• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7381-7384
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• 2015

This study was conducted to 1206 women who had cervical cancer screening at Chonburi Cancer Hospital. The spilt-sample study aimed to compare the efficacy of abnormal cervical cells detection between liquid-based cytology (LBC) and conventional cytology (CC). The collection of cervical cells was performed by broom and directly smeared on a glass slide for CC then the rest of specimen was prepared for LBC. All slides were evaluated and classified by The Bethesda System. The results of the two cytological tests were compared to the gold standard. The LBC smear significantly decreased inflammatory cell and thick smear on slides. These two techniques were not difference in detection rate of abnormal cytology and had high cytological diagnostic agreement of 95.7%. The histologic diagnosis of cervical tissue was used as the gold standard in 103 cases. Sensitivity, specificity, positive predictive value, negative predictive value, false positive, false negative and accuracy of LBC at ASC-US cut off were 81.4, 75.0, 70.0, 84.9, 25.0, 18.6 and 77.7%, respectively. CC had higher false positive and false negative than LBC. LBC had shown higher sensitivity, specificity, PPV, NPV and accuracy than CC but no statistical significance. In conclusion, LBC method can improve specimen quality, more sensitive, specific and accurate at ASC-US cut off and as effective as CC in detecting cervical epithelial cell abnormalities.

• 디지털융복합연구
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• 제20권5호
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• pp.681-693
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• 2022

본 연구는 근골격계 질환으로 입원한 환자의 의무기록지 키워드 네트워크 분석을 통해 근골격계와 관련된 표준의료용어를 유추하여 보건의료현장의 비정형화된 데이터 활용 방안을 제시하기 위함이다. 분석 대상은 2010년부터 2019년까지 근골격계 질환 환자의 입퇴원요약지 145부로, 더아이엠씨(The IMC)에서 개발한 빅데이터 분석 솔루션인 TEXTOM을 활용하여 분석하였다. 1차·2차 정제과정을 통해 도출된 177개의 근골격계 관련 용어를 최종 분석하였다. 연구결과 다빈도 용어는 'Metastasis', 의료용어 체계별 분석 결과에서 임상소견은 'Metastasis', 증상은 'Weakness', 진단은 'Hepatitis', 처치는 'Remove', 신체구조는 'Spine', 약물은 'Oxycodone'이 가장 많이 사용되었다. 이러한 결과를 바탕으로 정형화되지 않은 의료데이터의 분석과 활용 및 관리 방안에 대한 시사점을 제안하고자 한다.

• 대한한방내과학회지
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• 제32권2호
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• pp.232-242
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• 2011

Objectives : The purpose of this study was to develop the Korean standard pattern identifications for stroke-III (KSPIS-III). KSPIS-III includes 4 major pattern identifications (PIs) and clinical indicators for each. Methods : To extract the indicators for 4 major PIs, we analyzed 1548 clinical data from 15 traditional Korean medicine hospitals. Patients got acute stroke within 30 days from onset. Two physicians independently checked 65 indicators and performed pattern diagnosis. If the PI were diagnosed the same, PI would be confirmed. First we built an assumption model that set up the relationship among pattern identifications. Second, we extracted the indicators for fire-heat pattern and qi deficiency pattern by comparison between excessive and deficiency group, heat and non-heat group. By comparing yin deficiency pattern and 3 other patterns respectively, we extracted the indicators for yin deficiency pattern. Dampness-phlegm pattern indicators were extracted by the same method. Results : After cross tabulation with 65 indicators on the basis of our assumption model, we finally extracted 19 indicators for fire-heat pattern, 11 for qi deficiency pattern, 7 for yin deficiency pattern, and 7 for dampness-phlegm pattern. Conclusions : KSPIS-III was more improved than KSPIS-II because it was based on more clinical data. Further study to establish the PI diagnostic model would be required for practical use in the clinical field.

• Tuberculosis and Respiratory Diseases
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• 제59권1호
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• pp.47-52
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• 2005

연구배경 : 클라미디아 폐렴균은 임상적으로 중요한 균으로 혈청검사가 진단에 중요하다. 현재 이용되는 micro-immunofluorescence법은 주관적이고 시간이 많이 소요되므로 좀더 객관적으로 진단할 수 있는 ELISA법을 이용하여 만성 기침을 주소로 내원한 환자들의 혈청을 대상으로 검사하고 표준방법과 결과를 비교하였다. 방 법 : 2003년 8월부터 2004년 7월까지 강원대학교병원을 방문한 35명의 성인 환자에서 얻은 혈청을 ELISA법과 micoimmunofluorescence법으로 시행하였다. 비인두 스왑에서 PCR을 시행하였다. 두 방법의 비교는 비모수 상관계수 분석(Spearman)을 하였다. 결 과 : ELISA 검사결과 IgG는 민감도 84.0%, 특이도 60.0%, IgA는 민감도 84.0%, 특이도60.0%, IgM은 민감도 40.0%, 특이도 96.7%의 결과를 보였다. PCR은 3명의 환자에서 양성이었다. 결 론 : ELISA법이 많은 환자들을 대상으로 하는 역학적 연구에서는 좀더 유용하게 이용될 수 있을 것으로 사료된다. 임상적으로 적용되기 위해서는 좀더 연구가 필요할 것으로 사료된다.

• Pediatric Infection and Vaccine
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• 제28권2호
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• pp.118-123
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• 2021

세균 감염에서 적절한 항생제를 선택하려면 배양검사가 매우 중요하다. 저자들은 복부 연조직 감염의 농양을 혈액배양병을 사용하여 시행한 배양검사에서 Actinomyces radingae와 Clostridium ramosum이 배양된 증례를 경험하여 보고하고자 한다. 이전에 건강하였던 13세 남자 환자가 배꼽주변에 발생한 통증, 발적 및 발열을 주소로 응급실에 내원하였다. 환아는 복부 수술 및 외상의 병력은 없었다. 컴퓨터 단층 촬영에서 배꼽주위에 농양을 동반한 피부 연조직염이 확인되었고 선천성 기형은 없었다. 초음파 유도 흡인을 하여 8.5 mL의 화농성 농양이 흡인되었고, 농양은 혈액배양병을 이용하여 배양하였다. 농양 배양검사에서 A. radingae와 C. ramosum이 확인되었다. 감염증의 원인이 드문 세균일 가능성이 있는 경우 농양 배양을 할 때 일반적인 농양배양의 방법 보다는 혈액배양병을 사용하는 것이 원인균이 분리될 가능성을 높이고 더 빨리 확인할 수 있을 것으로 사료된다.

• 전기전자학회논문지
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• 제17권4호
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• pp.398-406
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• 2013

핵의학 영상 기기인 양전자 방출 단층 촬영 장치(Positron emission tomography: PET)와 같은 진단기기는 방사성의약품을 인체에 주입하여 질병을 진단한다. 이 때 사용되는 방사성의약품은 안전성을 위하여 적절한 수소 이온농도를 가져야 한다. 일반적으로 방사성 의약품의 수소 이온 농도를 측정하는 과정에서 흔히 사용되는 것이 pH시험지이다. 표본을 pH 시험지에 떨어뜨려 pH 시험지의 변색 정도를 표준색상표(Standard color chart)와 비교하여 표본의 pH를 알 수 있다. 그러나 이 방법은 측정자의 경험 정도에 따라 pH 측정값에 차이가 발생할 수 있다. 또한 pH 메타기는 고감도의 센서를 사용함으로 오염에 주의해야 한다. 이러한 불편함을 고려하여 쉽고 간단하게 정확한 pH를 측정하기 위한 새로운 장치 제작과 영상 기반 알고리즘을 통한 소프트웨어를 개발하였다. 이렇게 개발한 장치는 최종적으로 방사성의약품의 생산 시 품질관리(QC) 통합 제어 시스템으로 사용된다.

• 디지털융복합연구
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• 제11권8호
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• pp.273-279
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• 2013

본 연구에서는 변조전달함수(Modulation transfer function, MTF)를 이용한 컴퓨터 방사선영상의 감도 노출 분류에 따른 공간분해능을 평가하여 컴퓨터 방사선영상 획득의 기초자료로 제시하고자 하였다. 본 실험에서는 $100{\mu}mm$ 픽셀의 영상판을 이용하여 엣지법의 MTF를 측정하였다. 방사선 선질은 IEC 61267에서 권고하고 있는 RQA5를 이용하였다. X-선이 조사된 영상판은 감도 노출 분류를 50, 100, 200, 300, 400, 600, 800, 1200으로 각각 설정한 후 디지털 영상화하였다. 최종 획득된 영상들은 공인된 영상분석 프로그램인 image J와 Origin 8.0을 이용하여 MTF 50%와 10%를 구하여 평가하였다. 그 결과 감도 노출 분류 200에서 가장 우수한 MTF 50%($1.979{\pm}0.114lp/mm$)와 MTF 10%($3.932{\pm}0.041$)의 공간주파수를 구하였다. 따라서 골절 등과 같이 높은 공간분해능을 요구하는 질병진단에 유용할 것으로 사료된다.

• Journal of Preventive Medicine and Public Health
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• 제9권1호
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• pp.109-116
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• 1976

Reorganization of myun health care service is one of the main issues in health care delivery in rural Korea. The fundamenta, concept of the role and function of the myun health subcenter is that it is the basic unit of rural health care service and is to provide comprehensive health care service through the integration of curative and preventive services. The aim of this study is to analyze the patterns of curative activities in the myun health subcenter in terms of the most prevalent types of diseases, necessary diagnostic methods and required equipment, types of treatment, necessary drugs and materials, and finally the cost of curative services. The population on which this study was done was the 1596 patients who visited the two myun health subcenters (Sunwon Myun and Naega Myun) in Kang Wha County, the area of the Yonsei University Community Health Teaching Project, during period from May 1, 1975 to June 10, 1976. For the patient's record in the clinic, problem oriented medical records were used. Decisions regarding the disease classification, the diagnostic methods used and selection of the most appropriate and adequate medical treatment were made by a group of three experienced physicians after reviewing the medical records which had been written by public physicians who were treating patients in the study area. The records were reviewed by resident staff members of the Department of Preventive Medicine, of Yonsei University College of Medicine. A brief summary of results of the study is as follow: 1. 29.9% of the patients who visited the clinics were ages between 0-4. No sex difference was observed among patients less than 20 years of age. However, among patients over 20 years old, females predominated. Thus it is evident that the majority of patients were either children or mothers and grandmothers. 2. The distance from the individual villages to the myun health subcenter was one of important factors in determining the ratio of clinic visits. However, other factors such as the activities of the health workers also affected the rates substantially. 3. The most common 25 diseases comprised 90.2% of all the diseases recorded. Acute respiratory infection (25.5%), Skin (12.7%) , diarrheal diseases (6.8%), neuralgia and back pain (4.9%) and. all other injuries (3.9%) were the five most common diseases. 4. Of all the diseases diagnosed and treated, 9.2% required simple laboratory tests for diagnosis, 6.5% required X-ray examination, and altogether 13.6% required either laboratory test or X-ray examination. 5. Treatment and management of 42.0% of the cases could be accomplished with simple, inexpensive drugs, 12.8% required the use of more expensive drugs (mostly antibiotics) and injections were required in 19.7% of the cases. Minor surgery and referral were necessary in 5% of the cases. 6. The cost for diagnosis and treatment was estimated with a standard which was set by general concensus. The average cost of diagnosis was 144 per case and the cost of treatment was 726 per case, The Total average cost per visit was 870.

• 대한두경부종양학회지
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• 제19권2호
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• pp.142-147
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• 2003

Purpose: Accurate evaluation of metastatic cervical lymph nodes plays a decisive role in the treatment and prognosis of patients with squamous cell carcinoma of the head and neck. The purpose of this study is to investigate the usefulness of FDG-PET for diagnosis of cervical metastasis in the head and neck cancer by comparing with the conventional imaging study. Materials and Methods: The subjects on this study were 30 patients (24 males and 6 females, aged 39 to 76, mean 57.1) diagnosed as pathologic-proven squamous cell carcinomas of the head and neck. All patients underwent preoperative FDG-PET, CT(n=27) or MRI (n=3). Their medical records were reviewed retrospectively. Using pathologic reports as a golden standard, the results of FDG-PET were compared with conventional imaging study (CT/MRI) in the evaluation of cervical metastasis. Results: Thirty patients had five different primary sites which were tongue (11), supraglottis (10), glottis (6), hypopharynx (2) and tonsil (1). A total of 40 neck dissections were performed unilaterally in 20 patients and bilaterally in 10 patients. Of these, 16 showed pathologically positive for lymph node metastasis. The sensitivity and specificity of FDG-PET for the diagnosis of cervical metastasis was 75% and 100% respectively, compared with conventional imaging of 56.3% and 95.8%, respectively. The difference of sensitivity was not statistically significant (p=0.453). Of 5 cases with small metastatic node (<1cm), 3 were detected on PET detected correctly but none were detected by CT. Conclusion: FDG-PET was more accurate than conventional imaging study in the diagnosis of metastatic lymph nodes in squamous cell carcinomas of the head and neck, especially detection of small metastatic node. FDG-PET might be useful adjunct to conventional image in the preoperative evaluation of head and neck squamous cell carcinoma.

• Parasites, Hosts and Diseases
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• 제48권1호
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• pp.61-65
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• 2010

The objectives of this study were to conduct a prevalence survey of trichomoniasis in pregnant women and to evaluate the utility of different methods for its diagnosis. A total of 597 vaginal exudates from pregnant women who were examined at the Hospital de Clinicas in Buenos Aires, Argentina from 1 August 2005 to 31 January 2007, were prospectively and consecutively evaluated. The investigation of Trichomonas vaginalis was made by different microscopic examinations, and culture on liquid medium. The sensitivity and specificity of the microscopic examinations were assessed considering culture on liquid medium as the "gold standard". The prevalence of T. vaginalis obtained by culture on liquid medium was 4.0% (24/597). The prevalence of T. vaginalis obtained by direct wet smear, prolonged May-Grunwald Giemsa staining, and sodium acetate-formalin (SAF)/methylene blue staining-fixing technique was 1.8%, 2.3% and 2.5%, respectively. The sensitivity of the direct wet smear was 45.8%, that of the prolonged May-Grunwald Giemsa staining was 58.3%, and that of the SAF/methylene blue method was 62.5%. Considering the 3 microscopic examinations altogether, the sensitivity rose to 66.7% and the specificity was 100% for all of them. This is the first time that the prevalence data of T. vaginalis by culture in pregnant women are published in Argentina. Due to the low sensitivity obtained by microscopy in asymptomatic pregnant women, the use of the liquid medium is recommended during pregnancy, in order to provide an early diagnosis and treatment.