• Title/Summary/Keyword: scale-up production

Search Result 346, Processing Time 0.029 seconds

A Study on Forming Analysis for the Roll Forming Process of 3 Point Under Rail (3점 언더레일 슬라이드의 롤포밍 공정에 대한 성형해석연구)

  • Jung, D.W.;Park, S.H.;Jeong, J.H.
    • Journal of Power System Engineering
    • /
    • v.16 no.6
    • /
    • pp.52-58
    • /
    • 2012
  • Roll forming process is one of the most widely used processes in the world for forming metals such as a furniture drawer guide or an up and down slide guide. It can manufacture goods of the uniform cross section on a large scale throughout the continuous processing. In the domestic design and manufacture, roll forming process for production is taking most of the method of 2-point under rail slide. However, this method is vulnerable to the structural strength and stiffness is not suitable for high load conditions. Therefore, through systematic study of high load, low noise 3-point ball type of under rail slide its own design and manufacturing technology is the need to build. In this paper, to make center member of 3-point ball-type under rail slide for the refrigerator doors, the roll forming modeling and simulation are performed. Tensile test is performed about SCP-1 1/2H for determine the mechanical properties of materials. Modeling and simulation of roll forming is used MSC.MARC software of a dedicated analysis program used by rigid plastic finite element method. Interference between the roll and the final shape are predicted from the results of the simulation.

Reproduction-Nutrition Relationship in Dairy Buffaloes. I. Effect of Intake of Protein, Energy and Blood Metabolites Levels

  • Qureshi, Muhammad Subhan;Habib, Ghulam;Samad, Hafiz Abdus;Siddiqui, Muhammad Mohsin;Ahmad, Nazir;Syed, Mirajuddin
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.15 no.3
    • /
    • pp.330-339
    • /
    • 2002
  • Fifty one Nili-Ravi dairy buffaloes in their last two months of gestation were selected. After parturition, rectal examination of reproductive organs was carried out until the occurrence of the first oestrus (PEI). Milk samples were analyzed for milk progesterone levels (MPL). Ovulation (POI) was confirmed by rectal palpation and MPL. Feed and blood samples were collected fortnightly and analyzed. Body condition score (BCS) was recorded on a scale of 0 to 5. Crude protein (CP) intake varied among different seasons and correlated positively with serum urea levels, POI (p<0.01) and PEI (p<0.05). Excess CPI was lower in the group showing oestrus as compared to those remaining as anoestrus (p<0.05). The dietary ratio of crude protein - metabolizable energy (CP:ME) in the oestrus animals was narrow and constant, while the anoestrus animals had a widely fluctuating one. In normal breeding season (NBS) calvers, mean serum urea level (SUL) was lower than the low breeding season (LBS) calvers. SUL was positively correlated with PEI and POI (p<0.01). Up to six months postpartum, SUL were constantly higher in anoestrus than oestrus buffaloes. Mean metabolizable energy (ME) intake was lower in the NBS calvers than the LBS calvers (p<0.01). BCS and postpartum ovulation interval were correlated with ME intake (p<0.01). Prepartum ME intake was higher in oestrous as compared to anoestrous animals (p<0.05). Higher and lower ME intakes were associated with anoestrus, while a moderate energy intake was associated with a PEI of less than 75 days. Buffaloes with poor BCS belonged to the LBS calving group and most of the NBS calving buffaloes had good BCS. BCS was negatively correlated with PEI (p<0.01) and was higher in oestrous buffaloes than anestrus. It was concluded that excess intake of crude protein, associated with higher serum urea levels and low energy intake, associated with poor body condition, are the key factors for low reproductive efficiency. It may be corrected by adopting a proper feeding strategy.

Study of the Rheological Properties of a Fermentation Broth of the Fungus Beauveria bassiana in a Bioreactor Under Different Hydrodynamic Conditions

  • Nunez-Ramirez, Diola Marina;Medina-Torres, Luis;Valencia-Lopez, Jose Javier;Calderas, Fausto;Lopez-Miranda, Javier;Medrano-Roldan, Hiram;Solis-Soto, Aquiles
    • Journal of Microbiology and Biotechnology
    • /
    • v.22 no.11
    • /
    • pp.1494-1500
    • /
    • 2012
  • Fermentation with filamentous fungi in a bioreactor is a complex dynamic process that is affected by flow conditions and the evolution of the rheological properties of the medium. These properties are mainly affected by the biomass concentration and the morphology of the fungus. In this work, the rheological properties of a fermentation with the fungus Beauveria bassiana under different hydrodynamic conditions were studied and the rheological behavior of this broth was simulated through a mixture of carboxymethyl cellulose sodium and cellulose fibers (CMCNa-SF). The bioreactor was a 10 L CSTR tank operated at different stir velocities. Rheological results were similar at 100 and 300 rpm for both systems. However, there was a significant increase in the viscosity accompanied by a change in the consistence index, calculated according to the power law model, for both systems at 800 rpm. The systems exhibited shear-thinning behavior at all stir velocities, which was determined with the power law model. The mixing time was observed to increase as the cellulose content in the system increased and, consequently, the efficiency of mixing diminished. These results are thought to be due to the rheological and morphological similarities of the two fungal systems. These results will help in the optimization of scale-up production of these fungi.

A Study on the Improvement Effects of Soft Ground through In-Situ Construction of Quick Lime Pile (생석회파일 현장시험시공 통한 연약지반 개량효과에 관한 연구)

  • 천병식;고갑수;이용한
    • Proceedings of the Korean Geotechical Society Conference
    • /
    • 2000.11a
    • /
    • pp.41-48
    • /
    • 2000
  • Most land development projects and large scale civil works require a great amount of sand. And sand is also the most favorable material for soft ground improvement. The demand for sand is soaring rapidly due to increased number of projects regardless of its limited supply. Therefore, it is not difficult to predict that sand may become depleted and no longer be available as ground improvement material in the near future. Against this backdrop, developing an inexpensive sand-substitution material with an efficient accessibility will be necessary and urgently called for. So quick lime could be recommended as the substitutional material for sand. Quick lime is now preferred by forward developed nations. If Korea is able to take advantage of its abundant supply, economical efficiency could be achieved through massive production as well as being able to take advantage of utilization of natural resources. In this respect the purpose of this paper was to estimate improvement effect of soft ground though in-situ construction of quick lime pile. In-situ construction was peformed in road construction site of soft clay and in this study quick lime from Dan-yang that was estimated prominently in aspect of engineering characteristics was used. Quick lime piles were installed by 1.5m, 2.0m, 3.0m spacing to confirm improvement effect according to spacing and installed piles are 0.4m in diameter, up to 5m in length and the density of quick piles installed is 1.4 t/㎥. Vibrating wire pore water pressure cell was installed to confirm consolidation characteristics in surrounding of quick lime piles and both laboratory test and field test were carried out to confirm strength increase. In conclusion, soft ground improvement by quick lime piles was confirmed.

  • PDF

Thin Film Transistor Backplanes on Flexible Foils

  • Colaneri, Nick
    • 한국정보디스플레이학회:학술대회논문집
    • /
    • 2006.08a
    • /
    • pp.529-529
    • /
    • 2006
  • Several laboratories worldwide have demonstrated the feasibility of producing amorphous silicon thin film transistor (TFT) arrays at temperatures that are sufficiently low to be compatible with flexible foils such as stainless steel or high temperature polyester. These arrays can be used to fabricate flexible high information content display prototypes using a variety of different display technologies. However, several questions must be addressed before this technology can be used for the economic commercial production of displays. These include process optimization and scale-up to address intrinsic electrical instabilities exhibited by these kinds of transistor device, and the development of appropriate techniques for the handling of flexible substrate materials with large coefficients of thermal expansion. The Flexible Display Center at Arizona State University was established in 2004 as a collaboration among industry, a number of Universities, and US Government research laboratories to focus on these issues. The goal of the FDC is to investigate the manufacturing of flexible TFT technology in order to accelerate the commercialization of flexible displays. This presentation will give a brief outline of the FDC's organization and capabilities, and review the status of efforts to fabricate amorphous silicon TFT arrays on flexible foils using a low temperature process. Together with industrial partners, these arrays are being integrated with cholesteric liquid crystal panels, electrophoretic inks, or organic electroluminescent devices to make flexible display prototypes. In addition to an overview of device stability issues, the presentation will include a discussion of challenges peculiar to the use of flexible substrates. A technique has been developed for temporarily bonding flexible substrates to rigid carrier plates so that they may be processed using conventional flat panel display manufacturing equipment. In addition, custom photolithographic equipment has been developed which permits the dynamic compensation of substrate distortions which accumulate at various process steps.

  • PDF

Effectiveness Evaluation of Demand Forecasting Based Inventory Management Model for SME Manufacturing Factory (중소기업 제조공장의 수요예측 기반 재고관리 모델의 효용성 평가)

  • Kim, Jeong-A;Jeong, Jongpil;Lee, Tae-hyun;Bae, Sangmin
    • The Journal of the Institute of Internet, Broadcasting and Communication
    • /
    • v.18 no.2
    • /
    • pp.197-207
    • /
    • 2018
  • SMEs manufacturing Factory, which are small-scale production systems of various types, mass-produce and sell products in order to meet customer needs. This means that the company has an excessive amount of material supply to reduce the loss due to lack of inventory and high inventory maintenance cost. And the products that fail to respond to the demand are piled up in the management warehouse, which is the reality that the storage cost is incurred. To overcome this problem, this paper uses ARIMA model, a time series analysis technique, to predict demand in terms of seasonal factors. In this way, demand forecasting model based on economic order quantity model was developed to prevent stock shortage risk. Simulation is carried out to evaluate the effectiveness of the development model and to demonstrate the effectiveness of the development model as applied to SMEs in the future.

Botulinum A toxin for the treatment of focal hyperhidrosis -5 cases- (국소화 다한증에 대해 보툴리늄 독소를 이용한 치료 -5례보고-)

  • Lee, Song-Am;Kim, Kwang-Taik;Park, Sung-Min;Chung, Bong-Kyu;Sun, Kyung;Kim, Hyoung-Mook;Lee, IIn-Sung
    • Journal of Chest Surgery
    • /
    • v.33 no.3
    • /
    • pp.268-272
    • /
    • 2000
  • Thoracic sympathicotomy has been used safely and successfully to treat essential hyperhidrosis. However, it has been difficult to treat compansatory hyperhidrosis after thoracic sympathicotomy and focal hyperhidrosis. The sweat glands were innervated by post-ganglionic sympathetic fibers with acetylcholic serving as the transmitter. Botulinum A toxin has been reported to block neuro-transmission at the cholinergic autonomic nerve terminals. Prospecting its effect for the sweat gland, we treated 5 patients with focal hyperhidrosis with botulinum A toxin. Three patients received bilateral thoracic sympathectomy (1 case) and sympathicotomy(2 case) via VAT. The hyperhidrosis area was marked with betadine and was subdivided into squares of 2$\times$2 cm(4$\textrm{cm}^2$) each. Botulinum A toxin was injected intracutaneously in a dosage of 2.5U/0.1ml(100U/4ml) /4$\textrm{cm}^2$. A total dose of 100U of Botulinum A toxin was injected into the affected sites. Subjective assessment of sweat production by the patients using a visual analogue scale showed a 20~70% improvement. During the follow-up period, no toxic effects were observed.

  • PDF

Nannochloris eucaryotum growth: Kinetic analysis and use of 100% CO2

  • Concas, Alessandro;Lutzu, Giovanni Antonio;Locci, Antonio Mario;Cao, Giacomo
    • Advances in environmental research
    • /
    • v.2 no.1
    • /
    • pp.19-33
    • /
    • 2013
  • Microalgae are receiving an increasing attention because of their potential use as $CO_2$ capture method and/or as feedstock for biofuels production. On the other hand the current microalgae-based technology is still not widespread since it is characterized by technical and economic constraints that hinder its full scale-up. In such contest the growth kinetics of Nannochloris eucaryotum (a relatively unknown marine strain) in batch and semi-batch photobioreactors is quantitatively investigated with the aim of obtaining the corresponding kinetic parameters suitable for process engineering and its optimization. In particular the maximum growth rate was evaluated to be 1.99 $10^{-3}\;h^{-1}$. Half saturation concentrations for nitrates ($K_N$) and phosphates uptake ($K_P$) were evaluated as 5.4 $10^{-4}\;g_N\;L^{-1}$ and 2.5 $10^{-5}\;g_P\;L^{-1}$, respectively. Yield factors for nitrogen ($Y_N$) and phosphorus ($Y_P$) resulted to be 5.9 $10^{-2}\;g_N\;g^{-1}$ biomass and 6.0 $10^{-3}\;g_P\;g^{-1}{_{biomass}}$, respectively. The possibility of using 100% (v/v) $CO_2$ gas as carbon source is also evaluated for the first time in the literature as far as N. eucaryotum is concerned. The strain showed a good adaptability to high concentrations of dissolved $CO_2$ as well as to low pH. The lipid content under 100% $CO_2$ is about 16.16 %wt $wt^{-1}$ and the fatty acid methyl esters composition of the extracted oil is in compliance with the European regulation for quality biodiesel.

Large-Scale Production of Rotavirus VLP as Vaccine Candidate Using Baculovirus Expression Vector System (BEVS)

  • Park, Jin-Yong;Kim, Hun;Hwang, Hi-Ku;Lee, Su-Jeen;Kim, Hyun-Sung;Hur, Byung-Ki;Ryu, Yeon-Woo;An, Chang-Nam;Kim, Jong-Soo
    • Journal of Microbiology and Biotechnology
    • /
    • v.14 no.1
    • /
    • pp.35-40
    • /
    • 2004
  • Rotavirus virus-like particle (VLP) composed of VP2, VP6, and VP7 was expressed in the Baculovirus Expression Vector System (BEVS). Sf9 cell, a host of the baculovirus, was cultured from a 0.5-1 spinner flask to the 50-1 bioreactor system. Sf9 cell was maintained at cell density between 3.0E+05 and 3.0E+06 cells/ml and grew up to 1.12E+07 cells/ml in the bioreactor. Growth kinetics was compared under different culture systems and showed similar growth kinetics with 20.1-25.2 h of doubling time. Early exponentially growing cell culture was infected with three recombinant baculoviruses expressing VP2, VP6, and VP7 protein at 1.0, 2.0, and 0.2 moi, respectively. The expression of rotavirus proteins was confirmed by Western blot analysis and its three-layered virus-like structure was observed under an electron microscope. Rotavirus VLP was semipurified and immunized in ICR mice intramuscularly. Rotavirus-specific serum antibody was detected from 2 weeks after the immunization and lasted at least 21 weeks of the post-immunization, indicating its possible use as a vaccine candidate.

Optimum Condition for Mass Culture of Hairy Roots from Artemisia sylvatica MAX (국내 자생 그늘쑥 (Artemisia sylvatica MAX) 모상근의 대량배양을 위한 최적조건)

  • Shin, Sun-Hee;Yang, Deok-Cho
    • Journal of Plant Biotechnology
    • /
    • v.30 no.1
    • /
    • pp.65-71
    • /
    • 2003
  • This research aims the production of anti-tumor substances through in vitro culture of hairy roots transformed by Agrobacterium rhizogenes in Artemisia sylvatica MAX and the effect of culture conditions on optimum growth of hairy roots. We investigated the optimum medium, pH, carbon source, sucrose, light, Fe and polyamine conditions of various lines of hairy roots (NK3, NK4, YX. NK3-10) induced from Artemisia sylvatica to increase the optimum growth of hairy roots. MS medium was the best for optimum growth of hairy root clone, NK3-S10. The optimum culture period was 4 weeks for NK3-S10. The optimum sucrose concentration was 3.5%. The optimum concentration of FeSO$_4$, spermine and spermidine was 0.1 mM, 10 mM and 100 mM, respectively.