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The Korean Association of Immunobiologists (대한면역학회)
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Local Immunity of Pediatric Adenoid with Allergic Rhinitis & Sinusitis

알레르기 비염 및 부비동염에 의한 아데노이드의 국소 면역에 대한 고찰

  • Yeo, Seung-Geun (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University) ;
  • Park, Dong-Choon (Department of Obstetric and Gynecology, College of Medicine, The Catholic University of Korea) ;
  • Hong, Chang-Kee (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University) ;
  • Sim, Ju-Sup (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University) ;
  • Cha, Chang-Il (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University)
  • 여승근 (경희대학교 의과대학 이비인후과학교실) ;
  • 박동춘 (가톨릭대학교 의과대학 산부인과학교실) ;
  • 홍창기 (경희대학교 의과대학 이비인후과학교실) ;
  • 심주섭 (경희대학교 의과대학 이비인후과학교실) ;
  • 차창일 (경희대학교 의과대학 이비인후과학교실)
  • Published : 2007.06.30
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Abstract

Background: Chronic rhino-sinusitis and persistent allergic rhinitis is often cited as risk factor for developing adenoid hypertrophy or adenoiditis, but this relationship has not been studied extensively. In this study, we evaluated the mucosal barrier, squamous changes of ciliated epithelium, IgA secretion and BCL-6 expression in adenoids, and adenoid size. Methods: Six children with allergic rhinitis and sinusitis, nine children with only allergic rhinitis, nine children with only sinusitis and six children without any history of allergic rhinitis and sinusitis were enrolled. H-E stain of adenoid for squamous metaplasia, immunohistochemical study of adenoid for IgA and BCL-6, cytokeratin stain for evaluation of mucosal barrier and lateral view X-ray for adenoid size were performed. ANOVA test was used in the analysis and data showing p value of less than 0.05 were considered significant. Results: The number of ciliated cells had tendency to be decreased and squamous metaplasia had tendency to be increased in three experimental groups (p>0.05). Deterioration of mucosal barrier had tendency to be detected in three experimental groups than control group (p>0.05). BCL-6 had tendency to be increased and IgA secretion had tendency to be decreased in three experimental groups (p>0.05). There is no difference in adenoid size between three experimental groups and control group. Conclusion: Despite the expectation that adenoid would be affectecd by allergic rhinitis and rhino-sinusitis, we found no evidence for influence of adenoid immunity.

Keywords

References

  1. Chu KC, Chang BC: Diagnosis and treatment of pediatric adenotonsillar disease. J Clinical Otolaryngol 10;134-146, 1999
  2. Sung MW, Chung WH, Oh SH: Antigen presenting cells in the palatine tonsils and adenoids. Korean J Otolaryngol 40;34-41, 1997
  3. Perry M, Whyte A: Immunology of the tonsils. Immunol Today 19;414-421, 1998 https://doi.org/10.1016/S0167-5699(98)01307-3
  4. Brodscy L, Koch RJ: Anatomic correlates of normal and diseased adenoids in children. Laryngoscope 102;1268-1274, 1992 https://doi.org/10.1288/00005537-199211000-00013
  5. Ophir D, Gilboa S, Halperin D, Marshak G: Obstructing adenoids in adolescents: changing trends? J Otolaryngol 22;91-93, 1993
  6. Fujioka M, Young LW, Girdany BR: Radiographic evaluation of adenoidal size in children: adenoidal-nasopharyngeal ratio. AJR 133;401-404, 1979 https://doi.org/10.2214/ajr.133.3.401
  7. Lee D, Rosenfeld RM: Adenoid bacteriology and sinonasal symptoms in children. Otolaryngol Head Neck Surg 116;301-307, 1997 https://doi.org/10.1016/S0194-5998(97)70264-X
  8. Lusk RP, Lazar RH, Muntz HR: The diagnosis and treatment of recurrent and chronic sinusitis in children. Pediatr Clin North Am 36;1411-1421, 1989 https://doi.org/10.1016/S0031-3955(16)36810-9
  9. Don DM, Yellon RF, Casselbrant ML, Bluestone CD: Efficacy of a stepwise protocol that includes intravenous antibiotic therapy for the management of chronic sinusitis in children and adolescents. Arch Otolaryngol Head Neck Surg 127;1093-1098, 2001 https://doi.org/10.1001/archotol.127.9.1093
  10. Casselbrant ML: What is wrong in chronic adenoiditis/tonsillitis anatomical considerations. Int J Pediatr Otolaryngol 49;133-135, 1999 https://doi.org/10.1016/S0165-5876(99)00147-0
  11. Tuncer U, Aydogan B, Soylu L, Simsek M: Chronic rhinosinusitis and adenoid hypertrophy in children. Am J Otolaryngol 25;5-10, 2004 https://doi.org/10.1016/j.amjoto.2003.10.003
  12. Lagging E, Papatziamos G, Hallden G, Hemlin C, Harfast B, Hage-Hamsten M: T-cell subsets in adenoids and peripheral blood related to age, otitis media with effusion and allergy. APMIS 106;354-360, 1998 https://doi.org/10.1111/j.1699-0463.1998.tb01357.x
  13. Bernstein JM, Ballow M, Xiang S, O'Neil K: Th1/Th2 cytokine profiles in the nasopharyngeal lymphoid tissues of children with recurrent otitis media. Ann Otol Rhinol Laryngol 107;22-27, 1998 https://doi.org/10.1177/000348949810700105
  14. Lindberg K, Rynnel-Dagoo B, Sundqvist KG: Cytokines in nasopharyngeal secretions; evidence for defective IL-1 beta production in children with recurrent episodes of acute otitis media. Clin Exp Immunol 97;396-402, 1994 https://doi.org/10.1111/j.1365-2249.1994.tb06101.x
  15. Kamel RH, Ishak EA: Enlarged ad2noid and adenoidectomy in adults: endoscopic approach and histopathological study. J Laryngol Otol 104;965-967, 1990 https://doi.org/10.1017/S0022215100114495
  16. Park SK, Choi ES, Choi JB, Kang MS: The clinical and pathological study of the adenoid vegetation above the age of 20. Korean J Otolaryngol 47;437-443, 2004
  17. Fujihara K, Fujihara T, Yamanaka N: Secretory IgA and squamous epithelization in adenoids of children with otitis media with effusion. Acta Otolaryngol 523;155-157, 1996
  18. Forsgren J, Rynne B, Dagoo B, Christensson B: In situ analysis of the immune microenvironment of the adenoid in children with and without secretory otitis media. Ann Otol Rhinol Laryngol 104;189-196, 1995 https://doi.org/10.1177/000348949510400303
  19. Bernstein JM, Rich GA, Odziemiec C: Are thymus-derived lymphocytes (T cells) defective in the nasopharyngeal and palatine tonsils of children? Otolaryngol Head Neck Surg 109;693-700, 1993 https://doi.org/10.1177/019459989310900410
  20. Roh JL, Seong WJ, Sung MW, Lee DW: Frequency and distribution of lymphocytes related to innate immunity in palatine tonsil and adenoid. Korean J Otolaryngol 44;1073-1079, 2001
  21. Holder MJ, Abbot SD, Milner AE, Gregory CD, Casamayor M, Johnson GD, MacLennan IC, Gordon J: IL-2 expands and maintains IgM plasmablasts from a CD5+ subset contained within the germinal centre cell-enriched (surface IgG-/CD39-buoyant) fraction of human tonsil. Int Immunol 5;1059-1066, 1993 https://doi.org/10.1093/intimm/5.9.1059
  22. Baron BW, Nucifora G, McCabe N: Identification of the gene associated with the recurring chromosomal translocations in B-cell lymphomas. Proc Natl Acad Sci 90;5262-5266, 1993