The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Review of the Antioxidant Effect of Herbal Material in In Vivo Parkinson's Disease Models

파킨슨병 in vivo 모델에서 한약재 및 기능성 식품의 항산화 효과에 대한 고찰

  • Lee, Gi-hyang (Dept of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Jeon, Sang-woo (Dept of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Jeong, Min-jeong (Dept of Pediatrics, College of Korean Medicine, Woo-Suk University) ;
  • Kim, Hong-jun (Dept of Prescription, College of Korean Medicine, Woo-Suk University) ;
  • Jang, In-soo (Dept of Internal Medicine, College of Korean Medicine, Woo-Suk University)
  • 이기향 (우석대학교 한의과대학 한방내과학교실) ;
  • 전상우 (우석대학교 한의과대학 한방내과학교실) ;
  • 정민정 (우석대학교 한의과대학 소아과학교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실) ;
  • 장인수 (우석대학교 한의과대학 한방내과학교실)
  • Received : 2020.10.17
  • Accepted : 2020.12.21
  • Published : 2020.12.30
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Abstract

Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Antioxidant stress and inflammatory reactions are important causes of neurodegenerative diseases and are major causes of PD. Many animal experiments have been aimed at treating PD using the antioxidant effects of various traditional medicines and dietary supplements. This review reports the research investigating the antioxidant effects of herbs in in vivo PD models. Methods: The study consisted of a database search for articles related to PD and herbal treatments using the OASIS, NDSL, KTKP, Korean KISS, PubMed, Science Direct, CNKI, Wanfang, and J-STAGE databases. The search period was limited from the start of the search engine application to November 14, 2019. Studies were selected to confirm the antioxidant effects of herbal medicines in an in vivo PD model. Results: Eighty-two studies were summarized for plant species, extracts (or compounds), animal models, neurotoxins, and functional results. The most frequently used herbal materials were Bacopa monnieri, Camellia sinensis, Centella asiatica, and Withania somnifera. MPTP and 6-OHDA were the most commonly used neurotoxins for inducing PD. Most studies confirmed an increased expression and activation of antioxidant enzymes and a decrease in oxidative stress. Herbal materials showed their antioxidant effects regardless of the order of treatment and confirmed their possible use as treatments for the prevention and treatment of neurodegeneration. Conclusion: Many herbal medicines have antioxidant effects and are likely to be effective in delaying neurodegenerative damage by inhibiting or reducing oxidative stress by expression of antioxidant enzymes.

Keywords

References

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