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Effects of 8-Fluorociprofloxacin And Ciprofloxacin on the Central Nervous System

  • Kim, Young-Hoon;Kim, Dal-Hyun;Choi, Kyung-Eob
    • Toxicological Research
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    • v.8 no.2
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    • pp.161-170
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    • 1992
  • The objectives of this sutdy were to investigate the effects of 8-fluorociprofloxacin(8-FCP) on the central nervous system (CNS) and to compare with those of ciprofloxacin(CP). The $LD_{50}$ values of intravenous 8-FCP were similar or slightly lower in rat (M;203.6mg/kg, F;186.1mg/kg)and markedly lower in mice (M;126.5mg/kg, F;163.1mg/kg), as compared to those of CP. However, no recognizable differences in the clinical signs and recovery were found between 8-FCP and CP in both species. In combination with fenbufen, the convulsive liability of 8-FCP was higher than that of CP. At an intravenous dose of 10mg/kg, 8-FCP provoked convulsive signs and subsequent death in mice, whereas CP produced convulsion at a dose of 40mg/kg. The hexobabital -induced sleeping time was markedly lengthened by the oral administration of 8-FCP, but slightly increased by CP. In addition, the two quinolone derivatives had analgesic effects. The analgesic activity of 8-FCP was approximately two times higher than that at CP. However, both 8-FCP and CP had little effects of pentylenetetrazole-or strychnine-induced convulsion and muscle relaxation. Our finding that 8-FCP had more remarkable CNS effects than CP strongly suggests that there should be differences in the pharmacokinetic characteristics and/or in the binding affinity for specific biologic targets, or receptors, in the CNS.

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A Study on Stress of Primary Students in Korea (우리나라 국민학생의 스트레스에 관한 연구)

  • Kim, Mu Chae;Kim, Jong Kun;Kim, Gee Ju
    • Journal of the Korean Society of School Health
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    • v.6 no.1
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    • pp.78-92
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    • 1993
  • The purpose of this study is to find out the stress causes of the primary students in Korea, through the three major methods, life event score, multiple regression about stress causes and G.H.Q. path-diagram. A survey was made of 889 students who were selected among students of six primary schools in seoul and Ka-pyeng, from Sep. 28 to Oct. 2. 1992. The results of this study are summarized as follows : 1. Life event score Among the children's life events, (deaths of family) (degrade of school record) (the increase of absence days) (divorce of parents) (trouble with relationship) are high ranking in life event score. Besides, (scolded by teacher and parents) (beginning of extracurricular work) are spread stress causes. In conclusion, these stress causes are shown by two aspects, home, school, and so children are under stress circumstance in both places. These stress causes vary with area and sex. 2. Multiple regression about stress causes and G.H.Q. This study analysed how a stress caused by home life affects the children's health of mind and body. The most influential factors are , and these factors vary with area and sex. 3. Path-diagram This study proved that socio-psychological school environment raises children to secede from school, and this secession that operates as a stress cause affects children's health of mind and body. This serial process is analysed by path analysis, and made out a path-diagram. In conclusion, as expected socio-psychological,school environment affects the children's health of mind and body. This is shown by two aspects : positive, negative. This stress causes vary with area and sex.

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Factors Affecting the Control of HbA1c in Type 2 Diabetic Patients (제2형 당뇨환자의 당화혈색소(HbA1c) 수치 조절에 미치는 영향요인)

  • Kim, Hee Yeon;Kim, Hye Sook
    • Journal of Convergence for Information Technology
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    • v.8 no.6
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    • pp.75-84
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    • 2018
  • Objects: This study is a descriptive study to identify the factors influencing the glycated hemoglobin control in type 2 diabetes patients. Methods: This study used raw data from the third year of the National Health and Nutrition Examination Survey performed from 2015. The subjects were 285 people who were classified as type 2 diabetes patients among the 7,380 participants of the National Health and Nutrition Examination Survey. Findings: The factors influencing the glycated hemoglobin control in type 2 diabetes patients were found to be age, education level, prevalence period and sleeping time. Improvements: In type 2 diabetes patients, it is very important to have appropriate education on diabetes when they discovered the disease morbidity in the middle age rather than in the aged period and to have enough sleeping time. A practical program to help this education and training should be developed.

Case Report of Menopausal Vasomotor Symptoms (Heat Flashes and Sleep Disorders) in a Middle-Aged Female Patient Treated with Korean Medicine (중년 여성의 갱년기 혈관운동신경증상(안면홍조, 불면)에 대한 한방 치료 1례)

  • Park, Jin-hun;Kim, So-won;Kim, Sang-yoon;Wang, Yen-min;Baek, Gil-geun;Yun, Sang-hun;Kang, Man-ho;Park, Sung-hwan;Lee, Hyung-chul;Lim, Yong-ha
    • The Journal of Internal Korean Medicine
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    • v.43 no.5
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    • pp.940-950
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    • 2022
  • Objectives: The purpose of this study is to report on the efficacy of Korean medical treatment for treating menopausal vasomotor symptoms (heat flashes and sleep disorders). Methods: We treated a menopausal female patient with heat flashes and sleep disorders using Korean medical treatments (herbal medicines, acupuncture, pharmacopuncture, moxibustion, and chuna). To evaluate the results of this treatment, we used Kupperman's Index and the Numerical Rating Scale to measure heat flashes and total sleeping time, respectively. The patient's general health status was evaluated using the European Quality of Life 5 Dimensions Scale. Results: We observed improvements in Kupperman's Index, the Numerical Rating Scale, the patient's total sleeping time, and the European Quality of Life 5 Dimensions Scale following the treatments. Conclusions: This study suggests that Korean medicine may be an effective treatment for menopausal vasomotor symptoms (heat flashes and sleep disorders).

Individual and Occupational Factors Associated With Low Back Pain: The First-ever Occupational Health Study Among Bangladeshi Online Professionals

  • Hossian, Mosharop;Nabi, Mohammad Hayatun;Hossain, Ahmed;Hawlader, Mohammad Delwer Hossain;Kakoly, Nadira Sultana
    • Journal of Preventive Medicine and Public Health
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    • v.55 no.1
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    • pp.98-105
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    • 2022
  • Objectives: Low back pain (LBP) is a common chronic condition among sedentary workers that causes long-term productivity loss. This study aimed to identify the relationships of individual and occupational factors with LBP among Bangladeshi online professionals. Methods: We conducted a cross-sectional study involving 468 full-time online professionals who usually worked in a sitting position. One-month LBP complaints were assessed using a musculoskeletal subscale of subjective health complaints. The chi-square test was used to measure associations between categorical predictors and LBP, and multivariable logistic regression was conducted to identify the variables significantly associated with LBP. Results: LBP within the last month was reported by 65.6% of participants. Multivariable logistic regression analysis indicated that age >30 years (adjusted odds ratio [aOR], 0.40; 95% confidence interval [CI], 0.23 to 0.70) and being married (aOR, 0.59; 95% CI, 0.36 to 0.97) had significant negative associations with LBP. Significant positive associations were found for spending >50 hours weekly on average working in a sitting position (aOR, 1.61; 95% CI, 1.05 to 2.49), being overweight and obese (aOR, 1.87; 95% CI, 1.16 to 2.99), sleeping on a soft mattress (aOR, 2.01; 95% CI, 1.06 to 3.80), and ex-smoking status (aOR, 3.33; 95% CI, 1.41 to 7.87). Conclusions: A high prevalence of LBP was found among full-time online professionals. Long working hours in a sitting position showed a significant association with developing LBP. Smoking history, body mass index, and sleeping arrangements should also be considered while considering solutions for LBP prevalence among online professionals.

Refractive Power Changes after Removal of Contact Lenses (콘택트렌즈를 임시 제거한 상태에서의 착용 조건에 따른 굴절력 변화)

  • Cho, Yun-Kyung;Kim, Soo-Woon;Yu, Dong-Sik
    • Journal of Korean Ophthalmic Optics Society
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    • v.18 no.3
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    • pp.279-289
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    • 2013
  • Purpose: To evaluate the changes of refractive power when worn soft contact lenses were temporarily removed. Methods: 91 soft contact lens wearers (15 males and 76 females; total 182 eyes) from 17 to 39 years of age (average: $24{\pm}4.8$ years) were participated. Objective and subjective refraction, and corneal radius were measured at 0, 30, 60 and 90 min after lens removal. The changes in refractive power were evaluated between measurements over time. The other parameters such as types of lenses, fitting and wearing conditions were also assessed. Results: Objective refraction, subjective refraction and corneal radius were significantly changed according to measured time (p<0.0001). A moderate myopic shifts was observed at the beginning (30 min after lens removal) and a slight myopic shift at the late of measurement (60 min to 90 min after lens removal). There are no significant differences between lens types, fitting states, wearing time, wearing days and sleeping time in the previous day. However, there was significant interaction in changes for corneal radius between measuring time and lens type (p=0.017), fitting state (p=0.019), and sleeping time prior to the test (p=0.010). Conclusions: Time to reach refractive and corneal radius stability after contact lens removal revealed at least more than 60 min, regardless of types of lenses, fitting and wearing conditions. Therefore, refraction for correction should be performed after waiting for more than that time as possible.

A Study on Living Activity Degree Living Time of the Elderly in Rural Area (농촌지역 재택노인의 생활시간 및 활동과 관련요인)

  • Co Yoo-Hyang
    • Journal of Korean Public Health Nursing
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    • v.11 no.1
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    • pp.93-102
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    • 1997
  • The study aimed at investigating the living time as well as disability degree of the elderly based on daily living acting capability and living activity degree. The survey was conducted through the home-visit interview during half month at july, 1996 by the students of nursing department who were previously trained. The survey targeted the elderly aged 65 years or more living at home in rural area. The study tried to utilize Activity Inventory(AI) made for examing health and disease, disability degree, and living acting degree of the elderly. Among the AI's, there are Physical Activity of Daily Living(PADL), Instrumental Activity of Daily Living(IADL), maximum daily activity scope, and physical and mental activity level of the elderly. The daily living time is surveyed physiologic time(sleeping, eating and grooming), labor time(occupation, housekeeping and farming) and leisure time(reading, sport hobby-life). Results of the study show that social activity degree of the elderly is found to be lower than that PADL, LADL, and daily living scope. It seems that the elderly suffer from inability in daily life with lower social activity degree. But the labour time of the daily living time is the most amount time in the targeted 361 elderlys through random sampling. Therefore postponement of the disability of aging should be devised to encourage the labour activity of the elderly.

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Comparison of Urban Families and Rural Families in terms of Life Styles on Saturday-with-no-school by Using Time Diary Method (시간일지법으로 분석한 도시와 농촌 가족의 토요휴업일 생활실태)

  • Oh, Kyeong-Sook;Han, You-Me
    • Korean Journal of Human Ecology
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    • v.18 no.1
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    • pp.113-122
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    • 2009
  • This study aimed to examine the urban families and rural families in tenns of life styles on Saturday-with-no-school. The subjects were the 386 parents whose children were in the first or second grade in rural or urban area. The instruments of analysis were time diary method and parents' stress scale developed by Kim & Kang(l997). The main results were as follows: First, in comparison with urban children, rural children spent more time in viewing TV and playing computer but spend less time in sleeping. field trip and cleaning on Saturday-with-no-school. Second, the difference of child-rearing time between mothers and fathers was less marked in urban area than in rural area. Rural fathers spent more time in watching TV or playing computer, while rural mothers spent more time in feeding and bathing of their children, helping their children do homework, and total child-rearing. Third, unlike urban parents, rural parents ddid not have much parenting stress on Saturday-with-no-school. These results show that there is a need to focus on rural parents in the preparation for introduction of 5 days-school-week system.

An Analysis on Trend of Time Budgets of Korean Younger Generation (靑少年의 生活時間 使用變化傾向에 관한 硏究)

  • Lee, Chung-Duck
    • Journal of Families and Better Life
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    • v.9 no.1 s.17
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    • pp.203-221
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    • 1991
  • 1) The purpose of this study is to investigate the correlation between general social changes and time budgets of younger generation in Korea. 2) I use the statistics which appeared in the 'Studies of the Time Budgets of Korean people" carried out by the Korean Broadacasting system in 1981 and in 1990. 3) The result of this analysis may be summarized as the following : (1) Even in the cases of biologically necessary acts such as sleeping and eating, the average time used by Korean younger generation is remarkably influenced by general social changes. (2) It is in the cases of optional acts such as reading, listening music and enjoying a move that general social changes influence excessively the time Budgets of children and the youth. (3) It seems that time Budgets of Korean younger generation are losing their balance and rationally year after year during 1981 and 1990. For instance they spend too much time enjoying TV or popular music. 4) As a conclusion, I shall strongly suggest : (1) Parents and school teachers should pay more attention in their guidance of their Children or pupil concerning the importnace of the time Budgest. (2) the programmers of television and radio should consider sincerly the educational influence of their products.

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Analysis on the Hours of Living and Playtime of Children Depending on the Existence of a Protector After School (아동의 생활시간과 놀이시간 양태 연구: 방과 후 보호자 유무에 따른 비교)

  • Kim, JiHee
    • Journal of the Korean Home Economics Association
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    • v.50 no.8
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    • pp.13-19
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    • 2012
  • The present study explored the hours of living and playtime depending on existence of caregiver after school using the data from the Korean Children and Youth Panel Survey7071. KCYPS date collected on 1th, 4th and 7th grade children and their caregivers. The hours of living was categorized into sleeping, learning, reading and play times. Playtime was sub-categorized into time for using playing the computer/games, watching TV/DVD and playing with peer groups. The present study has shown that children in the fourth grade spent more time on learning, whereas reading children in the seventh grade spent more time on playing compared to those in other grades during the weekdays. Also, children in higher grades spent more time playing both on the weekdays and on the weekends. Students of all grades spent more time watching TV/DVD compared to other activities during the weekdays and the weekends. Children with a caregiver spent more time on learning and spent less time playing computer/game, watching TV/DVD and playing with peer groups than children without caregivers. As students moved up a grade, these results clearly appeared. Considering the results in this study, the allocation of hours of living and playtime of children altered depending on the existence of a caregivers.