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http://dx.doi.org/10.14348/molcells.2016.0121

A Pair of Oviduct-Born Pickpocket Neurons Important for Egg-Laying in Drosophila melanogaster  

Lee, Hyunjin (School of Life Sciences, Gwangju Institute of Science and Technology)
Choi, Hyun Woo (School of Life Sciences, Gwangju Institute of Science and Technology)
Zhang, Chen (School of Life Sciences, Gwangju Institute of Science and Technology)
Park, Zee-Yong (School of Life Sciences, Gwangju Institute of Science and Technology)
Kim, Young-Joon (School of Life Sciences, Gwangju Institute of Science and Technology)
Publication Information
Molecules and Cells / v.39, no.7, 2016 , pp. 573-579 More about this Journal
Abstract
During copulation, male Drosophila transfers Sex Peptide (SP) to females where it acts on internal sensory neurons expressing pickpocket (ppk). These neurons induce a post-mating response (PMR) that includes elevated egg-laying and refractoriness to re-mating. Exactly how ppk neurons regulate the different aspects of the PMR, however, remains unclear. Here, we identify a small subset of the ppk neurons which requires expression of a pre-mRNA splicing factor CG3542 for egg-laying, but not refractoriness to mating. We identify two CG3542-ppk expressing neurons that innervate the upper oviduct and appear to be responsible for normal egg-laying. Our results suggest specific subsets of the ppk neurons are responsible for each PMR component.
Keywords
CG3542; egg-laying; phosphoprotein; pickpocket; post mating response; sex peptide;
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