• Biomolecules & Therapeutics
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• v.28 no.1
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• pp.45-57
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• 2020

In the neurovascular unit, the neuronal and vascular systems communicate with each other. O₂ and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into neighboring cells, such as neural stem cells, and neurons. The proper function of neural circuits in adults requires sufficient O₂ and glucose for their metabolic demands through angiogenesis. In a central nervous system (CNS) injury, such as glioma, Parkinson's disease, and Alzheimer's disease, damaged ECs can contribute to tissue hypoxia and to the consequent disruption of neuronal functions and accelerated neurodegeneration. This review discusses the current evidence regarding the contribution of oxygen deprivation to CNS injury, with an emphasis on hypoxia-inducible factor (HIF)-mediated pathways and Notch signaling. Additionally, it focuses on adult neurological functions and angiogenesis, as well as pathological conditions in the CNS. Furthermore, the functional interplay between HIFs and Notch is demonstrated in pathophysiological conditions.

• Proceedings of the Korean Aquaculture Society Conference
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• 2006.05a
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• pp.326-327
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• 2006

• The Journal of the Convergence on Culture Technology
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• v.7 no.2
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• pp.185-190
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• 2021

The purpose of this study is to investigate the correlation between materialistic values and interpersonal relationship of adult university students and general university students and compare the two groups. The analysis was conducted using the SPSS Statistics 25.0 program targeting 228 adult students and 216 general students enrolled nationwide. First, as for the difference in the materialistic values of the adult and general university students according to the general characteristics, significant differences were found according to gender, religion, the type of school, grade, monthly income (allowance), monthly expense, items of expenditure, and hobby. Second, the analysis of the difference in the interpersonal relationship based on their general characteristics revealed differences based on gender, grade, monthly income (allowance), monthly expense, items of expenditure, and hobby. Third, the research subjects' materialistic values and interpersonal relationship showed a high correlation. Fourth, their materialistic values had significant effects on all the sub-factors of interpersonal relationship. The results of this study implies that materialistic values have negative effects on interpersonal relationship in both adult and general university students.

• Korean Journal of School Psychology
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• v.16 no.1
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• pp.65-87
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• 2019

The present study investigated the relationship between adult attachment and depression and the moderating effects of social support in secondary school teachers. Survey data was collected from 231 secondary school teachers working at three middle and high schools in the Seoul and Gyung-gi areas. Correlation and hierarchical multiple regression analyses were used to test the relationships among the main variables, namely adult attachment, social support, and depression, and the three moderating effects of social support in the relationship between adult attachment and depression, respectively. The main results were as follows. First, each sub-dimension of adult attachment, namely dependent attachment, anxiety attachment, and close attachment, were significantly correlated with depression levels. All of the variables except senior support and dependent attachment were significantly correlated with depression. Second, social support had a moderating effect in the relationship between anxiety attachment and depression. Colleague and family support had moderating effects in the relationship between dependent attachment and depression though senior support did not.

• Preventive Nutrition and Food Science
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• v.10 no.1
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• pp.40-45
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• 2005

Age-related changes in bone metabolism are well established by biochemical markers of bone matrix in serum and urine, but analysis of the residual bone matrix, which is still turning over, has not been investigated. In the present study, we measured in vivo rates of bone protein synthesis using a precursor-product method based on the exchange of ²H from ²H₂O into amino acids. Four percent ²H₂O was administered to mice in drinking water after intraperitonial (i.p) bolus injection of 99.9% ²H₂O. Mice were divided into the two groups: growing young mice were administered 4% ²H₂O for 12 weeks after an i.p bolus injection at 5 week of age, whereas weight stable adult mice started drinking 4% ²H₂O 8 weeks later than the growing group and continued 4% ²H₂O drinking for 8 weeks. Mass isotopomer abundance in alanine from bone protein was analyzed by gas chromatography/mass spectrometry. Body ²H₂O enrichments were in the range of 1.88-2.41% over the labeling period. The fractional synthesis rates (ks) of bone protein were 2.000±0.071%/d for growing mice and 0.243±0.014%/d for adult mice. These results demonstrate that the bone protein synthesis rate decreases with age and present direct evidence of age-related changes in bone protein synthesis.

• Journal of Ginseng Research
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• v.33 no.1
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• pp.48-54
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• 2009

Epileptifrom discharges were induced in the telencephalon of the adult zebrafish via perfusion with pentylenetetrazole (PTZ), bicuculline methiodide, kainic acid-treated artificial cerebrospinal fluid (aCSF), and $Mg^{2+}$-free aCSF. Ginseng total saponin [GTS ($50{\mu}g/ml$)] was shown to attenuate the occurrence rate of epilpetiform discharges by 50-75%, compared to the control. Ginsenoside $Rg_1$ ($130{\mu}M$) reduced the epileptiform discharges in the isolated telencephalon and delayed the occurrence of behavioral seizures observed from the adult zebrafish placed in the PTZ (10 mM)-containing aquarium water. However, Re was not effective in the suppression of epileptiform discharges and behavioral seizures. These results indicate that $Rg_1$ may be useful in the control of epileptiform discharges and effective in controlling behavioral seizures, and that the zebrafish can be used as a model animal for the testing of potential anticonvulsant drugs.

• Korean Journal of Adult Nursing
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• v.29 no.1
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• pp.76-86
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• 2017

Purpose: The purpose of the study was to provide deep understanding of the reported experiences of families with their loved one in the intensive care unit (ICU), focusing on interactions with healthcare providers. Methods: The data were collected by individual interviews of eleven participants. The transcribed data were analyzed using qualitative content analysis to identify major themes and sub-themes that represented the experiences of families. Results: Five themes and 13 sub-themes emerged. "Captive of patients' delayed death: Fear and anxiety" describes psychological problems arising when the family member became critically ill enough to warrant being admitted to the ICU. "Families as the weak: Suppression and resistance" describes interpersonal difficulties arising due to lack of information and trust with healthcare providers. "Deprivation of authority and duty as families: Helplessness" illustrate situational barriers in attempting to protect and support family member. "Re-establishment of trust relationship with healthcare providers: Gratitude and appreciation" describes how they satisfied with themselves by regaining trust relationship. Lastly, "Acceptance of reality through direct care participation: Relief and peace" illustrates peace of mind by gaining sense of reality through active direct care participation. Conclusion: This study demonstrates the positive and negative experiences of families with ICU patients. The results will be useful in developing family-centered nursing interventions.

• Fisheries and Aquatic Sciences
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• v.12 no.1
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• pp.49-53
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• 2009

We conducted a histological analysis to investigate the influence of nutritional changes on melano-macrophages (MMs) accumulation in the kidney of sub-adult rock bream (Oplegnathus fasciatus). Four experimental groups were established (initial control, control, fed and starved), and fed commercial feed amounting to 1-3% of their body weight for 2 weeks prior to initiation of experiments. Kidney MMs with dark brown pigment were randomly observed in the kidneys of starved fish, increasing rapidly after 4 weeks, while deposition levels remained low throughout the experiment in the control and fed groups. These results suggest that catabolic tissue breakdown is a major factor contributing to the formation of pigments within MMs. Results also suggest that the degree of MMs deposition in the kidney can be used as alternative indicators in identifying starvation in wild and cultured rock bream.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.32 no.2
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• pp.104-108
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• 2021

The etiology of laryngeal hemangioma is unclear, and it is classified into infant and adult types. The former is capillary hemangioma and relatively common, the latter is cavernous type and very rare. The adult laryngeal hemangioma mainly occurs in supraglottis and glottis. A 75-year-old man came to our clinic with a voice change that started four months ago. The laryngoscopic finding showed that the surface of oval-shaped mass is covered with turbid exudates. We performed the laryngeal microsurgery with CO₂ laser. The mass was pathologically proven as cavernous hemangioma. We report a very rare and didactic case with review of relevant literature.

• Journal of Radiation Protection and Research
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• v.47 no.2
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• pp.77-85
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• 2022

Background: After the Fukushima Daiichi Nuclear Power Station (FDNPS) accident, a model was developed to estimate the external exposure doses for residents who were expected to return to their homes after evacuation orders were lifted. However, the model's accuracy and uncertainties in parameters used to estimate external doses have not been evaluated. Materials and Methods: The model estimates effective doses based on the integrated ambient dose equivalent (H^*(10)) and life patterns, considering a dose reduction factor to estimate the indoor H^*(10) and a conversion factor from H^*(10) to the effective dose. Because personal dose equivalent (H_p(10)) has been reported to agree well with the effective dose after the FDNPS accident, this study validates the model's accuracy by comparing the estimated effective doses with H_p(10). The H_p(10) and life pattern data were collected for 36 adult participants who lived or worked near the FDNPS in 2019. Results and Discussion: The estimated effective doses correlated significantly with H_p(10); however, the estimated effective doses were lower than H_p(10) for indoor sites. A comparison with the measured indoor H^*(10) showed that the estimated indoor H^*(10) was not underestimated. However, the H_p(10) to H^*(10) ratio indoors, which corresponds to the practical conversion factor from H^*(10) to the effective dose, was significantly larger than the same ratio outdoors, meaning that the conversion factor of 0.6 is not appropriate for indoors due to the changes in irradiation geometry and gamma spectra. This could have led to a lower effective dose than H_p(10). Conclusion: The estimated effective doses correlated significantly with H_p(10), demonstrating the model's applicability for effective dose estimation. However, the lower value of the effective dose indoors could be because the conversion factor did not reflect the actual environment.