• 약학회지
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• 제43권5호
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• pp.559-565
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• 1999

The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.

• Archives of Pharmacal Research
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• 제29권11호
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• pp.952-956
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• 2006

A phytochemical investigation of stems from Salvadora persica resulted in the first isolation of four benzylamides from a natural source. The isolated compounds were identified as butanediamide, $N^{1},\;N^{4}$-bis(phenylmethyl)-2(S)-hydroxy-butanediamide (1), N-benzyl-2-phenylacetamide (2), N-benzylbenzamide (3) and benzylurea (4). The structure elucidation was accomplished using spectroscopic methods, especially 2D NMR and HREIMS. Compound 2 revealed a significant inhibitory effect on human collagen-induced platelet aggregation, and a moderate antibacterial activity against Escherichia coli.

• Bulletin of the Korean Chemical Society
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• 제16권10호
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• pp.968-971
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• 1995

The heme assignment of the 1H NMR spectrum of cytochrome c3 of Desulfovibrio vulgaris Hildenborough within the X-ray structure were fully cross established according to their redox potential. The major reduction of the heme turned out to take place in the order of hemes Ⅳ,Ⅰ,Ⅱ and Ⅲ(the heme numbers indicating the order of bonding to the primary sequence). This assignment can provide the physicochemical basis for the elucidation of electron transfer of this protein.

• Bulletin of the Korean Chemical Society
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• 제24권6호
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• pp.695-702
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• 2003

Recent experimental and theoretical advances on the aromatic alcohol-water clusters are reviewed, focusing on the structure of the hydrogen bonding between the alcoholic OH group and the binding water molecules. The interplay of experimental observations and theoretical calculations for the elucidation of the structure is demonstrated for phenol-water, benzyl alcohol-water, substituted phenol-water, naphthol-water and tropolone -water clusters. Discussion is made on assigning the role (either proton-donating or -accepting) of the hydroxyl group by measuring the shifts of infrared frequency of the OH stretching mode in the cluster from that of bare aromatic alcohol for the experimental determination of the cluster structure.

• 분석과학
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• 제21권2호
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• pp.65-83
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• 2008

식품에 첨가할 수 없는 의약품이나 화학합성물질이 함유된 부정유해식품이 증가하고 있는 실정이다. 특히 발기부전치료제 성분인 실데나필, 바데나필 및 타다라필의 화학구조를 변형한 미지의 물질이 검출되고 있다. 또한 기존 식품의 기준규격 검사에 따른 단속을 피하기 위하여 성기능강화 등 치료효능을 지닌 의약품 성분의 화학구조를 변형한 불법으로 합성한 부정유해물질은 안전성이 전혀 입증되지 않았으므로 그 위해성이 우려되고 있다. 따라서 식품의 안전성을 확보하기 위하여 발기부전치료제의 화학구조를 변형한 호모실데나필, 홍데나필, 슈도바데나필, 아미노타다라필, 하이드록시호모실데나필, 하이드록시홍데나필, 디메틸실데나필, 잔소안트라필, 하이드록시바데나필, 노르네오실데나필, 데메틸홍데나필, 피페리디노홍데나필, 카보데나필, 치오실데나필, 디메틸치오실데나필, 아세틸바데나필의 총 16개의 발기부전치료 성분의 유사물질 관련 자료와 식품 중 부정유해물질의 규명 및 분석 현황을 정리하였다.

• 분석과학
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• 제9권1호
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• pp.107-111
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• 1996

Bipolaris cynodontis의 배양 추출물로부터 이탈리안 라이그라스 뿌리의 생육저해 활성을 나타내는 물질을 분리 정제한 다음에 2차원 NMR을 포함한 각종 기기분석을 이용하여 구조를 결정하였다. 이 화합물의 분자식은 $C_{24}H_{30}O_5$ 이었으며 세스퀴테르펜류 화합물로 이탈리안 라이그라스 및 벼와 같은 벼과식물에 대해서 100ppm에서 100%의 활성을 나타내는 것으로 보아 병원균의 병징 발현에 관여하는 것으로 보여진다.

• Journal of Applied Biological Chemistry
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• 제61권1호
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• pp.79-82
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• 2018

An ${\alpha}-{\text\tiny{D}}-glucoside$ of sesterterpene, 11-epiterpestacin, was isolated from the culture of a filamentous fungus Bipolaris sorokiniana NSDR-011. The structure was elucidated by chemical studies and spectroscopic methods including NMR and ESI-MS. 11-ETG (1) named arbitrarily did not inhibit the root growth of Italian ryegrass seedlings even at the level of 200 ppm, while its aglycone 11-ET (2) completely inhibited root growth at level of 100 ppm.

• 생약학회지
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• 제23권1호
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• pp.14-19
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• 1992

A mixture of acylglucosyl sterols together with ${\beta}-sitosterol$, ${\beta}-sitosterol\;3{\beta}-O-glucoside$ and fatty acids was isolated from the roots of Caragana chamlagu as their acetate forms and the structure elucidated by chemical and spectroscopic means. The major acylglucosyl sterol was ${\beta}-sitosteryl\;3-O-[6'-O-oleoyl]-{\beta}-D-glucopyranoside$ while the minor components were $6'-O-palmitoyl-\;and\;6'-O-stearoyl-{\beta}-D-glucosyl$ sitosterol congeners. The isolation and structure elucidation of these acylglucosyl sterols are reported for the first time from the genus Caragana.

• 생약학회지
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• 제46권1호
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• pp.6-11
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• 2015

To clarify chemical constituents of Clematis heracleifolia, isolation and structure elucidation of the underground parts of C. heracleifolia were performed. Five compounds were isolated from $CHCl_3$ and n-BuOH soluble fraction of this plant. On the basis of spectral and physico-chemical data, the structure of isolated compounds were identified as coniferyl alcohol (1), scoparone (2), (+)-lariciresinol (3), phytosterols (4), and daucosterol (5), respectively. All compounds are isolated from this plant for the first time. To evaluate anti-acetylcholinesterase activity of the isolated compounds, compounds 1, 2, 3, and 5 were tested inhibition activity against acetylcholinesterase. Among tested compounds, daucosterol (5) showed acetylcholinesterase inhibitory activity with $IC_{50}$ value of $6.1{\mu}M$.

• Journal of the Korean Wood Science and Technology
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• 제24권2호
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• pp.81-93
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• 1996

To elucidate the structure of procyanidin in Korean red pine (Pinus densiflora S. et Z.), bark, the extractives were extracted with acetone-water mixture(7:3, v/v) from inner bark of Korean red pine. The extracts separated three fractions which were extracted by liquid-liquid extraction. The extracting solvents were chloroform and ethyl acetate and water. The part of ethylacetate soluble was chromatographed by liquid chromatography. The ethylacetate soluble portion yielded four natural procyanidin dimers, two known epicatechin-($4{\beta}{\rightarrow}6$)-catechin, catechin-($4{\alpha}{\rightarrow}8$)-catechin and two unknown catechin-($4{\beta}{\rightarrow}6$)-catechin and conformational isomer of epicatechin-($4{\alpha}{\rightarrow}6$)-catechin. The additional catechins was also isolated. The structures of these procyanidins were elucidated by their $^{13}C$-NMR spectra.