• Korean Chemical Engineering Research
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• v.57 no.3
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• pp.305-312
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• 2019

The discovery of nitric oxide (NO) as a major signaling molecule in a number of pathophysiological processes - vasodilation, immune response, platelet aggregation, wound repair, and cancer biology - has led to the development of various exogeneous NO delivery systems. However, the development of ideal delivery system for human body application is still left as a challenge due to its high reactivity and short half-life in physiological condition. In this article, an overview of several nano-structures as potential NO delivery system will be presented, along with their recent research results and biomedical applications. Nano-size delivery system has immense advantages compared to others due to its high surface-to-volume ratio and capability for surface modification; thus, it has been proven to be effective in delivering nitric oxide with enhanced performance. Through this novel nano-structure delivery system, we are expecting to achieve sustained release of nitric oxide within adequate range of concentration, which ensures desired drug effects at the target site. Among different nano-structures, in particular, nanoparticle, microemulsion and nanofilm will be reviewed and compared to each other in respect of nitric oxide release profile. The proposed nano-structures for exogeneous NO delivery have a biological significance in that it can be further utilized in diverse biomedical fields as a highly promising therapeutic method.

• Journal of Korean Society on Water Environment
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• v.34 no.6
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• pp.688-702
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• 2018

Since the 1970s regulations against the pollution of drinking water have been introduced in Lake Paldang watershed area. To understand the effects of water environment management policies and the impacts of climate changes on Lake Paldang, a long-term comprehensive study of this watershed and the changes in its water environment is required. In this study, we analyzed changes in the weather, hydrology, sources of pollution, water quality, and algal development from 2000 to 2015 year based on the statistical data provided by several national information systems. While the population and amount of sewage in the Lake Paldang watershed increased by about 1.5 times, the amount of animal manure showed a decreasing trend during the same period. The wastewater also increased by about 1.5 times while the amount of water intakes rose by about 1.14 times. The water quality in front of the Paldang Dam, which is the representative monitoring site of the Lake Paldang, was stable. The annual average BOD concentration remained within 2 mg/L, which is a "Good (lb)" level according to the environment standards of Republic of Korea. The development of phytoplankton and harmful cyanobacteria were largely influenced by meteorological factors.

• Journal of Conservation Science
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• v.35 no.2
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• pp.99-115
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• 2019

The Royal Tombs at Songsanri is one of the most important historic site for ancient historical study in Korean Peninsula. Since the excavation of the tombs, continuous exposure to the outside environment and the negative effects of the artificial air conditioning system have caused significant threats to the thermal environment stability of the tombs. Unlike the outside temperature that shows significant differences according to seasonal changes, the burial chamber of the tombs had a relatively stable temperature range of 11.4 to $22.2^{\circ}C$ throughout the year, and the standard deviation of temperature was within 3.5. It was revealed that major factors affecting the microclimate of the tombs were inflow of outdoor air, wind direction and speed, and all of them had closely related to airtightness of the tombs. The solar radiation was in inverse proportion to the thickness of burial mounds, and thus Royal Tomb of King Muryeong, which has the thickest burial mound, was least affected by solar radiation. Especially, microclimate of the tombs caused to the highest influence with artificial environmental changes due to access by people, which varied in proportion to the number of accessed people and time of stay. Currently, the inside of the tombs are sealed and always in saturated condition, it is very vulnerable to dew condensation. As a result of analyzing the possibility of condensation in each tomb, all the tomb No. 5, tomb No. 6 and Royal Tomb of King Muryeong had condensation most of the time throughout the year. It is required to make a proper conservation environment for the Royal Tombs at Songsanri.

• Journal of Convergence for Information Technology
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• v.9 no.4
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• pp.152-159
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• 2019

The purpose of this study is to investigate the effect of transaction characteristics on transaction cost and choice intention by applying transaction cost theory to experiential product. Experience-specificity, transaction uncertainty, and personal uncertainty are proposed to reflect the characteristics of experiential products, and the effects of these variables on transaction costs and transaction costs are assumed to have an influence on the choice intention. The results of this study are summarized as follows. First, experience-specificity(site, physical equipment, knowledge skill, temporal), transactional uncertainty(product-, process-), personal uncertainty (preference-, and situation-) have a significant positive effect on transaction cost. Second, transaction costs (search, comparison, examination, negotiation, payment, delivery) have a significant negative effect on the choice intention of the experiential product. The results of this study show that the increase of transaction costs can reduce the choice of experiential products and the strategic consideration of experience specificity, transaction uncertainty and individual uncertainty are required to reduce transaction costs. In addition, experiential products lacked access from a transactional and cost-based point of view, and this study contributes theoretically by compensating for the lack.

• Science of Emotion and Sensibility
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• v.24 no.3
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• pp.41-60
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• 2021

The purpose of this research was to determine whether multimodal cues in an online shopping environment could enhance tactile consumer mental imagery, purchase intentions, and attitudes towards an apparel product. One limitation of online retail is that consumers are unable to physically touch the items. However, as tactile information plays an important role in consumer decisions especially for apparel products, this study investigated the effects of multimodal cues on overcoming the lack of tactile stimuli. In experiment 1, to explore the product, the participants were randomly assigned to four conditions; picture only, video without sound, video with corresponding sound, and video with discordant sound; after which tactile mental imagery vividness, ease of imagination, attitude, and purchase intentions were measured. It was found that the video with discordant sound had the lowest average scores of all dependent variables. A within-participants design was used in experiment 2, in which all participants explored the same product in the four conditions in a random order. They were told that they were visiting four different brands on a price comparison web site. After the same variables as in experiment 1, including the need for touch, were measured, the repeated measures ANCOVA results revealed that compared to the other conditions, the video with the corresponding sound significantly enhanced tactile mental imagery vividness, attitude, and purchase intentions. However, the discordant condition had significantly lower attitudes and purchase intentions. The dual mediation analysis also revealed that the multimodal cue conditions significantly predicted attitudes and purchase intentions by sequentially mediating the imagery vividness and ease of imagination. In sum, vivid tactile mental imagery triggered using audio-visual stimuli could have a positive effect on consumer decision making by making it easier to imagine a situation where consumers could touch and use the product.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.26 no.3
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• pp.167-182
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• 2021

This study was carried out to investigate temporal and spatial distribution of macrobenthic community and elucidate effects of environmental factors on change of community structure in an intertidal flat, Hakseong-ri, Boryeong, Korea. Field surveys were seasonally conducted to collect samples of sediment and macrobenthos using can core in triplicate at nine stations in 2016 and 2017. Our results showed that sediment had high mud content (above 60%) in most samples and mean content of loss on ignition was 2.3% in 2016. A total of 79 species was collected in the study site during the study period. Mean density and biomass were 611 ind./m² and 64.1 gWWt/m², respectively. Heteromastus filiformis was the dominant species (48.6%, 297 ind./m²) followed by Macrophthalmus japonicus (10.1%, 62 ind./m²) and Upogebia major (6.9%, 42 ind./m²). Three assembly groups resulted from cluster analysis were more distinguished by interaction between organisms and frequency of dominant species than by physical and chemical environment characteristics. In addition, macrobenthic community in the Hakseong intertidal flat showed seasonal changes based on non metric multidimensional scaling using species abundance.

• Korean Journal of Construction Engineering and Management
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• v.22 no.2
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• pp.12-20
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• 2021

Unsafe working environments slow down working speed in that it takes a lot of time to respond in case of an accident, greatly reducing the productivity of construction work. Therefore, proper safety management that does not impede the productivity of construction works is a very important factor for successful construction project. However especially in mega project, the mutual effects of safety management and productivity are complex. Therefore, this study establishes a causal model between safety management and productivity influencing factors based on effectiveness metrics, and analyzes the effect of increased site congestion due to excessive personnel input, irregular safety measures and inefficient change of work schedules. The result of this study, is expected to contribute to enhancing the competitiveness of the construction industry as the basis for establishing a safety management plan that can secure appropriate productivity.

• Journal of Korean Elementary Science Education
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• v.40 no.1
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• pp.113-125
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• 2021

In this study, a problem-centered learning based STEAM field experience learning program was developed and the effects of applying it were investigated. The program was composed of 8 sessions by using problem-centered learning education method and integrating STEAM elements between disciplines. The contents of program are as follow. In the step of sharing problems and making a problem-solving plan, they understood the various examples and meanings of endangered species, explored the project activities, and made an inquiry plan. In the search and re-exploration phase, a smart device was used to investigate the appearance, habitat environment and cause of extinction for Clithon retropictus, and a site inquiry plan was established for each group. Then, they moved to the field to explore brackish-headed gallops and discuss ways to protect endangered species. In the step of creating a solution, a web-based report was produced as the final product using smart devices based on the results of the inquiry. In the presentation and evaluation stage, the produced web-based report was used to present each group, conduct mutual evaluation, and organize project activities. The developed program was applied to 6th grade 29 students enrolled in the J University Gifted Education Center. In order to find out the effectiveness of the program, tests of science process skill, creative problem-solving ability, and scientific attitude were conducted before and after of program learning, and the results were statistically analyzed by t-test. In addition, a STEAM program satisfaction test was conducted after project in order to find out the satisfaction of the class. As a result of application of the program, the results were significantly improved in openness, criticism, and creativity among the sub-factors of creative problem-solving ability and scientific attitude. Satisfaction with the STEAM program was also high, but no significant result was found in science process skill. Therefore, the program of this study could be influenced on improvement of creative problem-solving ability and scientific attitude of gifted students in elementary science.

• The Journal of Society for e-Business Studies
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• v.26 no.2
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• pp.95-122
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• 2021

As it recently became a non-face-to-face society because of the COVID-19 Pandemics, attempts have been made to experience heritage based on virtual reality (VR). Despite the satisfaction of VR contents, however, questions are being raised about whether the VR experience leads to visit a heritage tour or reduces to visit a heritage tour. This study examined how VR-based heritage experiences affect the visit intention of heritage sites. In addition, this study investigated how VR-based experiences differently affect the visit intention compared to web-based experiences. To this end, based on the information success model proposed by DeLone and McLean, this study examined how the perception for system quality and information quality through VR (vs. web) experience affects the intention of visiting the historical site. The results demonstrated that satisfaction was positively influenced by the convenience of system quality and the presence and usefulness of information quality and that the presence and satisfaction positively affected continuance intention. In addition, continuous intention to use positively affected the visit intention of heritage sites. Lastly, it has been shown that the usefulness of information quality in groups experiencing content through the Web (vs. VR) has a greater impact on the intent of continuous use. Based on the results of this study, we discussed ways to organize tourism content to increase the intention of visiting heritage sites.

• Journal of Dental Rehabilitation and Applied Science
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• v.37 no.2
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• pp.61-72
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• 2021

A beautiful smile is made when it is symmetrical and gums are displayed less than 2 - 3 mm. Excessive gingival display also known as "gummy smile" is often recognized to be unaesthetic. Causes of gummy smile can be caused by delayed eruption, vertical maxillary excess, hypermobile upper lip, or a short upper lip. Meanwhile botulinum toxin which is an exotoxin produced from Clostridium botulinum, works by blocking the release of acetylcholine from the cholinergic nerve end plates leading to inactivity of the muscles. The application site and weakens the muscle tone is drawing attention as a gummy smile treatment caused by hypermobile upper lip. There have been many studies about the method of injecting botulinum toxin into muscles around the lips, but there is still no standardized research method and treatment method, so there is controversy over the therapeutic effect. The aim of this study is to review the previous studies about the predictors of indication and effects of gummy smile treatment using botulinum toxin injection. Especially we tried to propose a protocol for optimal dose and efficient injection point through the anatomical considerations for gummy smile treatment using botulinum toxin.