present study, we explored the effect of activin A on BAFF expression by APCs. Methods: To investigate the effect of activin A on BAFF expression by mouse APCs, we measured the level of BAFF expression at the transcriptional and protein levels using RT-PCR and ELISA. Results: Activin A markedly enhanced BAFF expression in mouse macrophages and dendritic cells at both the transcriptional and protein levels. SB431542, an activin receptor-like kinase 4 (ALK4) inhibitor, completely abrogated activin A-induced BAFF transcription. Furthermore, overexpression of DN-Smad3 abolished activin-induced BAFF expression at the transcriptional and protein levels. Conclusion: These results demonstrate that activin A can enhance BAFF expression through ALK4-Smad3 pathway.

• Proceedings of the KIPE Conference
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• 2007.07a
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• pp.256-258
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• 2007

A charge equalization converter with parallel-connected primary windings of transformers is proposed in digest. The proposed work effectively balance the voltage among Lithium-Ion battery cells despite each battery cell has low voltage gap compared with its SOC. The principle of the proposed work is that the equalizing energy from all battery strings moves to the lowest voltage battery through the isolated dc/dc converter controlled by the corresponding bi-directional switch. In this digest, a prototype of four Lithium-Ion battery cells is optimally designed and implemented, and experimental results show that the proposed method has excellent cell balancing performance.

• Journal of Power Electronics
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• v.15 no.4
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• pp.1035-1046
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• 2015

This study presents a practical implementation of a multi-mode two-phase interleaved boost converter for fuel cell electric vehicle application. The main operating modes, which include two continuous conducting modes and four discontinuous conducting modes, are discussed. The boundaries and transitions among these modes are analyzed with consideration of the inductor parasitic resistance. The safe operational area is analyzed through a comparison of the different operating modes. The output voltage and power characteristics with open-loop or closed-loop operation are also discussed. Key performance parameters, including the DC voltage gain, input ripple current, output ripple voltage, and switch stresses, are presented and supported by simulation and experimental results.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.433-433
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• 2010

A microplasma current switch (MPCS) for a device operated in a current mode like organic light-emitting diodes (OLEDs), which features matrix addressability and current switching, is presented as well as its architecture and operational principle. The MPCS utilizes the intrinsic memory and conductivity of plasmas to achieve matrix addressability and current switching. We have fabricated a $100\;mm\;{\times}\;100\;mm$ MPCS panel in which its cell pitch is $1080\;{\mu}m\;{\times}\;1080\;{\mu}m$. The matrix addressability and current switching were verified. In addition, the current-voltage (I-V) characteristic of the unit cell was measured when plasmas were ignited. In principle, the scheme of the MPCS is equivalent to that of a double Langmuir probe diagnosing plasma parameters except for their relative dimensions to a plasma volume. Accordingly, the I-V characteristic was analyzed by a double Langmuir probe theory, and the plasma density and electron temperature were estimated from the I-V curve using a collisional double Langmuir probe theory.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.8
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• pp.7-13
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• 2002

In this paper, we propose an traffic control algorithm for efficient link utilization of ATM-ABR service based on fuzzy logic. The proposed algorithm, controls transmission rates of source according to switch buffer size and input cell tate by using the fuzzy rate . For this method we developed a model and algorithm of fuzzy traffic control method and fuzzy traffic controller which based on ER of VS/VD. For the fuzzy traffic controller, we also designed a membership function, fuzzy control rules, and a max-min inferencing method.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.2
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• pp.9-18
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• 1999

In this paper, large capacity Photonic ATM switch structure is proposed. It contains mixed routing structure using TDM and WDM methods. Through this structure, we can get not only required hardware reduction, and optical power loss reduction in cell routing procedure but also the less complexity of electrical parts using passive device. Also, it is designed for ease to simplicity of extension in throughput, so it is suitable structure for large capacity Photonic ATM switching system of the future.

• Proceedings of the KAIS Fall Conference
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• 2003.11a
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• pp.236-242
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• 2003

ATM ABR service controls network traffic using feedback information on the network congestion situation in order to guarantee the demanded service qualities and the available cell rates. In this paper we apply the control method using queue length prediction to the formation of feedback information for more efficient ABR traffic control. If backward node receive the longer delayed feedback information on the impending congestion, the switch can be already congested from the uncontrolled arriving traffic and the fluctuation of queue length can be inefficiently high in the continuing time intervals. The feedback control method proposed in this paper predicts the queue length in the switch using the slope of queue length prediction function and queue length changes in time-series. The predicted congestion information is backward to the node. NLMS and neural network are used as the predictive control functions, and they are compared from performance on the queue length prediction. Simulation results show the efficiency of the proposed method compared to the feedback control method without the prediction. Therefore, we conclude that the efficient congestion and stability of the queue length controls are possible using the prediction scheme that can resolve the problems caused from the longer delays of the feedback information.

• Proceedings of the KIPE Conference
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• 2012.07a
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• pp.289-290
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• 2012

This paper proposes a new active snubber boost PFC converter to provide a zero-voltage-switching (ZVS) turn-on condition and reduce electromagnetic interference (EMI) noise in home appliances and renewable energy applications, including solar or fuel cell electric systems. The proposed active snubber circuit enables a main boost switch of the boost-type PFC or grid converter to turn on under a ZVS condition and reduce the switching losses of the main boost switch. Moreover, for the purpose of a specialized intelligent power module (IPM) fabrication, the proposed boost circuit is designed to satisfy some design aspects such as space saving, low cost, and easy fabrication. Simulation and experimental results of a 2kW IPM boost-type PFC converter are provided to verify the effectiveness of the proposed active snubber boost circuit.

• Molecules and Cells
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• v.43 no.2
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• pp.198-202
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• 2020

Comprehensive inhibition of RUNX1, RUNX2, and RUNX3 led to marked cell suppression compared with inhibition of RUNX1 alone, clarifying that the RUNX family members are important for proliferation and maintenance of diverse cancers, and "cluster regulation of RUNX (CROX)" is a very effective strategy to suppress cancer cells. Recent studies reported by us and other groups suggested that wild-type RUNX1 is needed for survival and proliferation of certain types of leukemia, lung cancer, gastric cancer, etc. and for their one of metastatic target sites such as born marrow endothelial niche, suggesting that RUNX1 often functions oncogenic manners in cancer cells. In this review, we describe the significance and paradoxical requirement of RUNX1 tumor suppressor in leukemia and even solid cancers based on recent our findings such as "genetic compensation of RUNX family transcription factors (the compensation mechanism for the total level of RUNX family protein expression)", "RUNX1 inhibition-induced inhibitory effects on leukemia cells and on solid cancers through p53 activation", and "autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells". Taken together, these findings identify a crucial role for the RUNX cluster in the maintenance and progression of cancers and suggest that modulation of the RUNX cluster using the pyrrole-imidazole polyamide gene-switch technology is a potential novel therapeutic approach to control cancers.

• Journal of Software Assessment and Valuation
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• v.15 no.2
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• pp.67-72
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• 2019

The recent explosion of data traffic, including cloud services, coupled with the Internet penetration has led to a surge in the need for ultra-fast optical networks that can efficiently connect the data center's reconfiguable resources. In this paper, the algorithms for controlling switching cell operation in the optical switch connection structure are proposed, and the resulting performance is compared and analyzed through simulation. Performance analysis results showed that the algorithm proposed in this paper has improved the probability of successful multi-connection setup by about 3 to 7% compared to the existing algorithm.