• Journal of the Korean Data and Information Science Society
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• 제13권2호
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• pp.31-38
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• 2002

In the case of multiple survival times which might be censored at each covariate vector, we study the regression quantile estimations in this paper. The estimations are based on the empirical distribution functions of the censored times and the sample quantiles of the observed survival times at each covariate vector and the weighted least square method is applied for the estimation of the regression quantile. The estimators are shown to be asymptotically normally distributed under some regularity conditions.

• Communications for Statistical Applications and Methods
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• 제31권1호
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• pp.155-178
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• 2024

Regression discontinuity (RD) design is one of the most widely used methods in causal inference for estimation of treatment effect when the treatment is created by a cutpoint from the covariate of interest. There has been little attention to RD design, although it provides a very useful tool for analysis of treatment effect for censored data. In this paper, we define the causal effect for survival function in RD design when the treatment is assigned deterministically by the covariate of interest. We propose estimators of this causal effect for survival data by using transformation, which leads unbiased estimator of the survival function with local linear regression. Simulation studies show the validity of our approach. We also illustrate our proposed method using the prostate, lung, colorectal and ovarian (PLCO) dataset.

• Communications for Statistical Applications and Methods
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• 제17권1호
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• pp.117-126
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• 2010

Clinical researchers often analyze survival data as binary outcomes using the logistic regression method. This paper examines the information loss resulting from analyzing survival time as binary outcomes. We first demonstrate that, under the proportional hazard assumption, this binary discretization does result in a significant information loss. Second, when fitting a logistic model to survival time data, researchers inadvertently use the maximal statistic. We implement a numerical study to examine the properties of the reference distribution for this statistic, finally, we show that the logistic regression method can still be a useful tool for analyzing survival data in particular when the proportional hazard assumption is questionable.

• Journal of the Korean Data and Information Science Society
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• 제25권5호
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• pp.1151-1160
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• 2014

In DNA microarray studies, the number of genes far exceeds the number of samples and the gene expression measures are highly correlated. Partial least squares regression (PLSR) is one of the popular methods for dimensional reduction and known to be useful for the classifications of microarray data by several studies. In this study, we suggest a modified version of the partial least squares regression to analyze gene expression data with survival information. The method is designed as a new gene selection method using PLSR with an iterative procedure of imputing censored survival time. Mean square error of prediction criterion is used to determine the dimension of the model. To visualize the data, plot for variables superimposed with samples are used. The method is applied to two microarray data sets, both containing survival time. The results show that the proposed method works well for interpreting gene expression microarray data.

• Journal of the Korean Data and Information Science Society
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• 제19권2호
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• pp.487-496
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• 2008

Recently survival analysis becomes popular in a variety of fields so that a number of statistical packages are developed for analyzing the survival model. In this paper, several types of survival models are introduced and considered briefly. In addition, widely used three packages(SAS, SPSS, and STATA) for survival data are reviewed and their characteristics are investigated.

• Communications for Statistical Applications and Methods
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• 제23권3호
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• pp.259-268
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• 2016

High-dimensional survival data with large numbers of predictors has become more common. The analysis of such data can be facilitated if the dimensions of predictors are adequately reduced. Recent studies show that a method called sliced inverse regression (SIR) is an effective dimension reduction tool in high-dimensional survival regression. However, it faces incapability in implementation due to a double categorization procedure. This problem can be overcome in the right-censoring type by transforming the observed survival time and censoring status into a single variable. This provides more flexibility in the categorization, so the applicability of SIR can be enhanced. Numerical studies show that the proposed transforming approach is equally good to (or even better) than the usual SIR application in both balanced and highly-unbalanced censoring status. The real data example also confirms its practical usefulness, so the proposed approach should be an effective and valuable addition to usual statistical practitioners.

• Communications for Statistical Applications and Methods
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• 제25권5호
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• pp.523-544
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• 2018

Bivariate distributions play a fundamental role in survival and reliability studies. We consider a regression model for bivariate survival times under right-censored based on the bivariate Kumaraswamy Weibull (Cordeiro et al., Journal of the Franklin Institute, 347, 1399-1429, 2010) distribution to model the dependence of bivariate survival data. We describe some structural properties of the marginal distributions. The method of maximum likelihood and a Bayesian procedure are adopted to estimate the model parameters. We use diagnostic measures based on the local influence and Bayesian case influence diagnostics to detect influential observations in the new model. We also show that the estimates in the bivariate Kumaraswamy Weibull regression model are robust to deal with the presence of outliers in the data. In addition, we use some measures of goodness-of-fit to evaluate the bivariate Kumaraswamy Weibull regression model. The methodology is illustrated by means of a real lifetime data set for kidney patients.

• Communications for Statistical Applications and Methods
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• 제24권5호
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• pp.533-541
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• 2017

Sufficient dimension reduction (SDR) replaces original p-dimensional predictors to a lower-dimensional linearly transformed predictor. The sliced inverse regression (SIR) has the longest and most popular history of SDR methodologies. The critical weakness of SIR is its known sensitive to the numbers of slices. Recently, a fused sliced inverse regression is developed to overcome this deficit, which combines SIR kernel matrices constructed from various choices of the number of slices. In this paper, the fused sliced inverse regression and SIR are compared to show that the former has a practical advantage in survival regression over the latter. Numerical studies confirm this and real data example is presented.

• Communications for Statistical Applications and Methods
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• 제21권4호
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• pp.285-296
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• 2014

The quantile residual life function has been effectively used to interpret results from the analysis of the proportional hazards model for censored survival data; however, the quantile residual life function is not always estimable with currently available semi-parametric regression methods in the presence of heavy censoring. A parametric regression approach may circumvent the difficulty of heavy censoring, but parametric assumptions on a baseline hazard function can cause a potential bias. This article proposes a Bayesian semi-parametric regression approach for inference on an unknown baseline hazard function while adjusting for available covariates. We consider a model-based approach but the proposed method does not suffer from strong parametric assumptions, enjoying a closed-form specification of the parametric regression approach without sacrificing the flexibility of the semi-parametric regression approach. The proposed method is applied to simulated data and heavily censored survival data to estimate various quantile residual lifetimes and adjust for important prognostic factors.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2009년도 정보 및 제어 심포지움 논문집
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• pp.132-134
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• 2009

Hemorrhagic shock is a common cause of death in emergency rooms. Since the symptoms of hemorrhagic shock occur after shock has considerably progressed, it is difficult to diagnose shock early. The purpose of this study was to improve early diagnosis of hemorrhagic shock using a survival prediction model in rats. We measured ECG, blood pressure, respiration and temperature in 45 Sprague-Dawley rats, and then obtained a logistic regression equation predicting survival rates. Area under the ROC curves was 0.99. The Hosmer-Lemeshow goodness-of-fit chi-square was 0.86(degree of freedom=8, p=0.999). Applying the determined optimal boundary value of 0.25, the accuracy of survival prediction was 94.7%