• Title/Summary/Keyword: sex expression

Search Result 342, Processing Time 0.029 seconds

Estrogen Receptor-α Mediates the Effects of Estradiol on Telomerase Activity in Human Mesenchymal Stem Cells

  • Cha, Young;Kwon, Su Jin;Seol, Wongi;Park, Kyung-Soon
    • Molecules and Cells
    • /
    • v.26 no.5
    • /
    • pp.454-458
    • /
    • 2008
  • Sex steroid hormone receptors play a central role in modulating telomerase activity, especially in cancer cells. However, information on the regulation of steroid hormone receptors and their distinct functions on telomerase activity within the mesenchymal stem cell are largely unavailable due to low telomerase activity in the cell. In this study, the effects of estrogen ($E_2$) treatment and function of estrogen receptor alpha ($ER{\alpha}$) and estrogen receptor beta ($ER{\beta}$) on telomerase activity were investigated in human mesenchymal stem cells (hMSCs). Telomerase activity and mRNA expression of the catalytic subunit of telomerase (hTERT) were upregulated by treatment of the cells with $E_2$. The protein concentration of $ER{\alpha}$ was also increased by $E_2$ treatment, and enhancement of $ER{\alpha}$ accumulation in the nucleus was clearly detected with immunocytochemistry. When $ER{\alpha}$ expression was reduced by siRNA transfection into hMSCs, the effect of $E_2$ on the induction of hTERT expression and telomerase activity was diminished. In contrast, the transient overexpression of $ER{\alpha}$ increased the effect of $E_2$ on the expression of hTERT mRNA. These findings indicate that the activation of hTERT expression and telomerase activity by $E_2$ in hMSCs depends on $ER{\alpha}$, but not on $ER{\beta}$.

Responses of HSP Gene Expressions to Elevated Water Temperature in the Nile tilapia Oreochromis niloticus

  • Kwon, Joon-Yeong;Kim, Ju-Yeong
    • Development and Reproduction
    • /
    • v.14 no.3
    • /
    • pp.179-184
    • /
    • 2010
  • Water temperature influences on various key biological events in fish, but the internal pathway of the temperature effects are not well understood. Heat shock proteins (HSPs), known to respond in the level of cells to many environmental factors including temperature, could improve our understanding on the pathway. Some biological processes such as gonadal development and sex differentiation in the Nile tilapia Oreochromis niloticus is particularly sensitive to water temperature. In this study, we have investigated the expressions of HSP70 and HSP90 genes in young tilapia at an ordinary temperature ($28^{\circ}C$) and elevated water temperature ($36^{\circ}C$). The distribution of the expressions of HSP70 and HSP90 mRNA in this species were found to be almost ubiquitous, being detected in all tissues studied here (brain, gonad, liver and muscle), suggesting the house keeping functions of these genes. Heat shock by elevating temperature from $28^{\circ}C$ to $36^{\circ}C$ significantly increased the expression of HSP70 mRNA in the gonad, liver and muscle for several hours (P<0.05) (brain tissue was not examined for this). The increased level of HSP70 gene expression recovered to the level at control temperature ($28^{\circ}C$) when fish were kept continuously at high temperature ($36^{\circ}C$) for 24 hours. Contrary to this, expression of HSP90 mRNA did not show significant increase in the gonad and muscle by the same heat shock (P>0.05), except in the liver where the expression of HSP90 mRNA increased continuously for 24 hours at $36^{\circ}C$. The results obtained in this study suggest that response to temperature change in different tissue or organ may utilize different heat shock proteins, and that HSP70 may have some importance in temperature-sensitive gonadal event in the Nile tilapia.

A Study on the Relationship between Needs and Factors of Clothing Selection (의복선택요인과 욕구와의 상관성에 관한 연구 -여대생을 중심으로-)

  • Chung Ha Sin;Lee In Ja
    • Journal of the Korean Society of Clothing and Textiles
    • /
    • v.7 no.1
    • /
    • pp.27-35
    • /
    • 1983
  • The purpose of this study is to find out the relationship between needs and factors of clothing Selection. 400 women students from 4 universities and colleges in Seoul were selected and tested. And Hwang Jeongkyu's Needs inventory test sheets for need inventory test and the questionnaire based on Lee Eunju's study for factors of clothing selection were given to the sample. The test data was computerized to get the relationship. The results are as follows: (I) Behavior of clothing selection according to expression of individuality correlated significantly with achievement, aggression, dominance, emotionality, exhibitionism, sex, and autonomy at the .01 level. (2) Behavior of clothing selection according to utility correlated significantly with abasement, and affiliation at the .01 level. and with emotionality at the .05 level, (3) Behavior of clothing selection according to economy correlated significantly with abasement, affiliation, dominance, emotionality, and exhibitionism at the .05 level, and with achievement at the .01 level. (4) Behavior of clothing selection according to modesty correlated significantly with abasement, exhibitionism, and sex at the .01 level. (5) Behavior of clothing selection according to conformity correlated significantly with abasement, emotionality, and autonomy at the .01 level, and with dominance at the .05 level.

  • PDF

Mother-Toddler Verbal Interaction Comparative Study in Traditional, Free and Block Play (어머니-영아간 전통놀이, 자유놀이, 블록놀이의 언어적 상호작용 비교)

  • Lee, Heang-Suk;Han, Eu-Gene
    • Journal of Families and Better Life
    • /
    • v.27 no.1
    • /
    • pp.181-196
    • /
    • 2009
  • This study compared mother-toddler verbal interaction by play type (traditional play, free play, block play), and child's sex and age. Subjects were 10 boys and 10 girls ranging in age from 25- to 36-months and their mothers. An observer videotaped the children and their mothers at play in their homes. Results showed that (1) Mothers attempted more positive verbal interaction in traditional than in block play. (2) Mothers expressed more positive emotion in free than in traditional and block play. (3) Mothers more answer 'reflection' in traditional than in free play (4) Toddlers attempted more positive verbal interaction in block than in traditional and free play. (5) Toddler's positive emotion express was not distinguished by play type or by child's sex or age. (6) From 31- to 36-months's boys expressed more play situation than from 25- to 30-months' girls. This study provides groundwork for mother-toddler traditional play programs with potential for improving positive expression of emotion and language development.

Repression of $PPAR{\gamma}$ Activity on Adipogenesis by $17{\beta}$-estradiol in Differentiated 3T3-L1 Cell

  • Yoon, Mi-Chung;Jeong, Sun-Hyo
    • Biomedical Science Letters
    • /
    • v.15 no.3
    • /
    • pp.179-185
    • /
    • 2009
  • In our previous report, we showed that $PPAR{\gamma}$ does not influence adipogenesis in females with functioning ovaries, indicating that $PPAR{\gamma}$ activity on adipogenesis is associated with sex-related factors. Among the sex-related factors, estrogen has been recognized as a major factor in inhibiting adiposgenesis in females. Thus, we hypothensized that $17{\beta}$-estradiol (E) inhibits 3T3-L1 cell adipogenesis by preventing $PPAR{\gamma}$ activity. E decreased triglyceirde accumulation in differentiated 3T3-L1 cells compared with control group. E also decreased the expression of $PPAR{\gamma}$ mRNA as well as $PPAR{\gamma}$ dependent adipocyte-specific genes, such as adipocyte fatty acid binding protein and tumor necrosis factor $\alpha$. In addition, E not only decreased luciferase reporter activity by $PPAR{\gamma}$, but also transfection of estrogen receptor $\alpha$ ($ER{\alpha}$) or $ER{\beta}$ led to decreases in $PPAR{\gamma}$ reporter gene activation. Moreover, E-activated ERs significantly decreased the luciferase reporter gene activation induced by $PPAR{\gamma}$ transfection, suggesting that estrogen-activated ERs inhibit $PPAR{\gamma}$-dependent transactivation. Accordingly, our results demonstrate that E inhibits the action of $PPAR{\gamma}$ on adipogenesis through E activated ER, providing evidence that lack of estrogen may potentiate $PPAR{\gamma}$ action on adipogenesis.

  • PDF

A Study on Consumer's Response for Post-modernism Fashion Advertisement (포스트 모더니즘 의류광고에 대한 소비자 반응연구)

  • Won, Ul-Chi;Lee, Sun-Jae
    • Journal of the Korean Society of Costume
    • /
    • v.46
    • /
    • pp.187-207
    • /
    • 1999
  • The fashion advertisement is communication method between clothing and consumer. The development of mass communication accelerated that In modern society Post-modernism advertisement is a specialized and separated from so it confuses the consumers who are used in traditional AD. The peculiarities (non-form, destruction of description, compound of genre, mixing of reality and fiction) are more reflected in fashion advertisement. The sample consisted of 425 mail and female and the results were analyzed using frequency and percentage calculation Close tabs T-Test Oneway Anova Factor analysis Chi-square Test, Regression, Correlation Analysis. The result of this study were as follows: The post-modernism fashion ad is the separated and reflected from for young age's favorite. By the factor analysis of consumer response in each 5 emotional factors proved to be valid ones(fine, negative, sexual, stimulative, constructive aspects.) The fine and negative aspects of the factors are very concerned with the consumer's favorite attitude of fashion ad. There is no significant difference in age job but sex has a significant difference. In according to the method of the ad expression consumer's acceptance is difference in sex. There were no significant concern with excess effects and purchase intend in fashion advertisement.

  • PDF

A Study on Erotic Style of Fashion

  • Chun, Hei-Jung
    • International Journal of Costume and Fashion
    • /
    • v.7 no.2
    • /
    • pp.49-63
    • /
    • 2007
  • In this study, we inquire into the general concepts of eroticism as it appears in literature and the arts, and use this as a foundation to meditate on the eroticism of attire throughout history. We also ascertained external forms based on the range of "The way we look" by Delong. In this way we inclusively studied both the content and form of modes of eroticism in the perspective of Brodsky's "linked solution." The original concept of eroticism is a technique by which one attains physical passion, referring to a nature which is deeply rooted in the cultural traditions, myths, habits. religion and arts of mankind, inducing expressions of sensual love. We integrated this eroticism in 4 categories: sensuality, which induces beauty; naturality, denoting idealization or rational beauty; primitivity, characterized by grotesque expressions or direct and natural sexual depictions; and symbolism by which sex is symbolically or mechanically projected. The concept of eroticism contains both positive and negative aspects, but rather than dealing with sex in a mechanical or perverted manner to express eroticism, it is more appropriate to guide the direction of modes of eroticism by stimulating the "desire to show" and the "desire to see" with the dialectic of obstruction and exposure as a figurative expression of true passion, and narcistic phenomena in which beauty is expressed through exaggeration or magnification and adhesion.

A Study on the Relationship among Family strengths, Cultural disposition and Interpersonal relations dispositions in Adolescent's sex. (청소년의 성별에 따른 가족건강성 및 문화성향과 대인관계성향간의 관계분석)

  • Kim, Byung-Su
    • Journal of Korean Home Economics Education Association
    • /
    • v.21 no.4
    • /
    • pp.91-103
    • /
    • 2009
  • The purpose of this study was to examine how family strengths and cultural disposition were correlated to their interpersonal relationship. Participant of this research were 282 boys and girls who were high schools. Major findings of this study were as follows: 1) there was statistically significant differences in the interpersonal dispositions between sex. 2) boys and girls were significantly conncerning positive correlation among family strengths, cultural disposition and interpersonal dispositions. Multiple regression analysis showed that family strengths, cultural disposition and variables influenced social relation orientation and expression orientation.

  • PDF

A Study of Future Fashion Image Showed in S.F Movie (S­F 영화속에 표현된 미래패션의 Image에 관한 연구)

  • 이은영;나은강
    • Journal of the Korea Fashion and Costume Design Association
    • /
    • v.2 no.2
    • /
    • pp.19-40
    • /
    • 2000
  • It is supposed that the future fashion could be made by the scientist instead of fashion designer. Because it is so intellectual and avantguard. In addition to this the practical value and a certain identity is needed in this future fashion. Especially, the intention of no acceptance of categorization could be explained through the fashion clud of young people and the extremeness in the street. Paul Hedmus has insited that Tokyo club is closely related the fashion styles depended on the western historical street fashions. Fashion is mixeded contrasted, modified, resembled, reversed and finally it includes the new neaning. Instead of distinguishable logo there are lots of messages in the fashion. There are a few thousand of young people who wear silver max metal shoes. And they craze the neon picture and advertisement implies meaning the drug. It could be applied to the people of 90's. The difference between sex from the stone age is induced basically from the fashion and the part of discussion of sex. In this study we research the images of future fashion showed in SF Movie, Star Wars, Episode, The 5th Elements, Nirvana. Those were geometric and natural, technological expansion of space, corset fashion acessoruy image and geometric expression and these characteristics implied in modern fashion trend and future fashion images. Because it is supposed to the future image of current fashion. The millenium fashion is more realistic, practical, and natural instinct realization of ideal. but it is not the unrealistic, the vague of the regendary image.

  • PDF

A Pair of Oviduct-Born Pickpocket Neurons Important for Egg-Laying in Drosophila melanogaster

  • Lee, Hyunjin;Choi, Hyun Woo;Zhang, Chen;Park, Zee-Yong;Kim, Young-Joon
    • Molecules and Cells
    • /
    • v.39 no.7
    • /
    • pp.573-579
    • /
    • 2016
  • During copulation, male Drosophila transfers Sex Peptide (SP) to females where it acts on internal sensory neurons expressing pickpocket (ppk). These neurons induce a post-mating response (PMR) that includes elevated egg-laying and refractoriness to re-mating. Exactly how ppk neurons regulate the different aspects of the PMR, however, remains unclear. Here, we identify a small subset of the ppk neurons which requires expression of a pre-mRNA splicing factor CG3542 for egg-laying, but not refractoriness to mating. We identify two CG3542-ppk expressing neurons that innervate the upper oviduct and appear to be responsible for normal egg-laying. Our results suggest specific subsets of the ppk neurons are responsible for each PMR component.