• BMB Reports
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• v.47 no.5
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• pp.249-255
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• 2014

Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA is damaged in cells under various stress conditions, the checkpoint mechanism is activated to allow cells to have enough time for repair. When damage is repaired, cells progress continuously their division, which is called checkpoint recovery. If damage is too severe to repair, cells undergo apoptotic pathway. If damage is not completely repaired, cells undergo a process called checkpoint adaptation, and resume cell division cycle with damaged DNA. Plk1 targets and regulates many key factors in the process of damage response, and we deal with these subjects in this review.

• Journal of Korea Foundry Society
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• v.29 no.6
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• pp.265-269
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• 2009

The optimum RRA heat treating conditions and SCC (stress corrosion cracking) resistance of semi-solid Al-Zn-Mg-Cu alloy fabricated by inclined cooling plate were compared with those of conventional mould cast alloys. The non-stirring method characterized by using a cooling plate can effectively eliminate dendritic structure and form a fine globular semisolid microstructure in as-cast Al-Zn-Mg-Cu alloy and the SCC resistance of semi-solid Al-Zn-Mg-Cu alloy was higher than that of conventional mold cast alloy. Also, after retrogressed treatment at RRA heat treatment of semi-solid Al-Zn-Mg-Cu alloy, retrogressed treatment time has increased more than 10 minutes at $180^{\circ}C$ to recovery the T6 heat treatment strength.

• Computers and Concrete
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• v.1 no.3
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• pp.261-284
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• 2004

Two enhancements to a recently developed plastic-damage-contact model for concrete are presented. The model itself, which uses planes of degradation that can undergo damage and separation but that can regain contact according to a contact law, is described. The first enhancement is a new damage evolution function which provides a completely smooth transition from the undamaged to the damaged state and from pre-peak to post-peak regions. The second is an improved contact function that governs the potential degree of contact with increasing opening on a crack plane. The use of a damage evolution function with a pre-peak has implications for the consistent tangent matrix/stress recovery algorithm developed for the model implementation, and amendments to this algorithm to accommodate the new function are described. A series of unpublished experimental tests on notched specimens undertaken in Cardiff in the mid 1990s are then described. These include notched beam tests as well as prismatic and cylindrical torsion tests. The tests are then considered in three dimensional finite element analyses using the modified Craft model implemented in the finite element program LUSAS. Comparisons between experimental and numerical data show reasonable agreement except that the numerical simulations do not fully describe the latter stages of the softening responses for the torsion examples. Finally, it is concluded that the torsion tests described provide useful benchmark examples for the validation of three-dimensional numerical models for concrete.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2315-2320
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• 2016

Background: This study investigated the influence of religious beliefs on the health of cancer patients and identified the factors contributing to the influence. Materials and Methods: A questionnaire survey was conducted using a convenient sampling method. A structured questionnaire was used to the samplings, and the data of 200 cancer patients were collected. Results: The effects of religion on the health of cancer patients achieved an average score of 3.58. The top five effects are presented as follows: (a) Religion provides me with mental support and strength, (b) religion enables me to gain confidence in health recovery, (c) religion motivates me to cope with disease-related stress positively and optimistically, (d) religion helps me reduce anxiety, and (e) religion gives me courage to face uncertainties regarding disease progression. Moreover, among the demographic variables, gender, type of religion, and experience of religious miracles contributed to the significantly different effects of religion on patients. Specifically, the effect of religion on the health of patients who were female and Christian and had miracle experiences was significantly (p< .01) higher than that on other patients. Conclusions: These results are helpful in understanding the influence of religious beliefs on the health of cancer patients and identified the factors contributing to the influence. The result can serve as a reference for nursing education and clinical nursing practice.

• Journal of Power Electronics
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• v.12 no.3
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• pp.377-386
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• 2012

An interleaved bridgeless buck-boost AC/DC converter is presented in this paper to achieve the characteristics of low conduction loss, a high power factor and low harmonic and ripple currents. There are only two power semiconductors in the line current path instead of the three power semiconductors in a conventional boost AC/DC converter. A buck-boost converter operated in the boundary conduction mode (BCM) is adopted to control the active switches to achieve the following characteristics: no diode reverse recovery problem, zero current switching (ZCS) turn-off of the rectifier diodes, ZCS turn-on of the power switches, and a low DC bus voltage to reduce the voltage stress of the MOSFETs in the second DC/DC converter. Interleaved pulse-width modulation (PWM) is used to control the switches such that the input and output ripple currents are reduced such that the output capacitance can be reduced. The voltage doubler topology is adopted to double the output voltage in order to extend the useable energy of the capacitor when the line voltage is off. The circuit configuration, principle operation, system analysis, and a design example are discussed and presented in detail. Finally, experiments on a 500W prototype are provided to demonstrate the performance of the proposed converter.

• Journal of Power Electronics
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• v.18 no.3
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• pp.662-671
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• 2018

This paper presents a new structure for a step up dc-dc converter, which has several advantageous features. Firstly, the input dc source and the clamped capacitor are connected in series to transfer energy to the load through dual voltage multiplier cells. Therefore, the proposed converter can produce a very high voltage and a high conversion efficiency. Secondly, a double voltage clamped circuit is introduced to the primary side of the coupled inductor. The energy of the leakage inductance of the coupled inductor is recycled and the inrush current problem of the clamped circuits can be shared equally by two synchronous clamped capacitors. Therefore, the voltage spike of the switch tube is solved and the current stress of the diode is reduced. Thirdly, dual voltage multiplier cells can absorb the leakage inductance energy of the secondary side of the coupled inductor to obtain a higher efficiency. Fourthly, the active switch turns on at almost zero current and the reverse-recovery problem of the diodes is alleviated due to the leakage inductance, which further improves the conversion efficiency. The operating principles and a steady-state analysis of the continuous, discontinuous and boundary conduction modes are discussed in detail. Finally, the validity of this topology is confirmed by experimental results.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.5B no.4
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• pp.343-349
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• 2005

This paper proposes a novel zero-voltage-switching (ZVS) Push-pull DC-DC Converter for high input voltage and high power applications. This topology utilizes two switches in series to replace one switch in conventional push-pull converter, and two clamping diodes are introduced. The voltage stress of the switches is the input voltage, and the switches can realize ZVS with the use of the leakage inductance of the transformer. Furthermore, secondary full-wave rectifier with a clamping capacitor is used to eliminate the voltage oscillation and spike of the rectifier diodes due to the reverse recovery. Therefore, the electromagnetic interference is reduced effectively. The operation principle of the proposed converter is analyzed theoretically. The output characteristic, ZVS condition and design principle of the clamping capacitor are discussed. Experimental results obtained from a 270V input 2kW prototype with $95.8\%$ high efficiency confirms the design.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.4
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• pp.29-35
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• 2020

PURPOSE: This study examined the immediate effects of Graston instrument-assisted soft-tissue mobilization (GIASTM) and self-stretching on the muscular properties of the gastrocnemius in athletes. METHODS: Thirty subjects (All in their 20 s) were distributed randomly and evenly into two groups of 15 each: GIASTM and stretching. The subjects had no history of gastrocnemius damage in the previous three months. The muscle tone, stiffness, elasticity, and mechanical stress relaxation time (MSRT) of the gastrocnemius were blind-tested. RESULTS: The GIASTM group showed significant changes in all categories, while only MSRT changed significantly in the self-stretching group after intervention. A comparison of the two groups revealed significant differences in stiffness, elasticity, and MSRT (Time required for the muscle to recover after distortion after intervention in the GIASTM group. CONCLUSION: In this study, significant decreases in muscle tone and stiffness, as well as significant increases in elasticity, were observed in the gastrocnemius of the GIASTM group. On the other hand, sSelf-stretching showed significant differences in MSRT. Therefore, GIASTM is more effective in the recovery of the gastrocnemius muscle from fatigue than self-stretching. This study suggests that GIASTM can help prevent damage to the gastrocnemius in athletes and contribute to their training and rehabilitation programs.

• Journal of Preventive Medicine and Public Health
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• v.43 no.5
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• pp.387-395
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• 2010

Objectives: The purpose of this study was to compare the physical and mental health status of disaster victims according to disaster types, such as a typhoon disaster and an oil spill disaster, and to suggest adequate health care services for them. Methods: A total of 484 people who suffered disasters were selected for this study, and data were collected from July to August, 2008. The data-set for this study included 286 victims of typhoon disasters in Jeju and Jeollanamdo district in South Korea, and 198 victims of the oil spill disaster in Taean. Physical health status was measured using revised Patient Health Questionnaire and mental health status was measured using the Korean version of 'Post-traumatic Diagnostic Scale'. Results: According to the comparative analyses of typhoon disaster victims and oil spill disaster victims, poorer physical health outcomes were shown among the oil spill disaster victims when compared to the typhoon disaster victims. Also, the oil spill disaster victims showed symptoms of depression, anxiety, and post-traumatic stress disorder, at rates higher than those found among the typhoon disaster victims. Conclusions: These findings suggest that there is a need to provide adequate physical and mental health-related care services for oil spill disaster victims. The seriousness of oil spill disaster should be realized and reconsidered in developing recovery strategies and disaster preparedness for physical and mental health services.

• Transactions of Materials Processing
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• v.17 no.8
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• pp.570-578
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• 2008

A flexible forming apparatus is composed a number of punches which have spherical pin tip shape instead of conventional solid die. The flexible forming tool consisted of punch array in a matrix form was proposed as an alternative forming method to substitute the conventional line heating method which use heat source to induce residual stress along specified heating lines. In this study, application of the flexible forming process to the small scale curved plate forming was conducted. Numerical simulations for both solid and flexible die forming process were carried out to compare the shape of the products between flexible and conventional die forming process. In addition, spring-back analysis was conducted to figure out the feasibility of the flexible forming process comparing with the die forming process in view of final configuration of the specimens. Moreover, experiment was also carried out to confirm the formability of the process. Consequently, it was confirmed that the flexible die forming method has capability and feasibility to manufacture the curved plates for shipbuilding.