• Title/Summary/Keyword: self-calibration

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Microcantilever biosensor: sensing platform, surface characterization and multiscale modeling

  • Chen, Chuin-Shan;Kuan, Shu;Chang, Tzu-Hsuan;Chou, Chia-Ching;Chang, Shu-Wei;Huang, Long-Sun
    • Smart Structures and Systems
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    • v.8 no.1
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    • pp.17-37
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    • 2011
  • The microcantilever (MCL) sensor is one of the most promising platforms for next-generation label-free biosensing applications. It outperforms conventional label-free detection methods in terms of portability and parallelization. In this paper, an overview of recent advances in our understanding of the coupling between biomolecular interactions and MCL responses is given. A dual compact optical MCL sensing platform was built to enable biosensing experiments both in gas-phase environments and in solutions. The thermal bimorph effect was found to be an effective nanomanipulator for the MCL platform calibration. The study of the alkanethiol self-assembly monolayer (SAM) chain length effect revealed that 1-octanethiol ($C_8H_{17}SH$) induced a larger deflection than that from 1-dodecanethiol ($C_{12}H_{25}SH$) in solutions. Using the clinically relevant biomarker C-reactive protein (CRP), we revealed that the analytical sensitivity of the MCL reached a diagnostic level of $1{\sim}500{\mu}g/ml$ within a 7% coefficient of variation. Using grazing incident x-ray diffractometer (GIXRD) analysis, we found that the gold surface was dominated by the (111) crystalline plane. Moreover, using X-ray photoelectron spectroscopy (XPS) analysis, we confirmed that the Au-S covalent bonds occurred in SAM adsorption whereas CRP molecular bindings occurred in protein analysis. First principles density functional theory (DFT) simulations were also used to examine biomolecular adsorption mechanisms. Multiscale modeling was then developed to connect the interactions at the molecular level with the MCL mechanical response. The alkanethiol SAM chain length effect in air was successfully predicted using the multiscale scheme.

A study on the spray characteristics of a coaxial nozzle by LDV measurement (LDV계측에 의한 동축노즐의 분무특성 연구)

  • 윤석주;노병준
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.14 no.6
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    • pp.1613-1620
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    • 1990
  • For the purpose of the study on the spray characteristics of a coaxial nozzle, the measurement of the velocity and size of droplets, concentration, and the statistical correlation coefficient between the fluctuation of the velocity and that of the corresponding drop diameter have been carried out. Various method of simultaneous measurement of velocity and drop size have been developed from LDV techniques. The technique used here belongs to the method that supposed by Yule, Holve and Self. It has the advantages of making use of a standard LDV apparatus to which minor modifications have been brought, photomultiplier is equipped with a slit instead of a pinhole and observed the measuring volume at an angle of 90.deg.. The voltage supplied by the photomultiplier has undergone an appropriate analog and digital processing. The experimental results give a good idea of the two phase flow organization and can be helpful to find a drop diffusion model when suitable data are imput.

A Preliminary Study on UAV Photogrammetry for the Hyanho Coast Near the Military Reservation Zone, Eastern Coast of Korea (동해안 군사시설보호구역 주변 향호 연안역을 대상으로 무인항공사진측량에 관한 예비 연구)

  • Kim, Baeck-Oon;Yun, Kong-Hyun;Chang, Tae-Soo;Bahk, Jang-Jun;Kim, Seong-Pil
    • Ocean and Polar Research
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    • v.39 no.2
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    • pp.159-168
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    • 2017
  • To evaluate the accuracy of UAV photogrammetry for Hyangho coast, eastern coast of Korea, we conducted a field experiment wherein UAV photogrammetry test was repeated three times. Since the Haygho coast is located within a military reservation zone, it was necessary to obtain permission to gain access to the beach and to have sensitive aerial photographs showing military facilities inspected and cropped. The standard deviation of the UAV shooting position between the three tests was less than 1 m, but repeatability of footprint on the ground was low due to wind-driven variability of the UAV pose. Self-calibrating bundle adjustment(SCBA) of implementing non-metric camera calibration was failed in one test. In two tests, the vertical error was twice as large as the pixel size except for those areas that were subject to security inspection and cropping. Given the problems that can arise with regard to the repeatability of the shooting area as well as the possibility of failure with regard to SCBA, we strongly recommend that UAV photogrammetry in coastal areas needs to be repeated at least twice.

Comparison of bond strength between denture base resin and reline resin (의치상 레진과 이장 레진 간의 결합강도 비교)

  • Geum, Young-Hee;Kim, Busob
    • Journal of Technologic Dentistry
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    • v.39 no.3
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    • pp.161-167
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    • 2017
  • Purpose: We compare the bond strength of heat-cured PMMA of Lucitone 199 and QC-20 and Tokuyama Rebase Resin of self-cured resin, which are widely used and well accepted in clinical practice. In order to test the mechanical bonding and chemical bonding, we will compare the bond strength between EstheShot Bright, Smiletone, Repair and Rebase resins. Methods: The denture base resin used in this study was PMMA heat-cured QC-20 and Lucitone 199, polyamide resin EstheShot Bright, Smiletone. And Two types of self-curing Rapid Repair and Tokuyama Rebase were used as resection resins. To measure the bond strength, the denture specimens were fabricated in the size of $10{\times}64{\times}3.5mm$ as instructed by the manufacturer. A surface treatment agent was applied to the cut surfaces of each denture specimen, and the specimens were placed in a preformed silicone mold, and autoclaved excimer resins were prepared. The bending strength of the fabricated specimens was measured using a universal testing machine (STM-5, United Calibration Co., U.S.A.) to measure the three-point bending strength. Results: In both polycarbonate and polyacetal resin, a special resin surface treatment agent showed higher bonding strength than the resin surface treatment agent(p<0.05). Regardless of the type of surface treatment, polycarbonate showed higher bond strength than polyacetal resin(p<0.05). Conclusion: It is considered desirable to use a special surface treating agent for the thermoplastic denture base resin such as polycarbonate and polyacetal resin.

Accuracy Improvement and Systematic Bias Analysis of Scanning White Light Interferometry for Free-form Surfaces Measurements (자유 곡면 형상 측정을 위한 백색광 주사 간섭계의 정확도 향상 및 시스템 오차 분석)

  • Ghim, Young-Sik;Davies, Angela;Rhee, Hyug-Gyo
    • Journal of the Korean Society for Precision Engineering
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    • v.31 no.7
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    • pp.605-613
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    • 2014
  • Scanning white-light interferometry is an important measurement option for many surfaces. However, serious profile measurement errors can be present when measuring free-form surfaces being highly curved or tilted. When the object surface slope is not zero, the object and reference rays are no longer common path and optical aberrations impact the measurement. Aberrations mainly occur at the beam splitter in the interference objective and from misalignment in the optical system. Both effects distort the white-light interference signal when the surface slope is not zero. In this paper, we describe a modified version of white-light interferometry for eliminating these measurement errors and improving the accuracy of white-light interferometry. Moreover, we report systematic errors that are caused by optical aberrations when the object is not flat, and compare our proposed method with the conventional processing algorithm using the random ball test.

Eccentric strength and design of RC columns strengthened with SCC filled steel tubes

  • Lu, Yi-Yan;Liang, Hong-Jun;Li, Shan;Li, Na
    • Steel and Composite Structures
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    • v.18 no.4
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    • pp.833-852
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    • 2015
  • Self-compacting Concrete Filled steel Tubes (SCFT), which combines the advantages of steel and concrete materials, can be applied to strengthen the RC columns. In order to investigate the eccentric loading behavior of the strengthened columns, this paper presents an experimental and numerical investigation on them. The experimental results showed that the use of SCFT is interesting since the ductility and the bearing capacity of the RC columns are greatly improved. And the performance of strengthened columns is significantly affected by four parameters: column section type (circular and square), wall thickness of the steel tube, designed strength grade of strengthening concrete and initial eccentricity. In the numerical program, a generic fiber element model which takes in account the effect of confinement is developed to predict the behavior of the strengthened columns subjected to eccentric loading. After the fiber element analysis was verified against experimental results, a simple design formula based on the model is proposed to calculate the ultimate eccentric strength. Calibration of the calculated results against the test results shows that the design formula closely estimates the ultimate capacities of the eccentrically compressed strengthened columns by 5%.

DESIGN OF A RISE TIME DISCRIMINATION CIRCUIT FOR X-RAY PROPORTIONAL COUNTER (X-선 비례계수관용 상승시간 선별회로 제작)

  • 남욱원;최철성
    • Journal of Astronomy and Space Sciences
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    • v.12 no.1
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    • pp.66-77
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    • 1995
  • It is possible to distinguish X-ray events from non X-ray events in proportional conters using the method of rise time discrimination (RTD). In order to subtract non X-ray background, we have developed a simple RTD circuit which will be applied to the proportional counter planned for a sounding rocket experiment. The entire circuit consists of two parts ; the rise time measurement circuit and the time to amplitude conversion circuit which includes the self-calibration mode. From the test with X-ray detecting system, we obtained that the background can be rejected more than 80% in the energy band 2∼12 keV. However we confirmed that the RDT method is not proper to be used for the energy range above 12kV.

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Estimation of the Fundamental Matrix using a Non-linear Minimization Technique and Its Accuracy Analysis (비선형 최소화에 의한 F행렬 추정 및 정확도 분석)

  • Eom, Seong-Hun;Lee, Jong-Su
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.38 no.6
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    • pp.657-664
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    • 2001
  • It is possible to extract a 3D models from its multiple views using the self-calibration. Though it is possible to construct 3D models of objects from their multiple views, accuracy of 3D models depends on the fundamental matrix estimated between two views. In this paper, we show the fundamental matrix accuracy can be improved by taking a non-linear minimization technique. Furthermore, the corresponding points which are completely mismatches or have greater discrepancy errors in their locations, reduce the fundamental matrix accuracy. Thus, applying the Monte Carlo technique and the non-linear minimization Levenberg-Marquardt method to remove the outliers, we can estimate the fundamental matrix with the higher accuracy.

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A Study on the Sensor for Measuring the High Frequency Magnetic Fields (고주파자계측정용 센서에 관한 연구)

  • Lee, Bok-Hee;Jeong, Seung-Soo;Park, Hyung-Ki;Paek, Yong-Hyun;Yim, Dong-Mook
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1992.11a
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    • pp.114-117
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    • 1992
  • This paper presents the design and calibration methods of self-integrated magnetic sensor. Also the distance response measurement of magnetic field produced a transient large current and the frequency response measurement are carried out As the integrating resistance increases. the sensitivity of the sensor is improved, but the decay time constant of response decreases, Also the experimental results are well agreed with the theoretical analysis of the equivalent circuit.

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An Experimental Study on the design of the thermister thermometer (전기온도계 제작에 관한 실험적 연구)

  • Yun, Dork-Ro;Kim, Ik-Su
    • Journal of Preventive Medicine and Public Health
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    • v.6 no.1
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    • pp.65-70
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    • 1973
  • The study in the fild of medical instrument has been out of the interest by any of the life scientist in Korea. Especially, the recent developments in the medical electromics are remarkable one. Authors planned this study to ascertain the possibility of setting up the thermister thermometer with available accessories of demestic prouducts including some specific foreign assembly parts. By proper use of the thermister as one of the wheatstone bridge, we could detect tile resistance variations due to the environmental temperature variace. The intensive care for the bridge circuit and compensation scheme was required. The calibration procedure adopted here makes it possible to read the current as the temperature. The temperature range was determined by the examination and construction of the graph of the resistance-temperature variation. The determination of electric current, available ambient-temperature, the reduction of excessive current and self-heating of the thermister were made. Renovation in response-velocity was under taken too. This electronic thermometer was designed and assembled by the circuitry developed in accordance with the maximum availability of domestic products with some foreign-made parts. The result of our experiment showed very stable function and proved to be the most promissing item in the actual application as long as the thermistor thermister is concerned.

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