• 한국염색가공학회지
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• 제13권6호
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• pp.33-33
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• 2001

The physical properties and the dyeability of the easily dyeable polyester yarn(EDY) were investigated and compared with those of regular polyester (REG-PET). The EDY, copolymerized with small amount of polyethylene glycol(PEG), showed higher intensity of aliphatic CH peak in IR spectrum, lower density and lower compactness than those of the REG-PET from the analysis of IR, density gradient column and XRD respectively. In the physical properties, the EDY has lowers $T_g,\;T_m$, specific stress and initial modulus, and also has higher strain than that of the REG-PET. The EDY can be dyed under atmospheric pressure and its dyeing rate was faster than REG-PET due to low $T_d$, and this seems to be caused by the increased flexibility of Polymer chain in amorphous region of the EDY due to the copolymerization of PEG.ns being within the experimental error, the average values of lifetim.
$\tau$(t) are taken for further calculations. Rate constants such as Stern-Volmer quenching constants K$_{sv}$, quenching rate parameters k$_q$ and k''$_q$, static quenching constant V and kinetic distance r are determined using the modified Stern-Volmer eq.
tion and sphere of action static quenching model. In order to see whether the reactions are diffusion limited, equations k$_q$ = e$^{-Eq/RT}$ and k''$_q$ = e$^{-Eq/RT}$ are used to determine the values of E$_q$ and E''$_q$, the activati.
energies for collisional quenching and the values of E$_q$ are 14.53, 17.28 and 16.20 kJ mole$^{-1}$ for MPNO1, MPNO2 and 2-PI respectively and the values of E''$_q$ are 14.62 and 17.73 for MPNO1 and MPNO2 respectively. From the magnitudes of various quantities it has.
een concluded that the reactions are diffusion limited and the observed positive deviations in the S-V plot are due to static and dynamic quenching.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.205-212
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• 2001

One of the important characteristics of biological systems os their ability to change im-portant properties in response to small environmental signals. The molecular mechanisms that biological molecules utilize to sense and respond provide interesting models for the development of "smart" polymeric biomaterials with biomimetic properties. An important example of this is the protein coat of viruses, which contains peptide units that facilitate the trafficking of the virus into the cell via endocytosis, then out of the endosome into the cytoplasm, and from there into the nucleus, We have designed a family of synthetic polymers whose compositions have been de-signed to mimic specific peptides on viral coats that facilitate endosomal escape. Our biomimetic polymers are responsive to the lowered pH whinin endosomes, leading to distruption of the en-dosomal membrane and release of important biomolecular druges such as DNA, RNA, peptides and proteins to the cytoplasm before they are trafficked to lysosomes and degraded by lysosomal en-zymes. In this article, we review our work on the design, synthesis and action of such smart, pH-sensitive polymers.

• 대한한방내과학회지
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• 제18권1호
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• pp.1-14
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• 1997

An experimental study was done to investigate the spontaneous movements to the isolated ileum with liquid extracts of Samchulgunbitang. Then the action of gastric ulcer, gastric-juice secretion, the free acidity, total acidity, pepsin output, the transport ability in the intestine, analgesic effect and sleeping time were measured. The following results were obtained; 1. As to the spontaneous movements in the isolated ileum, the effect of contraction against suppression was recognized. 2. The effects of contraction against suppression induced by acetylcholine chloride and barium chloride were recognized on the gastric funds strip significantly. 3. The preventive effect of Samchulgunbitang on the pylorus-lightedulcer in rat was recognized significantly. 4. The anti-ulcer effect of Samchulgunbitang was not recognized on the gastric ulcer caused by indomethacin. 5. The effects of decreasing on the secretion gastric juice, the free acidity, total acidity and pepsin output of Samchulgunbitang were recognized significantly. 6. The transport rate in the small intestine of Samchulgunbitang was decreased. 7. The transport rate in the large intestine of Samchulgunbitang was increased. 8. The analgesic effect of Samchulgunbitang caused by acetic acid was recognized significantly. 9. The sleeping time caused by pentobarbital-Na of Samchulgunbitang was prolonged significantly. According to the results, it is considered that the Samchulgunbitang has effects of gastric ulcer, chronic gastritis, hyper-acidity, gastroptosis such as abdominal discomfort, gastric acid, indigestion and anorexia.

• 정보학연구
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• 제6권3호
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• pp.151-168
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• 2003

본 연구는 기본적으로 온라인과 오프라인의 통합마케팅을 설명하고 이에 관한 경험적 사례를 개발하기 위한 목적으로 진행되었다. 특히 중소 유통영역의 공생적 기반 위에 전개되는 온-오프라인의 경험적 사례를 개발하고 바람직한 마케팅방향을 방향을 제시하였다. 본 연구는 문헌연구와 사례연구를 병행하여 연구를 진행하였다. 사례는 인터넷 도매유통의 공생협력을 추진한 (주)Barokosa이다. 온-오프라인의 협력적 통합마케팅의 전략을 전개하기 위해서는 무엇보다도 온-오프라인의 뚜렷한 목표를 설정하고 성장방향에 대한 비전을 공유하고 나아가 온-오프라인의 사명을 감당하는 것이다. 실천적으로는 (1)항상 고객(customer)기반의 의사결정을 이루며 (2)철저한 협력적 돕는경쟁(competition) 의식과 (3)구성원 자신의 일에 대한 자신감(confidence)을 지니고 (4)실천을 위한 용기(courage)를 가지고 (5)혁신하여 변화(change)를 선도하는 것이다.

• 한국통신학회논문지
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• 제33권4B호
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• pp.207-214
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• 2008

미래 인터넷 환경에서 무선 센서 네트워크(Wireless Sensor Networks)는 광범위한 응용에 적용될 중요한 기술이다. 그러나 센서 네트워크는 기존의 네트워크와는 달리 소형이고 제한된 배터리 에너지로 운용되어야 하기 때문에 센서 네트워크가 설치된 지역에서 오랜 시간동안 많은 정보를 얻기 위해서는 에너지 효율적인 프로토콜 개발이 필수적이다. 또 센서 네트워크는 무선 멀티 홉 (multi hop) 통신을 통해 정보가 전달되기 때문에 전송 지연이 발생한다. 이런 전송 지연은 센싱된 정보가 적시에 전달되어 적절한 조치가 이루어지는 것을 어렵게 하기 때문에 센서 네트워크의 프로토콜을 설계할 때 전송 지연이 발생하지 않도록 해야 한다. 본 논문은 무선 센서 네트워크에서 일정 시간의 전송지연을 유지하면서 각 노드의 에너지의 소비를 최소화하는 데이터 전달 프로토콜을 제안한다. 제안된 프로토콜은 wakeup 스케줄링과 MAC 프로토콜을 통합하여 동작하며, 데이터를 전달하는 동안 네트워크 전체의 에너지 소모를 균등하게 해 준다. 제안된 프로토콜은 모의실험을 통해서 기존의 프로토콜과 비교하여 성능을 검증하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제2권1호
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• pp.63-68
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• 1998

Nitric oxide (NO)-mediated relaxation in vascular smooth muscle involves not only activation of guanylate cyclase but also hyperpolarization of the membrane. It has been shown that depolarization decreases the [$Ca^{2+}$] sensitivity of myosin light chain kinase in arterial smooth muscle, and nitric oxide (NO)-mediated relaxation was attenuated in this situation. However, why potassium inhibits or attenuates the action of EDRF/NO is not clear. Therefore, we investigated the magnitude of relaxation and cGMP contents using measures known to release NO, such as photorelaxation, photo activated NO-mediated relaxation, and NO-donor (SNP)-mediated relaxation in porcine coronary arterial rings in which contractile conditions were made by different degree of depolarization, i.e., contraction in response to U46619 or U46619 plus KCl. In all cases, the magnitude of relaxation was significantly greater (P＜0.05) in U46619-contracted rings than in U46619+KCl-contracted ones. Although accumulation of cGMP was evident with three measures employed in the present study, no difference was found in cGMP contents between U46619 and U46619+KCl conditions, indicating that the diminished relaxation in KCl containing solution is cGMP-independent mechanism(s). To understand this further, cytosolic $Ca^{2+}$ changes due to NO were compared in rat thoracic aorta by exploiting photoactivated NO using streptozotocin (STZ) that was contracted with either NE or KCl. Fura-3 $[Ca]_{cyt}$ signal caused by NO was small and transient in high $K^+$-, but large and sustained in NE-contracted aorta. The inhibitory potency of STZ expressed in terms of $IC_{50}$ was 5.14 and 3.88 ${\mu}M$ in NE and in high $K^+$, respectively. These results suggest that modification of the cellular mobilization of $Ca^{2+}$ rather than cGMP levels may be an important mechanism for the NO-mediated relaxation when vascular membrane is depolarized, such as atherosclerosis and hypertension.

• 한국안광학회지
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• 제18권2호
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• pp.93-99
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• 2013

목적: 본 연구는 현장현시 건성안 진단 테스트 중에 현재 사용되고 있으나 부정확한 결과로 신뢰도가 떨어지는 쉬르머 용지를 대체 할 수 있는 차세대 건성안 진단 테스트 용지를 미세유체공학을 이용하여 개발하고자 하였다. 방법: 왁스로 패턴을 제조한 친수성 크로마토그래피 용지를 pH에 따른 색 변화가 나타나도록 안토시안으로 염색을 하였다. 인공 누액의 젖음 속도를 인공 누액과 32명의 참가자의 눈물을 이용하여 임상 측정하였다. 결과: 인공 누액을 이용하였을 경우 쉬르머 용지에서는 소량의 용액은(0.5 ml이하) 흡수거리가 도출되지 않았으나 새로 개발된 용지는 시간에 따른 인공 누액의 흡수거리가 확연히 나타났다. 임상실험에서도 새로 개발된 검사 용지는 TBUT (tear break-up time)결과와 부합하는 건성안 진단 결과를 보였다. 결론: 개발된 건성안 진단 용지는 간편하게 사용될 수 있을 뿐만 아니라 기존 쉬르머 용지와 같은 현장현시 건성안 진단 매체와 비교 했을 경우 건성안 판별의 정확성이 높았다.

• 분석과학
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• 제26권1호
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• pp.61-66
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• 2013

얇은 유리판 위에 잘 정렬된 인지질 이중막에 작용하는 항균성 펩타이드 protegrin-1의 활성작용을 고체 $^2H$ 핵자기 공명 분광법을 이용하여 조사하였다. 수화 전후에 있어서 인지질 분자의 배향분포와 그 운동성을 고체 $^2H$ 핵자기 공명 스펙트럼을 통하여 확인하였다. 진공으로 건조된 상태에서는 인지질 분자의 운동성이 작다는 사실 외에는 인지질 분자들의 배향분포에 대한 정확한 상태를 알 수 없었다. 그러나 시료가 수화된 이후에는 시간이 지남에 따라 인지질 분자들이 잘 정렬되어 간다는 것과 원환체 기공이 형성되어 간다는 것을 확인할 수 있었다. Protegrin-1과 같은 항균성 펩타이드에 의한 인지질 이중막 변화를 본 연구논문에서 사용한 방법으로 확인하기 위해서는 상당히 긴 반응시간이 필요하다는 것을 확인하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제13권11호
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• pp.1529-1535
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• 2000

The aim of the present study was to determine whether brain corticotropin-releasing factor (CRF) and a new peptide, urocortin (UCN) have a direct action in brain mechanisms controlling feed, water and salt intake in sheep. We gave a continuous intracerebroventricular (ICV) infusion of the peptide at a small dose of $5{\mu}g/0.2ml/hr$ for 98.5 hrs from day 1 to day 5 in sheep not exposed to stress. Feed and water intake during ICV infusion of CRF or UCN decreased significantly compared to those during artificial cerebrospinal fluid (CSF) infusion. NaCl intake during infusion of CRF or UCN was the same as that during CSF infusion. Mean carotid arterial blood pressure (MAP) and heart rate during ICV infusion of CRF or UCN were not significantly different from that during CSF infusion. On the other hand, the plasma glucose concentration during ICV infusion of CRF or UCN tended to be higher than that during CSF infusion. These observations indicate that decreased feed intake induced by CRF and UCN infusion is not mediated by the activation of both the pituitary-adrenal axis and the sympathetic nervous system. The results suggested that brain CRF and UCN act directly in brain mechanisms controlling ingestive behavior to decrease feed and water intake, but do not alter salt intake in sheep.

• 한국농공학회지
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• 제17권3호
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• pp.3878-3884
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• 1975

This study was carried out to develop the throw-in type thresher with its size as small as possible. Developing the smallest possible size of the throw-in type thresher has been very important to increase mobility and to reduce the machine price. The thresher that developed for this purpose was tested as to threshing and separation performance for the samples collected in eight catch boxes under the concave while threshing. The amount of grain collected in each compartments was measured and the threshing and separating pattern along the total span of the threshing drum was determined. The performance of separating and threshing units of the test thresher and threshing loss was evaluated by use of the developed grain separating apparatus and the method for measuring the grain separating performance of threshers. The results are summarized as follows; 1. The unthreshed grain (drum losses) and semi-threshed grain did not appeared at all throughout the treatments. 2. When threshed by making use of the developed throw-in type thresher, the threshing grain loss at about 25 per cent grain moisture was about one-half when threshed at about 18 per cent grain moisture. 3. And its grain separating loss in higher feed rate was decreased in comparison with that of lower feed rate. These results suggests that the throw-in type thresher may be suitable for wet threshing and for higher feed rate of threshing. 4. Above 60 per cent of total grain passing through concave fell through the screen within a scant 30 cm from the feeding inlet. This threshing pattern may suggest that major threshing action may be finished before about one third of cylinder length. The required separating load extended over the whole drum span is so defferent that separating elements should be redesigned so as to accomodate this variable pattern of separation load. 5. It was apparent from the experiment that the length of the threshing drum of the throw-in type thresher could be reduced from 1285mm to about 1050mm without increasing grain separation loss greatly.