• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.1.1-1.13
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• 2016

Objectives To investigate the accuracy and scientific validity of the current very low risk factor for hereditary diseases in humans following exposures to ionizing radiation adopted by the United Nations Scientific Committee on the Effects of Atomic Radiation and the International Commission on Radiological Protection. The value is based on experiments on mice due to reportedly absent effects in the Japanese atomic bomb (A-bomb) survivors. Methods To review the published evidence for heritable effects after ionising radiation exposures particularly, but not restricted to, populations exposed to contamination from the Chernobyl accident and from atmospheric nuclear test fallout. To make a compilation of findings about early deaths, congenital malformations, Down's syndrome, cancer and other genetic effects observed in humans after the exposure of the parents. To also examine more closely the evidence from the Japanese A-bomb epidemiology and discuss its scientific validity. Results Nearly all types of hereditary defects were found at doses as low as one to 10 mSv. We discuss the clash between the current risk model and these observations on the basis of biological mechanism and assumptions about linear relationships between dose and effect in neonatal and foetal epidemiology. The evidence supports a dose response relationship which is non-linear and is either biphasic or supralinear (hogs-back) and largely either saturates or falls above 10 mSv. Conclusions We conclude that the current risk model for heritable effects of radiation is unsafe. The dose response relationship is non-linear with the greatest effects at the lowest doses. Using Chernobyl data we derive an excess relative risk for all malformations of 1.0 per 10 mSv cumulative dose. The safety of the Japanese A-bomb epidemiology is argued to be both scientifically and philosophically questionable owing to errors in the choice of control groups, omission of internal exposure effects and assumptions about linear dose response.

• 터널과지하공간
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• 제2권1호
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• pp.95-101
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• 1992

Norwegian technology related to preinvestigations, planning, design and construction of large underground caverns is wellknown worldwide. However, so far this technology is only slightly verified through scientiffic reports and documentation. The "Rock cavern stadium" research program is an interdisciplinary program related to the ongoing building and future use of Gjovik Olympic Subsite which is the largest cavern in the world for public purposes with a span of 61 meters and a height of 25 meters. The estimated budget for this program is about USD 4 million which is made possible through grants from The Royal Norwegian Council for Scientific and Industrial Research as well as through contributions from Norwegian and Swedish companies that are participating. The program is carried out in collaboration with The Foundation for Scientific and Industrial Research at the Norwegian Institute of Technology. The Norwegian Geotechnical Institute and The Eastern Norway Research Center. The research program will continue until the end of 1994 to ensure that input comes from a full period of use in this stadium with different activities like exhibitions, conferences, concerts etc being included as verification through full-scale measurements and observations. The research program has five subtasks. Three of these are related to subjects like Energy consumption. HVAC installations. Fire safety design, Engineering geology and Rock mechanics, Environmental aspects. The fourth subtask is concerned with the collection of basic data, results and experience from these three subtasks to provide a basis for national Norwegian guidelines related to this interdisciplinary subject area. The guidelines will first be presented as a manual for planning and engineering purposes. The realization of this research program is a unique opportunity to enhance the expertise that has been acquired from this cavern stadium. By involving research in this extraordinary project from the excavation and building phase to its subsequent use. this will give the participants know-how and expertise which is very much in demand internationally. The coordination of the international activities between the participants as well as preparation of participations and presentations in international conferences and symposium are included in the fifth task of this national research program.

• 인문언어
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• 제8집
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• pp.331-367
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• 2006

In this paper I attempted to investigate the matters related with the clarification of the close relationship between writing system and pronunciation. On the way of pursuing the research on the subject I found the fact that the same topic has been the main academic target in Korea. There have been some remarks about English alphabets and pronunciation. Nevertheless, the relation between alphabet codes and pronunciation tokens wasn't considered as the main key to master the English pronunciation correctly and completely. As the main target of this paper I argue that it is necessary to comprehend the connection. Then, we can recognize the significant role of alphabetic structure for understanding the gist of pronunciation exercise. This paper is classified into four parts. Each part consists of the material to affirm the fact that writing system should be the inevitable equivalent of sound system, and vice versa. In the first section I show that the development of the way of pronouncing English words is closely related with the endeavors of the scholars. While performing the survey of the studies about the alphabetic structure of the age many scholars found that the spelling construction was recorded without any common denominator. Thus, they not only sought to stage the bedrock for the standard written form of words but also to associate the alphabet letters with phonetic features. Secondly I mention the negative aspect of the 'only spelling based English pronunciation education' for the educational goal of 'Phonics methodology.' In this part I suggest the essentiality of phonemic properties with the phonetic prospect: phonemic awareness. Thirdly I refer to the standardization of the spelling system of English. As the realm of application of the language is extended toward the various professional areas such as commercial, scientific, and cultural spheres, it is quite natural to assume that the usage of the language will be transformed according to the areas in the world. Fourthly I introduce the first English-Korean grammar book with the section of 'the introduction to English pronunciation.' At the chapter the author explained the sound features of English based on the regulation of 'Scientific Alphabet' of U.S.A. In the transcribing system all the symbols were postulated on the basis of the English alphabet form instead of the separate phonetic signs of IPA.

• 한국응용곤충학회지
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• 제34권1호
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• pp.53-60
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• 1995

본 논문은 곤충학, 식물병리학, 잡초학 등의 식물보호학 분야와 양잠학 분야에서 발표된 북한의 단행본 종류, 학술논문 및 북한내 과학자들에게 소개하기 위하여 인용하는 외국 학술논문들의 내용을 검토하여 그들의 관심사항을 이해할려는 목적으로 시작하였다. 식물보호학 분야는 조선농업과학원의 식물보호연구소에서 주로 연구하고 있지만 이 분야의 연구논문을 전문적으로 다루는 학술지는 없으며 대부분은 일반 농학 학술지인 농업과학원의 "학보"에 실리고 있다. 다만 양봉학 분야의 논문들은 "수의축산"지에서 발견되어 축산학분야의 연구기관에서 다루는 것으로 곤충분류에 대한 연구는 북한과학원의 연구소에서 진행하는 것으로 판단된다. 북한에서 양잠학은 강조되는 분야로 잠업학연구소에서 주로 연구되고 학술논문들은 년 4회 발간되는 "잠업"지(호당 평균 30여쪽)에 실린다. 식물보호분야에서 발표되거나 소개되는 논문들은 주로 벼, 강냉이, 사과등에 대한 것들이고, 잠업에서는 누에와 뽕나무에 대해 거의 비슷하게 다루고 있다. 이 분야의 단행본들도 비교적 여러가지 발간되었다.

• 과학기술학연구
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• 제15권1호
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• pp.281-325
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• 2015

이 글은 시민참여를 주장하는 STS 연구들이 각기 다른 이론적 관심과 방법론에 의해 상이한 입장을 취하게 되었음을 보인 필자들의 선행연구를 심화하여, 이상이한 입장들이 위험 거버넌스의 두 가지 큰 방법론인 위험분석(또는 위험평가/위험관리의 구분)과 사전주의 원칙에 대한 서로의 해석과 평가에 반영됨을 보일것이다. 이를 통해, 이 글은 STS 영역 밖에서 발전한 위험분석(위험평가/위험관리)이나 사전주의 원칙에 대한 STS의 입장이 단일한 것이 아님을 드러내고, 나아가 STS의 시민참여 거버넌스와 위험 거버넌스 연구 사이의 이론적이고 실천적인 접점을 확인하면서 일부 STS 연구자가 제시한 참여적 거버넌스 모델의 문제를 지적할 것이다.

• 한국초등과학교육학회지:초등과학교육
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• 제30권2호
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• pp.129-140
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• 2011

As one of the casting plans to improve the scientific inquiry ability of the students, the aims of this study are to develop and apply a basic inquiry program for the inquiry subject of Seogwipo fossil formation, and analyze the basis inquiry ability of the students to show in the inquiry activity process actually. The results obtained in 5th grade 48 elementary school students of Seogwipo-city are as follows; Students executed observing activity using an appropriate senses such as senses of vision and touch, and showed the tendency which tries to observe the form overall rather than the partial form of the fossil formation. But the ability to utilize appropriately for predicting and inferring with the facts which could depend on observing activity was low. And we found out that the misconceptions influence on inquiry activity. Therefore, to help understanding deeper for the students' basic inquiry element, it is thought that a study of the various educational guidance ways is necessary to this. The teachers also have to study the various ways to induce the scientific conception through the application of proper teaching-learning for correction of misconceptions because misconceptions have an influence on inquiry activity together. If various inquiry programs considering the regional-specific characteristics are developed to cause students' interest, students would come to participate in inquiry activity aggressively a little more.

• 디지털융복합연구
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• 제14권11호
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• pp.45-51
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• 2016

개인정보 유출 사고를 불러일으키는 근거를 과학적으로 발굴해 보려는 연구는 아직까지 전무한 실정이다. 본 논문은 해킹을 통한 주민 정보 유출의 정도를 결정짓는 근거 요인을 찾아내기 위해 시도됐다. 연구의 중요도에 비추어 이를 위한 연구가 문헌상에 나타나지 않았던 점은 과학적인 연구방법론을 찾아내고 적용하기 곤란한 연구주제인 점에서 본 논문에서는 과학적 분석 모형을 제안하였고 그에 기반 한 분석 방법론을 개발하였다. 연구결과, 개인 식별에 동원되는 데이터의 경직성 요인이 유출 수위에 가장 결정적 역할을 하는 것으로 드러났다. 강도가 강할수록 해킹건수와 비례하는 것이 증명됐다. '주민 데이터 자유도' 개념을 정립함으로써 국가별 주민식별관련 주민 자유도 허용 순위를 결정할 수 있었다. 영국과 한국이 순위 열 양단에 위치하는 것으로 드러났으며 자유도 면에서 영국이 국민에게 가장 많은 자유를 허용하는 국가로, 또한 한국이 가장 좁은 의미의 자유를 허용하는 국가로 매겨졌다.

• 대한두개안면성형외과학회지
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• 제22권1호
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• pp.1-10
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• 2021

Botulinum toxin type A (BoNT-A), onabotulinumtoxinA (Botox) was approved by the United States Food and Drug Administration for temporary improvement of glabellar lines in patients 65 years and younger in 2002, and has also been used widely for aesthetic purposes such as hyperhidrosis, body shape contouring, and other noninvasive facial procedures. BoNT-A inhibits presynaptic exocytosis of acetylcholine (ACh)-containing vesicles into the neuromuscular junction at cholinergic nerve endings of the peripheral nervous system, thereby paralyzing skeletal muscles. ACh is the most broadly used neurotransmitter in the somatic nervous system, preganglionic and postganglionic fibers of parasympathetic nerves, and preganglionic fibers or postganglionic sudomotor nerves of sympathetic nerves. The scientific basis for using BoNT-A in various cosmetic procedures is that its function goes beyond the dual role of muscle paralysis and neuromodulation by inhibiting the secretion of ACh. Although the major target organs for aesthetic procedures are facial expression muscles, skeletal body muscles, salivary glands, and sweat glands, which are innervated by the somatic or autonomic nerves of the peripheral cholinergic nerve system, few studies have attempted to directly explain the anatomy of the areas targeted for injection by addressing the neural physiology and rationale for specific aesthetic applications of BoNT-A therapy. In this article, we classify the various cosmetic uses of BoNT-A according to the relevant component of the peripheral nervous system, and describe scientific theories regarding the anatomy and physiology of the cholinergic nervous system. We also review critical physiological factors and conditions influencing the efficacy of BoNT-A for the rational aesthetic use of BoNT-A. We hope that this comprehensive review helps promote management policies to support long-term, safe, successful practice. Furthermore, based on this, we look forward to developing and expanding new advanced indications for the aesthetic use of BoNT-A in the future.

• International Journal of Computer Science & Network Security
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• 제22권10호
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• pp.97-106
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• 2022

Objective. Nanotechnology is spreading among all areas of life, from everyday devices to medicine. The concept of nanotechnology argues that not only can new physical and chemical properties of materials be discovered, but also the new potential of nanostructures when reduced to the nanoscale. The growing interest in the application of nanomaterials in dentistry contributes to the proliferation of the range of nanomaterials used by specialists. The purpose of this review of information sources was to analyze the prospects for the use of nanomaterials in dentistry. Methods. We used the bibliographic semantic method of research, for which we analyzed electronic databases of primary literature sources Scopus, Web of Science, Research Gate, PubMed, MDPI, and MedLine. English-language scientific articles published after 2017 were taken into consideration. Results. According to the results of a search study among modern information primary sources, nanotechnology improves the preventive properties of oral care products, improves the structural-mechanical and aesthetic properties of composite mixtures for dentistry, overcomes the problems of the clinical application of dental implants. Despite the prospects of nanotechnology applications in medicine in general and dentistry in particular, the existing economic and technological problems require a thorough solution for further implementation of nanostructures. Scientific novelty. For the first time, the analysis of modern trends in the application of nanotechnology in dentistry is carried out and the peculiarities of materials are highlighted, the problems and prospects of nanostructures implementation in modern dental implantology are given, physical, chemical, mechanical, and antibacterial properties of nanomaterials are evaluated. The effect of nanomaterials on the microbial adhesion of the tooth or implant surface is described. Practical significance. The presented publication can become a scientific basis for the solution of urgent problems hindering the introduction of nanotechnology into dental practice. Conclusions. Thus, the use of nanostructures opens up great opportunities for the treatment of a wide range of diseases, not only of dental nature but also in medicine in general.

• 대한기관윤리심의기구협의회지
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• 제4권1호
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• pp.5-15
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• 2022

To suggest future directions for the improvement in the Institutional Review Board (IRB) review process and efficient operation of IRB, we have analyzed the IRB review results from 460 new research proposals submitted to the Review by the Convened IRB of the Keimyung University Dongsan Hospital IRB from January 2019 to July 2021. IRB is an independently established institutional committee to protect the human subjects by reviewing the research protocol in ethical as well as scientific aspects, so it is necessary to continuously contemplate the ethical versus scientific dilemma of 'what is ethical or scientific and what can actually protect human subjects.' Particularly, in this process, it is necessary to consider diverse ways to strengthen self-supervision through continuous Internal Audit rather than simple reporting outcomes. In addition, if it does not directly affect the protection of the human subjects, the discussion with the committee members is needed so that the comments such as administrative and typographical errors can be reduced as much as possible. Furthermore, as statistical analysis methods can have a significant impact on the safety of human subjects, if a legal basis and/or support related to statistics is provided for the composition of IRB members, a more specialized IRB review will be achieved.