• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.14 no.4
• /
• pp.194-200
• /
• 1981

Boiled-dried anchovy is one of nation-widely consumed dried fish foods in Korea. In this study, the taste compounds including nucleotides and their related compounds, free amino acids, trimethylamine oxide and total creatinine were analyzed, and their roles in tasting activity were investigated. IMP content in large size, middle size, small size and least size boiled-dried anchovy was $22.7{\mu}mole/g,\;18.6{\mu}mole/g,\;20.3{\mu}mole/g\;and\;4.0{\mu}mole/g$, respectively, and the ratio of IMP to the total nucleotides and their related compounds in each sample was $55.0\%,\;51.0\%,\;69.1\%\;and\;47.0\%$, respectively. In the free amino acid composition of the four size groups of boiled-dried anchovy, abundant amino acids were histidine, lysine, alanine and proline, and the sum of these amino acids occupied $69.0\%,\;67.7\%$. $66.8\%\;and\;45.9\%$ of the total free amino acid in each sample, respectively. Among these. histidine was the most dominant in all samples amounting to 589.0 mg/100g in lage size, 373.9 mg/100g in middle size, 437.8 mg/100g in small sire and 101.0 mg/100g in least size, while aspartic acid and methionine were poor in content. Among the organic bases, total creatinine was abundant, and its nitrogen content ranged from $21\%\;to\;39\%$ of the total extractive nitogen. From the results of omission test, the taste-active compounds of the boiled-dried anchovy are assumed to be IMP and free amino acids.

• Proceedings of the Korean Institute of Interior Design Conference
• /
• 2002.04a
• /
• pp.53-57
• /
• 2002

The purpose of this study was to investigate the remodeling of apartments according to the area type and size in order to provide some information for the future plans for more consumer-friendly dwelling units. To achieve this goal, quantitative data analyses was employed. The sample was a total of 100 apartments analysed on apartments remodeling. The data were analyzed by SPSS WIN program package in terms of frequency, percentage, and x 2-test on the actual remodeling behaviors according to the area type and size of apartments. For the future research case studies recommended small, medium, and large sizes of apartments respectively through interviews, actual surveys, and questionnaires on remodeling behavior, interior design, and interior atmosphere according to the area type and size of apartments.

• The Korean Journal of Applied Statistics
• /
• v.16 no.2
• /
• pp.455-467
• /
• 2003

There has been a long debate on the applicability of the chi-square approximation to statistics based on small sample size. Extending comparison results among Pearson chi-square Χ$^2$, generalized likelihood .ratio G$^2$, and the power divergence Ι(2/3) statistics suggested by Rudas(1986), recently developed disparity statistics (BWHD(1/9), BWCS(1/3), NED(4/3)) we compared and analyzed in this paper. By Monte Carlo studies about the independence model of two dimension contingency tables, the conditional model and one variable independence model of three dimensional tables, simulated 90 and 95 percentage points and approximate 95% confidence intervals for the true percentage points are obtained. It is found that the Χ$^2$, Ι(2/3), BWHD(1/9) test statistics have very similar behavior and there seem to be applcable for small sample sizes than others.

• Korea Journal of Hospital Management
• /
• v.4 no.2
• /
• pp.85-105
• /
• 1999

The main purpose of this article is to analyze the managerial performance of small and medium-size hospitals that are specialized in certain areas of medical services. Data of 189 hospitals were obtained from the data file of Korea Institute of Health Services Management The items include general characteristics of the hospitals, fianancial reports, and utilization records. Degree of specialization is measured by concentration(Herfindahl) index, and the sample hospitals are accordingly classified into specialized and unspecialized groups, by means of cluster analysis. These groups are compared in terms of various measures of managerial performance, which include several profitability indices such as operating margin, return on assets(ROA), and return on equity(ROE). To examine the relationship between specialization and managerial performance, we estimate the regression model, where the profitability indices are used as the dependent variables and the concentration index as the independent variable, controlling for the hospital characteristics such as size, type and location. Also, we perform 'Du Pont' analysis, to investigate the basic elements that can explain the differences in profitability between specialized and unspecialized hospitals. Major findings are as follows: 1. Managerial performance is better for the specilized hospitals than the unspecilized, in all aspects of profitability(operating margin, ROA, ROE). 2. Regression analysis suggests that there is a positive, statistically significant relationship beween the degree of specialization(i.e. concentration) and hospital profitability. 3. Main reason for the higher profitability of specialized hospitals lies in lower expenses rather than higher revenue. 4. In particular, personnel and material expenses are significantly smaller for the specialized hospitals, and this result seems to stem from the efficiency of operating fewer lines of business.(some kind of 'economies of scale') 5. Specialized hospitals also have fewer employees compared with the unspecialized, especially in administrative departments, which implies their efficient personnel management.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2006.11a
• /
• pp.65-74
• /
• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• Communications for Statistical Applications and Methods
• /
• v.9 no.3
• /
• pp.693-701
• /
• 2002

When the lowest dose level compared with zero-dose control has significant difference in effect, it is referred as minimum effective dose (MED). In this paper, we discuss several nonparametric methods for finding MED using updated rank at each sequential test step in small sample size and suggest new nonparametric procedures based on placement. Monte Carlo Simulation is adapted to compare power and Familywise Error Rate(FWE) of the new procedures with those of discussed nonparametric tests for finding MED.

• Journal of the Korean Data and Information Science Society
• /
• v.9 no.2
• /
• pp.263-273
• /
• 1998

In this paper, we consider some approximate testings for the reliability of the stress-strength model when the stress X and strength Y each depends linearly on some explanatory variables z and w, respectively. We construct a bootstrap procedure for testing for various values of the reliability and compare the power of the bootstrap test with the test based on Mann-Whitney type estimator by Park et.al.(1996) for small and moderate sample size.

• Journal of Korean Society for Quality Management
• /
• v.22 no.1
• /
• pp.162-168
• /
• 1994

In this paper we develop an unconditional method for inferences on the shape parameter of a gamma distribution. A simple numerical implementation of this unconditional method is developed; this is a computer program that takes the observed data as input and produces the confidence distribution function for the shape parameter, which in turn provides approximate observe significance levels and confidence intervals for that parameter, as output. These approximations are extremely accurate even for very small sample size and numerically simple and easy to obtain.

• Journal of Astronomy and Space Sciences
• /
• v.11 no.2
• /
• pp.147-153
• /
• 1994

We present a deep(B, V) color-magnitude diagram (CMD) of the Galactic globular cluster NGC 4372. According to the recent inside-out picture of Galaxy formation, this cluster is predicted to be one of the oldest globulat clusters in the Galaxy. Our CMD shows a well defined main-sequence extending ∼ 2 magnitudes below the trunoff. Despite the uncertainty that stems from the small sample size of bright stars, comparison with the Revised Yale Isochrones suggests that this cluster may indeed be one of the oldest (∼16.6 Gyrs) globular clusters in our Galaxy.

• The Bulletin of The Korean Astronomical Society
• /
• v.42 no.2
• /
• pp.64.3-64.3
• /
• 2017

For the detection of transient sources in optical wide field surveys like KMTNet Supernova Project, difference imaging technique is commonly used. As this method produces a fair amount of false positives, it is also common to utilize machine learning algorithms to screen likely true positives. While deep learning methods such as a convolutional neural network has been successfully applied recently, its application can be limited if the size of the training sample is small. I will discuss a variation of more conventional method that adopts the wavelet transform for feature engineering and its performance.