• Journal of Pharmaceutical Investigation
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• 제30권4호
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• pp.267-271
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• 2000

The effect of cyclodextrins on the solubility and stability of aspalatone (acetylsalicylic acid maltol ester, AM, CAS 147249-33-0), which has been recently found to have an antithrombotic effect, was investigated. The addition of ${\beta}-cyclodextrin\;({\beta}-CD),\;dimethyl-{\beta}-cyclodextrin\;(DMCD)\;or\;2-hydroxypropyl-{\beta}-cyclodextrin\;(HPCD)$ to the aqueous solution increased the solubility of AM concentration-dependently. From the phase solubility diagram, stability constants for $AM-{\beta}-CD$, -DMCD or -HPCD complexes were calculated to be 43.1, 78.3 and $53.0\;M^{-1}$. The addition of ${\beta}-CD$, DMCD or HPCD to AM solution retarded the degradation rate of AM in the acidic region. However, ${\beta}-CD$ and HPCD rather acted as an accelerator of degradation in the neutral and alkaline regions. DMCD had a stabilizing effect at all pHs studied.

• 한국정밀공학회지
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• 제21권11호
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• pp.179-185
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• 2004

The effect of viscous damping on stability of beam resting on an elastic foundation subjected to a dry friction force is analytically studied. The beam resting on an elastic foundation subjected to dry friction force is modeled for simplicity into a beam resting on Kelvin-Voigt type foundation subjected to distributed follower load. In particular, the effects of four boundary conditions (clamped-free, clamped-pinned, pinned-pinned, clamped-clamped) on the system stability are considered. The critical value and instability type of columns on the elastic foundation subjected to a distributed follower load is investigated by means of finite element method for four boundary conditions. The elastic foundation modulus, viscous damping coefficient and boundary conditions affect greatly both the instability type and critical load. Also, the increase of damping coefficient raises the critical flutter load (stabilizing effect) but reduces the critical divergence load (destabilizing effect).

• Journal of Microbiology and Biotechnology
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• 제22권9호
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• pp.1271-1278
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• 2012

Genetic fusion of two proteins frequently induces beneficial effects to the proteins, such as increased solubility, besides the combination of two protein functions. Here, we study the effects of the bacterial surface layer protein SgsE from Geobacillus stearothermophilus NRS 2004/3a on the folding of a C-terminally fused enhanced green fluorescent protein (EGFP) moiety. Although GFPs are generally unable to adopt a functional confirmation in the bacterial periplasm of Escherichia coli cells, we observed periplasmic fluorescence from a chimera of a 150-amino-acid N-terminal truncation of SgsE and EGFP. Based on this finding, unfolding and refolding kinetics of different S-layer-EGFP chimeras, a maltose binding protein-EGFP chimera, and sole EGFP were monitored using green fluorescence as indicator for the folded protein state. Calculated apparent rate constants for unfolding and refolding indicated different folding pathways for EGFP depending on the fusion partner used, and a clearly stabilizing effect was observed for the SgsE_C fusion moiety. Thermal stability, as determined by differential scanning calorimetry, and unfolding equilibria were found to be independent of the fused partner. We conclude that the stabilizing effect SgsE_C exerts on EGFP is due to a reduction of degrees of freedom for folding of EGFP in the fused state.

• 한국지반신소재학회논문집
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• 제10권1호
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• pp.43-51
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• 2011

연약 점성토 지반에 성토를 할 경우 과도한 침하와 측방유동으로 인한 피해를 최소화하기 위해 토목섬유/성토지지말뚝공법이 주로 사용되고 있다. 본 공법은 연약지반 층을 관통하여 지지층에 관입시킴으로써 상재하중을 지지하게 하여 상재하중으로 인한 침하와 측방유동 발생을 최소화한다. 본 연구에서는 연약 점성토 지반에 설치된 토목섬유/성토지지말뚝공법의 보강효과를 정량적으로 검토함을 목적으로 하였다. 실내모형실험을 통하여 무보강 및 성토지지말뚝 보강의 경우에 대한 지반 거동을 재현하고 성토지지말뚝에 의한 측방유동 억지효과를 분석하였다. 이때 성토지지말뚝을 설치한 경우에 대해서는 상재하중의 크기를 다르게 설정하여 완속 재하와 급속 재하의 경우에 대한 측방유동의 억지효과를 분석하였다.

• 한국방재학회 논문집
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• 제11권2호
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• pp.93-101
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• 2011

국토의 70% 이상이 산지인 국내 지형 조건에서 도로, 철도 등 크고 작은 건설 공사에서는 필연적으로 사면이 형성된다. 그러나, 최근 국내외적으로 빈번히 발생하는 지진에 대한 사면안정 보강공법에 대한 연구는 전무한 실정이다. 이에 본 연구에서는 1 g 진동대 실험 및 등가정적해석을 이용하여 사면의 내진 보강공법으로써 억지말뚝의 적용성을 평가하고, 억지말뚝이 적용된 사면 및 억지말뚝의 지진시 거동을 분석하였다. 1 g 진동대 실험 결과로부터, 억지말뚝 보강 사면의 지진시 사면파괴 억지효과를 검증하였으며, 등가정적해석을 통해 억지 말뚝을 사면 하부 또는 상부보다 사면 파괴면의 중앙부에 말뚝을 설치했을 때 사면파괴 억지효과가 가장 큼을 알 수 있었다. 또한, 말뚝이 사면 중앙부에 설치되었을 경우, 말뚝의 중심 간격에 따른 안전율 변화를 등가정적해석으로부터 분석하였다.

• 한국융합학회논문지
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• 제9권7호
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• pp.117-124
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• 2018

본 연구의 목적은 고유수용성신경근촉진법의 안정적 반전기법 후에 손목테이핑 적용이 손목통증환자의 통증과 악력에 미치는 영향을 융복합적으로 알아보기 위해 실시하였다. 손목통증환자 20명을 대상으로 안정적 반전기법 후에 손목테이핑을 적용한 실험군(n=10)과 스트레칭 후에 손목테이핑을 적용한 대조군(n=10)으로 무작위 배정하였다. 전체 중재시간은 휴식시간 포함 최대 10분으로 구성, 주 5회 2주간 시행하였다. 통증정도는 시각적상사척도로 측정하였고, 악력은 악력계로 측정하였다. 중재결과, 집단 내 통증과 악력은 두 군 모두 유의한 변화가 있었고(p<0.01), 집단 간 통증과 악력은 실험군이 대조군보다 효과적인 통증의 감소와 악력의 향상을 보였다(p<0.01). 그러므로 고유수용성신경근촉진법의 안정적 반전기법과 손목테이핑 융합은 손목통증환자를 위한 효과적인 중재로 활용될 수 있으며, 다양한 손목통증환자를 위한 지속적인 융합중재개발이 요구된다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.3033-3038
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• 2007

In this research, Rayleigh instability of gas-liquid flow in annular pipe is studied in film boiling using viscous potential flow. Viscous potential flow is a kind of approximation of gas-liquid interface considering velocity field as potential including viscosity. A dispersion relation is obtained including the effect of heat and mass transfer and viscosity. New expression for dispersion relation in film boiling and critical wave number is obtained. Viscosity and heat and mass transfer have a stabilizing effect on instability and its effect appears in maximum growth rate and critical wave number. And the existence of marginal stability region is shown.

• 한국자동차공학회논문집
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• 제2권4호
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• pp.72-79
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• 1994

In an automotive spark ignition, it is important to form the proper mixture(air/fuel) on each driving condition for developing the stabilizing combustion and exhaust characteristics. Since most of supply fuel is attached on the inside wall of the intake manifold for unadequate atomization by fuel injection system, it brings a bad effect on combustion and exhaust caused by nonuniformity of fuel distribution to each cylinder and mixture variation. Also it affects engine performance variation and causes noises and vibration. In this study, we verified the effect of the mixture variation which is caused by fuel liquid film in an intake manifold on combustion characteristics and engine performance.

• Geomechanics and Engineering
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• 제32권1호
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• pp.85-96
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• 2023

Microbially induced carbonate precipitation (MICP) is extensively discussed as a promising topic for ground stabilization. The practical effect of stabilizing the expansive soil is presented in this paper with a logical process from the bacterial activity to the treatment technology. Temperature, pH, shaking frequency, and inoculation amount are discussed to evaluate the bacterial activity. The physic-mechanic properties are also evaluated to discuss the effect of the MICP process on expansive soil. Results indicate that the MICP method achieves the mitigation of expansion. The treated soil has a low proportion of fine particles (< 5 ㎛), the plasticity index significantly decreases, and strength values improve much. MICP process has a significant cementation effect on the soil matrix. Moreover, the infiltration model test presents the coating effect on the topsoil. According to the relation between the CaCO₃ content and the treatment effect, the topsoil has better treatment than the deeper soil.

• 수산경영론집
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• 제53권4호
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• pp.15-26
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• 2022

This paper analyzed the price stabilization before and after the fisheries outlook project for seaweed, flatfish, and abalone. First, the stabilization effect was analyzed through the price variation coefficient before and after the observation project. In terms of the variation coefficient, there was no effect that the price was stabilized through the seaweed outlook project. However, it can be seen that flatfish and abalone have a price-stabilizing effect. Second, as a result of analyzing the price stabilization effect through the improved ARMA-T-GARCH model, it was confirmed that seaweed was not statistically significant while flatfish and abalone had a price stabilization effect by statistically significantly reducing volatility of real prices after the introduction of the fisheries outlook project. Third, as a result of analyzing the factors affecting price stability, it was found that the price of seaweed was stabilized after the WTO, but the Japanese earthquake expanded the price volatility. In the case of flatfish, it was analyzed that the price stabilized after the WTO and the Great Japanese Earthquake. Finally, the price of abalone has stabilized since the WTO and the Great Japanese Earthquake.