• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2751-2756
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• 2015

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can specifically induce apoptosis limited to various cancer cells, so this reagent is considered a promising medicine for cancer therapy. TRAIL also exerts effects on non-apoptotic signals, relevant to processes such as metastasis, autophagy and proliferation in cancer cells. However, the mechanisms of TRAIL-regulated non-apoptotic signals are unclear. The purpose of this study was to investigate MADD/CXCR7 effects in TRAIL-mediated breast cancer cell migration. Materials and Methods: The ability of MADD/CXCR7 to regulate MVP signaling in TRAIL-mediated breast cancer cells migration was evaluated by transwell migration assay, quantitative RT-PCR, Western blotting and knock down experiments. Results: In this study, we found that treatment with TRAIL resulted in induced expression levels of MADD and CXCR7 in breast cancer cells. Knock down of MADD followed by treatment with TRAIL resulted in increased cell migration compared to either treatment alone. Similarly, through overexpression and knockdown experiments, we demonstrated that CXCR7 also positively regulated TRAIL-inhibited migration. Surprisingly, knock down of MADD lead to inhibition of TRAIL-induced CXCR7 mRNA and protein expression and overexpression of CXCR7 lead to the reduction of MADD expression, indicating that MADD is an upstream regulatory factor of TRAIL-triggered CXCR7 production and a negative feedback mechanism between MADD and CXCR7. Furthermore, we showed that CXCR7 is involved in MADD-inhibited migration in breast cancer cells. Conclusions: Our work defined a novel signaling pathway implicated in the control of breast cancer migration.

• Journal of Chest Surgery
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• 제30권11호
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• pp.1105-1110
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• 1997

본태성 다한증이란 신체의 일부에서 과도하게 땀이 많이 나는 병적인 상태이며 대부분에서 일상 생활을 영위하는데 어려움이 있다. 연세대학교 의과대학 영동세브란스병원 호흡기센터 흉부외과에서는 1992년 6월부터 1996년 5월까지 211예 에서 흉강내시경을 이용한 홉부교감 신경절 절제수술을 시행하였으며 이중 192예가 수부다한증이었으며 19예가 안면 다한증이었다. 이중 남자가 121예, 여자가 90예이었으며 연령분포는 10세에서 67세 사이로서 평균 24.82이었다. 평균 수술시간은 91.94분이었고 입원기간은 4.31일이었다. 수술전후 합병증은 없었으며 수술후 즉시 증상호전이 있었으며 등과 가슴 일부에 보상성 다한증이 발견되었으나 우려 할 상황은 아니었다. 안면 다 한증등과 같은 경우 흉강내시경 수술에서 개흉수술로의 전환 가능성은 배제할 수 없겠으나 흉강내 시경 흉부교감신경절 절제수술은 다한증 수술치료에선 매우 안전하고 유용한 수술로 생각되어진다.

• The Journal of Korean Physical Therapy
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• 제14권1호
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• pp.197-203
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• 2002

Heating of injured tissue has been used for centuries for pain relief and reduction of muscle spasm. In physical therapy locally applied heating gents are used not only to promote relaxation and provide pain relief, but they are also used to increase blood flow, to facilitate tissue healing, and to prepare stiff joints and tight muscles for exercise. Superficial heating agents primarily cause in increases in skin and superficial cutaneous tissue temperature. Superficial heating agents such as hot packs, paraffin wax, Deep heating agents, including shortwave diathermy and continuous-wave ultrasound, can increase tissue temperature at depths ranging from 3to 5cm without overheating the skim and subcutaneous tissue.

• The Journal of Korean Physical Therapy
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• 제13권2호
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• pp.399-405
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• 2001

Attainment of the goals of functional electrical stimulation(FES) applications such as strengthening of muscle, increasing muscular endurance, improvement in joint range of motion or the reduction of spasticity does not insure that patients will be able to produce voluntary muscle contraction sufficient to maintain posture or produce purposeful movements. In many patients who have sustained CNS damage, the control exerted by higher nervous system center over muscle contraction may impaired. In Searched patients, a variety of advanced therapeutic exercise techniques have been employed traditionally to facilitate the return of controlled functional muscular activity or maintain postural alignment until recovery from dysfunction occurs Among the most common clinical applications of FES for functional muscle contraction is as a substitute for static or dynamic orthotic devices

• The Korean Journal of Pain
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• 제10권1호
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• pp.28-33
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• 1997

Background : Analgesic effect of intra-articular morphine or ketoronac treatment alone, or a combination of both drugs, on postoperative pain were evaluated in 40 healthy male patients undergoing arthroscopic knee surgery. Method : Upon completion of surgery under spinal anesthesia, each patients knee joint was injected with 30 ml of 0.25% bupivacaine. Then, via parenteral or intra-articular route, one study group received morphine and other group received ketorolac. Results : Groups who received either intra-articular ketorolac, or morphine, experienced decreased postoperative pain reducing need for additional analgesics. The combination treatment of intra-articular morphine and ketorolac did not improved results. Conclusions : Singular use of either intra-articular morphine, or ketorolac, improves postoperative analgesia in patients undergoing arthroscopic sugery: Combination of these drugs offered no further advantage over its single prescription.

• 대한치과의사협회지
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• 제49권7호
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• pp.389-397
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• 2011

Bisphosphonate inhibits the function of osteoclast, so they are widely used for multiple myeloma, Paget's disease, metastatic malignant bone disease, and severe osteoporosis. This drug is very effective for preventing severe complication of osteoporosis, some unpredictable complication occurred such as esophageal malignancy, atypical fracture of femur, and osteonecrosis of the jaw. Bisphosphonate related osteonecrosis of the jaw (BRONJ) is closely related with invasive, open bone surgery like tooth extraction. BRONJ associated with dental implant is rare, however, as the use of bisphosphonate increase, BRONJ cases with dental implant are increasing. In this article, we will describe the considerations during dental implant treatment for patient under bisphosphonate therapy.

• 대한세포병리학회지
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• 제18권1호
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• pp.81-86
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• 2007

Desmoplastic small round cell tumor (DSRCT) is a rare malignant mesenchymal neoplasm. It mainly involves the abdominal or pelvic peritoneum of male adolescents. We report here the imprint cytologic features of a case of DSRCT occurring in the intraabdominal cavity of a 21-year-old man. A microscopic examination showed moderate cellularity. The tumor cells were singly arranged and arranged in clusters. The cells had round to oval nuclei with finely granular chromatin, inconspicuous nucleoli and scanty cytoplasm. Some tumor cells showed nuclear molding, and some cells had an epitheloid appearance with a large amount of lightly eosinophilic cytoplasm. A rosette-like pattern was present. Spindle-shaped, fibroblastic stromal cells were occasionally found. The tumor cells were immunoreactive for the markers cytokeratin (AE1/AE3), epithelial membrane antigen (EMA), desmin, vimentin and neuron specific enolase (NSE).

• Journal of Oral Medicine and Pain
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• 제7권1호
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• pp.71-76
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• 1982

To analyze the outpatient of the Dental Infirmary Yonsei Medical Center, anthor ruled out the charts of 1,622 patients which were sampled from 18.921 patients among the selected years 1973.1977 and 1981. The results are as follows : 1. By the age-group the twenties and thirties were about 50% of the total patients. 2. According to the analysis by the district, the distance from residence was most influencial to select the hospital. 3. The frequency of the patient by the service departments, many patients wanted oral sugery tretment, and operative & periodontic tretments followed, And there were some necessities of dental health education for the early care and the protective tretment. 4. Of the season, there were more patients in Summer and Winter, especially in July and August than Spring and Autumn. It might be related with the vacations. 5. The ratio of professor's and general patients, were decreasing compared with the data of three selected years, and the fact might be studied to improve for the better quality of service, even the application of the medical and dental insurance is getting wider.

• 한국임상수의학회지
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• 제19권3호
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• pp.353-356
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• 2002

A 9-year-old male Yorkshire terrior with recurrent chronic otitis externa and otitis interna was referred to the Veterinary Medical Teaching Hospital of Seoul National University. Radiographic findings indicated mineralization around the right ear canal. A tan nodular mats, 1 cm in diameter. was noted near the tympanum after total ear canal ablation. Cytologically. the imprint smear of the cut surface of the mass produced clusters of cells with abundant and weakly basophilic cytoplasm, one small round nucleus and one or two nucleoli, mixed with both degenerate and non degenerate neutrophils. The location of the nuclei was eccentric, and some cells contained somewhat coarse black granules in their cytoplasms, on which the mass was diagnoted as ceruminous gland adenoma or hyperplasia associated with inflammation. Histopathologic examination of the tumor was compatible with a diagnosit of ceruminous gland adenoma. The patient is responding well to sugery and antimicrobial treatment.

• 대한두경부종양학회지
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• 제7권2호
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• pp.120-128
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• 1991

Reconstruction of the pharynx and cervical esophagus presents a tremendous surgical challenge to the Head and Neck Surgeon. Because life expectancy of patients with advanced carcinoma of the hypopharynx, and cervical esophagus is limited, treatment must be aimed at palliation. A variety of techiques have been proposed over the years with none proving entirely satisfactory. These techiques include prosthesis; skin graft; cervical flaps; tubed cutaneous and myocutaneous chest flaps; visceral reconstruction with stomach, colon. and jejunum; and jejunal free autografts. Many factors dictate the best method of reconstruction in any given clinical situation. The goal of the surgery is a one-stage reconstruction of swallowing function with minimal morbidity to allow as short a hospital stay as posible. Nine patients underwent the free jejunal autograft reconstruction of the pharyngoesophagus after the ablative surgery for the advanced hypopharyngeal cancer. Postoperative complications included one perioperative death, two abdominal wound dehiscences, two neck hematomas, one carotid rupture, one funtional dysphagia, one late strictures. There were no graft failure, no immediate stenosis and no fistula. An oral diet was started between days 8 and 16, with an average of 9 days and median of 8 days. Patients left the hospital between days 9 and days 38, with an average of 23.4 days and median of 23 days. This method of reconstruction is advocated as reliable palliative procedure with short-term follow-up. In conclusion, we at Korea Cancer Center Hospital are of the opinion that the free jejunal autograft offers an excellent, safe and relative easy method of the pharyngeal and cervical esophageal reconstruction with significant advantages over other techiques.