• Journal of Ginseng Research
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• v.46 no.5
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• pp.621-627
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• 2022

Background: Panax ginseng (ginseng) is a traditional medicine that is reported to have cardioprotective effects; ginsenosides are the major bioactive compounds in the ginseng root. Methods: Magnetic molecularly imprinted polymer (MMIP) nanoparticles might be useful for both the extraction of the targeted (imprinted) molecules, and for the delivery of those molecules to cells. In this work, plant growth regulators were used to enhance the adventitious rooting of ginseng root callus; imprinted polymeric particles were synthesized for the extraction of ginsenoside Rb₁ from root extracts, and then employed for subsequent particle-mediated delivery to cardiomyocytes to mitigate hypoxia/reoxygenation injury. Results: These synthesized composite nanoparticles were first characterized by their specific surface area, adsorption capacity, and magnetization, and then used for the extraction of ginsenoside Rb₁ from a crude extract of ginseng roots. The ginsenoside-loaded MMIPs were then shown to have protective effects on mitochondrial membrane potential and cellular viability for H9c2 cells treated with CoCl₂ to mimic hypoxia injury. The protective effect of the ginsenosides was assessed by staining with JC-1 dye to monitor the mitochondrial membrane potential. Conclusion: MMIPs can play a dual role in both the extraction and cellular delivery of therapeutic ginsenosides.

• Tunnel and Underground Space
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• v.32 no.6
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• pp.345-352
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• 2022

The existing NATM (New Austrian Tunneling Method) has induced civil compliants due to blasting vibration and noise. Machanized excavation methods such as TBM (Tunnel Boring Machine) are being adopted in the planning and construction of tunneling projects. Shield TBM method is composed of repetition processes of TBM excavation and segment installation, the machine has to be stopped during the later process. Consecutive excavation technology using helical segment is under developing to minimize the stoppage time. The modification of thrust jacks and module are planned to ensure the advance force acting on the inclined surface of helical segment. Also, the integrated system design of hydraulic circuit will be remodeled. This means that the system deactivate the jacks on the installing segment while the others automatically act the thrusting forces on the existing segments. This report briefly introduces the mechanical research part of the current consecutive excavation technological development project of TBM.

• Smart Structures and Systems
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• v.29 no.2
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• pp.267-278
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• 2022

Pre-stressed concrete circular spun piles are widely used in various infrastructure projects around the world and offer an economical deep foundation system with consistent and superior quality compared to cast in-situ and other concrete piles. Conventional methods for measuring the lateral response of piles have been limited to conventional instrumentation, such as electrical based gauges and pressure transducers. The problem with existing technology is that the sensors are not able to assist in recording the lateral stiffness changes of the pile which varies along the length depending on the distribution of the flexural moments and appearance of tensile cracks. This paper describes a full-scale bending test of a 1-m diameter spun pile of 30 m long and instrumented using advanced fibre optic distributed sensor, known as Brillouin Optical Time Domain Analysis (BOTDA). Optical fibre sensors were embedded inside the concrete during the manufacturing stage and attached on the concrete surface in order to measure the pile's full-length flexural behaviour under the prescribed serviceability and ultimate limit state. The relationship between moments-deflections and bending moments-curvatures are examined with respect to the lateral forces. Tensile cracks were measured and compared with the peak strains observed from BOTDA data which corroborated very well. By analysing the moment-curvature response of the pile, the structure can be represented by two bending stiffness parameters, namely the pre-yield (EI) and post-yield (EI_cr), where the cracks reduce the stiffness property by 89%. The pile deflection profile can be attained from optical fibre data through closed-form solutions, which generally matched with the displacements recorded by Linear Voltage Displacement Transducers (LVDTs).

• Geomechanics and Engineering
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• v.31 no.5
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• pp.439-452
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• 2022

A forecast of slope behavior during catastrophic events, such as earthquakes is crucial to recognize the risk of slope failure. This paper endeavors to eliminate the significant supposition of predefined slip surfaces in the slope stability analysis, which questions the relevance of simple conventional methods under seismic conditions. To overcome such limitations, a methodology dependent on the slip line hypothesis, which permits an automatic generation of slip surfaces, is embraced to trace the extreme slope face under static and seismic conditions. The effect of earthquakes is considered using the pseudo-static approach. The current outcomes developed from a parametric study endorse a non-linear slope surface as the extreme profile, which is in accordance with the geomorphological aspect of slopes. The proposed methodology is compared with the finite element limit analysis to ensure credibility. Through the design charts obtained from the current investigation, the stability of slopes can be assessed under seismic conditions. It can be observed that the extreme slope profile demands a flat configuration to endure the condition of the limiting equilibrium at a higher level of seismicity. However, a concurrent enhancement in the shear strength of the slope medium suppresses this tendency by offering greater resistance to the seismic inertial forces induced in the medium. Unlike the traditional linear slopes, the extreme slope profiles mostly exhibit a steeper layout over a significant part of the slope height, thus ensuring a more optimized solution to the slope stability problem. Further, the susceptibility of the Longnan slope failure in the Huining-Wudu seismic belt is predicted using the current plasticity approach, which is found to be in close agreement with a case study reported in the literature. Finally, the concept of equivalent single or multi-tiered planar slopes is explored through an example problem, which exhibits the appropriateness of the proposed non-linear slope geometry under actual field conditions.

• Journal of Microbiology and Biotechnology
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• v.32 no.12
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• pp.1589-1598
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• 2022

Microfibrillated cellulose (MFC) is a valuable material with wide industrial applications, particularly for the food and cosmetics industries, owing to its excellent physiochemical properties. Here, we prepared high-solid microfibrillated cellulose (HMFC) from the centrifugation of Gelidium amansiiderived MFC right after fibrillation. Dispersion properties, morphology, and structural changes were monitored during processing. HMFC has a five-fold higher solid concentration than MFC without significant changes to dispersion properties. SEM images and FTIR spectra of HMFC revealed a stable surface and structure against centrifugal forces. HMFC exhibited 2,2'-azino-bis (3-ethylbenzothiazoline6-sulfonic acid) (ABTS) radical scavenging activity, although it could not scavenge 2,2-diphenyl-1- picrylhydrazyl (DPPH). Moreover, HMFC inhibited the generation of LPS-induced excessive nitrite and radial oxygen species in murine macrophage RAW264.7 cells. Additionally, HMFC suppressed LPS-induced Keap-1 expression in the cytosol but did not alter iNOS expression. HMFC also attenuated the UVB-induced phosphorylation of p38, c-Jun N-terminal kinase (JNK) 1/2, and extracellular-signal-regulated kinase (ERK) 1/2, as well as the phosphorylation of c-Jun in the immortalized human skin keratinocyte HaCaT cells. Therefore, the application of centrifugation is suitable for producing high-solid MFC as a candidate material for anti-inflammatory and antioxidative marine cosmeceuticals.

• Journal of the Korea Society for Simulation
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• v.19 no.1
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• pp.33-39
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• 2010

As future warfare becomes network-centric, war-game simulators require high interoperability between networked forces and dynamic reconfiguration in accordance with war events. In this paper, we propose an event-driven methodology to develop dynamic war-game simulations. Federates are developed by event-driven web services. The event-driven web services consistently sense war events and response them only if they are interested. By the sense-and-response mechanism and asynchronous event processing, we are able to save simulation time. An Anti-Surface-Warfare simulator is constructed to demonstrate the methodology and suggests that event-driven web services are efficient to model and simulate warfare where numerous events are generated from hardware systems and people dispersed on the network.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.10
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• pp.154-160
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• 1996

The control of diamond turning is usually achieved through a laser-interferometer feedback of slide position. The limitation of this control scheme is that the feedback signal does not account for additional dynamics of the tool post and the material removal process. If the tool post is rigid and the material removal process is relatively static, then such a non-collocated position feedback control scheme may surfice. However, as the accuracy requirement gets tighter and desired surface cnotours become more complex, the need for a direct tool-tip sensing becomes inevitable. The physical constraints of the machining process prohibit any reasonable implementation of a tool-tip motion measurement. It is proposed that the measured force normal to the face of the workpiece can be filtered through an appropriate admittance transfer function to result in the estimated dapth of cut. This can be compared to the desired depth of cut to generate the adjustment control action in additn to position feedback control. In this work, the design methodology on the admittance model-based control with a conventional controller is presented. The recursive least-squares algorithm with forgetting factor is proposed to identify the parameters and update the cutting process in real time. The normal cutting forces are measured to identify the cutting dynamics in the real diamond turning process using the precision dynamoneter. Based on the parameter estimation of cutting dynamics and the admitance model-based nanodynamic control scheme, simulation results are shown.

• Journal of the Korean Geotechnical Society
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• v.22 no.3
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• pp.37-43
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• 2006

An analytical solution method capable of determining the geometric configuration and developed tensile forces of mooring lines associated with fixed plate/pile or drag anchors has been developed. The solution method, satisfying complete equilibrium conditions, is capable of analyzing multi-segmented mooring lines that can consist of either chains, cables, or synthetic wires embedded in layered seafloor soils. The solution method utilizes a systematic iterative search method based on specific boundary conditions. This paper describes the principles associated with the development of the solution for the mooring line analysis. Comparisons of predictions with results from a series of field tests of mooring lines on various types of drag anchors are also described. Comparisons include the tension in anchor, the length of mooring line on the bottom, and the angle of mooring line at the water surface buoy. The results indicate that the analytical solution method is capable of predicting the behavior of mooring lines with high degree of accuracy.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.36 no.3
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• pp.214-225
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• 2023

Piezoelectric actuators, which utilize piezoelectric crystals or ceramics, are commonly used in precision positioning applications, offering high-speed response and precise control. However, the use of low-performance ceramics and expensive single crystals is limiting their versatile use in the actuator market, necessitating the development of both high-performance and cost-effective piezoelectric materials capable of delivering higher forces and displacements. The use of textured Pb (lead)-based piezoelectric ceramics formed by so-called templated grain growth method has been identified as a promising strategy to address the performance and cost issue. This review article provides insights into recent advances in texturing Pb-based piezoelectric ceramics for improved performance in actuation applications. We discussed the relevant issues in detail focusing on current challenges and emerging trends in the textured piezoelectric ceramics for their reliability and performance in actuator applications. We discussed in detail focusing on current challenges and emerging trends of textured piezoelectric ceramics for their reliability and performance in actuator applications. In conclusion, the article provides an outlook on the future direction of textured piezoelectric ceramics in actuator applications, highlighting the potential for further success in this field.

• Journal of Aerospace System Engineering
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• v.17 no.2
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• pp.26-37
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• 2023

Urban air mobility (UAM) is being developed as part of the next-generation aircraft, which could be a viable solution to entrenched problems of urban traffic congestion and environmental pollution. A new airport platform called vertiport as a space where UAM can take off and land vertically is also being introduced. Noise regulations for UAM will be strict due to its operation in a highly populated urban area. Ground effects caused by vertiport can directly affect aerodynamic forces and noise characteristics of UAM. In this study, ground effects of vertiport on aerodynamic loads, vorticity field, and far-field noise were analyzed using Lattice-Boltzmann Method (LBM) simulation and Ffowcs Williams and Hawkings (FW-H) acoustic analogy with a permeable surface method.