• YAKHAK HOEJI
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• v.35 no.2
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• pp.135-141
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• 1991

The general pharmacological tests with rhGM-CSF indicated that it had no influences on rotarod and locomotor activity tests, but shortened hexobarbital-sleeping time at the large dose of 3 mg/kg s.c. in mice. It elicited no hypothermic, analgesic and antiepileptic action. No influences on blood pressure and respiration in rabbits were observed at the dose of 1 mg/kg, i.v. and it did neither affect the receptors of adrenaline, acetylcholine, serotonin, histamine, kinin and oxytocin, nor antagonize the actions of histamine, serotonin and oxytocin at its concentrations of 1$\times$$10^{-6}$g/ml. However, this substance was demonstrated to stimulate the formation of leucocytes in rats.

• Korean Journal of Pharmacognosy
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• v.33 no.2 s.129
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• pp.151-155
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• 2002

Previously, we have reported that the butanol fraction of the head of Panax ginseng had significant gastroprotective activity on gastritis and gastric ulcer models of rats. Considering the safety of the fraction for development of new anti-ulcerative agent or food supplement, general pharmacological study was carried on. The fraction was revealed that have no influence on spontaneous activity, phenobarbital-induced sleeping time, rotarod test, body temperature, gastro-intestinal motility, respiration and blood pressure. The fraction showed weak analgesic action in writhing syndrome and did not show any sign of acute toxicity in mice.

• Korean Journal of Pharmacognosy
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• v.19 no.3
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• pp.208-215
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• 1988

To investigate the experimental effects of Chunwangboshimdan which have been widely used for aterial or auricular flutter, neurosis, insomnia and disease caused by cardiac malfunction, we have done the effects on the central nervous and cardiovascular system. The result as follow; It inhibited the convulsion induced by caffeine, the writhing syndrome induced by acetic acid and the spontaneous movement. Furthermore it prolonged the sleeping time induced by thiopental-Na in mice. It also showed the negative inotropic action on the isolated heart of frog, the vasodilative action as to peripheral bloods of rabbit ear and the hypotensive action in the anesthetized rabbit.

• Archives of Pharmacal Research
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• v.12 no.3
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• pp.196-200
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• 1989

The methanolic extract of the Rhizome of Curcuma zedoaria exhibited a significant prolongation of hexobarbital (HB)-induced hypnosis. Through liquid chromatography of an ether soluble fraction. monitoring by bioassay, three sequiterpenes, germacrone (A), curzerenone (B) and germacrone epoxide (C) were isolated as active consituents. A single treatment (100-200 mg/kg, i.p.) of each compound showed not only a significant prolongation of HB-induced sleeping time but also a significant inhibition of aminopyrine N-demethylase activity in mice, and further exhibited a typical type I binding spectra with oxidized rat hepatic cytochrome P-450 induced by phenobarbital. All of the compounds provoked a sleep episode at a subhypnotic dose of HB, implying that they possess CNS depressant properties.

• Biomolecules & Therapeutics
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• v.7 no.2
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• pp.170-177
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• 1999

PEG-hemoglobin SB1 (SB1), which is a hemoglobin-based oxygen carrier, is intended to use as a safe blood substitute against brain ischemia and stroke. The general pharmacological profiles of SB1 were studied. The doses given were 0, 5, 10, 20 ml/kg and drugs were administered intravenously. The animals used for this study were mouse, rat and guinea pig. SB1 showed no effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital sleeping time, anticonvulsant activity, analgesic activity, blood pressure and heart rate, left ventricular peak systolic pressure, left ventricular end diastolic pressure, left ventricular developing pressure, double product, heart rate, coronary flow rate, smooth muscle contraction using guinea pig ileum, gastrointestinal transport, gastric secretion, urinary volume and electrolyte excretion at all doses tested except the decrease of body temperature. These findings demonstrated that SB1 possesses no general pharmacological effects at all doses tested.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.12
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• pp.1273-1277
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• 2011

This paper proposes a control-based approach for duty cycle adaptation in wireless sensor networks. The proposed method, QCon, controls duty cycle through queue management in order to achieve high performance under variable traffic rates. To minimize energy consumption while meeting delay requirement, we design a feedback controller, which adapts the sleeping time according to dynamically changing traffic by constraining the queue length at a predetermined value. Based on control theory, we analyze the adaptive behavior of QCon and derive conditions for system stability. Results from asymptotic analysis and simulations indicate that QCon outperforms existing scheduling protocol by achieving more energy savings while satisfying delay requirement.

• Korean Journal of Occupational Health Nursing
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• v.21 no.1
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• pp.37-45
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• 2012

Purpose: This study was conducted to identify health promotion lifestyle (HPL), farmers' syndrome and related factors of workers in agricultural industry. Methods: A total of 454 agricultural workers were selected through convenient sampling. Data were collected from July 1 to August 10, 2009. Data analysis included frequency, t-test, ANOVA, Scheff$\acute{e}$ test, and stepwise multiple regression using SPSS/WIN 17.0. Results: 1. The mean score of HPL was 3.30 and the prevalence of farmers' syndrome was 29.3%. 2. Analysis of farmers' syndrome showed there were statistically significant differences for gender, age, sleeping time, perceived health status, breakfast and exercise. 3. Gender, age, perceived health status, breakfast and exercise were identified as variables influencing the farmers' syndrome. Conclusion: This study suggested that we should develop health promotion programs for workers of agricultural industry considering these results.

• The Journal of Korean Medicine
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• v.15 no.2 s.28
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• pp.269-280
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• 1994

To elucidate the effects of Onkyungtang. after oral administration of Onkyungtang water extract in mice and rats, acute toxicity. analgesic. sedative, estrogenic actions. action on isolated uterine muscle were measured. The results obtained were as follows: 1. The yield of water extract of Onkyungtang was 24.5%, minimum lethal dose was 4,000mg/kg, which rarely had the acute toxicity in mice and rats. 2. The analgesic effects of Onkyungtang by acetic acid induced writhing syndrome in mice were not remarkably observed. 3. The relaxant action of Onkyungtang on oxytocin induced contracted uterine muscle in estrogenized rats were not remarkably observed. 4. The sedative effects of Onkyungtang by hexobarbital sodium induced sleeping time in mice were remarked. 5. Administration of Onkyungtang caused remarkable increase in weight of rat's uterus.

• The Journal of Pediatrics of Korean Medicine
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• v.13 no.2
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• pp.139-148
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• 1999

The purpose of this study was to prepare the new effective oriental medical treatments. This study was performed at Dongeui Oriental Medical Hospital from October, 1, 1999 to November, 30, 1999, and 59 patients with cough persisting for longer than 3 weeks were evaluated. The following results were obtained. 1. In sex, male was 32 patients(54.24%) and female was 27 patients(45.76%), and in age group, between 2 and 6 years was 43 patients(72.88%) as first. 2. In the distribution of complicated signs, sputum was 42 patients(7l.18%) as first, rhinorrhea was 24(40.68%) as second. 3. In the style of cough. attack on morning or sleeping time was 32 patients(54.24%) as first. 4. In the past history, pulmonary diseases, such as pneumonia, bronchitis were 10 patients(16.95%) as first. 5. In the family history of allergy, allergic dermatitis was 6 patients(10.l7%) and allergic rhinitis was 4 patients(6.78%)

• Biomolecules & Therapeutics
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• v.6 no.3
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• pp.303-311
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• 1998

The general pharmacological properties of new platinum (II) coordination complexes, SA : [Pt(trans-ι-DACH)(DPPE)] . 2NO$_3$, SB : [Pt(cia-DACH)(DPPP)] 2NO$_3$ and SC : [Pt(cia-DACH)(DPPE)] 2NO$_3$on central nervous, respiratory, cardiovascular and digestive systems were studied in various experimental animals. These platinum (II) anticancer agents had no effects on analgesia, thiopental-induced sleeping time, body temperature, strychnine-induced convulsion, inflammation and local anesthetic action in mice and rats. Intestinal motility, stomach-ulcer induced by serotonin and bile-secretion of rats were not influenced by the dose of 30 mg/kg. However SB and SC induced a mild decrease in heart rate in anesthetized rats. Based on these results, these new platinum (II) complexes may be regarded as a valuable lead compound in the development of new anticancer chemotherapeutic agents with marked antitumor activity and low toxicity.