• Natural Product Sciences
• /
• 제17권3호
• /
• pp.234-238
• /
• 2011

We investigated the effects of fucoidan and lutein against dextran sulfate sodium (DSS)-induced mice colitis. Evaluations were made of the body weight, histological index such as crypt injury and inflammation score, biochemical factor such as serum amyloid (SAA) and MPO level data. The combination of fucoidan and lutein reduced the score of crypt injury and inflammation and markedly showed more decrease of the SAA and MPO levels than 5-ASA group. In addition, each sample of fucoidan and lutein was reduced the level of IL-6 which is stimulated by a lipopolysaccharide (LPS) in HT-29 cell line in vitro. Therefore, fucoidan and lutein may be useful as a dietary substance for preventing inflammatory bowel disease in humans.

• Journal of Plant Biotechnology
• /
• 제7권4호
• /
• pp.219-223
• /
• 2005

We investigated chemical-wounding effect on Agrobacterium-mediated Chinese cabbage transformation via vacuum infiltration. Pre-germinated or germinating Chinese cabbage seeds were infiltrated with Agrobacterium tumefaciens LBA4404 cells carrying either GUS gene (pBI121) or hepatitis B virus surface antigen DNA (pBIHBsAg). Prior to agroinfiltration process, the seeds were soaked in sodium hydrosulfite (SHS) solution or just in sterile water as a control. Comparative transformation efficiency was determined by both of histochemistry and ELISA. We could demonstrate that SHS solution treatment especially to 1-day or 2-days old germinating seeds efficiently improved transformation process, and therefore, transient expression level. This strongly indicated that Agrobacterium infection could be facilitated indeed by SHS-causing wounds on Chinese cabbage seeds.

• 한국미생물·생명공학회지
• /
• 제23권4호
• /
• pp.378-383
• /
• 1995

Antifungal activity of caproic acid against Botrytis cinerea was investigated in this research. In vitro 200 ppm of caproic acid was inhibited on the germination and the mycelium growth of B. cinerea. 250 ppm of caproic acid showed the fungicidal activity against sensitive B. cinerea. To compared the inhibitory effect of treatments against B. cinerea, the field essay was carried out in the grape vineyard. The rot (%) of control, 3000 ppm of caproic acid, 3000 ppm of sodium caproate, and sumisclex were 30.7%, 10.2%, 22.8%, and 3.1%, respectively. The anti-Botrytis efficiency (%) was also evaluated as follows; 3000 ppm of caproic acid 66.8%, 3000 ppm of sodium caproate 25.7%, and sumisclex 89.9%. The efficiency between sumisclex and 3000 ppm of caproic acid was no significant difference at the 1% level by Tukey test. These results suggest that 3000 ppm of caproic acid may be greater than that of sodium caproate.

• 대한가정학회지
• /
• 제23권1호
• /
• pp.25-31
• /
• 1985

This study designed not only to elucidate free amino acid, fatty acid composition and mineral content in dried alaska pollack but also to examine calcium, magnesium, poassium and sodium contents in its cooking broth according to each boiling time such as 2.5, 5, 10, 20, and 30 minutes. RESULTS : 1. Glutamic acid in dried alaska pollack was the most abundant free amino acid and was followed in order of aspartic acid, lysin, leucine and histidine. They composed of 50.95% of the total amino acid contents. 2. In dried alaska pollack the most abundant fatty acid was palmitic acid. Essential fatty acid content was 26.57% of the total fatty acid. 3. The calcium, magnesium, potassium and sodium contents in dried alaska pollack showed 10.721 mg%, 9.235mg%, 4072.5mg% and 2299.8% respectively. The amount of magnesium and potassium in cooking broth arrived at the highest level when 20 minute boiling was undertaken and the quantities of magnesium and sodium were the highest when 30 minute boiling was made.

• Asian-Australasian Journal of Animal Sciences
• /
• 제1권2호
• /
• pp.65-71
• /
• 1988

This study reports light and electron microscope examination of rumen fungal colonization of alkali-treated roughage feeds incubated in decron bags in the rumen of cannulated sheep for varying time intervals. Six roughages, pre-treated with ammonium hydroxide or sodium hydroxide at 4% (w/w) level were examined together with untreated control samples. Alkali pre-treatment was associated with an earlier and more pronounced fungal colonization than all control roughages. Sodium hydroxide pre-treatment was significantly more effective than ammonium hydroxide in improving the susceptibility of roughages to rumen fungal colonization and studies by SEM showed that the pre-treatment permitted greater penetration of feeds by fungi. Sodium hydroxide pre-treatment also significantly increased dry matter disappearance from feed held in Dacron bags in the rumen with all feeds except Lucerne stem. It is not known to what extent fungal activity contributed to increased breakdown of the feeds.

• Macromolecular Research
• /
• 제17권2호
• /
• pp.79-83
• /
• 2009

The oral delivery of heparin is the preferred therapy in the treatment of patients with a high risk of deep vein thrombosis and pulmonary embolism. New conjugates of heparin and sodium deoxycholate were synthesized in order to enhance the heparin absorption in the GI tract. After oral administration of DOC-heparin, the concentration in anti-FXa assay was increased with increasing amount of coupled DOC. The maximum concentration of DOC-heparin VIII conjugate was $3.3{\pm}0.5\;IU/mL$ at an oral dose of 10 mg/kg, which was 3-fold higher than the baseline level. Finally, DOC coupled to heparin greatly enhanced the absorption of heparin in the GI tract, and this enhancing effect was not induced by changing the tissue structure of the GI wall.

• 대한지역사회영양학회지
• /
• 제17권3호
• /
• pp.341-352
• /
• 2012

It is well established that excessive sodium intake is related to a higher incidence of chronic diseases such as hypertension, stroke, coronary heart disease, cardiovascular disease and gastric cancer. Although the upper limit of the current sodium intake guideline by WHO is set at 2,000 mg/day for adults, sodium intake of Koreans is well over 4,700 mg/capita/day implying an urgent need to develop and implement sodium intake reduction policy at the national level. This study investigated the cost-effectiveness of the sodium intake reduction policy, for the first time, in Korea. Analyses were performed using most recent and representative data on national health insurance statistics, healthcare utilization, employment information, disease morbidity/mortality, etc. The socioeconomic benefits of the policy, resulting from reduced morbidity of those relevant diseases, included lower medical expenditures, transportation costs, caregiver cost for inpatients and income losses. The socioeconomic benefits from diminished mortality included reductions in earning losses and welfare losses caused by early deaths. It is estimated that the amount of total benefits of reducing sodium intake from 4.7 g to 3.0 g is 12.6 trillion Korean Won; and the size of its cost is 149 billion Won. Assuming that the effect of sodium intake reduction would become gradually evident over a 5-year period, the implied rate of average return to the sodium reduction policy is 7,790% for the following 25 years, suggesting a very high cost-effectiveness. Accordingly, development and implementation of a mid-to-long term plan for a consistent sodium intake reduction policy is extremely beneficial and well warranted.

• 한국산학기술학회논문지
• /
• 제15권5호
• /
• pp.2923-2929
• /
• 2014

본 연구는 국내 중년 직장인을 대상으로 나트륨 과다섭취 특성과 영향요인을 파악하여 심뇌혈관질환을 예방하고 관리하는데 도움을 주고자 실시하였다. 연구 대상은 2010년 국민건강영양조사 자료 중 40~59세의 직장인 인구 1,438명으로 하였다. 연구방법은 대상자를 나트륨 4,000mg이상 섭취군과 나트륨 4,000mg미만 섭취군으로 나누고, 일반적 특성, 나트륨 관련 질환, 건강행태 및 외식빈도를 조사하였다. 연구결과 여성보다 남성이, 교육수준이 높을수록, 흡연자와 음주자에서 나트륨 4000mg이상 섭취군이 높게 나타났다. 또한 외식빈도가 높을수록 나트륨 4000mg이상 섭취군이 높게 나타났다. 따라서 심뇌혈관질환 예방과 관리를 위해 중년 남성 직장인을 대상으로 한 나트륨 감소 교육 및 정책이 필요하며, 외식환경을 변화시켜 나트륨 섭취 감소를 유도해야 한다.

• 대한가정학회:학술대회논문집
• /
• 대한가정학회 1997년도 Program & Abstracts * The 7th Korea-Japan Home Economics Joint Syposium
• /
• pp.133-133
• /
• 1997

• 한국응용과학기술학회지
• /
• 제35권3호
• /
• pp.826-835
• /
• 2018

NaF를 용량별로 Sprague Dawley계 수컷 흰쥐에 경구 투여했을 때, 체중 및 장기 중량, 혈청 지질성분, 혈당 및 단백질 함량과 기본식이를 급여한 대조군인 BD군을 비롯하여 기본식이에 농도별 NaF를 경구 투여한 군들로 나누어 5주간 실험 사육한 결과, 흰쥐의 체중 증가량은 NF25군, NF30군 및 NF50군에서 대조군보다 유의적인 차이를 보이며 높게 나타났다(p<0.05). 각 장기무게에서의 변화 중 간장과 심장에서는 대조군에 비해 NaF 경구 투여 군에서 낮게 나타나는 경향이 관찰 되었으며(p<0.05), 폐, 뇌, 신장, 비장 및 고환에서의 각 군의 장기무게는 유의적인 차이가 없었다(p<0.05). 혈청 중 총 콜레스테롤, LDL 콜레스테롤, 유리 콜레스테롤, 중성지방, 인지질, 혈당 농도는 대조군보다 NaF 경구 투여한 군에서 NaF 농도가 높아짐에 따라 증가하였고, HDL 콜레스테롤 농도는 NaF 농도에 따라 점차 감소하는 것으로 관찰되었다. 혈청 중 총 단백질은 NF50군에서 유의적인 차이를 보이며 낮게 나타났으나 나머지 군에서 유의적 차이가 없는 것으로 나타났으며(p<0.05), 알부민 농도와 글로불린 농도 또한 NF50군에서 가장 낮은 결과치로 나타났다. 반면 알부민/글로불린 비는 NaF 농도와 관계가 없는 것으로 관찰되었다. 따라서 일정 이상 농도의 NaF 경구 투여는 흰쥐의 체중 및 지질성분을 증가시키는 것으로 판단되며, 이는 비만 및 이상지질혈증을 초래할 수 있을 것으로 추정된다.