• 한국압력기기공학회 논문집
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• 제17권1호
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• pp.1-7
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• 2021

This paper presents sensitivity analysis results of strain on notches under cycling loading to 2-D finite element density considering plasticity. Cylindrical notched specimens having some stress concentrations were modeled with 2-D axisymmetrical finite element having various finite element densities. Elasto-plastic finite element analysis was performed for the various finite element models subjected to cycling loading considering plasticity. The finite element analysis results were compared to investigate sensitivity of the finite element analysis variables such as von-Mises effective stress, accumulated equivalent plastic strain, and equivalent plastic strain to 2-D finite element density. As a result of the comparison, it was found that the accumulated equivalent plastic strain is more sensitive than the others whereas the von-Mises effective stress is much less sensitive.

• 소성∙가공
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• 제15권2호
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• pp.132-137
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• 2006

This paper is concerned with the thermo-mechanical behavior including temperature dependent strain-rate sensitivity of steel sheet for an auto-body. In order to identify the temperature dependent strain-rate sensitivity of SPRC35R and SPRC45E, uniaxial tension tests are performed with the variation of the strain-rates from 0.001 /sec to 200 /sec at environmental temperatures varied from $-40^{\circ}C\;to\;200^{\circ}C$. The thermo-mechanical response at the quasi-static state is obtained with the static tensile test and at the intermediate strain-rate is from the high speed tensile test. Experimental results show that the strain-rate sensitivity increases at low temperature. It represents that as the strain-rate increases, the variation of flow stress becomes sensitive on the temperature. The results indicate that the flow stress of SPRC35R is more dependent on the changes of strain-rate and temperature than those of SPRC45E.

• 한국정밀공학회지
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• 제23권8호
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• pp.54-63
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• 2006

Enhancement methods of sensitivity to in-plane strain measurement by micro-ESPI(Electronic Speckle Pattern Interferometry) technique were proposed using TiN and Au thin films. Micro-tensile strain over the micro-tensile specimens, prepared in micro-scale by those films, was measured by micro-tensile loading system and micro-ESPI system developed in this study. The subsequent measurement of in-plane tensile strain in the micro-sized specimens was introduced using the micro-ESPI technique, and the micro-tensile stress-strain curves for these films were determined. To enhance the sensitivity to measurement of in-plane tensile strain, algorithms of the phase estimation by using curve fitting of inter-fringe and the discrete Fourier Transform with object-induced dynamic phase shifting were developed. Using these two algorithms, the micro-tensile strain-stress curves were generated. It is shown that the algorithms for enhancement of the sensitivity suggested in this study make the sensitivity to measurement of the in-plane tensile strain increase.

• 대한기계학회논문집A
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• 제35권11호
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• pp.1369-1375
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• 2011

쇼트피닝 공정은 쇼트볼이 소재에 충돌을 일으킬 때 생기는 압축잔류응력에 의해 소재의 피로 강도를 향상 시키는데 그 목적이 있다. 본 연구는 변형률 속도 민감도 변화가 압축잔류응력에 미치는 영향을 분석하기 위해서 수행되었다. 본 연구자는 변형률 속도 민감도의 영향을 고려한 쇼트피닝 다중 충돌을 ABAQUS 6.9-1 를 사용하여 모사하였다. 사용된 소재는 AISI 4340 강종이다. 본 연구자는 변형률 속도 민감성이 높은 재료와 낮은 재료를 비교하였다. 결과적으로 변형률 속도 민감성이 증가하면 압축 잔류응력은 감소하였다. 또한 경도가 낮은 소재의 압축잔류응력이 경도가 높은 소재보다 더 크게 발생 하였다.

• 정신신체의학
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• 제3권2호
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• pp.159-165
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• 1995

본 연구의 목적은 시험과 같은 심리적 스트레스와 혈청 cortisol 및 prolactin과의 관계를 알아보고, 주관적인 스트레스지각 및 정신병리가 혈청 cortisol 및 prolactin치 간의 상관성을 알아보는데 있다. 본 연구에는 의과대학 남학생 20명이 참여하였다. 이들을 대상으로 시험기간과 수업기간 중에 각각 global assessment of recent stress(GARS)척도와 SCL-90R척도를 사용하여 스트레스지각 및 정신병리를 평가하였다. 혈청 cortisol 및 prolactin치는 방사성 면역측정법에 의해 측정되었다. 혈청 cortisol치는 수업기간보다 시험기간 중에 유의하게 더 높았으나 혈청 prolactin치는 두 군 간에 유의한 차이를 보이지 않았다. 한편 시험기간 및 수업기간 중 스트레스지각점수는 혈청 cortisol치 및 prolactin치와 각각 유의한 상관성을 보이지 않았다. 그러나 정신병리에 있어서는 시험기간 중 대인예민척도점수가 혈청 cortisol치와 유의한 음 상관성을 보였다. 이상의 결과는 시험과 같은 심리적 스트레스가 prolactin보다 cortisol과 더 밀접하게 관련될 가능성이 높음을 시사한다. 그리고 대인예민과 같은 특정 정신병리는 낮은 혈청 cortisol치와 관련될 수 있음을 시사한다.

• 한국생활과학회지
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• 제21권4호
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• pp.715-728
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• 2012

This research aims at examining the relationships between mother-toddler interaction and its related variables. A total of 49 toddlers and their mothers were participated and observed in the child lab during free play. The main results of this study are as follows. First, among the mother-toddler interaction, 'involvement' was frequently used in comparison with the 'rejection' was the hardly used in their interaction. Second, the mothers' sensitivity, parenting stress, and the mother-toddler interaction had no significant difference by the mothers' job status or gender of toddlers. However, their parenting stress was lower in working mothers or mothers who have girls. Third, mother-toddler interaction was significantly correlated with the mothers' sensitivity, parenting stress, parenting style, and the temperament of toddlers. On the basis of this results, the implication related to the variables influencing mother-toddler interaction was discussed.

• 대한기계학회논문집A
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• 제31권2호
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• pp.182-189
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• 2007

This paper is concerned with the empirical flow stress constitutive equation of steel sheets for an auto-body with the variation of temperature and strain rate. In order to represent the strain rate and temperature dependent behavior of the flow stress at the intermediate strain rates accurately, an empirical hardening equation is suggested by modifying the well-known Khan-Huang-Liang model. The temperature and strain rate dependent sensitivity of the flow stress at the intermediate strain rate is considered in the hardening equation by coupling the strain, the strain rate and the temperature. The hardening equation suggested gives good correlation with experimental results at various intermediate strain rates and temperatures. In order to verify the effectiveness and accuracy of the suggested model quantitatively, the standard deviation of the fitted result from the experimental one is compared with those of the other two well-known empirical constitutive models such as the Johnson-Cook and the Khan-Huang-Liang models. The comparison demonstrates that the suggested model gives relatively well description of experimental results at various strain rates and temperatures.

• Biomolecules & Therapeutics
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• 제29권4호
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• pp.434-444
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• 2021

BRAF inhibitors are insufficient monotherapies for BRAF-mutated cancer; therefore, we investigated which inhibitory pathway would yield the most effective therapeutic approach when targeted in combination with BRAF inhibition. The oncogenic BRAF inhibitor, PLX4720, increased basal autophagic flux in BRAF-mutated cells compared to wild-type (WT) BRAF cells. Interestingly, early autophagy inhibition improved the effectiveness of PLX4720 regardless of BRAF mutation, whereas late autophagy inhibition did not. Although ATG5 knockout led to PLX4720 resistance in both WT and BRAF-mutated cells, the MEK inhibitor trametinib exhibited a synergistic effect on PLX4720 sensitivity in WT BRAF cells but not in BRAF-mutated cells. Conversely, the prolonged inhibition of endoplasmic reticulum (ER) stress reduced basal autophagy in BRAF-mutated cells, thereby increasing PLX4720 sensitivity. Taken together, our results suggest that the combined inhibition of ER stress and BRAF may simultaneously suppress both pro-survival ER stress and autophagy, and may therefore be suitable for treatment of BRAF-mutated tumors whose autophagy is increased by chronic ER stress. Similarly, for WT BRAF tumors, therapies targeting MEK signaling may be a more effective treatment strategy. Together, this study presents a rational combination treatment strategy to improve the efficacy of BRAF inhibitors depending on BRAF mutation status.

• 대한토목학회논문집
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• 제40권2호
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• pp.183-189
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• 2020

이 논문은 인장 응력, 주변 온도 및 인가 주파수에 대한 강선의 전기적 임피던스 민감도에 관한 실험적 조사이다. 다양한 응력 수준 및 온도에 대해서, 강선의 전기적 임피던스가 자가진단 시스템에서 측정되었다. 세 가지 경우의 실험이 다양한 온도 조건, 응력 수준 및 적용 주파수에 대해서 수행되었다. 주어진 주파수에서 온도가 상승하고 응력이 감소하면 강선의 전기 임피던스가 증가한다. 실험 결과는 전기적 임피던스와 온도 사이의 상관관계가 모든 응력 수준에서 선형 관계임을 보여준다. 온도에 대한 임피던스의 감도는 응력보다 훨씬 높다는 점이 주목 된다.

• The Plant Pathology Journal
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• 제35권5호
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• pp.393-405
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• 2019

Survival factor 1 (Svf1) is a protein involved in cell survival pathways. In Saccharomyces cerevisiae, Svf1 is required for the diauxic growth shift and survival under stress conditions. In this study, we characterized the role of FgSvf1, the Svf1 homolog in the homothallic ascomycete fungus Fusarium graminearum. In the FgSvf1 deletion mutant, conidial germination was delayed, vegetative growth was reduced, and pathogenicity was completely abolished. Although the FgSvf1 deletion mutant produced perithecia, the normal maturation of ascospore was dismissed in deletion mutant. The FgSvf1 deletion mutant also showed reduced resistance to osmotic, fungicide, and cold stress and reduced sensitivity to oxidative stress when compared to the wild-type strain. In addition, we showed that FgSvf1 affects glycolysis, which results in the abnormal vegetative growth in the FgSvf1 deletion mutant. Further, intracellular reactive oxygen species (ROS) accumulated in the FgSvf1 deletion mutant, and this accumulated ROS might be related to the reduced sensitivity to oxidative stress and the reduced resistance to cold stress and fungicide stress. Overall, understanding the role of FgSvf1 in F. graminearum provides a new target to control F. graminearum infections in fields.