Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Swimming Exercise and Achyranthes Radix Extracts on Inflammatory and Pain Responses in Rheumatoid Arthritis Rats

류마티스 관절염 흰쥐에서 수중운동과 우슬추출물이 염증 및 통증 반응에 미치는 영향

  • Choi, Ki-Bok (Department of Physical Therapy, Dongshin University) ;
  • Nam, Ki-Won (Department of Physical Therapy, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University) ;
  • Sim, Ki-Cheol (Department of Physical Therapy, Dongshin University) ;
  • Kim, Eun-Jung (Department of Physical Therapy, Dongshin University)
  • Published : 2009.02.25
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Abstract

This study was performed to investigate the effects in inflammatory and pain status on rheumatoid arthritis(RA) induced rats by swimming exercise and Achyranthes Radix(AR) extracts ointment according to the application methods with the change of motor-behavioral and histochemistry study through the change of safranin o-fast green stain in the knee joint and prostaglandin $E_2(PGE_2)$ concentration production in serum for 28 days. They were randomly divided into four groups; Group I: RA induction, Group II: application of only swimming exercise after RA induction, Group III: application of only AR extracts ointment after RA induction, Group IV: application of both AR extracts ointment and swimming exercise after RA induction. The following results were obtained. Volume change of hind paw edema and arthritis indices test and arthritic dorsal flexion & plantar flexion pain test, group II, III, IV were showed that significantly decrease to each scores compared with group I (p<.01). Safranin o-fast green stain were showed histological indices, group II, III, IV were showed that significantly decrease the scores of cellular infiltration and synovial hyperplasia(p<.05), pannus formation and cartilage destruction(p<.01) compared with group I. Group IV were the most decreased compared with group II, III. The $PGE_2$ concentration of the group II, III, IV were decreased compared to the group I (p<.01) In conclusion, swimming exercise and AR extracts ointment acts were the most therapeutic intervention in inflammatory and pain control of RA induced rats.

Keywords

References

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