• Journal of Pharmaceutical Investigation
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• v.30 no.4
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• pp.267-271
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• 2000

The effect of cyclodextrins on the solubility and stability of aspalatone (acetylsalicylic acid maltol ester, AM, CAS 147249-33-0), which has been recently found to have an antithrombotic effect, was investigated. The addition of ${\beta}-cyclodextrin\;({\beta}-CD),\;dimethyl-{\beta}-cyclodextrin\;(DMCD)\;or\;2-hydroxypropyl-{\beta}-cyclodextrin\;(HPCD)$ to the aqueous solution increased the solubility of AM concentration-dependently. From the phase solubility diagram, stability constants for $AM-{\beta}-CD$, -DMCD or -HPCD complexes were calculated to be 43.1, 78.3 and $53.0\;M^{-1}$. The addition of ${\beta}-CD$, DMCD or HPCD to AM solution retarded the degradation rate of AM in the acidic region. However, ${\beta}-CD$ and HPCD rather acted as an accelerator of degradation in the neutral and alkaline regions. DMCD had a stabilizing effect at all pHs studied.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.11
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• pp.179-185
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• 2004

The effect of viscous damping on stability of beam resting on an elastic foundation subjected to a dry friction force is analytically studied. The beam resting on an elastic foundation subjected to dry friction force is modeled for simplicity into a beam resting on Kelvin-Voigt type foundation subjected to distributed follower load. In particular, the effects of four boundary conditions (clamped-free, clamped-pinned, pinned-pinned, clamped-clamped) on the system stability are considered. The critical value and instability type of columns on the elastic foundation subjected to a distributed follower load is investigated by means of finite element method for four boundary conditions. The elastic foundation modulus, viscous damping coefficient and boundary conditions affect greatly both the instability type and critical load. Also, the increase of damping coefficient raises the critical flutter load (stabilizing effect) but reduces the critical divergence load (destabilizing effect).

• Journal of Microbiology and Biotechnology
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• v.22 no.9
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• pp.1271-1278
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• 2012

Genetic fusion of two proteins frequently induces beneficial effects to the proteins, such as increased solubility, besides the combination of two protein functions. Here, we study the effects of the bacterial surface layer protein SgsE from Geobacillus stearothermophilus NRS 2004/3a on the folding of a C-terminally fused enhanced green fluorescent protein (EGFP) moiety. Although GFPs are generally unable to adopt a functional confirmation in the bacterial periplasm of Escherichia coli cells, we observed periplasmic fluorescence from a chimera of a 150-amino-acid N-terminal truncation of SgsE and EGFP. Based on this finding, unfolding and refolding kinetics of different S-layer-EGFP chimeras, a maltose binding protein-EGFP chimera, and sole EGFP were monitored using green fluorescence as indicator for the folded protein state. Calculated apparent rate constants for unfolding and refolding indicated different folding pathways for EGFP depending on the fusion partner used, and a clearly stabilizing effect was observed for the SgsE_C fusion moiety. Thermal stability, as determined by differential scanning calorimetry, and unfolding equilibria were found to be independent of the fused partner. We conclude that the stabilizing effect SgsE_C exerts on EGFP is due to a reduction of degrees of freedom for folding of EGFP in the fused state.

• Journal of the Korean Geosynthetics Society
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• v.10 no.1
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• pp.43-51
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• 2011

Pile-supported embankment is one of the reinforcing methods to minimize damage due to the severe subsidence and lateral flow when soft clay ground is supported with embankment. pile-supported embankment mainly penetrates soft ground into the bearing stratum in order to support surcharge load which minimizes the subsidence and lateral flow due to the surcharge load. The aim of this research is to review quantitatively reinforcing effect of pile-supported embankment which is installed in soft clay ground. From the model test, it reproduced the ground movement with regard to the non-reinforced and reinforcing embankment-pile and also analyzed stabilizing effects of lateral flow due to the pile-supported embankment. With regard to the case of installing pile-supported embankment, its were analyzed stabilizing effects of lateral flow in cases of quick-load and slow-load to make different surcharge load.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.2
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• pp.93-101
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• 2011

Korea has about 70% of its land classified as the mountain area, which has led to cut-slope being the result of substantial road and railway construction. However, there is currently a lack of research about the seismic retrofit design of a slope, even though many earthquakes have recently occurred at home and abroad. In this study, in order to investigate the stabilizing effect of piles against sliding during an earthquake, a series of 1 g shaking table tests and pseudo-static analyses were carried out. As a result, the stabilizing effect of piles against sliding during an earthquake was verified by the 1 g shaking table tests and the most effective result from the pseudo-static analyses was that the installation of the piles on the central part of the slope, where the failure surface included piles unlike the lower part and upper part of the slope. Furthermore, when the pile was installed on the central part of the slope, the change of the safety factor depending on the distance between the center of two piles was evaluated.

• Journal of the Korea Convergence Society
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• v.9 no.7
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• pp.117-124
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• 2018

This study investigated the effect of wrist taping (WT) after application of stabilizing reversal technique (SRT) of proprioceptive neuromuscular facilitation (PNF) on pain and grip strength (GS) in patients with wrist pain (WP). Twenty patients with WP were randomly assigned to an experimental group (n=10) that received WT after application of SRT, and a control group (n=10) that received WT after application of stretching. The total intervention time consisted of a maximum of 10 minutes including breaks, and was performed 5 times a week for 2 weeks. Pain reduction was measured using a visual analogue scale. GS was measured using a dynamometer. Within group changes in pain and GS were significant in both experimental and control groups (p<0.01). Between group changes in pain and GS were greater in the experimental group than in the control group (p<0.01). This findings indicate that SRT of PNF and WT convergence can be an effective intervention for patients with WP. Continued development of convergence interventions for patients with WP various conditions in practice, is suggested.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3033-3038
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• 2007

In this research, Rayleigh instability of gas-liquid flow in annular pipe is studied in film boiling using viscous potential flow. Viscous potential flow is a kind of approximation of gas-liquid interface considering velocity field as potential including viscosity. A dispersion relation is obtained including the effect of heat and mass transfer and viscosity. New expression for dispersion relation in film boiling and critical wave number is obtained. Viscosity and heat and mass transfer have a stabilizing effect on instability and its effect appears in maximum growth rate and critical wave number. And the existence of marginal stability region is shown.

• Transactions of the Korean Society of Automotive Engineers
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• v.2 no.4
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• pp.72-79
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• 1994

In an automotive spark ignition, it is important to form the proper mixture(air/fuel) on each driving condition for developing the stabilizing combustion and exhaust characteristics. Since most of supply fuel is attached on the inside wall of the intake manifold for unadequate atomization by fuel injection system, it brings a bad effect on combustion and exhaust caused by nonuniformity of fuel distribution to each cylinder and mixture variation. Also it affects engine performance variation and causes noises and vibration. In this study, we verified the effect of the mixture variation which is caused by fuel liquid film in an intake manifold on combustion characteristics and engine performance.

• Geomechanics and Engineering
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• v.32 no.1
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• pp.85-96
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• 2023

Microbially induced carbonate precipitation (MICP) is extensively discussed as a promising topic for ground stabilization. The practical effect of stabilizing the expansive soil is presented in this paper with a logical process from the bacterial activity to the treatment technology. Temperature, pH, shaking frequency, and inoculation amount are discussed to evaluate the bacterial activity. The physic-mechanic properties are also evaluated to discuss the effect of the MICP process on expansive soil. Results indicate that the MICP method achieves the mitigation of expansion. The treated soil has a low proportion of fine particles (< 5 ㎛), the plasticity index significantly decreases, and strength values improve much. MICP process has a significant cementation effect on the soil matrix. Moreover, the infiltration model test presents the coating effect on the topsoil. According to the relation between the CaCO₃ content and the treatment effect, the topsoil has better treatment than the deeper soil.

• The Journal of Fisheries Business Administration
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• v.53 no.4
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• pp.15-26
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• 2022

This paper analyzed the price stabilization before and after the fisheries outlook project for seaweed, flatfish, and abalone. First, the stabilization effect was analyzed through the price variation coefficient before and after the observation project. In terms of the variation coefficient, there was no effect that the price was stabilized through the seaweed outlook project. However, it can be seen that flatfish and abalone have a price-stabilizing effect. Second, as a result of analyzing the price stabilization effect through the improved ARMA-T-GARCH model, it was confirmed that seaweed was not statistically significant while flatfish and abalone had a price stabilization effect by statistically significantly reducing volatility of real prices after the introduction of the fisheries outlook project. Third, as a result of analyzing the factors affecting price stability, it was found that the price of seaweed was stabilized after the WTO, but the Japanese earthquake expanded the price volatility. In the case of flatfish, it was analyzed that the price stabilized after the WTO and the Great Japanese Earthquake. Finally, the price of abalone has stabilized since the WTO and the Great Japanese Earthquake.