• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.1432-1436
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• 2006

Feasibility of optimizing Zwicker's loudness has been shown by using MSC/NASTRAN, SYSNOISE, and a semi-analytical design sensitivity by Wang and Kang. Design sensitivity analysis of Zwicker's loudness is developed by using ANSYS, COMET, and an adjoint variable method in order to reduce computation. A numerical example shows significant reduction of computation time for design sensitivity analysis.

• Proceedings of the KSR Conference
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• 1998.05a
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• pp.299-306
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• 1998

Design sensitivity analysis of a mechanical system is an essential tool for design optimization and trade-off studies. This paper presents an efficient algorithm for the design sensitivity analysis of railway vehicle systems, using the direct differentiation method. The cartesian coordinate is employed as the generalized coordinate. The governing equations of the design sensitivity analysis are formulated as the differential equations. Design sensitivity analysis of railway vehicle systems is performed to show the validity and efficiency of the proposed method.

• Journal of Industrial Technology
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• v.18
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• pp.233-240
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• 1998

In this study, ride sensitivity analysis of train with non-linear suspension elements is performed. Non-linear characteristics of springs and dampers for primary and secondary suspensions of a train is parameterized. Equation of motion of the train model is derived, and using the direct differentiation method, sensitivity equations are obtained. For a nominal ride quality performance index, sensitivity analysis with respect to various design parameters regarding non-linear suspension parameters is carried out.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.482-485
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• 1993

This paper deals with structured singular value and mixed sensitivity problem for robust performance. We derive the sufficient condition that mixed sensitivity problem satisfies structured singular value in robust performance problem. And we show the bound of perturbation between structured singular value and norm of mixed sensitivity functions.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.1
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• pp.23-34
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• 2016

Purpose: In the present study, the effect of circle contact lenses wear on contrast sensitivity and glare sensitivity in a refractive surgery group was investigated. Methods: The contrast sensitivity and glare sensitivity were evaluated using by CGT-1000 for a non-refractive surgery group as control group(40 eyes) and a refractive surgery group(30 eyes) applied plano circle contact lenses, and pupil size was also measured. The correlation between contrast/glare sensitivity and the pupil size was analyzed. Results: In the refractive surgery group, contrast sensitivity in the range of high spatial frequency decreased with wearing circle contact lenses, and amount of decrease for the refractive surgery group was larger than for the control group. The correlation between pupil size and the change of contrast sensitivity was decreased by wearing circle contact lenses, and the correlation was lower in the refractive surgery group than the control group. Furthermore, the wear of circle contact lenses affected on glare sensitivity. In analyzing the change of glare sensitivity by pupil size, the glare was larger in the refractive surgery group than control group. Circle contact lenses in refractive surgery group were not fitted on the center of cornea. Conclusions: In the present study, it is suggested that the sufficient understanding and consideration about the decrease of contrast sensitivity and the increase of glare by wearing circle contact lenses after the refractive surgery is necessary.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.3
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• pp.355-362
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• 2015

Purpose: To investigate the effects of the transmittance of diffusive blurson visual acuity and contrast sensitivity. Methods: Visual acuity and contrast sensitivity were measured by using Optec$^{(R)}$ 6500 in Healthy 30 subjects aged $22.83{\pm}0.50$ (male 13, female 17) who were recruited from university students. Cataract simulator was used as a tool for diffusive blur. Visual acuity and contrast sensitivity were measured with varying the transmittance of diffusive blur in order to simulate progression of cataract and concentration in fog. Results: Visual acuity was reduced proportionally with decreasing the transmittance of the diffusive blur as follows: $VA(T)=1.84{\times}10^{-2}T-0.645$. Contrast sensitivity was decreased in all spatial frequencies. Contrast sensitivity in a high spatial frequency band was a greater effect and was off the normal range of contrast sensitivity. The peak of contrast sensitivity was moved in the direction to low frequency. From an intersection point of contrast sensitivity function, we could calculated the transmittance of the diffusive blur being off the normal range and the shift to peak spatial frequency. The peak of contrast sensitivity function was observed to move from 6 to 3 cpd at transmittance of about 78.70%, the contrast sensitivities for all frequencies at transmittance of about 69.71% were deviated from the normal range. Conclusions: The transmittance of diffusive blur causes a reduction in visual acuity and contrast sensitivity, a deviation of normal range of contrast sensitivity, and a shift of peak contrast sensitivity. Therefore the more attention is required when suffering from cataracts or driving in fog.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2010.10a
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• pp.491-496
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• 2010

The direct design modification of problematic component is disallowed in order to sacrifice other major factors such as a stability or a major performance. So, the best design policy is to risvise the immature structural medchanism under the minimal design change as soon as possible. For this paper presents a new design sensitivity analysis based on transmissibility rtio (TR) of response acceleration to find a proper candidate for the minimal design modification. The new sensitivity analysis is based on the fact that the sensitivity of TR over a small design change is inversly proportinal to the magnitude of TR. The theory of proposed design sensitivity analysis is simulated with the variance of TR over a dynamic change. Then, new methodology is appplied for a linear elastic specimen to detect the most sensitive node over a design change using measured accleration data during uni-axial vibration test, The physical verification of the sensitivity method is conducted on the CAE model of a linear elastic specimen by adding concentration mass and the vibration fatigue of the simple specimen is analyzed to estimate the relationship between fatigue behaviors and sensitivity consequences.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.10
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• pp.1590-1597
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• 2004

Three methods of design sensitivity analysis for structures such as numerical method, analytical method and semi-analytical method have been developed for the last three decades. Although analytical design sensitivity analysis can provide very exact result, it is difficult to implement into practical design problems. Therefore, numerical method such as finite difference method is widely used to simply obtain the design sensitivity in most cases. The numerical differentiation is sufficiently accurate and reliable fur most linear problems. However, it turns out that the numerical differentiation is inefficient and inaccurate in nonlinear design sensitivity analysis because its computational cost depends on the number of design variables and large numerical errors can be included. Thus the semi-analytical method is more suitable for complicated design problems. Moreover, semi-analytical method is easy to be performed in design procedure, which can be coupled with an analysis solver such as commercial finite element package. In this paper, implementation procedure fur the semi-analytical design sensitivity analysis outside of the commercial finite element package is studied and the computational technique is proposed for evaluating the partial differentiation of internal nodal force, so called pseudo-load. Numerical examples coupled with commercial finite element package are shown to verify usefulness of proposed semi-analytical sensitivity analysis procedure and computational technique for pseudo-load.

• Journal of Microbiology and Biotechnology
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• v.16 no.11
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• pp.1760-1772
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• 2006

Mature acetylcholinesterase (AChE) gene (gm, 1,836 bp) was cloned from the housefly and successfully expressed in the E. coli CodonPlus (DE3) RIL system (GM-E, 72 kDa) with a yield of 1,630 mU/g fresh cells. Using the gm, 10 kinds of mutants were constructed and expressed for enhancing sensitivity to insecticides. The sensitivity of these mutants to five kinds of organophosphate (OP) and three carbamate insecticides was investigated by measuring the apparent bimolecular inhibition constant ($k_i=k_2/K_d$). Surprisingly, the sensitivity of quadruple mutant IGFT was enhanced as much as 7-fold for acephate, 164-fold for demeton-S-methyl, 484-fold for dichlorvos, 523-fold for edifenphos, 30-fold for ethoprophos, 30-fold for benfuracarb, 404-fold for carbaryl, and 107-fold for furathiocarb, compared with that of GM-E, although the sensitivity of each single point mutant was slightly increased. These mutational studies indicated that (i) contradictory to Walsh et al. [39], the residue 327 is the important key residue for enhancing sensitivity as much as the residue 262, (ii) the residue 82 and additional residues of 234, 236, and 585 are also important, and (iii) sensitivity was cooperatively accelerated as the number of strategic mutations increased.

• Computational Structural Engineering
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• v.7 no.1
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• pp.91-98
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• 1994

Design sensitivity analysis method for the vibration of vehicle structure is developed using adjoint variable method. A variational approach with complex response method is used to derive sensitivity expression. To evaluate sensitivity, FEM analysis of ship deck and vehicle structure are performed using MSC/NASTRAN installed in the super computer CRAY2S, and sensitivity computation is performed by PC. The accuracy of sensitivity is verified by the results of finite difference method. When compared to structural analysis time on CRAY2S, sensitivity computation is remarkably economical. The sensitivity of vehicle frame can be used to reduce the vibration responses such as displacement and acceleration of vehicle.