• 대한한방내과학회지
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• 제31권4호
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• pp.775-791
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• 2010

Objectives : Woohwangchungsim-won has been used for acute diseases such as cerebrovascular disease (stroke), heart disease. The aim of this study was to determine the effects, significance & necessity of Woohwangchungsim-won in acute stages of these disease by reviewing Korean articles about Woohwangchungsim-won. Methods : Article searches were performed on 8 major Korean web article search engine from January 1980 to August 2010. There were no restrictions on the types of publication, including grey articles. Results : Forty-three articles were included. Twenty one were efficacy tests, thirteen were comparative efficacy tests, eight were toxicity tests, and one was new method development. Eighteen articles were multicenter studies and twenty five were single center studies. Thirty two articles were animal testing, only ten articles were clinical articles. Thirty seven articles presented the composition and quantity of Woohwangchungsim-won, but six did not. Conclusions : The results of Korean articles about Woohwangchungsim-won can not strongly support the effects, significance & necessity of Woohwangchungsim-won. More rigorous studies are required for determination of the effects of Woohwangchungsim-won.

• Communications for Statistical Applications and Methods
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• 제16권3호
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• pp.397-408
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• 2009

마이크로어레이 기술은 수만 개 유전자의 발현 패턴을 동시에 관찰하는 것을 가능하게 하였고, 이들을 하나씩 검정하여 찾아낸 특이발현 현상을 보이는 유전자를 중심으로 질병의 진단, 치료법 정립과 신약 개발을 위한 기본 정보를 확립하였다. 그러나 개별 유전자분석의 여러 문제점이 발견되면서 유전자들을 생물학적 대사경로나 염색체 위치가 같은 것끼리 묶은 집단을 분석하여 질병의 발생이나 생존에 영향을 미치는 집단을 찾는 방법이 제시되었다. 이러한 유전자 집단의 유의성에 대한 연구는 2002년에 MIT에서 비롯되어 GSEA, SAM-GS와 중심극한 정리의 개념을 이용한 모수적 방법인 PAGE 등이 사용되고 있다. 본 논문에서는 이들 통계량의 구조적 한계를 극복하고 계산이 간단한 새로운 모수적 방법을 제안하고 자료 분석을 통하여 효율성을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.325-327
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• 2013

Objective: To differentiate between benign and malignant hyperparathyroidism on the basis of excretion of HCG and its malignant isoforms in urine. Materials and Methods: This hospital based study was carried out using data retrieved from the register maintained in Manipal Teaching Hospital from $1^{st}$ January, 2008 and $31^{st}$ August, 2012. The variables collected were urinary HCG and HCG malignant isoform, calcium and parathyroid hormone. Preceding the study, approval was obtained from the institutional research ethical committee. Analysis was by descriptive statistics and testing of hypothesis. A p-value of <0.05 (two-tailed) was used to establish statistical significance. Results: Out of the 20 cases, 10 were primary hyperparathyroidism and the remainder were parathyroid carcinomas. The urinary HCG $6.1{\pm}0.6$ fmol/mgCr was with in normal range in benign hyperthyroidism but was markedly elevated in three cases of malignant hyperparathyroidism (maximum value of excretion in urine for HCG was 2323 fmol/mgCr). The excretion of malignant isoform of HCG in urine was 0 in benign hyperparathyroidsm and in four cases of malignant hyperparathyroidism which fell into the category of persistantly low HCG. The maximum excretion of the malignant isoform of HCG in urine was 1.8, in the category of very high HCG. Calcium and parathyroid hormone were mildly raised in benign parathyroidism, while parathyroid hormone was markedly elevated in cases of malignant hyperparathyroidism falling into the category of very high HCG. Conclusions: The excretion of urinary HCG in urine has the ability to distinguish between parathyroid adenomas and carcinomas and thus has potential to become a marker of disease progression in malignant parathyroid disease.

• 대한지리학회지
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• 제40권2호
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• pp.187-201
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• 2005

경제 클러스터와 도시 고용중심지에 대한 연구는 최근 지리학 분야에서 매우 중요하게 다루어지고 있다. 그러나 경제 클러스터 탐색을 위한 기존 연구들은 탐색방법의 내재적 한계, 선형 클러스터 탐색의 비효율성, 경제적 유의성 검증의 부족등의 문제를 내포하고있다 본 연구의 목적은 경제 클러스터 탐색방법으로서 통계적, 경제적 유의성을 검증하는 VCEC(Variable Clumping method for Economic Clusters)를 제안하는 것이고, 이를 바탕으로 미국 뉴욕주 이리 카운티(Erie County)의 경제 중심지 탐색을 위한 실증적 경험 사례분석을 하는 것이다. 다양한 탐색 반경과 총 고용인구 한계치의 적용을 통해 통계적, 경제적인 유의성을 가진 경제중심지 탐색이 가능하였다.

• Genomics & Informatics
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• 제8권1호
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• pp.28-33
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• 2010

Increased exposure of human to RF fields has raised concerns for its potential adverse effects on our health. To address the biological effects of RF radiation, we used genome wide gene expression as the indicator. We exposed normal WI-38 human fibroblast cells to 1763 MHz mobile phone RF radiation at a specific absorption rate (SAR) of 60 W/kg with an operating cooling system for 24 h. There were no alterations in cell numbers or morphology after RF exposure. Through microarray analysis, we identified no differentially expressed genes (DEGs) at the 0.05 significance level after controlling for multiple testing errors with the Benjaminiochberg false discovery rate (BH FDR) method. Meanwhile, 82 genes were differentially expressed between RF-exposed cells and controls when the significance level was set at 0.01 without correction for multiple comparisons. We found that 24 genes (0.08% of the total genes examined) were changed by more than 1.5-fold on RF exposure. However, significant enrichment of any gene set or pathway was not observed from the functional annotation analysis. From these results, we did not find any evidence that non-thermal RF radiation at a 60-W/kg SAR significantly affects cell proliferation or gene expression in WI-38 cells.

• Asian-Australasian Journal of Animal Sciences
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• 제16권8호
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• pp.1087-1092
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• 2003

As an experimental reference population, crosses between Korean native pig and Landraces were established and information on growth traits was recorded. Animals were genotyped for 24 microsatellite markers covering chromosomes 2, 6, and 7 for partial-genome scan to identify chromosomal regions that have effects on growth traits. quantitative trait loci (QTL) effects were estimated using interval mapping by the regression method under the line cross models with a test for imprinting effects. For test of presence of QTL, chromosome-wide and single position significance thresholds were estimated by permutation test and normal significance threshold for the imprinting test were derived. For tests against the Mendelian model, additive and dominance coefficients were permuted within individuals. Thresholds (5% chromosome-wide) against the no-QTL model for the analyzed traits ranged from 4.57 to 4.99 for the Mendelian model and from 4.14 to 4.67 for the imprinting model, respectively. Partial-genome scan revealed significant evidence for 4 QTL affecting growth traits, and 2 out of the 4 QTLs were imprinted. This study demonstrated that testing for imprinting should become a standard procedure to unravel the genetic control of multi-factorial traits. The models and tests developed in this study allowed the detection and evaluation of imprinted QTL.

• Journal of Korean Neurosurgical Society
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• 제37권2호
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• pp.89-95
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• 2005

Objective: The biomechanical stabilities between the anterior plate fixation after anterior discectomy and fusion (ACDFP) and the posterior transpedicular fixation after ACDF(ACDFTP) have not been compared using human cadaver in bilateral cervical facet dislocation. The purpose of this study is to compare the stability of ACDFP, a posterior wiring procedure after ACDFP(ACDFPW), and ACDFTP for treatment of bilateral cervical facet dislocation. Methods: Ten human spines (C3-T1) were tested in the following sequence: the intact state, after ACDFP(Group 1), ACDFPW(Group 2), and ACDFTP(Group 3). Intervertebral motions were measured by a video-based motion capture system. The range of motion(ROM) and neutral zone(NZ) were compared for each loading mode to a maximum of 2.0Nm. Results: ROMs for Group 1 were below that of the intact spine in all loading modes, with statistical significance in flexion and extension, but NZs were decreased in flexion and extension and slightly increased in bending and axial rotation without significances. Group 2 produced additional stability in axial rotation of ROM and in flexion of NZ than Group 1 with significance. Group 3 provided better stability than Group 1 in bending and axial rotation, and better stability than Group 2 in bending of both ROM and NZ. There was no significant difference in extension modes for the three Groups. Conclusion: ACDFTP(Group 3) demonstrates the most effective stabilization followed by ACDFPW(Group 2), and ACDFP(Group 1). ACDFP provides sufficient strength in most loading modes, ACDFP can provide an effective stabilization for bilateral cervical facet dislocation with a brace.

• The Journal of Advanced Prosthodontics
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• 제4권3호
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• pp.121-126
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• 2012

PURPOSE. The aim of the study was to evaluate the effect of 3 silicone primers and 3 surface characterization of acrylic resin surface on bond strength between silicone elastomer and acrylic resin. MATERIALS AND METHODS. 96 Cosmesil silicones bonded to heat-curing acrylic resin were fabricated with the dimension of $75{\times}10{\times}3$ mm. The 3 primers used in this study were G611 platinum primer, A-330 Gold platinum primer, and cyanoacrylates resin. Specimens without primer were used as control. The 3 types of surface characterization done were retentive holes with 1.5 mm in diameter and 0.5 mm deep, retentive beads of 0.6 mm diameter and the third type which was plain without any characterization. The specimens were then checked for bond strength by subjecting them to $180^{\circ}$ peel test on a universal testing machine. The obtained results were then subjected to statistical analysis using 2-way ANOVA and Scheff$\acute{e}$ multiple post hoc procedures. The statistical significance was set at 5% level of significance. RESULTS. The maximum bond strength was seen for samples in which A-330G primer was used followed by G611 primer. The control group showed the minimum bond strength. Surface characterization of retentive holes increased the bond strength considerably as compared to retentive beads and samples without any surface characterization. CONCLUSION. Within the limitations of the study, A-330G primer was more compatible with Cosmesil M511 silicone and has better bonding of Cosmesil to acrylic resin. Retentive holes made on acrylic surface increased the bond strength considerably than those without any surface characterization.

• 한국지능시스템학회논문지
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• 제18권1호
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• pp.139-144
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• 2008

일반적으로 의사결정의 대상이 되는 현실 시스템은 매우 가변적(variable)이며 때로는 많은 불확실성(uncertainty)이 포함된 상황에 놓일 수 있다. 이러한 문제를 해결하기 위해서, 통계적 방법으로 유의수준이나 확신도, 민감도 분석 등이 사용된다. 본 논문에서는 유사성 평가를 가진 분류 결과의 명확성을 개선하기 위해 MFAC(Multiple Fuzzy Alpha Cut)을 기반으로한 퍼지 의사결정에 대한 방법을 제안한다. 제안된 방법에서 MFAC는 상대적 해밍거리와 max-min 방법 사이의 근접관계에서 근접도를 가지고 다수의 ${\alpha}$-level를 추출하기 위해 그리고 MFAC에 의해 추출된 데이터사이의 분할 구간과 연관된 데이터의 개수를 줄이기 위해 사용된다. 의사결정의 최종 대안을 선택하기 위해서 가중치를 계산한다. 실험결과로부터 제안된 방법은 기존 방법의 분류 성능보다 더 간단하고 명백하며 통계적 방법을 통해 표본 데이터의 유의성을 검정함으로써 의사결정자를 위해 효율적으로 대안을 결정한다는 사실을 알 수 있다.

• 한국의류산업학회지
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• 제22권6호
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• pp.789-802
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• 2020

This study analyzes the experiences of a color therapy program that uses color and fashion directing to influence the psychological characteristics of adolescents, such as emotional intelligence, self-efficacy, and color expression. The subjects of this study were 15 adolescents who participated in B-City Winter School (January 6-15, 2020). Pre- and post-tests for emotional intelligence and self-efficacy were conducted to confirm the effect of the color therapy program that indicated a significant difference at the p<.05 level. Statistical significance was confirmed through the GEE model for formal characteristics used in pre/post and fashion-directed color expression. Peter pre- and post-changes in vocabulary emergence were investigated with a Word Cloud analysis using R program 4.0.2 that extracted the lower and upper categories. The significance of this study is that by expressing both color expression and fashion direction together, a program was provided for adolescents to have richer emotional experiences and career-related experiences. This study examined changes within a short period of time in 15 subjects; consequently, a follow-up in-depth qualitative analysis of the program effect and a post-testing study on maintaining the long-term effect is expected to secure further validity and usefulness of the study results. In addition, new studies are expected to contribute to the development of differentiated fashion-related education programs.