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Transport of Selected Veterinary Antibiotics (Tetracyclines and Sulfonamides) in a Sandy Loam Soil: Laboratory-Scale Soil Column Experiments  

Lee, Hyeon-Yong (Department of Biological Environment, Kangwon National University)
Lim, Jung-Eun (Department of Biological Environment, Kangwon National University)
Kim, Sung-Chul (Department of Biological Environment, Kangwon National University)
Kim, Kwon-Rae (National Academy of Agricultural Science, Rural Development Administration)
Kwon, Oh-Kyung (National Academy of Agricultural Science, Rural Development Administration)
Yang, Jae-E. (Department of Biological Environment, Kangwon National University)
Ok, Yong-Sik (Department of Biological Environment, Kangwon National University)
Publication Information
Abstract
Antibiotics are biologically active substances and commonly used for therapeutic treatment of infectious disease in humans and for treating and protecting the health of animals. In recent years, antibiotics have attracted worldwide attention because of their side effects on the environment. Consequently, efforts have been made to monitor the residual of antibiotics in the environment. This study tested the mobility of tetracyclines and sulfonamides in soil and leachate through column experiments. The three tetracycline antibiotics showed higher mass recovery rates in all kinds of soils(28.00~44.11%) than in leachate(10.54~27.43%). This seems attributable to the high adsorption coefficient values($K_d$) of tetracyclines representing strong and active adsorbability to organic and mineral phases in soil, ending up relatively small amount being detected in surface water. By contrast, the sulfonamides(sulfamethazine and sulfathiazole) showed higher mass recovery rates in leachate(23.19~26.20%) compared to in soil(10.41~14.21%) due to lower adsorption coefficient values and higher mobility of sulfonamides, enabling easier movement to surface water through the runoff in the environment.
Keywords
Soil; Water; Antibiotics; Tetracycline; Sulfonamide; Transport;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Tolls, J.,“Sorption of veterinary pharmaceuticals in soils: A reiview,” Environ. Sci. Technol., 35(17), 3397-3406(2001)   DOI   PUBMED   ScienceOn
2 손희종, 정종문, 황영도, 노재순, 유평종, “활성탄 재질 및 사용연수에 따른 Tetracycline계 항생물질 흡착특성,” 대한환경공학회지, 30(9), 925-932(2008)
3 Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., and Buxton, H. T., “Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance,” Environ. Sci. Technol., 36(6), 1202-1211(2002)   DOI   ScienceOn
4 Haggard, B. E., Galloway, J. M., Green, W. R., and Meyer, M. T., “Pharmaceuticals and other organic chemicals in selected northcentral and northwestern Arkansas streams,” J. Environ. Qual., 35(4), 1078-1087(2006)   DOI   ScienceOn
5 옥용식, 작물재배환경에서 중금속 및 항생물질의 안정성 평가, 농업과학기술개발공동연구사업 연차보고서, 농촌진흥청 (2008)
6 임정은, 김성철, 이현용, 권오경, 양재의, 옥용식, “국내 우분 퇴비화 시설 인근 농경지 및 수계 중 Tetracycline 및 Sulfonamide 계열 항생물질의 분포특성,” 대한환경공학회지, 31(10), 845-854
7 Kim, S. C., and Carlson, K., “Quantification of human and veterinary antibiotics in water and sediment using SPE/LC/MS/MS,” Anal. Bio. Chem., 387(4), 1301-1315(2007)   DOI   ScienceOn
8 Migliore, L., Cozzolino, S., and Fiori, M., “Phytotoxicity to and uptake of enrofloxacin in crop plants,” Chemosphere, 52(7), 1233-1244(2003)   DOI   ScienceOn
9 Thiele-Bruhn, S., “Pharmaceutical antibiotic compounds in soils - a review,” J. Plant Nutrition and Soil Science, 166(2), 145-167(2003)   DOI   ScienceOn
10 Kim, Y., Jung, J., Kim, M., Park, J., Boxall, A. B. A., and Choi, K., “Prioritizing veterinary pharmaceuticals for aquatic environment in Korea,” Environ. Toxicol. Pharm., 26(2), 167-176(2008)   DOI   ScienceOn
11 Kim, S. C., and Carlson, K., “Temporal and spatial treands in the occurrence of human and veterinary antibiotics in aqueous and river sediment matrices,” Environ. Sci. Technol., 41(1), 50-57(2007)   DOI   ScienceOn
12 Lin, A. Y. C., Yu, T. H., and Lin, C. F., “Pharmaceutical contamination in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan,” Chemosphere, 74(1), 131-141(2008)   DOI   ScienceOn
13 Sithole, B. B., and Guy, R. D., “Models for oxytetracycline in aquatic environments. II. Interactions with humic substances,” Water, Air, and Soil Pollution, 32(3-4), 315-321(1987)   DOI
14 Halling-S􀝚rensen, B., Sengel􀝚v, G., Ingerslev, F., and Jensen, L. B., “Reduced antimicrobial potencies of oxytetracycline, tylosin, sulfadiazin, streptomycin, ciprofloxacin, and olaquindox due to environmental processes,” Arch. Environ. Contam. Toxicol., 44(1), 7-16(2003)   DOI   ScienceOn
15 Ingerslev, F., and Halling-S􀝚rensen, B., “Biodegradability properties of sulfonamides in activated sludge,” Environ. Toxicol. Chem., 19(10), 2467-2473(2000)   DOI   ScienceOn
16 Diaz-Cruz, M. S., and Barcelo, D., “Determination of antimicrobial residues and metabolites in the aquatic environment by liquid chromatography tandem mass spectrometry,” Anal. Bio. Chem., 386(4), 973-985(2006)   DOI   ScienceOn
17 Karci, A., and Balcioglu, I. A., “Investigation of the tetracycline, sulfonamide, and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey,” Sci. Total Environ., 407(16), 4652-4664(2009)   DOI   ScienceOn
18 Kay, P., Blackwell, P. A., and Boxall, A. B. A., “Column studies to investigate the fate of veterinary antibiotics in clay soils following slurry application to agricultural land,” Chemosphere, 60(4), 497-507(2005)   DOI   ScienceOn
19 Kim, S. D., Cho, J., Kim, I. S., Vanderford, B. J., and Snyder, S. A., “Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters,” Water Res., 41(5), 1013-1021(2007)   DOI   ScienceOn
20 이현용, 임정은, 권오경, 김성철, 양재의, 옥용식, “토양 및 수질 중 항생물질 처리기술에 대한 최근 연구동향,” 농생명과학연구, 20, 45-54(2009)
21 Maia, P. P., da Silva, E. C., Rath, S., and Reyes, F. G. R., “Residue content of oxytetracycline applied on tomatoes grown in open field and greenhouse,” Food Control, 20(1), 11-16(2009)   DOI   ScienceOn
22 Loftsson, T., and Hreinsdottir, D. “Determination of aqueous solubility by heating and equilibration: a technical note,” AAPS PharmSciTech, 7(1), E1-E4(2006)   DOI   PUBMED   ScienceOn
23 Seo, Y. H., Choi, J. K., Kim, S. K., Min, H. K., and Jung, Y. S., “Prioritizing environmental risks of veterinary antibiotics based on the use and the potential to reach environment,” Korean Journal of Soil Science Fertilizer, 40(1), 43-50(2007)
24 김성철, 이현용, 임정은, 김종진, 김동국, 용석호, 권오경, 양재의, 옥용식, “돈분 퇴비의 부숙화 정도에 따른 잔류항생제의 저감효율 평가,” 2008 대한환경공학회 추계학술연구발표회 논문 요약집, 대한환경공학회, 서울, pp. 169(2008)
25 식품의약품안전청, 축산 항생제내성 및 항생제 사용실태 조사, 국립수의과학검역원 연구결과보고서(2007)
26 Kim, S. C., "Occurrence, fate, and transport of human and veterinary antibiotics in the watershed," Ph.D thesis, , Colorado State University, Fort Collins, Colorado, USA(2006)
27 김성철, “환경에 잔류하는 항생제의 모니터링 및 이동, 그리고 거동에 대한 연구,” 2008 한국환경농학회 학술논문 발표대회 초록집, 한국환경농학회, 무주, pp. 91-92(2008)
28 한국환경정책평가연구원(KEI), 의약물질의 환경위해성 평가체계 구축 방안, 연구보고서(2006)
29 Jorgensen, S. E., and Halling-Sorensen, B., “Drugs in the environment,” Chemosphere, 40(7), 691-699(2000)   DOI   ScienceOn
30 Choi, K., Kim, Y., Park, J., Park, C. K., Kim, M., Kim, H. S., and Kim, P., “Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea,” Sci. Total Environ., 405(1-3), 120-128(2008)   DOI   ScienceOn
31 Christian, T., Schneider, R. J., F rber, H. A., Skutlarek, D., Meyer, M. T., and Goldbach, H. E., “Determination of antibiotic residues in manure, soil, and surface waters,” Acta hydrochimica et hydrobiologica, 31(1), 36-44(2003)   DOI   ScienceOn
32 Rab${\o}$lle, M., and Spliid, N. H., “Sorption and mobility of metronidazole, olaquindox, oxytetracycline and tylosin in soil,” Chemosphere, 40(7), 715-722(2000)   DOI   ScienceOn
33 Sithole, B. B., and Guy, R. D., “Models for oxytetracycline in aquatic environments. I. Interaction with bentonite clay systems,” Water, Air, and Soil Pollut., 32(3-4), 303-314(1987)   DOI
34 Holten L$\ddot{u}$tzh${\o}$ft, H. C., Vaes, W. H., Freidig, A. P., Halling-S${\o}$ rensen, B., and Hermens, J. L., “1-Octanol/water distribution coefficient of oxolinic acid influence of pH and its relation to the interaction with dissolved organic carbon,” Chemosphere, 40(7), 711-714(2000)   DOI   ScienceOn
35 Boxall, A. B. A., Blackwell, P., Cavallo, R., Kay, P., and Tolls, J., “The sorption and transport of a sulphonamide antibiotic in soil systems,” Toxicol. Lett., 131(1-2), 19-28(2002)   DOI   PUBMED   ScienceOn