• Bulletin of the Korean Chemical Society
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• v.34 no.9
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• pp.2680-2684
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• 2013

Protein kinases (PKs) are an important source of drug targets, especially in oncology. With 500 or more kinases in the human genome and only few kinase inhibitors approved, kinase inhibitor discovery is becoming more and more valuable. Because the discovery of kinase inhibitors with an increased selectivity is an important therapeutic concept, many researchers have been trying to address this issue with various methodologies. Although many attempts to predict the activity and selectivity of kinase inhibitors have been made, the issue of selectivity has not yet been resolved. Here, we studied kinase selectivity by generating predictive models and analyzing their descriptors by using kinase-profiling data. The 5-fold cross-validation accuracies for the 51 models were between 72.4% and 93.7% and the ROC values for all the 51 models were over 0.7. The phylogenetic tree based on the descriptor distance is quite different from that generated on the basis of sequence alignment.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.6
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• pp.570-578
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• 2009

Excitation and propagation of guided waves are very complex problems in pipes due to their dispersive nature. Pipes are commonly used in the oil, chemical or nuclear industry and hence must be inspected regularly to ensure continued safe operation. The normal mode expansion(NME) method is given for the amplitude with which any propagating waveguide mode is generated in the pipes by applied surface tractions. Numerical results are calculated based on the NME method using different sources, i.e., non-axisymmetric partial loading and quasi-axisymmetric loading sources. The sum of amplitude coefficients for 0~nineth order of the harmonic modes are calculated based on the NME method and the dispersion curves in pipes. The superimposed total field which is namely the angular profile, varies with propagating distance and circumferential angle. This angular profile of guided waves provides information for setting the transducer position to find defects in pipes.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.22 no.12
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• pp.1005-1008
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• 2009

In this study, adaptively coupled plasma (ACP) source was used for dry etching of $Al_2O_3$ thin film. During the etching process, the wafer surface temperature is an important parameter to influent the etching characteristics. Therefore, the experiments were carried out in ACP to measuring the etch rate, the selectivities of $Al_2O_3$ thin film to mask materials and the etch profile as functions of $Cl_2$/Ar gas ratio and substrate temperature. The highest etch rate of $Al_2O_3$ was 65.4 nm/min at 75% of $Cl_2/(Cl_2+Ar)$ gas mixing ratio. The etched profile was characterized using field effect scanning electron microscopy (FE-SEM). The chemical states of $Al_2O_3$ thin film surfaces were investigated with x-ray photoelectron spectroscopy (XPS).

• Atmosphere
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• v.20 no.4
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• pp.505-518
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• 2010

We investigated the impacts of the diabatic heating location, vertical profile and basic state on the Rossby wave propagation. To examine the dynamical process of individual responses on the regional heat source, a dry version of the linear baroclinic model was used with climatological summertime (JJA) mean basic state and vertical structure of the diabatic heating for 1979-2008. Two sets of diabatic heating were constructed of those positioned in the mid-latitudes (Tibetan Plateau, eastern Mediterranean Sea, and the west-central Asia) and the tropics (the southern India, Bay of Bengal, and western Pacific). It was found that using the principal component analysis, atmospheric response to diabatic heating reaches to the steady state in 19th days in time. The prescribed mid-latitude forcing forms equivalent barotropic Rossby wave propagation along the westerly Asia jets, whereas the tropical forcing generates the Rossby wave train extending from the tropics to mid-latitudes. In relation to the maximum vertical profile, the mid-level forcing reveals a stronger response than the lower-level forcing, which may be caused by more effective Rossby wave response by the upper-level divergent flow. Under the different sub-seasonal mean state, both of the tropical and mid-latitude forcing induce the different sub-seasonal response intensity, due to the different basic-state wind.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.3
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• pp.207-216
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• 2016

A gerotor is suitable for miniature manufacturing because it has high discharge per 1 cycle and a simple structure, while also being widely used for lubrication oil of engines and as a hydraulic source of automatic transmission. In the automobile industry, improvements in fuel efficiency and noise reduction have recently come to the fore. It has also been necessary to continuously improve the flow rate and noise of internal gear pumps for better fuel efficiency through optimal gerotor and port shape design. In this study, to develop an optimal gerotor with a new lobe shape, 2-ellipses-combined, the equation of the lobe shape was derived, and CFD analysis results were compared for 2-ellipses with those of the previous gerotors (3-ellipses and ellipse1-involuteellipse2). A performance test for the oil pump with the optimal rotor (2-ellipses) was carried out and showed good agreement with the results obtained from CFD analysis.

• Microbiology and Biotechnology Letters
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• v.47 no.4
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• pp.555-564
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• 2019

Biodiesel is produced through the transesterification process in the presence of alcohol and a catalyst that catalyzes the conversion of triglycerides to esters and glycerol compounds. A more optimal product conversion can be achieved using enzymes, such as lipase. Lipase is reported to be produced in osmophilic yeasts due to the low water content in their natural habitats. Wild forest honey is one of the osmophilic natural habitats in Indonesia. However, lipase-producing yeast has not been reported in the Indonesian honey. In this study, we screened the lipase-producing yeasts isolated from wild forest honey collected from Central Sulawesi. The production profile and activity of lipase were determined at different pH values and temperatures. One promising yeast was isolated from the honey, which was identified as Zygosaccharomyces mellis SG 1.2 based on ITS sequence. The maximum lipase production (24.56 ± 1.30 U/mg biomass) was achieved by culturing the strain in a medium containing 2% olive oil as a carbon source at pH 7 and 30℃ for 40 h. The optimum pH and temperature for lipase activity were 6 and 55℃, respectively. The enzyme maintained 80% of its activity upon incubation at 25℃ for 4 h. However, the enzyme activity decreased by more than 50% upon incubation at 35 and 40℃ for 2 h. This is the first study to report the lipase producing capability of Z. mellis. Further studies are needed to optimize the enzyme production.

• Journal of KIISE:Software and Applications
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• v.35 no.12
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• pp.705-715
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• 2008

Today raises its head on the issue of interoperability caused by the complexity of the embedded software and the diverse development environment about SUGV(Small Unmanned Ground Vehicle). So, we propose to adopt the original MDA mechanism for this heterogeneous embedded development. To solve this problem, we apply for developing SUGV with MDA(Model Driven Architecture) using the original UML profile mechanism. Through this method, it can be semi-automatically transformed into TSM(Target specific model) after modeling TIM(Target Independent Model). Then we can also automatically generate the heterogeneous source codes. Therefore it will be reduced the development cycle and effort of the heterogeneous systems. We verify the benefits of our proposed approach and the reliability through analyzing the generated codes.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.03a
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• pp.142-152
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• 2008

SPT-Uphole method was introduced for the evaluation of near subsurface shear wave velocity (Vs) profile. In SPT-Uphole method, SPT (Standard Penetration Test) which is common in geotechnical site investigation was used as a source and several surface geophones in line were used as receivers. 1D shearwave velocity profile can be obtained in the manner of downhole method, Vs distribution map which is the triangular shape around the boring point can be developed by tomography inversion. To obtain the exact travel time information of shear wave component, a procedure using the magnitude summation of vertical and horizontal components was used based on the evaluation of particle motion at the surface. It was verified that proposed method could give reliable Vs distribution map through the numerical study using the FEM (Finite Element Method) model. Finally, SPT-Uphole method was performed and the feasibility of proposed method was verified in the field.

• International Journal of Precision Engineering and Manufacturing
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• v.9 no.3
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• pp.3-6
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• 2008

Electrolytic in-process dressing (ELID) grinding is a new technique for achieving a nanoscale surface finish on hard and brittle materials such as optical glass and ceramics. This process applies an electrochemical dressing on the metal-bonded diamond wheels to ensure constant protrusion of sharp cutting grits throughout the grinding cycle. In conventional ELID grinding, a constant source of pulsed DC power is supplied to the ELID cell, but a feedback mechanism is necessary to control the dressing power and obtain better performance. In this study, we propose a new closed-loop wheel dressing technique for grinding wheel truing that addresses the efficient correction of eccentric wheel rotation and the nonuniformity in the grinding wheel profile. The technique relies on an iterative control algorithm for the ELID power supply. An inductive sensor is used to measure the wheel profile based on the gap between the sensor head and wheel edge, and this is used as the feedback signal to control the pulse width of the power supply. We discuss the detailed mathematical design of the control algorithm and provide simulation results that were confirmed experimentally.

• Proceedings of the KSR Conference
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• 2005.05a
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• pp.673-679
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• 2005

Urban conditions such as underground facilities and ambient noises due to cultural activity restrict the application of conventional geophysical techniques in general. We used the linear array microtremor technique which uses these noises as strong energy source. The result parameter of the survey is shear wave velocity profile which had been applied as an fundamental information for the determination of the rock support type in tunnel design. This study was the first case in Korea which utilized a surface geophysical technique yielding successful result in urban area especially under the existing rail ways. The quantitative relation between the shear wave velocity from this method and the rock mass rating(RMR) determined from the inspection of the cores recovered from the same boreholes showed high statistical relationship. These correlations were then used to relate the shear-wave velocity to RMR along the entire profile.