• Asian Pacific Journal of Cancer Prevention
• /
• 제15권1호
• /
• pp.205-213
• /
• 2014

The outcomes of first-generation EGFR-TKIs (Gefitnib and Erlotinib) have shown great advantages over traditional treatment strategies in patients with non-small cell lung cancer (NSCLC), but unfortunately we have to face the situation that most patients still fail to respond in the long term despite initially good control. Up to now, the mechanism of acquired resistance to EGFR-TKIs has not been fully clarified. Herein, we sought to compile the available clinical reports in the hope to better understanding the subsequent treatment choices, particularly on whether restoring after a drug holiday or switching to another EGFR-TKI is the better option after failure of one kind of EGFR-TKI.

• Journal of Plant Biology
• /
• 제33권2호
• /
• pp.87-96
• /
• 1990

The role of S-adenosylmethionine (SAM) as an intermediate in interrelation between polyamine and ethylene biosynthesis was studied in suspension cultures of Nicotiana tabacum L. Exogenous SAM stimulated the polyamine and ethylene biosynthesis in 4 day-cultured cells, which were in active cell divisions, and 10 day cultured cells, which went on with active cell elongation and senescence. SAM-induced ethylene production was more effective in 10 day-cultured cells than in 4 day-cultured cells, but SAM-induced polyamine biosynthesis was more effective in 4 day-cultured cells than in 10 day-cultured cells. Polyamine contents were increased by the blockage of ethylene biosynthetic pathway in the conversion of SAM to ethylene via 1-aminocyclopropane-1-carboxylinc acid (ACC) with aminooxyacetic acid (AOA). Also, ethylene production was increased by the inhibitors of polyamine biosynthesis such as methylglyoxal bis-(guanylhydrazone) (MGBG), dicyclohexylamine (DCHA), $\alpha$-difluoromethylarginine (DFMA) and $\alpha$-difluoromethylorinithine (DFMO). These results suggest that there may be interrelations between polyamine and ethylene biosynthesis for the competition of SAM and the inherent mechanism of switch on-off in polyamine and ethylene biosynthetic activity with the progress of cell growth and senescence.

• IMMUNE NETWORK
• /
• 제12권6호
• /
• pp.230-239
• /
• 2012

Activation-induced cytidine deaminase (AID) is an enzyme that is predominantly expressed in germinal center B cells and plays a pivotal role in immunoglobulin class switch recombination and somatic hypermutation for antibody (Ab) maturation. These two genetic processes endow Abs with protective functions against a multitude of antigens (pathogens) during humoral immune responses. In B cells, AID expression is regulated at the level of either transcriptional activation on AID gene loci or post-transcriptional suppression of AID mRNA. Furthermore, AID stabilization and targeting are determined by post-translational modifications and interactions with other cellular/nuclear factors. On the other hand, aberrant expression of AID causes B cell leukemias and lymphomas, including Burkitt's lymphoma caused by c-myc/IgH translocation. AID is also ectopically expressed in T cells and non-immune cells, and triggers point mutations in relevant DNA loci, resulting in tumorigenesis. Here, I review the recent literatures on the function of AID, regulation of AID expression, stability and targeting in B cells, and AID-related tumor formation.

• Journal of Power Electronics
• /
• 제10권3호
• /
• pp.235-244
• /
• 2010

This paper presents a new isolated soft-switching bidirectional buck-boost inverter for fuel cell applications. The buck-boost inverter combines an isolated DC-DC converter with a conventional inverter to implement buck-boost DC-DC and DC-AC conversion. The main switches achieve zero voltage switching and zero current switching by using a novel synchronous switching SVPWM and the volume of the transformer in the forward and fly-back mode is also minimized. This inverter is suitable for wide input voltage applications due to its high efficiency under all conditions. An active clamping circuit reduces the switch's spike voltage and regenerates the energy stored in the leakage inductance of the transformer; therefore, the overall efficiency is improved. This paper presents the operating principle, a theoretical analysis and design guidelines. Simulation and experimental results have validated the characteristics of the buck-boost inverter.

• 한국통신학회논문지
• /
• 제37B권10호
• /
• pp.956-964
• /
• 2012

본 논문에서는 동적 셀 선택 기반의 기회적 간섭 정렬 기법을 제안한다. 제안된 방법은 각 사용자의 수신 신호 공간과 간섭 공간을 선택함으로써 기존의 기회적 간섭 정렬 기법을 통해 얻을 수 있는 다중 사용자 다이버시티 이득에 추가적인 선택적 다이버시티 이득을 얻을 수 있다. 제안된 방법의 합용량 성능 검증을 위해 확률 모델을 사용하여 전체 시스템의 합용량 성능을 수학적으로 유도하였다. 전산모의실험을 통해 제안된 방법이 기존의 방법에 비해 성능이 향상됨을 검증하였고 분석한 성능과 실험 결과의 일치함을 보였다.

• Journal of Microbiology
• /
• 제44권3호
• /
• pp.311-319
• /
• 2006

Bud6p is a component of a polarisome that controls cell polarity in Saccharomyces cerevisiae. In this study, we investigated the role of the Candide albicans Bud6 protein (CaBud6p) in cell polarity and hyphal development. CaBud6p, which consists of 703 amino acids, had 37% amino-acid sequence identity with the Bud6 protein of S. cerevisiae. The homozygous knock-out of CaBUD6 resulted in several abnormal phenotypes, such as a round and enlarged cells, widened bud necks, and a random budding pattern. In hypha-inducing media, the mutant cells had markedly swollen tips and a reduced ability to switch from yeast to hypha. In addition, a yeast two-Hybrid analysis showed a physical interaction between CaBud6p and CaAct1p, which suggests that CaBud6p may be involved in actin cable organization, like Bud6p in S. cerevisiae. Taken together, these results indicate that CaBud6 plays an important role in the polarized growth of C. albicans.

• 한국전기전자재료학회:학술대회논문집
• /
• 한국전기전자재료학회 1998년도 춘계학술대회 논문집
• /
• pp.243-246
• /
• 1998

This paper presents a 6-bit self-calibrated D/A converter designed with current cell matrix structure. This structure is based on the current-cell matrix configuration using a regulated gate cascode current cell with 3-way switch. using from CMOS process and 5V power supply, the simulated conversion rate is 45.78MHz and the average mismatching properties among current sources are reduced to 0.02% and 0.005%, respectively when 1% and 0.5% errors of current sources are considered.

• 한국정보처리학회논문지
• /
• 제6권3호
• /
• pp.742-749
• /
• 1999

This paper proposes the mechanism of cell buffering in the output buffer of ATM switch for the traffic with the different QOS in the ATM environment. The proposed mechanism, VQS(Variable Queue Sharing) can minimize the cell loss ratio(CLR) of bursty traffic through the sharing of CBR queue, VBR queue, ABR queue to maximize the utilization of queue resource. To evaluate VQS performance, we make simulator using Visual Slam 2.0. We compare the CLP and cell average delay of VQS and HOL, QLT_HOL using the bursty traffic patterns.

• 생명과학회지
• /
• 제29권11호
• /
• pp.1179-1191
• /
• 2019

암세포는 epithelial mesenchymal transition (EMT)를 통해 tumor invasion과 metastasis가 일어나며, 또한 정상세포와 다른 oncogenic metabolic phenotypes 획득 즉, glycolytic switch 등이 암 발생과 진행에 깊이 연관되어 있음이 잘 알려져 있다. High-mobility group box 1 (HMGB1)은 chromatin-associated nuclear protein으로 알려져 있으나, dying cells 또는 immune cells로부터 방출되기도 한다. 방출된 HMGB1은 damage-associated molecular pattern (DAMP)로서 작용하여 EMT 및 invasion, metastasis를 유도함으로서 tumor progression에 기여한다고 알려졌다. 본 연구에서 HMGB1에 의해 EMT와 glycolytic switch 유도되며, 이 과정은 Snail 의존적임을 확인하였다. 또한 HMGB1/Snail cascade는 COX subunits인 COXVIIa와 COXVIIc의 발현 억제를 통해 mitochondrial repression과 cytochrome c oxidase (COX) inhibition을 유도하였다. HMGB1은 Snail를 통해 glycolytic switch의 주요 효소인 hexokinase 2 (HK2), phosphofructokinase-2/fructose-2,6-bisphosphatase 2 (PFKFB2), phosphoglycerate mutase 1 (PGAM1)의 발현을 증가시켰다. 이들 효소는 glycolytic switch에 중요하게 관여하는 것으로 알려져 있다. 이들 해당과정의 효소들을 knockdown한 결과 HMGB1에 의한 EMT를 억제함으로써 glycolysis와 HMGB1-induced EMT가 밀접하게 연관되어 있을 제시하였다. 이상의 연구 결과들은 HMGB1/Snail cascade가 EMT 및 glycolytic switch, mitochondrial repression에 중요하게 작용할 것임을 시사한다.

• 전력전자학회:학술대회논문집
• /
• 전력전자학회 2008년도 하계학술대회 논문집
• /
• pp.274-276
• /
• 2008

This paper proposes an individual charge equalization converter using selective two current paths for series connected lithium-ion battery strings. In the proposed equalizer, a central equalization converter acting as a controllable current source is sequentially connected in parallel with individual batteries through an array of cell selection switches. A flyback converter with a modified rectifier realizes a controllable current source. A central equalization converter is shared by every battery cells through the cell selection switch, instead of a dedicated charge equalizer for each cell. With this configuration, although the proposed equalizer has one dc-dc converter, individual charge equalization can be effectively achieved for the each cell in the strings. Furthermore, since the proposed equalizer would not allocate the separated dc-dc converter to each cell, such that the implementation of great size reduction and low cost can be allowed. In this paper, an optimal power rating design guide is also employed to obtain a minimal balancing size while satisfying equalization requirements. A prototype for eight lithium-ion battery cells is optimally designed and implemented. Experimental results verify that the proposed equalization method has good cell balancing performance showing small size, and low cost.