Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Preventive Effects of Co-treatment with Fucoidan and Lutein on the Development of Inflammatory Bowel Disease in DSS Mouse Model

  • Received : 2011.05.12
  • Accepted : 2011.09.02
  • Published : 2011.09.30
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Abstract

We investigated the effects of fucoidan and lutein against dextran sulfate sodium (DSS)-induced mice colitis. Evaluations were made of the body weight, histological index such as crypt injury and inflammation score, biochemical factor such as serum amyloid (SAA) and MPO level data. The combination of fucoidan and lutein reduced the score of crypt injury and inflammation and markedly showed more decrease of the SAA and MPO levels than 5-ASA group. In addition, each sample of fucoidan and lutein was reduced the level of IL-6 which is stimulated by a lipopolysaccharide (LPS) in HT-29 cell line in vitro. Therefore, fucoidan and lutein may be useful as a dietary substance for preventing inflammatory bowel disease in humans.

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References

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