YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Antitumor Activity of Novel Gericudranin E Derivatives

새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성

  • 박재호 (숙명여자대학교 약학대학) ;
  • 박경란 (숙명여자대학교 약학대학) ;
  • 호현순 (숙명여자대학교 약학대학) ;
  • 김희두 (숙명여자대학교 약학대학) ;
  • 표명윤 (숙명여자대학교 약학대학)
  • Published : 1999.10.01
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Abstract

The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.

Keywords

References

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