• KSBB Journal
• /
• v.27 no.4
• /
• pp.199-206
• /
• 2012

Chiral crown ethers are synthetic macrocyclic polyethers that bind protonated chiral primary amines with high selectivity and affinity. They have been widely used to separate or distinguish the enantiomers of chiral compounds containing a primary amino moiety by high-performance liquid chromatography, capillary electrophoresis, and NMR spectroscopy. In this paper, two important chiral crown ethers including chiral binaphthyl unit and (18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selectors are focused. And several chiral resolution techniques and their applications in chirotechnology using these chiral crown ethers with related chiral recognition mechanism studies are reviewed. Especially, it was shown that the commercially available HPLC columns based on (18-crown-6)-2,3,11,12-tetracarboxylic acid have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.

• KSBB Journal
• /
• v.27 no.4
• /
• pp.232-236
• /
• 2012

Comparative liquid chromatographic enantiomer separation of ${\alpha}$-amino acids, their esters and primary amino compounds was performed using two chiral stationary phases (CSPs) prepared by covalently bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) of the same chiral selector. In general, the separation factors and resolution factors for these analytes on CSP 1 were greater than on CSP 2, while these capacity factors on CSP 2 were quite greater than on CSP 1. Except for leucine methyl ester and phenylalanine methyl ester, the elution orders of all analytes including ${\alpha}$-amino ${\alpha}$-alkyl acids and phenylglycine alkyl esters on CSP 1 are identical to those on CSP 2. This study showed that different connecting structures for these two CSPs might influence their ability to resolve the analytes depending on their structures related to the chiral recognition mechanism.

• Journal of the Korean Mathematical Society
• /
• v.53 no.4
• /
• pp.795-834
• /
• 2016

The main purpose of this paper is to propose a scheme of a proof of the nonsimpleness of the group $Homeo^{\Omega}$ ($D^2$, ${\partial}D^2$) of area preserving homeomorphisms of the 2-disc $D^2$. We first establish the existence of Alexander isotopy in the category of Hamiltonian homeomorphisms. This reduces the question of extendability of the well-known Calabi homomorphism Cal : $Diff^{\Omega}$ ($D^1$, ${\partial}D^2$)${\rightarrow}{\mathbb{R}}$ to a homomorphism ${\bar{Cal}}$ : Hameo($D^2$, ${\partial}D^2$)${\rightarrow}{\mathbb{R}}$ to that of the vanishing of the basic phase function $f_{\underline{F}}$, a Floer theoretic graph selector constructed in [9], that is associated to the graph of the topological Hamiltonian loop and its normalized Hamiltonian ${\underline{F}}$ on $S^2$ that is obtained via the natural embedding $D^2{\hookrightarrow}S^2$. Here Hameo($D^2$, ${\partial}D^2$) is the group of Hamiltonian homeomorphisms introduced by $M{\ddot{u}}ller$ and the author [18]. We then provide an evidence of this vanishing conjecture by proving the conjecture for the special class of weakly graphical topological Hamiltonian loops on $D^2$ via a study of the associated Hamiton-Jacobi equation.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.16 no.12
• /
• pp.2725-2730
• /
• 2012

In this paper, for improving the H.264/AVC hardware performance, we propose an inter predictor hardware design using a multi reference frame selector and an implicit weighted predictor. previous reference frame are reused for Low Memory Bandwidth. The size of the reference memory in the predictor was reduced by about 46% and the external memory access rate was reduced by about 24% compared with the one in the reference software JM16.0. We designed the proposed system with Verilog-HDL and synthesized inter predictor circuit using the Magnachip 0.18um CMOS standard cell library. The synthesis result shows that the gate count is about 2,061k and the design can run at 91MHz.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.19 no.6
• /
• pp.1046-1055
• /
• 1994

In this paper, to design high speed 1 line VRAM(Video RAM) suitable for image signal processing with ASIC(Application Specific IC) method, the VRAM memory core has been designed using 3-TR dual-port dynamic cell which has excellent access time and integration characteristics. High speed pipeline operation was attained by separating the first row from the subarray 1 memory core and the simultaneous I/Q operation for a selected single address was made possible by adopting data-latch scheme. Peripheral circuits were designed implementing address selector and 1/2V voltage generator. Integrated ASIC has been optimized using 1.5[ m] CMOS design rule.

• Archives of Pharmacal Research
• /
• v.29 no.9
• /
• pp.808-813
• /
• 2006

Two methods for the chiral purity determination of bevantolol were developed, namely capillary electrophoresis (CE) using carboxymethyl-${\beta}$-cyclodextrin (CM-${\beta}$-CD) as a chiral selector and high-perfomance liquid chromatography (HPLC) using a chiral stationary phase. In the HPLC method, the separation of bevantolol enantiomers was performed on a Chiralpak AD-H column by isocratic elution with n-hexane-ethanol-diethylamine (10:90:0.1, v/v/v) as mobile phase. In the CE method, bevantolol enantiomers were separated on an uncoated fused silica capillary with 50 mM amonium phosphate dibasic adjusted to a pH 6.5 with phosphoric acid containing 15 mM CM-${\beta}$-CD as running buffer. Validation data such as linearity, recovery, detection limit, and precision of the two methods are presented. The detection limits of S-(-)-bevantolol were 0.1% and 0.05% for CE and HPLC method, respectively and R-(+)-bevantolol were 0.15% and 0.05% for CE and HPLC method, respectively. There was generally good agreement between the HPLC and CE results.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.34 no.12B
• /
• pp.1506-1513
• /
• 2009

This paper presents a synchronization method to determine the exact demodulation time using the MFM Flag of the 18000-3 PJM mode, along with the hardware structure to implement the proposed method. The proposed system detects an incipient peak using ITS(Initial Time Selector) and a correlator and achieves the final synchronization via identifying the peak position from the comparison of the outputs of two followed additional correlators. The peak detection algorithm and the choice of the templates of the correlators are described. Simulation results show that the proposed system performs successfully in noisy environment.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.34 no.8
• /
• pp.953-964
• /
• 2010

In this study, we proposed duty executions to confine a robot in a specific place with multiple robots. The proposed method involved the use of a role classifier for assigning labor roles, behavior selector for each robot, and a collaboration manager for handling complex situations. Further, we verified the validity of the proposed method by performing simulations to confine a robot in the specific location by using multiple robots.

• Proceedings of the IEEK Conference
• /
• 2001.06b
• /
• pp.365-368
• /
• 2001

This paper described a design and implementation of the division/square-root for a redundant floating point binary number using high-speed quotient selector. This division/square-root used the method of a redundant binary addition with 25MHz clock speed. The addition of two numbers can be performed in a constant time independent of the word length since carry propagation can be eliminated. We have developed a 16-bit VLSI circuit for division and square-root operations used extensively in each iterative step. It peformed the division and square-root by a redundant binary addition to the shifted binary number every 16 cycles. Also the circuit uses the nonrestoring method to obtain a quotient. The quotient selection logic used a leading three digits of partial remainders in order to be implemented in a simple circuit. As a result, the performance of the proposed scheme is further enhanced in the speed of operation process by applying new quotient selection addition logic which can be parallelly process the quotient decision field. It showed the speed-up of 13% faster than previously presented schemes used the same algorithms.

• Journal of Korea Foundry Society
• /
• v.21 no.1
• /
• pp.41-47
• /
• 2001

Computer simulation of the solidification grain structure was applied to the casting process by using CA-DFDM. The Direct Finite Difference Method (DFDM) for temperature field calculation and latent heat treatment was coupled with Cellular Automaton (CA) method for the grain growth. 2-dimensional simulation of the solidification grain structures and calculation of the concentration fields were carried out and the calculated concentration distributions were compared with exact solution. Castings having complex geometries such as turbine blades were applied for 3-dimensional CA-DFDM. Effects of grain selector and mold extraction speed on the solidification grain structures in the turbine blade were examined.