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Preparation and Characterization of Water-Dispersible Silver Nanoparticles Stabilized by PEO-Conjugated Pro-Drugs  

Kim, Tae-Hwan (Department of Chemistry, Kyunghee University)
Kim, Keun-Suk (Department of Chemistry, Kyunghee University)
Park, Geon-Hee (Department of Chemistry, Kyunghee University)
Choi, Jin-Hee (Department of Chemistry, Kyunghee University)
Lee, Sang-Mi (Department of Chemistry, Kyunghee University)
Kang, Ho-Jung (Department of Chemistry, Kyunghee University)
Lee, Jae-Yeol (Department of Chemistry, Kyunghee University)
Kim, Jung-Ahn (Department of Chemistry, Kyunghee University)
Publication Information
Macromolecular Research / v.17, no.10, 2009 , pp. 770-775 More about this Journal
Abstract
$\omega$-Anhydride-functionalized poly(ethylene oxide) (PEO) obtained from chain-end functionalization and anionic ring-opening polymerization of ethylene oxide using n-butyllithium with potassium t-butoxide in the presence of dimethylsulfoxide (DMSO) was found to be an efficient material for the preparation of water-soluble, polymeric pro-drugs. The reaction of $\omega$-anhydride-functionalized PEO with sulfonamide or with vancomycin provided an efficient method to produce corresponding, water-soluble, PEO-conjugated sulfonamide or PEO-conjugated, vancomycin pro-drugs. These were used successfully to prepare water-dispersible, silver nanoparticles. In this study, the particle sizes were in the range of $5{\sim}40$ nm. The resulting products were characterized by $^1H$ NMR spectroscopy, transmission electron microscopy, electron and X-ray diffraction, size exclusion chromatography, and UV/Visible spectroscopy.
Keywords
water-dispersible Ag nanoparticle; PEO-conjugated pro-drugs; PEO-sulfadiazine;
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