• 대한한방내과학회지
• /
• 제41권6호
• /
• pp.993-1014
• /
• 2020

Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Antioxidant stress and inflammatory reactions are important causes of neurodegenerative diseases and are major causes of PD. Many animal experiments have been aimed at treating PD using the antioxidant effects of various traditional medicines and dietary supplements. This review reports the research investigating the antioxidant effects of herbs in in vivo PD models. Methods: The study consisted of a database search for articles related to PD and herbal treatments using the OASIS, NDSL, KTKP, Korean KISS, PubMed, Science Direct, CNKI, Wanfang, and J-STAGE databases. The search period was limited from the start of the search engine application to November 14, 2019. Studies were selected to confirm the antioxidant effects of herbal medicines in an in vivo PD model. Results: Eighty-two studies were summarized for plant species, extracts (or compounds), animal models, neurotoxins, and functional results. The most frequently used herbal materials were Bacopa monnieri, Camellia sinensis, Centella asiatica, and Withania somnifera. MPTP and 6-OHDA were the most commonly used neurotoxins for inducing PD. Most studies confirmed an increased expression and activation of antioxidant enzymes and a decrease in oxidative stress. Herbal materials showed their antioxidant effects regardless of the order of treatment and confirmed their possible use as treatments for the prevention and treatment of neurodegeneration. Conclusion: Many herbal medicines have antioxidant effects and are likely to be effective in delaying neurodegenerative damage by inhibiting or reducing oxidative stress by expression of antioxidant enzymes.

• BMB Reports
• /
• 제51권8호
• /
• pp.400-405
• /
• 2018

Chronic stress induces neuronal cell death, which can cause nervous system disorders including Parkinson's disease and Alzheimer's disease. In this study, we evaluated the neuroprotective effects of Clematis terniflora extract (CTE) against corticosterone-induced apoptosis in rat pheochromocytoma (PC12) cells, and also investigated the underlying molecular mechanisms. At concentrations of 300 and $500{\mu}g/ml$, CTE significantly decreased apoptotic cell death and mitochondrial damage induced by $200{\mu}M$ corticosterone. CTE decreased the expression levels of endoplasmic reticulum (ER) stress proteins GRP78, GADD153, and mitochondrial damage-related protein BAD, suggesting that it downregulates ER stress evoked by corticosterone. Furthermore, our results suggested that these protective effects were mediated by the upregulation of p-AKT and p-ERK1/2, which are involved in cell survival signaling. Collectively, our results indicate that CTE can lessen neural damage caused by chronic stress.

• 대한한방소아과학회지
• /
• 제18권1호
• /
• pp.193-206
• /
• 2004

Objective: The study aimed to evaluate the anti-stress effect of YST on the cold-stressed Mice. Method: The experimental animals were stressed in cold room ($4{\pm}0.5^{\circ}C$) for 1 hour in a day during 2weeks, and administerd 115mg/100g YST extract for 2weeks before stress. For 2weeks, we conducted a research about the change of weight and content of norepinephrine, epinephrine, dopamine, cortisol and GOT, GPT in the mice serum. Results: YST significantly inhibited the decrease of body weight induced by stress, compared with the control group. YST had no significant decreasing effect on the change of content of the serum GOT But decreased the content of the serum GPT. YST decreased the content of the serum cortisol. YST decreased the content of the serum dopamine a little and decreased the content of the serum epinephrine significantly. Conclusion: According to the above results, it is concluded that YST will be useful as a remedy against stress disease.

• 임상간호연구
• /
• 제14권3호
• /
• pp.153-163
• /
• 2008

Purpose: The purpose of this research, using descriptive correlation design was to identify the extent to which the mothers having children with rare genetic metabolic diseases(MPS, PWS) have parenting stress and guilt feeling. Method: This study used PSI /SF(Abidin, 1995) and Guilt Index as devised herein. From 156 mothers, data were collected from February to July 2006, using self-administered questionnaires. This study received the approval from IRB at S Hospital (IRB File No: 2006-02-014). Data were analyzed with descriptive statistics, t-test, ANOVA, and correlation. Results: Mothers felt very high level of parenting stress and sense of guilt. Parenting stress was related positively to guilt feeling. Conclusion: These findings could help understand the families of children with rare genetic metabolic diseases and those provide basic information in developing effective counseling and education programs for relief of parenting stress and guilt feeling. This study would be significant in the fact that it is the first research, targeting on the families of children with rare genetic metabolic diseases in Korea.

• Journal of Applied Biological Chemistry
• /
• 제65권1호
• /
• pp.23-31
• /
• 2022

Oxidative stress and neuroinflammation play important roles in the pathogenesis of Alzheimer's disease (AD). This study investigated the protective effects of paeoniflorin (PF) against neuronal oxidative stress and neuroinflammation in lipopolysaccharide (LPS)-induced mice. The brains of LPS-injected control group showed significantly increased neuroinflammation by activating the nuclear factor kappa B (NF-κB) pathway and increasing inflammatory mediators. However, administration of PF significantly attenuated oxidative stress by inhibiting lipid peroxidation, nitric oxide levels, and reactive oxygen species production in the brain; PF at doses of 5 and 10 mg/kg/day downregulated the expression of NF-κB pathway-related proteins and significantly decreased inflammatory mediators including inducible nitric oxide synthase and cyclooxygenase-2. Moreover, the levels of brain-derived neurotrophic factor and its receptor, tropomycin receptor kinase B, were significantly increased in PF-treated mice. Furthermore, acetylcholinesterase activity and the ration of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X were significantly reduced by PF in the brains of LPS-induced mice, resulting in the inhibition of cholinergic dysfunction and neuronal apoptosis. Thus, we can conclude that administration of PF to mice prevents the development of LPS-induced AD pathology through the inhibition of neuronal oxidative stress and neuroinflammation, suggesting that PF has a therapeutic potential for AD.

• 한국식물병리학회:학술대회논문집
• /
• 한국식물병리학회 2002년도 총회 및 추계학술발표회
• /
• pp.54.1-54
• /
• 2002

• 치위생과학회지
• /
• 제12권5호
• /
• pp.469-476
• /
• 2012

본 연구는 스트레스 대처방법이 치주질환에 미치는 영향을 파악하여 적절한 스트레스 대처방법을 통한 치주질환의 예방과 발생 및 진행 정도에 긍정적인 성과를 위한 기초 자료를 제공하기 위하여 실시되었다. 연구대상은 창원시 소재 MY치과의원에 내원한 40~50대 성인 남녀와 같은 지역 소재 M대학 치위생과에 예방적 치석제거에 동의한 40~50대 성인 남녀로 총 326명을 대상으로 하여 설문지와 치주건강상태를 측정하여 조사 분석하였다. 자료의 분석방법은 SPSS ver. 19.0 (IBM Co.)을 이용하여 빈도와 백분율, t-검증, MANOVA, 다중회귀분석의 통계방법을 사용하였으며 분석결과는 다음과 같다. 1. 여자보다 남자에서 치은염 지수(p<0.001), 치주낭 깊이(p<0.001), 임상적 부착소실(p<0.01)에 대한 평균이 높게 나타났다. 2. 치은염 지수에 영향을 미치는 요인으로 정서 중심적 스트레스 대처방법($\beta$=0.341, p<0.001)이 영향을 미치는 것으로 조사되었다. 3. 치주낭 깊이에 영향을 미치는 요인으로 정서 중심적 스트레스 대처방법($\beta$=0.239, p<0.002)이 영향을 미치는 것으로 조사되었다. 4. 임상적 부착소실에 영향을 미치는 요인으로 정서 중심적 스트레스 대처방법($\beta$=0.158, p<0.042)이 영향을 미치는 것으로 조사되었다.

• 한국산학기술학회논문지
• /
• 제15권3호
• /
• pp.1663-1670
• /
• 2014

스트레스는 구강질환과 밀접한 관련성이 있으며, 구강건강 및 삶의 질 향상을 위한 중요한 문제로 제기되고 있다. 본 연구는 2012년 7월 1일부터 2013년 2월 28일까지 550명의 성인을 대상으로 신체적 스트레스 증상과 심리적 스트레스 증상이 구강 건조감, 구강점막 질환 및 구취에 미치는 영향을 경로분석을 통하여 검증하였다. 본 연구 결과, 신체적 증상과 심리적 증상은 구강건조와 구강점막 증상에 직접적인 영향을 미치는 것으로 나타났다. 구강점막은 구취, 구강건조는 구취에 직접적인 영향을 미치는 것으로 나타났다. 구강건조와 구강점막은 매개변수로써 스트레스 증상과 구취와의 영향에 간접적인 영향을 미치는 것으로 나타났다. 구강건조감은 구강점막에 직접적인 영향을 미치는 것으로 나타났다. 따라서, 성인들의 신체적 스트레스 증상과 심리적 스트레스 증상은 구강건조감, 구강점막 질환 및 구취와 직·간접적인 영향을 미친다는 알 수 있었다. 성인은 스트레스와 구강질환은 높은 관계성을 갖고 있으므로 스트레스를 올바르게 대처할 수 있는 해결책을 강구하여 보다 향상된 삶을 영위할 수 있는 해결방안이 요구되어진다.

• 한국치위생학회지
• /
• 제17권3호
• /
• pp.465-478
• /
• 2017

Objectives: The purpose of this study was to investigate the relationship between the level of subjective stress recognition and oral symptom experiences including toothache, gum diseases, and oral soft tissue diseases in the Korean adolescents. Methods: The subjects were 68,043 adolescents recruited using a web-based survey, National Korean Youth Risk Behavior in 2015 by the Korean Center for Disease Control. For statistical analysis, SPSS 21.0 for Windows was used. Descriptive analysis and a Chi-square test were conducted to determine the factors associated with general characteristics, health behaviors, oral health behaviors, and level of subjective stress recognition. Finally, to investigate the relationship between the level of subjective stress recognition and oral symptom experiences, logistic regression analysis was performed. Results: Toothache related subjective stress recognition level was significantly higher in the moderate group with the score of 1.59 (95% CI; 1.49-1.68), and was greater in the high group with 2.38 (95% CI; 2.24-2.53) compared to the low group. Gum disease related subjective stress recognition level was significantly higher in the moderate group with 1.41 (95% CI; 1.32-1.51), and was greater in the high group with 1.99 (95% CI; 1.86-2.13). Oral soft tissue disease related subjective stress recognition level was significantly higher in the moderate group with 1.59 (95% CI; 1.45-1.74), and was greater in the high group with 2.55 (95% CI; 2.33-2.79). Bad breath related subjective stress recognition level was significantly higher in the moderate group with 1.48 (95% CI; 1.39-1.57), and was greater in the high group with 2.10 (95% CI; 1.97-2.25). Conclusions: Higher subjective stress recognition level was found to affect the oral symptoms experienced. Therefore, the stress management plan should be prepared through the cause identification of the main stress in the adolescents. Practical and systematic education is needed for oral health management in the schools.

• 치위생과학회지
• /
• 제15권2호
• /
• pp.119-128
• /
• 2015

본 연구는 제5기 3차년도 국민건강영양조사(2012) 자료를 이용하여 한국 성인의 비만과 스트레스가 구강관련 질환에 미치는 요인을 파악하기 위해 19세 이상 64세 이하 성인 4,627명을 대상으로 SPSS Windows ver. 18.0 통계프로그램을 이용하여 분석한 결과 다음과 같은 결론을 얻었다. 비만도는 남자인 경우, 40~64세의 연령집단이, 교육수준과 소득수준은 낮을수록 유의하게 높게 나타났으며(p<0.05), 스트레스는 여자인 경우, 19~39세의 연령집단이, 교육수준은 높을수록 스트레스가 있는 비율이 유의하게 높게 나타났다(p<0.05). 비만도에 따른 구강관련 질환 관련성은 BMI 분류에 있어 비만인 경우 치주질환과 악관절 증상이 정상보다 약간은 높았으나 통계적으로 차이는 보이지 않았고(p>0.05), WHR 분류에서는 복부비만인 경우 치주질환이 있는 경우가 약간은 높았으나 통계적 유의성은 없었다(p>0.05). 스트레스에 따른 구강관련 질환 관련성에서 악관절 증상과는 통계적으로 유의한 차이를 보였으나(p<0.05), 치주질환, 저작문제와는 차이가 없는 것으로 나타났다(p>0.05). 스트레스가 있는 대상자들이 비만이거나 복부비만인 경우에는 치주질환이 정상보다 약간 높았으나 유의하지 않았고 다른 구강질환과도 유의한 차이를 보이지 않았다(p>0.05). 각 변수들 간의 상관관계는 비만일수록 복부비만일 가능성이 높고, 스트레스를 받는 경우 악관절 증상이 나타나며, 저작문제가 있는 경우 치주질환과 악관절 증상이 나타났다(p<0.05). 일반적 특성, 비만도, 스트레스가 구강관련 질환에 미치는 영향은 악관절 증상은 연령이, 저작 문제는 연령과 복부비만이 영향을 미치는 변수로 나타났다(p<0.05). 현대사회에서는 개인과 개인을 둘러싼 환경이 복잡하고, 삶의 질까지 포함하는 건강의 개념은 과거보다 더 복합적인 의미를 가진다. 다양한 요인들이 비만과 스트레스에 영향을 미치고 있고 이들이 구강건강과 행동에도 영향을 미치고 있다. 따라서 비만과 스트레스를 감소시키려는 노력뿐만 아니라 구강건강을 개선하기 위한 다른 관점으로의 접근도 필요하리라 생각된다.