• Food Science and Biotechnology
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• 제16권6호
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• pp.1035-1040
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• 2007

Epidemiologic studies have shown important relationships between oxidative stress and Alzheimer's disease (AD) brain. In this study, free radical scavenging activity and neuronal cell protection effect of aqueous methanol extracts of Acanthopanax senticosus (A. senticosus) were examined. $H_2O_2$-induced oxidative stress was measured using 2',7'-dichlorofluorescein diacetate (DCF-DA) assay. Pretreatment with the phenolics of A. senticosus prevented oxidative injury against $H_2O_2$ toxicity. Since oxidative stress is known to increase neuronal cell membrane breakdown, leading to cell death, lactic dehydrogenase release, and trypan blue exclusion assays were utilized. We found that phenolics of A. senticosus have neuronal cell protection effects. It suggests that the phenolics of A. senticosus inhibited $H_2O_2$-induced oxidative stress and A. senticosus may be beneficial against the oxidative stress-induced risk in AD.

• 보건의료산업학회지
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• 제6권2호
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• pp.111-119
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• 2012

The purpose of the study were to investigate the effect of the neuro-feedback program which improves brain function and stress reduction effect. The research design is one group pretest-posttest survey. 121 nursing students of a college in the Busan region took part in the study. Training involving the neuro-feedback program was conducted twice a week, 30 minutes per session, for a total of 10 weeks. The collected data was encoded and analyzed using SPSS 12.0 Version. The brain function and stress levels of the subjects were analyzed through the before-and-after results of the training were analyzed using a paired t-test. The results of the study showed that the BQ and SQ were enhanced as a result of the neuro-feedback. In particular, there were significant increases in the SRQ, ATQ, ACQ, and EQ of the BQ. SQ is correlated with the prevalence rate and resistance to disease, meaning not only psychological anxiety, uneasiness and excitement, but also physical anxiety and response to disease. Based on the study, by using the neuro-feedback training as a program for stress reduction, it is expected that nursing students will receive less stress from internal and external factors, and their ability to cope with stress will be enhanced.

• Restorative Dentistry and Endodontics
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• 제25권3호
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• pp.321-337
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• 2000

Dental caries, one of the most frequent dental disease, become larger because it can be thought as a simple disease. Further more, it can progress to unexpected root canal therapy with fabrication of crown that needs reduction of tooth structure. Base is required in a large caries and ZOE, ZPC, glass ionomer are used frequently as base material. They, with restorative material, can affect the longevity of the restoration. In this study, we assume that the mandibular 1st molar has deep class I cavity. So, installing the 3 base material, 3 kinds of fillings were restored over the base as follows; 1) amalgam only, 2) amalgam with ZPC, 3) amalgam with ZOE, 4) amalgam with GI cement, 5) gold inlay with ZPC, 6) gold inlay with GI cement, 7) composite resin only, 8) composite resin with GI cement. After develop the 3-dimensional model for finite element analysis, we observe the distribution of stress and temperature with force of 500N to apical direction at 3 point on occlusal surface and temperature of 55 degree, 15 degree on entire surface. The analyzed results were as follow : 1. Principal stress produced at the interface of base, dentin, cavity wall was smallest in case of using GI cement as base material under the amalgam. 2. Principal stress produced at the interface of base, dentin, cavity wall was smaller in case of using GI cement as a base material than ZPC under gold inlay. 3. Composite resin-filled tooth showed stress distributed over entire tooth structure. In other words, there was little concentration of stress. 4. ZOE was the most effective base material against hot stimuli under the amalgam and GI cement was the next. In case of gold inlay, GI cement was more effective than ZPC. 5. Composite resin has the small coefficient of thermal conductivity. So, composite resin filling is the most effective insulating material.

• Animal Bioscience
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• 제37권2호
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• pp.193-202
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• 2024

Objective: Oxidative stress (OS) is a pathological process arising from the excessive production of free radicals in the body. It has the potential to alter animal gene expression and cause damage to the jejunum. However, there have been few reports of changes in the expression of long noncoding RNAs (lncRNAs) in the jejunum in piglets under OS. The purpose of this research was to examine how lncRNAs in piglet jejunum change under OS. Methods: The abdominal cavities of piglets were injected with diquat (DQ) to produce OS. Raw reads were downloaded from the SRA database. RNA-seq was utilized to study the expression of lncRNAs in piglets under OS. Additionally, six randomly selected lncRNAs were verified using quantitative real-time polymerase chain reaction (qRT-PCR) to examine the mechanism of oxidative damage. Results: A total of 79 lncRNAs were differentially expressed (DE) in the treatment group compared to the negative control group. The target genes of DE lncRNAs were enriched in gene ontology (GO) terms and Kyoto encyclopedia of genes and genomes (KEGG) signaling pathways. Chemical carcinogenesis-reactive oxygen species, the Foxo signaling pathway, colorectal cancer, and the AMPK signaling pathway were all linked to OS. Conclusion: Our results demonstrated that DQ-induced OS causes differential expression of lncRNAs, laying the groundwork for future research into the processes involved in the jejunum's response to OS.

• 한국주거학회논문집
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• 제7권2호
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• pp.9-17
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• 1996

The Purpose of this study is to understand the relationship between residential environment and healthy behavior by examining the effect of environmental stress on psychology and physiology. With anxiety, the acute environmental stressor activates sympathy nerve system and the chonic environmental stressor activates the intenal secretion system because this stress induces depression. Thus, we could find that the continuity of these kinds of stresses brings the chronic disease.

• 동아시아식생활학회지
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• 제14권3호
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• pp.207-216
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• 2004

This study was performed in oder to investigate to dietary behavior, perceived stress and their correlations of University students. The number of subjects was 549 and the results of this study are as followed: Only 13.9% of students-20% of male students, 10% of female students-exercise regularly. Regular exercise and health condition had no statistical relationship in this study. 83.9% of subjects had experience of alcohol drinking (19.4% of male students, 7.3% of female students). Many students replied that they drink alcohol 1∼2 times per a week. 24.4% of students-only 2.6% of female students-were smoking and great number of smokers were drinking also. The BMI of 46.7% of subjects were in normal range. 48.2% were in under weighted and 5.1% were in over weighted or obesity. The stress factor of University students were analyzed into 12. Inner stress factors like as identity, coursework, friendship, health problem were more potent in female students than male. Among the health related habits, disease itself had a great effect on many stress factors but regular exercise had a little.

• Journal of Ginseng Research
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• 제41권4호
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• pp.589-594
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• 2017

Ginseng effectively regulates the immune response and the hormonal changes due to stress, thus maintaining homeostasis. In addition to suppressing the occurrence of psychological diseases such as anxiety and depression, ginseng also prevents stress-associated physiological diseases. Recent findings have revealed that ginseng is involved in adjusting the hypothalamic-pituitary-adrenal axis and controlling hormones, thus producing beneficial effects on the heart and brain, and in cases of bone diseases, as well as alleviating erectile dysfunction. Recent studies have highlighted the potential use of ginseng in the prevention and treatment of chronic inflammatory diseases such as diabetes, rheumatoid arthritis, and allergic asthma. However, the mechanism underlying the effects of ginseng on these stress-related diseases has not been completely established. In this review, we focus on the disease pathways caused by stress in order to determine how ginseng acts to improve health. Central to our discussion is how this effective and stable therapeutic agent alleviates the anxiety and depression caused by stress and ameliorates inflammatory diseases.

• 동의생리병리학회지
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• 제21권1호
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• pp.190-198
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• 2007

Alzheimer's disease, a representative neurodegenerative disorder, is characterized by the presence of senile plaques and neurofibrillary tangles accompanied by neuronal damages. b-Amyloid peptide is considered to be responsible for the formation of senile plagues that accumulate in the brains of patients with Alzheimer's disease. There has been compelling evidence supporting that b-amyloid-induced cytotoxicity is mediated through generation of reactive oxygen species. In this study, we have investigated the possible protective effect of Rehmannia glutihosaagainst b-amyloid-induced oxidative ceil death in cultured human neuroblastoma SH-SY5Y cells. SH-SY5Y cells treated with b-amyloid underwent apoptotic death as determined by morphological features and positive in situterminal end-labeling (TUNEL staining). Rehmannia glutinosawater extract, wine, and vinegar pretreatments attenuated b-amyloid-induced cytotoxicity and apoptosis. Rehmannia glutinosa vinegar exhibited maximum protective effect by increasing the expression of anti-apoptotic protein, Bcl-2. in addition to oxidative stress, b-amyloid-treatment caused nitrosative stress via marked increase in the levels of nitric oxide, which was effectively blocked by Rehmannia glutinosa. To further explore the possible molecular mechanisms underlying the protective effect of Rehmannia glutinosa, we assessed the mRNA expression of cellular antioxidant enzymes. Treatment of Rehmannia glutinosa vinegar led to up-regulation of heme oxygemase-1 and catalase. These results suggest that Rehmannia glutinosa could modulate oxidative neuronal cell death caused by b-amyloid and may have preventive or therapeutic potential in the management of Alzheimer's disease. Particularly, Rehmannia glutinosa vinegar can augment cellular antioxidant capacity, there by exhibiting higher neuroprotective potential.

• 보건의료산업학회지
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• 제4권2호
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• pp.73-84
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• 2010

This study conducted a secondary analysis by using original data of performed by Korea Institute for Health and Social Affairs to determine factors affecting doctor's diagnosed disease-related mental health for the elderly aged over 65 years living in Korea. The survey was conducted in 2007 and it evaluated finally 720 cases by excluding cases with no answer or a wrong answer. The results were as follows. The proportion of the elderly who stress cognition was influenced when subjects were female and older, lower subjective health condition and osteoporosis, showed statistically significant difference. The proportion of the elderly who experience depression was influenced when subjects were older, had not health insurance or medical care, and lower subjective health condition, showed statistically significant difference. The proportion of the elderly who have suicide thoughts was influenced when subjects were female and higher educational background, lower subjective health condition, COPD(Chronic obstructive pulmonary disease), and diabetes mellitus, showed statistically significant difference. We knew that the relationship between diseases and depression in the elderly influenced on the depression about most of the diseases. Particularly, Depression and suicide had a high correlation. The results suggest that it should be necessary to systematic management of diseases in the depression treatment of the Elderly in Korea.

• 환경위생공학
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• 제21권2호
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• pp.57-68
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• 2006

This study was designed to provide basic data on preventive plans by affecting factors that have analysed on musculoskeletal diseases. The survey were conducted from July 1 to 30, 2004 among 600 hair dressers working in Seoul and Gwangju using self-administration questionnaire. The results of this study are summarized as follows: The pain experience rate of musculoskeletal diseases. in the last one yea was 55.2%. 35.7% of respondents answered they had pain on shoulders, 30.6% had pain on legs and feet, 28.9% had pain on waist, 26.8% had hands, fingers and wrist, 22.3% had pain on necks and 17.6% had pain arms and elbows more than disease on necks, shoulders, arms and elbows, hands, fingers and wrists, waist, shoulders legs and feet. The prevalence rate of the last week was 40.3%. The prevalence rate in each body parts of the last week was 23.3% on legs and feet, 21.2% on shoulders, 20.8% on waist, 14.9% on hands, fingers and wrists, 14.4% on necks, 9.3% on arms. The affecting factors on musculoskeletal disease index were analysed by multiple linear regression analysis. there are working posture$(\beta=0.27)$; authority of task$(\beta=0.18)$, self-conscious stress $(\beta=0.16)$, age$(\beta=0.14)$, physical burden from work$(\beta=0.13)$, and task required$(\beta=0.10)$. Determinant coefficients was 22.7%. Based on the results above, working posture, job stress and physical burden from task are highly related with pain. In order to prevent musculoskeletal disease of hairdressers, working posture shall be improved and leisure opportunities to relieve stress, and health management education shall be provided.