• Journal of Chest Surgery
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• 제29권9호
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• pp.1031-1035
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• 1996

폐의 편평상피암종에서 기관지표면상피의 화생에 대해서는 많은 이들에 의해서 밝혀진 바 있지만 그 외의 다른 종류의 폐암과 연관된 기관지 표면상피의 변화에 대해서는 그 예가 많지 않고 소세포폐암종에 대해서는 더욱 그러하다. 한편 소세포암종의 조직학적 분류와그아형에 대해서 지난수십년 간많은 관심이 모아져 왔다. 이 종량의 아형을분류하는기본적인 근거는 그 형태학적 판정 기준에 있다. 1967년 WHO폐암종 분류법이 제긍된 이후 3여러 기관에서 SCLC의 임상경과나 치료에 대한 반응, 그 아형을 연구하였다. 1988년 IASLC에서는 소세포암종을 그 형태학적 구분으로 세가지 아형 : Small cell carcinoma (2) Mixed small cel1/1arge ceil carcinoma (3) Combined small cell carcinoma로 분류하고 예후와 치료에 대한 반응의 차이에 대해서 언급하였다. 최근 저자들은 68세 남자환자에서 소세포암종에서 국소적으로 편평양분화를 보이는 세포가 함께 혼합되어 있는 주종괴와 분리되 어서 존재하는 기관지 상피세포에 편평상피암종이 동반된 예를 전폐 절제 술을 하고 조직 검사상 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한세포병리학회지
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• 제2권2호
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• pp.127-133
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• 1991

Mixed squamous cell carcinoma and papillary carcinoma in the thyroid gland is a very rare malignant tumor characterized by rapidly progressive clinical course and radioresistance. A 63-year-old woman had mixed squamous cell carcinoma and papillary carcinoma in the thyroid gland diagnosed by fine needle aspiration cytology (FNA), and the diagnosis was confirmed by histological examination. She had complained of a fixed, egg-sized mass of the anterior neck with hoarseness for 1 year. The findings of FNA consisted of sheets and clusters of polygonal epithelial cells with hyperchromatic, pleomorphic nuclei and eosinophilic, abundant, laminated cytoplasm. These findings were consistent with squamous cell carcinoma. Also, fool of papillary carcinoma were noted, and the cells exhibited nuclear groovings and intranuclear cytoplasmic inclusions. Total thyroidectomy specimen showed a diffusely infiltrating tumor in the left thyroid which was composed of mixed papillary carcinoma and well-differentiated squamous cell carcinoma. In junction between two components, squamous metaplasia of papillary carcinoma was noted.

• 대한두경부종양학회지
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• 제26권2호
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• pp.240-242
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• 2010

Primary squamous cell carcinoma of the thyroid gland is a very rare event, representing much less than 1% of all malignant tumors of the thyroid gland. The cancer is characterized by rapidly progressive clinical course in spite of its differentiated morphologic features. In most cases, a squamous epithelium is believed to be a result of metaplasia of a follicular epithelium, although in rare exceptions, it can originate from a remnant of the thyroglossal duct or ultimobranchial body. Squamous cell carcinoma of the thyroid gland can occur in a pure form or mixed with adenocarcinoma. Because their clinical behavior is more aggressive than that of other malignant neoplasm of thyroid gland, the tumor should be treated more vigorously at its initial stage. Recently, authors experienced one case of primary squamous cell carcinoma of the thyroid gland. We report our case with a brief review of literature.

• Journal of Yeungnam Medical Science
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• 제5권2호
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• pp.189-193
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• 1988

저자들은 최근 영남대학교 의과대학 부속병원에서 경험한 위에 발생한 원발성 선편평세포암종 3예를 경험하고 문헌고찰과 함께 보고하는 바이다.

• Preventive Nutrition and Food Science
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• 제1권2호
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• pp.168-173
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• 1996

The effect of methanol soluble fraction(MSF) of kimchi on the proliferating and differentiating activity of normal rat mammary epithelial cells or organoids in culture were studied. Reconstituted basement membrane, Matrigel, supported the growth and development several different multicellular structures from mammary organoids. The five type colonies of multicellular structures, stellate, ductal, webbed, squamous, and lobulo-ductal colonies, were observed in Matrigel culture. In methanol extract groups, webbed colonies were more and squamous colonies were less than control group. and the lobulo-ductal colonies which is known that it formed in well differentiated mammary epoithelial cells were developed more in MSF treated group than control group. These results showed that methanol extract of kimchi affected on the proliferation and differentiation of normal rat mammary epithelial cells cultured in serum free medium condition.

• IMMUNE NETWORK
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• 제7권2호
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• pp.87-94
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• 2007

Background: Chronic rhino-sinusitis and persistent allergic rhinitis is often cited as risk factor for developing adenoid hypertrophy or adenoiditis, but this relationship has not been studied extensively. In this study, we evaluated the mucosal barrier, squamous changes of ciliated epithelium, IgA secretion and BCL-6 expression in adenoids, and adenoid size. Methods: Six children with allergic rhinitis and sinusitis, nine children with only allergic rhinitis, nine children with only sinusitis and six children without any history of allergic rhinitis and sinusitis were enrolled. H-E stain of adenoid for squamous metaplasia, immunohistochemical study of adenoid for IgA and BCL-6, cytokeratin stain for evaluation of mucosal barrier and lateral view X-ray for adenoid size were performed. ANOVA test was used in the analysis and data showing p value of less than 0.05 were considered significant. Results: The number of ciliated cells had tendency to be decreased and squamous metaplasia had tendency to be increased in three experimental groups (p>0.05). Deterioration of mucosal barrier had tendency to be detected in three experimental groups than control group (p>0.05). BCL-6 had tendency to be increased and IgA secretion had tendency to be decreased in three experimental groups (p>0.05). There is no difference in adenoid size between three experimental groups and control group. Conclusion: Despite the expectation that adenoid would be affectecd by allergic rhinitis and rhino-sinusitis, we found no evidence for influence of adenoid immunity.

• 대한두경부종양학회지
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• 제6권2호
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• pp.91-96
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• 1990

Squamous cell carcinoma of the thyroid gland is an extremely rare primary neoplasm, comprising only 1.1% of all primary thyroid cancers. The cancer is characterized by rapidly progressive clinical course in spite of its differentiated morphologic feature. Histogenetic origin of the cancer has also been debated. In most cases, a squamous epithelium is believed to be a result of metaplasia of a follicullar epithelium, although in rare exceptions, it can originate from a remnant of the thyroglossal duct or ultimobrachial body. Squamous cell carcinoma of the thyroid can occur in a pure form or mixed with adenocarcinoma; the latter may be designated as adenoacanthoma. Because this lesion typically runs a fulminant course, radical surgical resection at the earliest opportunity offers the best hope for cure. The lesions are usually radioresistant, and chemotherapy has not been shown to alter the course of this disease. We experienced a case of squamous carcinoma of the thyroid. This report summarize our experience and review of the literatures.

• Investigative Magnetic Resonance Imaging
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• 제15권2호
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• pp.160-164
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• 2011

췌장의 편평세포암종은 도관의 원주세포의 편평상피화생으로 특징되는 드문 종양이다. 저자들은 만성췌장염 환자에서 생긴 편평세포암종의 영상소견들을 보고하고자 한다.

• Journal of Chest Surgery
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• 제27권11호
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• pp.957-960
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• 1994

The endobronchial hamartoma is a relatively rare benign tumor of the lung. The symptoms of the endobronchial hamartoma are produced by obstruction of the bronchus and its sequelae. This patient was 51 year old male and complained dypnea, cough and purulent sputum for 2 years. On bronchoscopic view, a yellowish pedunculated mass nearly total occluding right main bronchial lumen was found. Endoscopic biopsy revealed squamous cell metaplasia of the bronchial mucosa. The operation was done with the right pneumonectomy. The pathologic result of the operative specimen was endobronchial hamartoma arisen from the right upper lobe bronchus.

• 대한수의학회지
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• 제13권1호
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• pp.63-66
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• 1973

A 16-year-old female Bengal tiger (Panthera tigris tigris) infected with Paragonimus kellicotti was described. Noticeable clinical symptom was not observed before death. At autopsy, numerous cysts were found on the pleural surface of the lung. The cysts were spherical, approximately 1.0 cm in diameter, bulge the pleura, and dark red-brown in color. Such cysts were also found in the deeper lung parenchyma, and usually contained adult flukes in pairs. Histopathologically, the cyst was lined with stratified squamous epithelium which arose from metaplasia of bronchial epithelium. Partial hyperplasia and necrotic foci accompanied with inflammatory cells were often observed in the squamous epithelium. The outer part of the cyst was consisted of fibrous connective tissue in which leukocytes were infiltrated. Catarrhal pneumonia was manifested in the adjacent lung tissues.