• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.8
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• pp.196-202
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• 2013

Basal cell carcinoma (BCC) is the most common skin cancer and its incidence is increasing rapidly. In this paper, we propose a diagnosis method of basal cell carcinoma by Raman spectra of skin tissue using the NMF(non-negative matrix factorization) algorithm. After preprocessing steps, measured Raman spectra is used classification experiments. The weight and the basis can be obtained in a simple matrix operation and a column vector of the matrix decompsed by the NMF. Linear combination of bases and weights, it is possible to approximate the average of Raman spectra. The classification method is to select the class which to minimize the root mean square of the difference of the linear combination and the objective spectrum. According to the experimental results, the proposed method shows the promising results to diagnosis BCC. In addition, it confirmed that the proposed method compared with the previous research result could be effectively applied in the analysis of the Raman spectra.

• Korean Journal of Pharmacognosy
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• v.44 no.1
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• pp.10-15
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• 2013

This study was carried to establish a simple isolation and purification method of ginsenoside $F_1$ from leaves of Panax ginseng and was to evaluate the inhibitory effect of purified ginsenoside $F_1$ on the activities of elastase and tyrosinase. The content of ginsenoside $F_1$ was 90-fold higher in leaves than in root of ginseng. Ginsenoside $F_1$ was isolated from EtOAc fraction between EtOAc and alkalized water of 80% EtOH extract after remove of hydrophobic components. The 50% inhibitory concentration ($IC_{50}$) of ginsenoside $F_1$ on elastase activity and tyrosinase activity was 1.07 mM and 1.81 mM, respectively. Especially, inhibitory effect of ginsenoside $F_1$ on tyrosinase activity was higher than that of arbutin ($IC_{50}$; 2.20 mM). These results indicate that ginsenoside $F_1$ have a potential for industrial cosmetic materials.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.1
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• pp.203-209
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• 2009

The purpose of this study is to develop a minimally constraint joint angle measurement system for the feedback control of FES (functional electrical stimulation) locomotion. Feedback control is desirable for the efficient FES locomotion, however, the simple on-off control schemes are mainly used in clinic because the currently available angle measurement systems are heavily constraint or cosmetically poor. We designed a new angle measurement system consisting of a magnet and magnetic sensors located below and above the ankle joint, respectively, in the rear side of ipsilateral leg. Two magnetic sensors are arranged so that the sensing axes are perpendicular each other. Multiple positions of sensors attachment on the shank part of the ankle joint model and also human ankle joint were selected and the accuracy of the measured angle at each position was investigated. The reference ankle joint angle was measured by potentiometer and motion capture system. The ankle joint angle was determined from the fitting curve of the reference angle and magnetic flux density relationship. The errors of the measured angle were calculated at each sensor position for the ankle range of motion (ROM) $-20{\sim}15$ degrees (dorsiflexion as positive) which covers the ankle ROM of both stroke patients and normal subjects during locomotion. The error was the smallest with the sensor at the position 1 which was the nearest position to the ankle joint. In case of human experiment, the RMS (root mean square) errors were $0.51{\pm}1.78(0.31{\sim}0.64)$ degrees and the maximum errors were $1.19{\pm}0.46(0.68{\sim}1.58)$ degrees. The proposed system is less constraint and cosmetically better than the existing angle measurement system because the wires are not needed.

• Korean Journal of Environmental Agriculture
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• v.33 no.3
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• pp.194-197
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• 2014

BACKGROUND: Herbal extracts have been screened for their inhibitory effect of seed germination and root development on weeds, but there is a scarcity of reports for crop growth regulation. The objective of this research was to develop a growth inhibitor on Brassica campestris, and its effective extraction method from herbal medicine extract. METHODS AND RESULTS: Eighty four herbal medicine extracts were tested for their plant growth inhibition activity on B. campestris. The alcohol extracts of Artemisia annua, Cinnamomum cassia, and Mentha arvensis inhibited over 30% of germination and the extract of A. annua, and C. cassia inhibited over 70% of radicle growth at 0.1 % w/w treatment. The partially purified extracts of A. annua, and C. cassia with dichloromethane and hexane showed stronger radicle growth inhibition than the crude extracts on B. campestris. The diethyl ether extract of A. annua showed a similar 50% radicle growth inhibition ($RI_{50}$ = 45 mg/L) to its partially purified extract with dichloromethane or hexane, but the diethyl ether extract of C. cassia showed a worse $RI_{50}$ than the purified extract. CONCLUSION: The alcohol extracts of A. annua, and C. cassia showed potent radicle growth inhibition properties on B. campestris. Diethyl ether proved to be a good solvent for simple extraction from A. annua.

• Journal of Sensor Science and Technology
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• v.9 no.4
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• pp.316-326
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• 2000

A new signal processing algorithm for white light interferometry has been proposed and investigated theoretically. The goal of the algorithm is to determine the absolute optical path length of an interferometer with very high precision (<< one optical wavelength). The algorithm features cross-correlation of interferometer fringe scans and hypothesis testing. The hypothesis test looks for a zero order fringe peak candidate about which the cross-correlation is symmetric minimizing the uncertainty of misidentification. The shot noise limited performance of the proposed signal processing algorithm has been analyzed using computer simulations. Simulation results were extrapolated to predict the misidentification rate at Signal to-Shot noise ratio (SNR) higher than 31 dB. Root-mean-square phase error between the computer-generated zero order fringe peak and the estimated zero order fringe peak has been calculated for the changes of three different parameters (SNR, fringe scan sampling rate, coherence length of light source). Results of computer simulations showed the ability of the proposed signal processing algorithm to identify the zero order fringe peak correctly. The proposed signal processing algorithm uses a software approach, which is potentially inexpensive, simple and fast.

• Annals of Clinical Neurophysiology
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• v.8 no.1
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• pp.1-5
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• 2006

The head thrust maneuver is a simple bedside test of the higher frequency vestibulo-ocular reflex, which is based on Ewald's second law. It is performed by grasping the patient's head and applying a brief, small-amplitude, high-acceleration head turn, first to one side and then to the other. The patient fixates on the examiner's nose and the examiner watches for corrective rapid eye movements (saccades), which are a sign of decreased vestibular response. The "catch-up" saccades after a head thrust in one direction indicate a peripheral vestibular lesion on that side (in the labyrinth or the $8^{th}$ nerve including the root's entry zone in the brain stem). An individual pair of vertical semicircular canals can also be stimulated by turning the head to the right or left by $45^{\circ}$ and then by rotating the head in the pitch plane relative to the body. Recent studies have suggested that assessment of individual semicircular canal function by head thrust test may provide useful information for anatomical and functional details of a variety of peripheral vestibulopathies and for predicting the prognosis of vestibular neuritis. In central vestibulopathy, the head thrust test may also be valuable sign to determine dysfunction of the central pathways from individual semicircular canals and its role for the development of diverse central nystagmus.

• Journal of the military operations research society of Korea
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• v.33 no.2
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• pp.61-73
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• 2007

We examined technological forecasting of extended TFDEA(Technological Forecasting with Data Envelopment Analysis) and thereby apply the extended method to the technological forecasting problem of main battle tank. The TFDEA has the possibility of using comparatively inefficient DMUs(Decision Making Units) because it is based on DEA(Data Envelopment Analysis), which usually leads to multiple efficient DMUs. Therefore, TFDEA may result in incorrect technological forecasting. Instead of using the simple DEA, we incorporated the concept of Super-efficiency, Cross-efficiency, and CCCA(Constrained Canonical Correlation Analysis) into the TFDEA respectively, and applied each method to the case study of main battle tank using verifiable practical data sets. The comparative analysis shows that the use of CCCA with TFDEA results in very comparable prediction accuracies with respect to MAE(Mean Absolute Error), MSE(Mean Squared Error), and RMSE(Root Mean Squared Error) than using the concept of Super-efficiency and Cross-efficiency.

• Journal of Biosystems Engineering
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• v.27 no.4
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• pp.341-348
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• 2002

Quality evaluation of red ginsengs is determined by outer shape and inner qualities. Especially, the inner qualities are main grading criteria. Currently, red ginsengs are classified into 3-grades; heaven, earth and good. The best heaven grade must not include inner holes and sponge tissues. This study was conducted to develop a red ginseng sorting system using x-ray image processing technique. Because of lens characteristic, gray values of the central region in the x-ray image are higher and gradually decreased towards the edge regions. This difference of gray values gives trouble in segmentation and detection of inner holes in red ginseng image, so preprocessing technique is necessary. The preprocessing was done by subtracting source image from an empty background image. But, simple subtraction was not quite appropriate because of too small contrast between inner holes and sound part. Scaled subtraction images were obtained by multiplying all gray values by some numbers. However this method could not help to set threshold value because the gray values of root part are generally lower than body part when red ginseng is exposed to the x-ray. To determine threshold value for detecting inner holes, an algorithm was developed by increasing overall gray values of less clear images.

• Analytical Science and Technology
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• v.12 no.3
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• pp.260-264
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• 1999

A simple and rapid procedure, called FoLT-PCR(Formamide Low Temperature-Polymerase Chain Reaction) was applied to amplifying DNA directly from various forensic biological evidences including human blood, saliva, hair root, or semen without any DNA preparative steps. We added washing step with non-ionic detergent, 1% Triton X-100, and used Taq DNA polymerase instead of Tth DNA polymerase to amplify 3 STR loci and gender allele simultaneouly. Optimal concentration of formamide and annealing temperature were determined empirically to 8%(v/v), and $48^{\circ}C$ respectively. We also compared this method with standard PCR.

• Journal of Pharmaceutical Investigation
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• v.24 no.3
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• pp.155-165
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• 1994

Some mucoadhesive polymers such as hydroxypropylcelluose (HPC) and carbopol-934 (CP) have been employed for the preparation of mucoadhesive polymeric systems, and their physical properties including mucoadhesion, swelling, and drug release were evaluated. A new simple experimental technique that can quantitatively measure the bioadhesive properties of various polymeric systems has been developed by the methods of detachment force test. As the polymeric systems, the discs of freeze-dried HPC/CP solid dispersions were prepared. The mucosa used in these tests were upper, middle, and lower parts of small intestine of male rats weighing $300{\sim}350\;g$. Detachment forces were increased as the mole fraction of CP increased in discs of HPC/CP solid dispersions. In the points of intestinal site dependence of mucoadhesion, the solid dispersions revealed non-specific mucoadhesion to the intestine. Swelling and drug release characteristics of mucoadhesive polymeric systems were studied extensively to find out the feasibility for the oral controlled delivery systems. Swelling ratio, expressed as the final height/initial height, has been determined in various pH buffer solutions. Hydrochlorothiazide (HCT) was employed as a model drug for release study. Apparent swelling and drug release rate constants, $K_s$ and $K_r$ respectively, were obtained from the square-root time plot of either swelling ratio or released amount of drug, particularly for the time periods before reaching the equilibrium. As a result, the swelling ratio of HPC/CP solid dispersions was increased as the weight percentage of CP increased. Similarly, the release of HCT from the solid dispersions was dependent on pH changes and CP contents, resulted in the slower release of HCT with the increases of pH and CP contents.