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The Development and Application of Chirotechnology Using Chiral Crown Ethers for Enantiomer Separation  

Paik, Man-Jeong (College of Pharmacy, Sunchon Nationnal University)
Yun, Won-Nam (College of Pharmacy, Chosun University)
Lee, Won-Jae (College of Pharmacy, Chosun University)
Publication Information
KSBB Journal / v.27, no.4, 2012 , pp. 199-206 More about this Journal
Chiral crown ethers are synthetic macrocyclic polyethers that bind protonated chiral primary amines with high selectivity and affinity. They have been widely used to separate or distinguish the enantiomers of chiral compounds containing a primary amino moiety by high-performance liquid chromatography, capillary electrophoresis, and NMR spectroscopy. In this paper, two important chiral crown ethers including chiral binaphthyl unit and (18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selectors are focused. And several chiral resolution techniques and their applications in chirotechnology using these chiral crown ethers with related chiral recognition mechanism studies are reviewed. Especially, it was shown that the commercially available HPLC columns based on (18-crown-6)-2,3,11,12-tetracarboxylic acid have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.
Chiral crown ether; 18-Crown-6-2,3,11,12-tetracarboxylic acid; Chiral selector; High-performance liquid chromatography; Capillary electrophoresis; NMR spectroscopy;
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Times Cited By KSCI : 9  (Citation Analysis)
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