General Pharmacology of the New Platinum (II) Anticancer Agents with Diaminocyclohexane as a Carrier Ligand

Diaminocyclohexane을 배위자로 한 새로운 항암성 백금(II)착체류의 일반약리작용

  • 고석태 (조선대학교약학대학/의과대학) ;
  • 강선영 (조선대학교약학대학/의과대학) ;
  • 임동윤 (조선대학교약학대학/의과대학) ;
  • 신현준 (경희대학교약학대학) ;
  • 최승기 (경희대학교약학대학) ;
  • 노영수 (경희대학교약학대학) ;
  • 정지창 (경희대학교의과대학)
  • Published : 1998.09.01

Abstract

The general pharmacological properties of new platinum (II) coordination complexes, SA : [Pt(trans-ι-DACH)(DPPE)] . 2NO$_3$, SB : [Pt(cia-DACH)(DPPP)] 2NO$_3$ and SC : [Pt(cia-DACH)(DPPE)] 2NO$_3$on central nervous, respiratory, cardiovascular and digestive systems were studied in various experimental animals. These platinum (II) anticancer agents had no effects on analgesia, thiopental-induced sleeping time, body temperature, strychnine-induced convulsion, inflammation and local anesthetic action in mice and rats. Intestinal motility, stomach-ulcer induced by serotonin and bile-secretion of rats were not influenced by the dose of 30 mg/kg. However SB and SC induced a mild decrease in heart rate in anesthetized rats. Based on these results, these new platinum (II) complexes may be regarded as a valuable lead compound in the development of new anticancer chemotherapeutic agents with marked antitumor activity and low toxicity.

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