• 동의생리병리학회지
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• 제29권6호
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• pp.498-502
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• 2015

Yukmijihwang-tang (YM) is a well-known prescription to treat kidney inflammation on Korea. However, the effects of YM on maximal exercise performance (MEP) is not-well investigated. In this study, we aimed to evaluate the effects of YM on MEP using forced swimming test (FST) model. Mice were largely divided into three group; a non-swimming group, saline treated-swimming load test group, and YM treated-swimming load group. Swimming load test groups were re-divided into swimming control group (Control), YM fed group (YM). YM was administrated orally for 2 weeks before FST. After FST, immobility time, oxygen consumption was measured by physiological test, and serum was collected for biochemical analysis. FST induced MEP identified by increased immobility, oxygen consumption, and biochemical factors. Immobility time was significantly reduced by YM treatment compared with control group. Oxygen consumption was also significantly reduced by YM treatment. The increase on lactic acid and lactate dehydrogenase after FST was inhibited by YM　treatment. In addition, consumption of energy source (free fatty acid, and triglyceride) and recovery of energy was enhanced by YM treatment after FST. In conclusion, YM inhibited the elevation of immobility time, oxygen consumption, and biochemical factors after FST. YM could be used as a beneficial agents to enhance maximal endurance exercise performance and an effective ergogenic aid in exercise training.

• 동의생리병리학회지
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• 제23권1호
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• pp.113-120
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• 2009

This study was performed to investigate the effects in inflammatory and pain status on rheumatoid arthritis(RA) induced rats by swimming exercise and Achyranthes Radix(AR) extracts ointment according to the application methods with the change of motor-behavioral and histochemistry study through the change of safranin o-fast green stain in the knee joint and prostaglandin $E_2(PGE_2)$ concentration production in serum for 28 days. They were randomly divided into four groups; Group I: RA induction, Group II: application of only swimming exercise after RA induction, Group III: application of only AR extracts ointment after RA induction, Group IV: application of both AR extracts ointment and swimming exercise after RA induction. The following results were obtained. Volume change of hind paw edema and arthritis indices test and arthritic dorsal flexion & plantar flexion pain test, group II, III, IV were showed that significantly decrease to each scores compared with group I (p<.01). Safranin o-fast green stain were showed histological indices, group II, III, IV were showed that significantly decrease the scores of cellular infiltration and synovial hyperplasia(p<.05), pannus formation and cartilage destruction(p<.01) compared with group I. Group IV were the most decreased compared with group II, III. The $PGE_2$ concentration of the group II, III, IV were decreased compared to the group I (p<.01) In conclusion, swimming exercise and AR extracts ointment acts were the most therapeutic intervention in inflammatory and pain control of RA induced rats.

• 운동영양학회지
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• 제13권3호
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• pp.203-209
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• 2009

Periventricular leukomalacia (PVL) is a common white matter lesion affecting the neonatal brains. PVL is closely associated with cerebral palsy (CP). It has been suggested that maternal or placental infection can induce damage to the neonatal brains. In the present study, we investigated the effects of treadmill running and swimming of rat pups on the GFAP and MBP expressions in the brains of rat pups with maternal lipopolysaccharide (LPS)-induced CP. The rats were divided into the six groups for experiment 1: the control group, the control with mild exercise group, the control with moderate exercise group, the LPS-treated group, the LPS-treated with mild exercise group, and the LPS-treated with moderate exercise group (n=6 in each group). The rats in the running groups were forced to run on a motorized treadmill for 30 min 5 times a week for 4 weeks. For experiment 2, the rats were divided into four groups: the control group, the LPS-treated group, the LPS-treated with swimming group, and the LPS-treated with treadmill running group (n = 5 in each group). The rats in the swimming group were made to swim for 30 min once a day for 5 times per week during 2 weeks. The rats in the treadmill running group were made to run for 30 min once a day for 5 times per week during 2 weeks. The present results showed that intracervical maternal LPS injection during pregnancy significantly increased GFAP expression in the striatum and significantly decreased MBP expression in the corpus callosum of rat pups. The present results also showed that treadmill running and swimming significantly suppressed GFAP expression and significantly enhanced MBP expression in the brains of rat pups with maternal LPS-induced CP. This effect of treadmill running was shown as equally both in the mild-intensity exercise and in the moderate-intensity exercise. The present study revealed that exercise, both the treadmill running and swimming, is effective for the treatment of astrogliosis and hypomyelination associated with CP. Here in this study, we showed that treadmill running and swimming are effective for alleviating the detrimental effects of CP.

• The Journal of Korean Physical Therapy
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• 제19권3호
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• pp.1-9
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• 2007

Purpose: Previous studies have suggested that BDNF has a role in plasticity and survival following spinal cord injury and treadmill exercise increases BDNF levels in the normal brain and spinal cord. We attempted to determine whether swimming exercise improve motor function following experimental contusive spinal cord injury and whether motor outcome is associated with BDNF expression. Methods: Thirty six Sprague-Dawley rats (weight, 250 to 300 g) were divided into control (n=18) and experimental swimming group (n=18). Spinal cord injury was produced using NYU-spinal impactor at the eleven thoracic levels in both groups. Swimming exercise started $7^{th}$ day from SCI operation, lasted 5 min per day, 5 days a week for 4 weeks and then exercise times a day were increased in one number to each week. Motor functional recovery was determined by the Basso-Beattie-Bresnahan (BBB) locomotor rating scale, modified inclined board plane test, histological findings, H&E and BDNF expression observed at $1^{th}$, $3^{rd}$, $7^{th}$, $14^{th}$, $21^{st}$ and $28^{th}$day after injury. Results: 1. The BBB scores were higher in experimental group than control group at $14^{th}$, $21^{st}$ day (left hind limb) and at $21^{th}$ day (right hind limb) (p<0.05) after injury. 2. The inclined board plane test were significantly greater in experimental group than control group at $7^{th}$ day (p<0.05), $14^{th}$ and $28^{th}$ day (p<0.01) after injury. 3. The BDNF expression was severe revealed in experimental group than control group at $7^{th}$, $14^{th}$ and $28^{th}$ day after injury. Conclusion: This study suggests that swimming applied from the early phase after spinal cord injury be beneficial effects in motor functional recovery.

• The Journal of Korean Physical Therapy
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• 제21권2호
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• pp.117-124
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• 2009

Purpose: This study examined the effects of swimming exercise and Achyranthes Radix extracts on the inflammatory and behavioral responses in type II collagen-induced arthritic rats for 28 days. Methods: Sprague-Dawley rats were allocated randomly to one of the following four groups: only type II collageninduced (group Ⅰ), application of swimming exercise after type II collagen-induced (group II), application of Achyranthes Radix ointment after type II collagen-induced (group III), application of swimming exercise and Achyranthes Radix ointment after type II collagen-induced (group IV). Arthritis was established in SD rats by an intradermal injection of Chick type II collagen plus incomplete Freund's adjuvant at the base of the tail of the animals. The swimming exercise program consisted of a 25 min swimming session/day with a load corresponding to 5.5% of the weight bearing, three days/week for four weeks. The Achyranthes Radix ointment (0.1g) was applied twice a day for five days. The changes in behavior, H & E stain, and cyclooxygenase-2 (COX-2) level in the knee joint were assessed. Results: The gross and histological examination, after RA induction showed reddening, edema and erythema. The H & E stain revealed the destruction of articular cartilage, bony erosion and the infiltration of inflammatory cells after RA induction. The mechanical allodynia test results were significantly higher in group I than in groups II, III and IV (p<0.01). The immunohistochemistrical response of COX-2 in the knee joint showed that groups II, III, IV had a lower response effect than group I. Conclusion: Swimming exercise training and Achyranthes Radix ointment decreased the inflammatory responses and enhanced the behavioral responses in the arthritic rats.

• 한국응용과학기술학회지
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• 제38권3호
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• pp.735-749
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• 2021

COVID-19사태로 인하여 현재 대학교에서 제공하는 비대면 형식의 교양 수영 수업에 대한 평가는 전반적으로 부정적이라는 점에 대해서는 이견이 없는 것이 사실이다. 이러한 이유로 대학교의 교양수영 수업의 질은 지도자가 갖추고 있는 전문성에 의존할 수밖에 없다. 하지만 학생들은 실기가 절대적으로 부족한 현재 상황에서 운동몰입을 경험하고, 이를 바탕으로 지속적으로 참여할 것인가에 대해서는 쉽게 확답을 할 수 없는 실정이다. 이는 수영 종목뿐만 아니라 모든 교양 체육 및 생활 체육 종목에 있어서 앞으로 상당한 위협이 될 것으로 판단된다. 본 연구는 교양 수영 수업을 수강한 경험이 있는 281명의 비체육 전공 대학생을 대상으로 대학교 수영 수업 지도자의 전문성이 비체육 전공 대학생이 인지한 운동몰입과 참여지속의도간의 구조적 관계에 연구의 필요성을 발견하고 그 결과를 분석하였다. 도출한 연구 결과는 다음과 같다. 첫째, 비체육 전공 대학생이 인지한 교양 수영 수업 지도자의 전문성(인성, 강의기술, 학생관리, 실습능력, 기초지식)이 운동몰입(인지몰입, 행동몰입)에 미치는 영향에 있어서 인지몰입에 영향을 미치는 요인으로는 강의기술이 통계적으로 정(+)의 영향이 있는 것으로 나타났고, 행위몰입에 영향을 미치는 요인으로는 인성, 강의기술, 학생관리, 기초지식에서 통계적으로 정(+)의 효과가 있는 것으로 나타났다. 둘째, 비체육 전공 대학생이 인지한 운동몰입(인지몰입, 행동몰입)이 지속적 참여의도에 미치는 영향에 대해서는 행동몰입 요인이 통계적으로 정(+)의 영향을 미치는 것으로 나타났다.

• 한국응용과학기술학회지
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• 제37권5호
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• pp.1454-1464
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• 2020

연구목적은 성인 지적장애인들의 수영 프로그램 참여에 따른 자아효능감과 운동 몰입, 건강관련 삶의 질의 변화를 분석하는 데 있다. 연구대상은 지적장애인 거주시설에서 거주하고 있는 성인 지적장애인 12명이며, 수영 프로그램에 12주간 참여하였다. 이에 따라 대상자들의 자아효능감과 운동 몰입, 건강관련 삶의 질의 변화를 분석하였다. 자아효능감 평가는 전반적 자아효능감 척도를 활용하였으며, 일반적, 사회적 신체적 자아효능감을 평가하였다. 운동 몰입 평가는 스포츠 몰입척도를 활용하였으며, 인지몰입과 행위몰입의 수준을 평가하였다. 건강관련 삶의 질 평가는 건강관련 삶의 질 척도를 활용하여 전반적 건강관련 삶의 질의 수준을 평가하였다. 그 결과, 대상자들은 수영 프로그램 참여에 따라 자아효능감과 운동 몰입, 건강관련 삶의 질의 수준이 통계적으로 유의미하게 향상되었다. 수영 프로그램의 참여는 성인 지적장애인들의 자아효능감과 운동 몰입, 건강관련 삶의 질의 수준을 향상시키는 데 긍정적으로 작용한다. 이에 따라서, 성인 지적장애인들을 대상으로 수영 프로그램의 적용을 고려해볼 필요가 있을 것이다.

• 대한한의학회지
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• 제22권4호
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• pp.90-100
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• 2001

Objectives : Bambusae Caulis in Liquamen (BCL) has been used for stamina fortification in Oriental Medicine for thousand years. The goal of the present study was to investigate the muscle antifatigue effect of BCL. Methods : The mice were divided into three groups. The control group was allowed to swim for 10 minutes without BCL infusion. For the preventive effect of BCL, another group referred to BCL-1 was fed with BCL an hour before the swimming exercise. BCL-2 group for the reversion effect was forced to swim for 10 minutes at first, then fed with BCL followed by half an hour rest and another 10 minute swimming exercise. All the serum samples collected by heart puncture were used for the measuring biochemical factors such as LDH, CPK, glucose, lactate, triglycerides and total cholesterol. Results : In the BCL-2 group, lactate and LDH were significantly reduced compared to the control. BCL infusion during the exercise was effective in metabolizing LDH, reducing the conversion ratio of pyruvate into lactate. In the BCL-1 group, it was not effective in antifatigue function. The level of glucose was significantly reduced in BCL-1 group compared to the control. When the BCL was infused before the exercise, it is assumed that glycogenolysis seen during the exercise was prevented. When the BCL was infused during the exercise, the triglycerides and total cholesterol were increased significantly compared to the control. BCL seems to cause the increase of lipolysis to utilize the fat as an energy source. Unlike other parameters, CPK did not show any changes from BCL infusion. Conclusions : Based on the above results, BCL is found to be involved in energy metabolism. Further studies are needed to find out the underlying mechanism of BCL for its effect on stamina fortification.

• 한국전문물리치료학회지
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• 제13권3호
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• pp.57-66
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• 2006

Ischemic stroke results from a transient or permanent reduction in cerebral blood flow that is restricted to the territory of a major brain artery. Thus, this study was performed to examine (1) the effects of swimming exercise on the improvement of muscle atrophy, and (2) exercise and HSP 70 expression in an ischemic stroke model induced by middle cerebral artery occlusion. The results of this study were as follows: One week after ischemic stroke was induced, changes appeared in the muscle weight of the gastrocnemius muscle due to muscle atrophy in the affected side. Group II showed statistically significant difference from group III eight weeks after ischemic stroke was induced. (p<.05). One week and eight weeks after ischemic stroke was induced there was significant decrease in the relative muscle weight of the gastrocnemius muscle in each group except Group IV, while there was statistically significant increase in group II eight weeks after ischemic stroke was induced, compared to group III (p<.05). For neurologic exercise behavior tests, Group II generally had the highest score, compared to other groups. In immunohistochemical observations, Group II showed a decrease in HSP 70. The above results suggest that swimming exercise improved muscle atrophy, changed the HSP 70 expression of ischemic stroke in rats, and contributed to the improvement of exercise function.

• 한국노년학
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• 제29권2호
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• pp.657-667
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• 2009

본 연구는 규칙적인 유산소 운동이 성장에 따른 세포 복제현상에 미치는 영향을 살펴보기 위하여 염색체 말단에 위치한 텔로미어의 길이와 결합단백질인 TRF 2(telomere repeat binding factor 2)의 발현량을 분석하였다. 흰쥐를 대상으로 장기간 운동집단, 단기간 운동집단, 비교집단 그리고 기준수준 검증을 위한 기준집단의 4집단으로 각각 7마리씩 총28마리를 배정하였으며, 수영 운동은 무부하 자유유영의 형태로 주 5회, 매회 1시간씩 실시하였다. 마지막 운동 종료 후 24시간 뒤 쥐를 희생시켜 심장, 간, 가자미근을 적출하여 genomic DNA를 추출, 텔로미어의 길이와 관련단백질인 TRF 2의 발현량을 분석하였다. 연구 결과, 간조직의 텔로미어 길이와 TRF 2 단백질의 발현량은 집단 간 차이를 발견할 수 없었으나, 심장조직의 텔로미어 길이는 장기간 운동집단이 비교집단 및 단기간 운동집단에 비해 길게 나타났고, TRF 2의 단백질 발현 또한 높게 나타나, 장기간의 수영 운동이 성장에 따른 심장의 텔로미어 단축현상을 지연시키는 효과가 있는 것으로 나타났다. 또한, 가자미근에서는 4주령의 기준집단에 비해 비교집단과 단기간 운동집단의 텔로미어의 길이는 유의하게 짧았으나, 장기간 운동집단과는 유의한 차이가 나타나지 않은 것으로 미루어 장기간의 수영 운동이 골격근의 복제적 노화현상도 억제할 수 있는 가능성을 관찰할 수 있었다.