The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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The Effect of Behavioral Response and Arthritic Tissue on Swimming Exercise and Achyranthes Radix Extracts in Type II Collagen-Induced Arthritic Rat

제 2형 콜라겐 유도 관절염에서 수중운동과 우슬추출물이 행동반응과 관절 조직에 미치는 영향

  • Choi, Ki-Bok (Department of Physical Therapy, College of Health and welfare, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, College of Health and welfare, Dongshin University) ;
  • Nam, Ki-Won (Department of Physical Therapy, College of Health and welfare, Dongshin University) ;
  • Kim, Kyong-Yoon (Department of Physical Therapy, College of Health and welfare, Dongshin University) ;
  • Kim, Eun-Jung (Department of Physical Therapy, College of Health and welfare, Dongshin University)
  • 최기복 (동신대학교 일반대학원 물리치료학과) ;
  • 김계엽 (동신대학교 보건복지대학 물리치료학과) ;
  • 남기원 (동신대학교 보건복지대학 물리치료학과) ;
  • 김경윤 (동신대학교 보건복지대학 물리치료학과) ;
  • 김은정 (동신대학교 보건복지대학 물리치료학과)
  • Received : 2009.04.29
  • Accepted : 2009.06.08
  • Published : 2009.06.25
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Abstract

Purpose: This study examined the effects of swimming exercise and Achyranthes Radix extracts on the inflammatory and behavioral responses in type II collagen-induced arthritic rats for 28 days. Methods: Sprague-Dawley rats were allocated randomly to one of the following four groups: only type II collageninduced (group Ⅰ), application of swimming exercise after type II collagen-induced (group II), application of Achyranthes Radix ointment after type II collagen-induced (group III), application of swimming exercise and Achyranthes Radix ointment after type II collagen-induced (group IV). Arthritis was established in SD rats by an intradermal injection of Chick type II collagen plus incomplete Freund's adjuvant at the base of the tail of the animals. The swimming exercise program consisted of a 25 min swimming session/day with a load corresponding to 5.5% of the weight bearing, three days/week for four weeks. The Achyranthes Radix ointment (0.1g) was applied twice a day for five days. The changes in behavior, H & E stain, and cyclooxygenase-2 (COX-2) level in the knee joint were assessed. Results: The gross and histological examination, after RA induction showed reddening, edema and erythema. The H & E stain revealed the destruction of articular cartilage, bony erosion and the infiltration of inflammatory cells after RA induction. The mechanical allodynia test results were significantly higher in group I than in groups II, III and IV (p<0.01). The immunohistochemistrical response of COX-2 in the knee joint showed that groups II, III, IV had a lower response effect than group I. Conclusion: Swimming exercise training and Achyranthes Radix ointment decreased the inflammatory responses and enhanced the behavioral responses in the arthritic rats.

Keywords

References

  1. Stoerk HC, Bielinski LC, Budzilovich T. Chronic polyarthritis in rats injected with spleen in adjuvants. Am J Pathol. 1954;30:616.
  2. Boissier MC, Bessis N. Therapeutic gene transfer for rheumatoid arthritis. Reumatismo. 2004;56(Suppl 1):51-61.
  3. Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Inc, 2005.
  4. Guyton AC, Hall JE. Tratado de fisiologia medica. Rio de Janeiro, Guanabara Koogan, 2002:516-26.
  5. Hawkey CJ. COX-1 and COX-2 inhibitors. Best Pract Res Clin Gastroenterol. 2001;15(5):801-20. https://doi.org/10.1053/bega.2001.0236
  6. Spangler RS. Cyclooxygenase 1 and 2 in rheumatic disease: implications for nonsteroidal anti-inflammatory drug therapy. Semin Arthritis Rheum. 1996;26(1):435-46. https://doi.org/10.1016/S0049-0172(96)80024-2
  7. Pedersen BK, Toft AD. Effects of exercise on lymphocytes and cytokines. British Journal of Sports Medicine. 2000;34(4):246-51. https://doi.org/10.1136/bjsm.34.4.246
  8. Nieman DC. Influence of carbohydrate on the immune response to intensive prolonged exercise. Exerc Immunol. 1998;4:64-76.
  9. Shavit Y, Terman GW, Martin FC et al. Stress, opioid peptides, the immune system, and cancer. Journal of immunology. 1985;135:834S-7S.
  10. Contarteze RV, Manchado Fde B, Gobatto CA et al. Stress biomarkers in rats submitted to swimming and treadmill running exercises. Comp Biochem Physiol A Mol Integr Physiol. 2008;151(3):415-22. https://doi.org/10.1016/j.cbpa.2007.03.005
  11. Gobatto CA, de Mello MA, Sibuya CY et al. Maximal lactate steady state in rats submitted to swimming exercise. Comp Biochem Physiol A Mol Integr Physiol. 2001;130(1):21-7. https://doi.org/10.1016/S1095-6433(01)00362-2
  12. Seo DW, Pyen SB, Kim SJ. Changes of local temperature and pain produced by superficial heat. The Journal of Korean Academy of Rehabilitation Medicine. 1994;18(2):227-33.
  13. Kim JI. An effect of aquatic exercise program with self-help group activities and strategies for promoting self-efficacy on pain, physiological parameters and quality of life in patients having rheumatoid arthritis. Seoul University. Dissertation of Doctorate Degree. 1994.
  14. Kim EH. Effect and principal of rhythmical exercise and swimming exercise. The Journal of Rheumatology Health. 1998;5(2):296-302.
  15. Basmajian JV. Therapeutic exercise in the management of rheumatic diseases. J Rheumatol Suppl. 1987;14(15):22-5.
  16. Fang JN, Zhang ZH, Liu BN. Chemical studies on polysaccharide of Achyrantes bidentate. Yaoxue xuebao. 1990;25:526-9.
  17. Eum HA, Lee WY, Kim SH et al. Anti-inflammatory activity of CML-1: an herbal formulation. Am J Chin Med. 2005;33(1):29-40. https://doi.org/10.1142/S0192415X05002631
  18. Trentham DE. Collagen arthritis as a relevant model for rheumatoid arthritis. Arthritis Rheum. 1982;25(8):911-6. https://doi.org/10.1002/art.1780250801
  19. Chen Q, Wei W. Effects mechanisms of glucosides of chaenomeles speciosa on collagen-induced arthritis in rats. Int Immunopharmacol. 2003;3(4):593-608. https://doi.org/10.1016/S1567-5769(03)00051-1
  20. Campion M. Hydrotherapy principles and practice. In: Tinsley LM, eds, Rheumatic Diseases, Oxford, Butterworth-Heinemann, 1998:3-13.
  21. Lee HS. Transdermal permeation to hydrophilic vitamin $B_{2}$(riboflavin) of chitosan ointments in vitro. Bull Nat Sci Yong-In Univ. 2001;6(1):1-7. https://doi.org/10.1007/BF03160221
  22. Shimizu I, Iida T, Guan Y et al. Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain. 2005;116(1-2):96-108. https://doi.org/10.1016/j.pain.2005.03.030
  23. Chaplan SR, Bach FW, Pogrel JW et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53(1):55-63. https://doi.org/10.1016/0165-0270(94)90144-9
  24. John R. Human interferon action; Reciprocal regulation by retinoic acid and $\beta$-carotene. J Natl Cancer Inst. 1983;70(5):833-7.
  25. Jung WJ. Effects of dietary antioxidants on inflammtory responses and rheumatoid arthritis. Sookmyung Women's University. Dissertation of Master's Degree. 2005.
  26. Park W. The treatment effect of Honghwa-ja herbal acupuncture to inhibitory MIF activation on synovial membrane by LPS-induced arthritis. Dongguk University. Dissertation of Master's Degree. 2006.
  27. Kim SJ, Park JB, Kwon YH et al. Therapeutic effects Archyranthes Radix on hard tissue regeneration. The Journal of Applied Pharmacology. 2002;10(4):253-257.
  28. Lee JC. The effects of Achyrantes radix and electroacupuncture on type II collagen-induced arthritis. Dongshin University. Dissertation of Master's Degree. 2007.
  29. Cho YM. The effect of hydrotherapy on the balance in stroke patient. Chonnam National University. Dissertation of Master's Degree. 2007.
  30. Fallon KE, Fallon SK, Boston T. The acute phase response and exercise: court and field sports. Br J Sports Med. 2001;35(3):170-3. https://doi.org/10.1136/bjsm.35.3.170
  31. Sugiura H, Nishida H, Inaba R et al. Immunomodulation by 8-week voluntary exercise in mice. Acta Physiol Scand. 2000;168(3):413-20. https://doi.org/10.1046/j.1365-201x.2000.00674.x
  32. Surh YJ, Chun KS, Cha HH et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res. 2001;480-481:243-68.
  33. Kim DH, Park LJ, Jern KH. The effect of cryotherapy on release of inflammation in patient with rheumatoid arthritis. J Kor Soc Phys Ther. 2001;13(1):175-88.
  34. Rothktter HJ, Pabst R, Bailey M. Lymphocyte migration in the intestinal mucosa: entry, transit and emigration of lymphoid cells and the influence of antigen. Vet Immunol Immunopathol. 1999;72(1-2):157-65. https://doi.org/10.1016/S0165-2427(99)00128-2
  35. Han GY. Protective Effects of Monotropin Isolated from Morinda officinalis against FCA-Induced Oxidative Stress in Rheumatoid Arthritis. Kyungsung University. Dissertation of Doctorate Degree. 2006.
  36. Cuzzocrea S, Ayroldi E, Di Paola R et al. Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis. FASEB J. 2005;19(10):1253-65. https://doi.org/10.1096/fj.04-3556com
  37. Korotkova M, Westman M, Gheorghe KR et al. Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway. Arthritis Rheum. 2005;52(11):3439-47. https://doi.org/10.1002/art.21390
  38. Olszanecki R, Gebska A, Korbut R. Production of prostacyclin and prostaglandin E2 in resting and IL-1beta-stimulated A549, HUVEC and hybrid EA.HY 926 cells. J Physiol Pharmacol. 2006;57(4):649-60.