• Journal of Environmental Health Sciences
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• v.5 no.1
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• pp.51-57
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• 1978

Antibiotics susceptibilities of Staphylococci were tested to get useful data for prevention food contamination and treatment of food poisoning. Tested were colony counts, isolation of Staphylococci, identification for the Staphylococcus aureus and resistant patterns to antimcrobial agents. The colonies and Staphylococci isolated from the atmosphere of 37 home kitchens in the morning (07:00-08:00) on Nov. 19, 1977 in Busan. The findings are as follows: 1. The average of colony counts was shown to be 9.6 ranging from 47 to 1 at mean temperature of 18$\circ$C (the highest 21$\circ$C, the lowest 15$\circ$C) 2. Out of total 37 kitchens, 18 Staphylococci were isolated from 15 kitchens with 40.5 per cent, and 4 Staphylococcus aureus were identified with 22.2 per cent from 18 Staphylococci. 3. Isolated Staphylococci were resistant to penicillin(100%), dihydrostreptomycin(93.3%), tetracycline (93.3%) and oleandomycin(66.6%), while the strains were sensitive to sulfonamide(88.6%) and colistin(83.3%). 4. Staphylococcus aureus identified were resistant to dihydrostreptomycin, penicillin and tetracycline, while the strains were sensitive to sulfonamide and colistin.

• Korean Journal of Veterinary Research
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• v.34 no.1
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• pp.141-146
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• 1994

돈육의 가열과 냉동저장시 잔류된 설폰아미드가 증가 또는 감소되는 정도를 조사하였다. 설파메라진, 설파메타진, 설파모노메톡신, 설파디메톡신, 설파퀴녹사린을 돈육에 100ng/g씩 주사하고 30분간 $60^{\circ}C$로 가열하였을 때 설파메타진은 40%증가하였으나, $60-120^{\circ}C$로 가열한 다른 설폰아미드는 12-22% 감소하였다. 4주간 $-20{^{\circ}C}$이하로 냉동하였을 때, 설파메라진과 설파퀴녹사린은 각각 12%, 19% 감소하였으나 다른 설폰아미드는 변화가 없었다. 설폰아미드의 검출한계는 고상분산을 이용한 정제시 2.6-27ng/g이있으며, 액상분배를 이용한 정제시 25-36ng/g이었다. 본 실험의 결과 돈육중의 설폰아미드는 가열과 냉동저장에 따라 안정성이 변화될 수 있으며, 잔류물 정제방법으로는 고상분산과 액상분배방법을 이용할 수 있을 것으로 생각된다.

• Bulletin of the Korean Chemical Society
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• v.35 no.1
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• pp.111-116
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• 2014

The kinetics and mechanism of oxidation of sulfanilic acid by N-chloro-p-toluene sulfonamide (chloramine-T) have been studied in acid medium. The species of chloramine-T were analysed on the basis of experimental observations and predominantly reactive species was taken into account for proposition of most plausible reaction mechanism. The derived rate law (1) conforms to such a mechanism. $$-\frac{d[CAT]}{dt}=\frac{kK_1[RNHCl][SA]}{K_1+[H^+]}$$ (1) All kinetic parameters were evaluated. Activation parameters such as energy and entropy of activation were calculated to be $(61.67{\pm}0.47)kJmol^{-1}$ and $(-62.71{\pm}2.48)kJmol^{-1}$ respectively employing Eyring equation.

• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2507-2510
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• 2013

• Journal of the Korean Applied Science and Technology
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• v.16 no.4
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• pp.293-298
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• 1999

Dual-action agents are unique chemical entities comprised of two different types of antibacterial compounds covalently linked together in a single molecule in such a way that both components are able to exert their bactericidal properties. Crosslinked sulfadiazine-sulfacetamide such as antibiotics synthesized by crosslingking reaction such as glutaraldehyde. These structures of the compounds were confirmed by IR, NMR. 4 strains of Gram(+) and Gram(-) revealed effective susceptibility to synthetic crosslinked sulfadiazine-sulfacetamide.

• Bulletin of the Korean Chemical Society
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• v.15 no.7
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• pp.592-595
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• 1994

• Journal of Korean Society of Environmental Engineers
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• v.31 no.12
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• pp.1105-1112
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• 2009

Antibiotics are biologically active substances and commonly used for therapeutic treatment of infectious disease in humans and for treating and protecting the health of animals. In recent years, antibiotics have attracted worldwide attention because of their side effects on the environment. Consequently, efforts have been made to monitor the residual of antibiotics in the environment. This study tested the mobility of tetracyclines and sulfonamides in soil and leachate through column experiments. The three tetracycline antibiotics showed higher mass recovery rates in all kinds of soils(28.00~44.11%) than in leachate(10.54~27.43%). This seems attributable to the high adsorption coefficient values($K_d$) of tetracyclines representing strong and active adsorbability to organic and mineral phases in soil, ending up relatively small amount being detected in surface water. By contrast, the sulfonamides(sulfamethazine and sulfathiazole) showed higher mass recovery rates in leachate(23.19~26.20%) compared to in soil(10.41~14.21%) due to lower adsorption coefficient values and higher mobility of sulfonamides, enabling easier movement to surface water through the runoff in the environment.

• Korean Journal of Environmental Agriculture
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• v.28 no.3
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• pp.266-273
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• 2009

This study was conducted to develop more convenient simultaneous determination method by matrix solid phase dispersion (MSPD) and HPLC for sulfonamides such as sulfamerazine (SMR), sulfamethazine (SMT), sulfamonomethoxine (SMM), sulfadimethoxine (SDM), sulfaquinoxaline (SQX), and tetracyclines including oxytetracycline (OTC), tetracycline (TC) chlortetracycline (CTC) in prok and flatfish. The limits of detection were 0.047 $mg{\cdot}kg^{-1}$ for OTC, TC, SMR, SMT and SMM, and 0.033 $mg{\cdot}kg^{-1}$ for CTC, SDM, and SQX, respectively. So it is sufficiently possible to detect the eight tetracyclines and sulfonamides under their MRLs ($0.1{\sim}0.2mg{\cdot}kg^{-1}$). The average percentage recoveries of sulfonamides and tetracyclines from pig muscle and flatfish spiked standard solution were approximately $80.25{\sim}101.25%$ and $85.77{\sim}121.42%$, respectively. Therefore this method was efficient for simultaneous analysis of eight tetracyclines and sulfonamides.

• YAKHAK HOEJI
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• v.1 no.1
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• pp.22-29
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• 1948

미국약품의 해설은 이미 Pamphlet, 혹은 의학잡지등에 소개되여서 이에 사족을 부칠 필요가 없으나 전자의 기재가 주로 의사를 대상으로 하여 사용법에 치중한 감이 있으므로 이번에는 각도를 달리하여 약제사의 입장에서 본 물리학적 화학적 상수를 주로한 해설을 하여보았다. 특히 Sulfonamide 제는 요즈음 위조품이 횡행하므로 감정법도 기재하였다. 그러나 워낙 둔재이고 천학비식한 자가 한일이라 두찬과 오류가 허다 할 것이다. 널리 양해하기를 바라는 바이다.

• Macromolecular Research
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• v.17 no.10
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• pp.770-775
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• 2009

$\omega$-Anhydride-functionalized poly(ethylene oxide) (PEO) obtained from chain-end functionalization and anionic ring-opening polymerization of ethylene oxide using n-butyllithium with potassium t-butoxide in the presence of dimethylsulfoxide (DMSO) was found to be an efficient material for the preparation of water-soluble, polymeric pro-drugs. The reaction of $\omega$-anhydride-functionalized PEO with sulfonamide or with vancomycin provided an efficient method to produce corresponding, water-soluble, PEO-conjugated sulfonamide or PEO-conjugated, vancomycin pro-drugs. These were used successfully to prepare water-dispersible, silver nanoparticles. In this study, the particle sizes were in the range of $5{\sim}40$ nm. The resulting products were characterized by $^1H$ NMR spectroscopy, transmission electron microscopy, electron and X-ray diffraction, size exclusion chromatography, and UV/Visible spectroscopy.